Molecular and Cellular Biology, Volume 24, Issue 15 (2004)

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Molecular and Cellular Biology, Volume 24, Issue 15 (2004)

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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
Mnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development
Takeshi Ueda, Rie Watanabe-Fukunaga, Hidehiro Fukuyama, Shigekazu Nagata & Rikiro Fukunaga
Pages: 6539-6549
Published online: 27 Mar 2023
AbstractforMnk2 and Mnk1 Are Essential for Constitutive and Inducible Phosphorylation of Eukaryotic Initiation Factor 4E but Not for Cell Growth or Development | Full Text | References | PDF (425.8 KB)
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Article
Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway
Y. Jeffrey Chiang, Sahn-Ho Kim, Lino Tessarollo, Judith Campisi & Richard J. Hodes
Pages: 6631-6634
Published online: 27 Mar 2023
AbstractforTelomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway | Full Text | References | PDF (123 KB)
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Article
Gene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling
Elisabeth Sock, Stefanie D. Rettig, Janna Enderich, Michael R. Bösl, Ernst R. Tamm & Michael Wegner
Pages: 6635-6644
Published online: 27 Mar 2023
AbstractforGene Targeting Reveals a Widespread Role for the High-Mobility-Group Transcription Factor Sox11 in Tissue Remodeling | Full Text | References | PDF (1.1 MB)
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Article
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
Mirei Murakami, Tomoko Ichisaka, Mitsuyo Maeda, Noriko Oshiro, Kenta Hara, Frank Edenhofer, Hiroshi Kiyama, Kazuyoshi Yonezawa & Shinya Yamanaka
Pages: 6710-6718
Published online: 27 Mar 2023
AbstractformTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells | Full Text | References | PDF (487 KB)
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Article
Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis
Masashi Morita, Gordon Stamp, Peter Robins, Anna Dulic, Ian Rosewell, Geza Hrivnak, Graham Daly, Tomas Lindahl & Deborah E. Barnes
Pages: 6719-6727
Published online: 27 Mar 2023
AbstractforGene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis | Full Text | References | PDF (660.7 KB)
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Transcriptional Regulation

Article
The Microphthalmia Transcription Factor (Mitf) Controls Expression of the Ocular Albinism Type 1 Gene: Link between Melanin Synthesis and Melanosome Biogenesis
Francesco Vetrini, Alberto Auricchio, Jinyan Du, Barbara Angeletti, David E. Fisher, Andrea Ballabio & Valeria Marigo
Pages: 6550-6559
Published online: 27 Mar 2023
AbstractforThe Microphthalmia Transcription Factor (Mitf) Controls Expression of the Ocular Albinism Type 1 Gene: Link between Melanin Synthesis and Melanosome Biogenesis | Full Text | References | PDF (536.5 KB)
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Article
Cross Talk between Retinoic Acid Signaling and Transcription Factor GATA-2
Shinobu Tsuzuki, Kenji Kitajima, Toru Nakano, Annegret Glasow, Arthur Zelent & Tariq Enver
Pages: 6824-6836
Published online: 27 Mar 2023
AbstractforCross Talk between Retinoic Acid Signaling and Transcription Factor GATA-2 | Full Text | References | PDF (626.2 KB)
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Article
A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p
Fan Zhang, Laarni Sumibcay, Alan G. Hinnebusch & Mark J. Swanson
Pages: 6871-6886
Published online: 27 Mar 2023
AbstractforA Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p | Full Text | References | PDF (772 KB)
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Cell Growth and Development

