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Molecular and Cellular Biology Volume 24, 2004 - Issue 15
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis

Masashi Morita1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Gordon Stamp2 Department of Histopathology, Faculty of Medicine, Imperial College, LondonW12-0NN, United Kingdom
,
Peter Robins1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Anna Dulic1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Ian Rosewell1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Geza Hrivnak1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Graham Daly1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
,
Tomas Lindahl1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LDCorrespondence[email protected]
&
Deborah E. Barnes1 Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertfordshireEN6 3LD
 show all
Pages 6719-6727 | Received 11 Feb 2004, Accepted 01 May 2004, Published online: 27 Mar 2023

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Yang Zhao, Matthew Simon, Andrei Seluanov & Vera Gorbunova. (2022) DNA damage and repair in age-related inflammation. Nature Reviews Immunology 23:2, pages 75-89.
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K. Acevedo-Whitehouse & R. Bruno. (2023) Potential health risks of mRNA-based vaccine therapy: A hypothesis. Medical Hypotheses 171, pages 111015.
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Kevin MJ Gao, Ann Marshak-Rothstein & Katherine A Fitzgerald. (2023) Type-1 interferon-dependent and -independent mechanisms in cyclic GMP–AMP synthase–stimulator of interferon genes-driven auto-inflammation. Current Opinion in Immunology 80, pages 102280.
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Monisankar Ghosh, Suchandrima Saha, Jinyu Li, David C. Montrose & Luis A. Martinez. (2023) p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression. Molecular Cell 83:2, pages 266-280.e6.
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Jiao Ding, Yijie Dai, Jiahui Zhu, Xuemei Fan, Hao Zhang & Bo Tang. (2022) Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches. Frontiers in Molecular Neuroscience 15.
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Aditi & Peter J. McKinnon. (2022) Genome integrity and inflammation in the nervous system. DNA Repair 119, pages 103406.
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Susan MacLauchlan, Katherine A. Fitzgerald & Ellen M. Gravallese. (2022) Intracellular Sensing of DNA in Autoinflammation and Autoimmunity . Arthritis & Rheumatology 74:10, pages 1615-1624.
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Yang Yu, Jingyang Liu, Cun Liu, Ruijuan Liu, Lijuan Liu, Zhenhai Yu, Jing Zhuang & Changgang Sun. (2022) Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation. Cells 11:19, pages 3043.
Crossref
Yanick J. Crow & Daniel B. Stetson. (2021) The type I interferonopathies: 10 years on. Nature Reviews Immunology 22:8, pages 471-483.
Crossref
Roy Anindya. (2022) Cytoplasmic DNA in cancer cells: Several pathways that potentially limit DNase2 and TREX1 activities. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1869:8, pages 119278.
Crossref
Joan Manils, Laura Marruecos & Concepció Soler. (2022) Exonucleases: Degrading DNA to Deal with Genome Damage, Cell Death, Inflammation and Cancer. Cells 11:14, pages 2157.
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Giulia Amico, Wayne O. Hemphill, Mariasavina Severino, Claudio Moratti, Rosario Pascarella, Marta Bertamino, Flavia Napoli, Stefano Volpi, Francesca Rosamilia, Sara Signa, Fred Perrino, Marialuisa Zedde & Isabella Ceccherini. (2022) Genotype-Phenotype Correlation and Functional Insights for Two Monoallelic TREX1 Missense Variants Affecting the Catalytic Core. Genes 13:7, pages 1179.
Crossref
Sezer Okay. (2022) Involvement of retroelements in the autoimmune response in humans. Exploration of Medicine, pages 280-288.
Crossref
Zhiping Cao, Jessica Minnier, Lijuan Liu, Kristin L. Lyon Scott, Ashok P. Reddy, Phillip A. Wilmarth, Larry L. David, Anthony P. Barnes, Marjorie R. Grafe, Sanjiv Kaul, Nabil J. Alkayed & Catherine M. Davis. (2022) Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart. Scientific Reports 12:1.
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Nadja Schubert, Tina Schumann, Elena Daum, Karolin Flade, Yan Ge, Lara Hagedorn, Winfried Edelmann, Luise Müller, Marc Schmitz, Gunnar Kuut, Veit Hornung, Rayk Behrendt & Axel Roers. (2022) Genome Replication Is Associated With Release of Immunogenic DNA Waste. Frontiers in Immunology 13.