Article
Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6
Toru Ogasawara, Hiroshi Kawaguchi, Shigeki Jinno, Kazuto Hoshi, Keiji Itaka, Tsuyoshi Takato, Kozo Nakamura & Hiroto Okayama
Pages: 6560-6568
Published online: 27 Mar 2023
AbstractforBone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6 | Full Text | References | PDF (469.1 KB)
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Article
Menin Missense Mutants Associated with Multiple Endocrine Neoplasia Type 1 Are Rapidly Degraded via the Ubiquitin-Proteasome Pathway
Hiroko Yaguchi, Naganari Ohkura, Maho Takahashi, Yuko Nagamura, Issay Kitabayashi & Toshihiko Tsukada
Pages: 6569-6580
Published online: 27 Mar 2023
AbstractforMenin Missense Mutants Associated with Multiple Endocrine Neoplasia Type 1 Are Rapidly Degraded via the Ubiquitin-Proteasome Pathway | Full Text | References | PDF (958.4 KB)
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Article
Metastasis-Associated Protein 1 Interacts with NRIF3, an Estrogen-Inducible Nuclear Receptor Coregulator
Amjad H. Talukder, Anupama Gururaj, Sandip K. Mishra, Ratna K. Vadlamudi & Rakesh Kumar
Pages: 6581-6591
Published online: 27 Mar 2023
AbstractforMetastasis-Associated Protein 1 Interacts with NRIF3, an Estrogen-Inducible Nuclear Receptor Coregulator | Full Text | References | PDF (702.2 KB)
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Article
Association of Active Caspase 8 with the Mitochondrial Membrane during Apoptosis: Potential Roles in Cleaving BAP31 and Caspase 3 and Mediating Mitochondrion-Endoplasmic Reticulum Cross Talk in Etoposide-Induced Cell Death
Dhyan Chandra, Grace Choy, Xiaodi Deng, Bobby Bhatia, Peter Daniel & Dean G. Tang
Pages: 6592-6607
Published online: 27 Mar 2023
AbstractforAssociation of Active Caspase 8 with the Mitochondrial Membrane during Apoptosis: Potential Roles in Cleaving BAP31 and Caspase 3 and Mediating Mitochondrion-Endoplasmic Reticulum Cross Talk in Etoposide-Induced Cell Death | Full Text | References | PDF (1.4 MB)
  • 49 Views
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Article
Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β
Juan M. Cárcamo, Alicia Pedraza, Oriana Bórquez-Ojeda, Bing Zhang, Roberto Sanchez & David W. Golde
Pages: 6645-6652
Published online: 27 Mar 2023
AbstractforVitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β | Full Text | References | PDF (599 KB)
  • 19 Views
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Article
Genetic Evidence for Functional Dependency of p18Ink4c on Cdk4
Xin-Hai Pei, Feng Bai, Tateki Tsutsui, Hiroaki Kiyokawa & Yue Xiong
Pages: 6653-6664
Published online: 27 Mar 2023
AbstractforGenetic Evidence for Functional Dependency of p18Ink4c on Cdk4 | Full Text | References | PDF (1.4 MB)
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Article
Nucleotide Exchange Factor ECT2 Interacts with the Polarity Protein Complex Par6/Par3/Protein Kinase Cζ (PKCζ) and Regulates PKCζ Activity
Xiu-Fen Liu, Hiroshi Ishida, Razi Raziuddin & Toru Miki
Pages: 6665-6675
Published online: 27 Mar 2023
AbstractforNucleotide Exchange Factor ECT2 Interacts with the Polarity Protein Complex Par6/Par3/Protein Kinase Cζ (PKCζ) and Regulates PKCζ Activity | Full Text | References | PDF (662.3 KB)
  • 21 Views
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Article
Drosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways
Renee D. Read, Erika A. Bach & Ross L. Cagan
Pages: 6676-6689
Published online: 27 Mar 2023
AbstractforDrosophila C-Terminal Src Kinase Negatively Regulates Organ Growth and Cell Proliferation through Inhibition of the Src, Jun N-Terminal Kinase, and STAT Pathways | Full Text | References | PDF (1.7 MB)
  • 34 Views
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Article
Rap1 Regulates the Formation of E-Cadherin-Based Cell-Cell Contacts
Catherine Hogan, Norberto Serpente, Patricia Cogram, Catherine Rose Hosking, Carl Uli Bialucha, Stephan Michael Feller, Vania M. M. Braga, Walter Birchmeier & Yasuyuki Fujita
Pages: 6690-6700
Published online: 27 Mar 2023
AbstractforRap1 Regulates the Formation of E-Cadherin-Based Cell-Cell Contacts | Full Text | References | PDF (878.5 KB)
  • 78 Views
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Article
In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation
Susan Erster, Motohiro Mihara, Roger H. Kim, Oleksi Petrenko & Ute M. Moll
Pages: 6728-6741
Published online: 27 Mar 2023
AbstractforIn Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation | Full Text | References | PDF (1.5 MB)
  • 47 Views
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Article
Dissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line
Alexei A. Aravin, Mikhail S. Klenov, Vasilii V. Vagin, Frédéric Bantignies, Giacomo Cavalli & Vladimir A. Gvozdev
Pages: 6742-6750
Published online: 27 Mar 2023
AbstractforDissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line | Full Text | References | PDF (317.2 KB)
  • 54 Views
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Article
Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase
Punya Shrivastava, Cristen Pantano, Richard Watkin, Brian McElhinney, Amy Guala, Matthew L. Poynter, Rebecca L. Persinger, Ralph Budd & Yvonne Janssen-Heininger
Pages: 6763-6772
Published online: 27 Mar 2023
AbstractforReactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase | Full Text | References | PDF (535.2 KB)
  • 14 Views
  • 46 CrossRef citations
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Article
RACK1 Regulates G1/S Progression by Suppressing Src Kinase Activity
Vidya Mamidipudi, Jian Zhang, Kelly C. Lee & Christine A. Cartwright
Pages: 6788-6798
Published online: 27 Mar 2023
AbstractforRACK1 Regulates G1/S Progression by Suppressing Src Kinase Activity | Full Text | References | PDF (599 KB)
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Article
Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane
Barak Rotblat, Ian A. Prior, Cornelia Muncke, Robert G. Parton, Yoel Kloog, Yoav I. Henis & John F. Hancock
Pages: 6799-6810
Published online: 27 Mar 2023
AbstractforThree Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane | Full Text | References | PDF (438.9 KB)
  • 21 Views
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Article
Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents
Giulio Francia, Shan Man, Beverly Teicher, Luigi Grasso & Robert S. Kerbel
Pages: 6837-6849
Published online: 27 Mar 2023
AbstractforGene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents | Full Text | References | PDF (598.5 KB)
  • 49 Views
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Nucleocytoplasmic Communication

Article
Nucleocytoplasmic Shuttling of JAZ, a New Cargo Protein for Exportin-5
Ting Chen, Amy M. Brownawell & Ian G. Macara
Pages: 6608-6619
Published online: 27 Mar 2023
AbstractforNucleocytoplasmic Shuttling of JAZ, a New Cargo Protein for Exportin-5 | Full Text | References | PDF (860.9 KB)
  • 26 Views
  • 44 CrossRef citations
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Article
Thrombopoietin Induces HOXA9 Nuclear Transport in Immature Hematopoietic Cells: Potential Mechanism by Which the Hormone Favorably Affects Hematopoietic Stem Cells
Keita Kirito, Norma Fox & Kenneth Kaushansky
Pages: 6751-6762
Published online: 27 Mar 2023
AbstractforThrombopoietin Induces HOXA9 Nuclear Transport in Immature Hematopoietic Cells: Potential Mechanism by Which the Hormone Favorably Affects Hematopoietic Stem Cells | Full Text | References | PDF (970.5 KB)
  • 17 Views
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Dna Dynamics and Chromosome Structure

Article
Functional Complementation of Human Centromere Protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae
Gerhard Wieland, Sandra Orthaus, Sabine Ohndorf, Stephan Diekmann & Peter Hemmerich
Pages: 6620-6630
Published online: 27 Mar 2023
AbstractforFunctional Complementation of Human Centromere Protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae | Full Text | References | PDF (598 KB)
  • 32 Views
  • 100 CrossRef citations
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Article
BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function
Martin F. Arlt, Bo Xu, Sandra G. Durkin, Anne M. Casper, Michael B. Kastan & Thomas W. Glover
Pages: 6701-6709
Published online: 27 Mar 2023
AbstractforBRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function | Full Text | References | PDF (461.1 KB)
  • 32 Views
  • 88 CrossRef citations
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Article
DNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated
Pallabi De, Mandy M. Peak & Karla K. Rodgers
Pages: 6850-6860
Published online: 27 Mar 2023
AbstractforDNA Cleavage Activity of the V(D)J Recombination Protein RAG1 Is Autoregulated | Full Text | References | PDF (377.3 KB)
  • 6 Views
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Gene Expression

Article
Global mRNA Stabilization Preferentially Linked to Translational Repression during the Endoplasmic Reticulum Stress Response
Tomoko Kawai, Jinshui Fan, Krystyna Mazan-Mamczarz & Myriam Gorospe
Pages: 6773-6787
Published online: 27 Mar 2023
AbstractforGlobal mRNA Stabilization Preferentially Linked to Translational Repression during the Endoplasmic Reticulum Stress Response | Full Text | References | PDF (1.1 MB)
  • 29 Views
  • 66 CrossRef citations
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Article
SMU-2 and SMU-1, Caenorhabditis elegans Homologs of Mammalian Spliceosome-Associated Proteins RED and fSAP57, Work Together To Affect Splice Site Choice
Angela K. Spartz, Robert K. Herman & Jocelyn E. Shaw
Pages: 6811-6823
Published online: 27 Mar 2023
AbstractforSMU-2 and SMU-1, Caenorhabditis elegans Homologs of Mammalian Spliceosome-Associated Proteins RED and fSAP57, Work Together To Affect Splice Site Choice | Full Text | References | PDF (436.8 KB)
  • 31 Views
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Article
La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro
Mauro Costa-Mattioli, Yuri Svitkin & Nahum Sonenberg
Pages: 6861-6870
Published online: 27 Mar 2023
AbstractforLa Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro | Full Text | References | PDF (386 KB) | Supplemental
  • 43 Views
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Errata

Correction
Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells
Page: 6887
Published online: 27 Mar 2023
CitationforFibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells | Full Text | PDF (17.7 KB)
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Free Access

Author's Correction

Correction
HuD RNA Recognition Motifs Play Distinct Roles in the Formation of a Stable Complex with AU-Rich RNA
Page: 6888
Published online: 27 Mar 2023
CitationforHuD RNA Recognition Motifs Play Distinct Roles in the Formation of a Stable Complex with AU-Rich RNA | Full Text | PDF (96.9 KB)
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Free Access
Correction
Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation
Page: 6889
Published online: 27 Mar 2023
CitationforPolypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation | Full Text | PDF (18.2 KB)
  • 88 Views
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Free Access
Correction
Potentiation of Tumor Necrosis Factor-Induced NF-κB Activation by Deacetylase Inhibitors Is Associated with a Delayed Cytoplasmic Reappearance of IκBα
Page: 6890
Published online: 27 Mar 2023
CitationforPotentiation of Tumor Necrosis Factor-Induced NF-κB Activation by Deacetylase Inhibitors Is Associated with a Delayed Cytoplasmic Reappearance of IκBα | Full Text | PDF (19.6 KB)
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