Crossref
Qing Wang, Juan Du, Shucheng Hua & Ke Zhao. (2022) TREX1 plays multiple roles in human diseases. Cellular Immunology 375, pages 104527.
Crossref
Anna Maria Sole Giordano, Marco Luciani, Francesca Gatto, Monah Abou Alezz, Chiara Beghè, Lucrezia Della Volpe, Alessandro Migliara, Sara Valsoni, Marco Genua, Monika Dzieciatkowska, Giacomo Frati, Julie Tahraoui-Bories, Silvia Clara Giliani, Simona Orcesi, Elisa Fazzi, Renato Ostuni, Angelo D’Alessandro, Raffaella Di Micco, Ivan Merelli, Angelo Lombardo, Martin A.M. Reijns, Natalia Gromak, Angela Gritti & Anna Kajaste-Rudnitski. (2022) DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes. Journal of Experimental Medicine 219:4.
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Debasish Halder, Su-Jin Jeon, Ji-Yong Yoon, Jeong-Ju Lee, Soo Young Jun, Min-Hyuk Choi, Bohyeon Jeong, Duk Hyun Sung, Da Yong Lee, Byoung Joon Kim & Nam-Soon Kim. (2022) TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca2+ Homeostasis. Molecular Neurobiology 59:3, pages 1398-1418.
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Taisuke Ohto, Ahmed Abu Tayeh, Ryuta Nishikomori, Hiroto Abe, Kyota Hashimoto, Shiro Baba, Anahi-Paula Arias-Loza, Nobumasa Soda, Saya Satoh, Masashi Matsuda, Yusuke Iizuka, Takashi Kondo, Haruhiko Koseki, Nan Yan, Takahiro Higuchi, Takashi Fujita & Hiroki Kato. (2022) Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis. Journal of Autoimmunity 127, pages 102794.
Crossref
Zhi-Dong Zhang & Bo Zhong. (2022) Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight 1:1, pages 100001.
Crossref
Tong Li, Seoyun Yum, Minghao Li, Xiang Chen, Xiaoxia Zuo & Zhijian J. Chen. (2022) TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance. Journal of Experimental Medicine 219:1.
Crossref
Patrick Kwabena Oduro, Xianxian Zheng, Jinna Wei, Yanze Yang, Yuefei Wang, Han Zhang, Erwei Liu, Xiumei Gao, Mei Du & Qilong Wang. (2022) The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. Acta Pharmaceutica Sinica B 12:1, pages 50-75.
Crossref
Mohamad-Gabriel Alameh & Drew Weissman. 2022. RNA Therapeutics. RNA Therapeutics 141 169 .
Demet Kivanc & Selcuk Dasdemir. (2021) The relationship between defects in DNA repair genes and autoinflammatory diseases. Rheumatology International 42:1, pages 1-13.
Crossref
Xinfeng Guo, Clayton A. Wiley, Richard A. Steinman, Yi Sheng, Beihong Ji, Junmei Wang, Liyong Zhang, Tony Wang, Mazen Zenatai, Timothy R. Billiar & Qingde Wang. (2021) Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain. Journal of Neuroinflammation 18:1.
Crossref
Aditi, Susanna M. Downing, Patrick A. Schreiner, Young Don Kwak, Yang Li, Timothy I. Shaw, Helen R. Russell & Peter J. McKinnon. (2021) Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron 109:24, pages 3962-3979.e6.
Crossref
Mirjam A Beck, Heinz Fischer, Lisa M Grabner, Tamara Groffics, Mircea Winter, Simone Tangermann, Tina Meischel, Barbara Zaussinger‐Haas, Patrick Wagner, Carina Fischer, Christina Folie, Julia Arand, Christian Schöfer, Bernard Ramsahoye, Sabine Lagger, Georg Machat, Gregor Eisenwort, Stephanie Schneider, Alexandra Podhornik, Michael Kothmayer, Ursula Reichart, Martin Glösmann, Ido Tamir, Michael Mildner, Raheleh Sheibani‐Tezerji, Lukas Kenner, Peter Petzelbauer, Gerda Egger, Maria Sibilia, Andrea Ablasser & Christian Seiser. (2021) DNA hypomethylation leads to cGAS‐induced autoinflammation in the epidermis. The EMBO Journal 40:22.
Crossref
Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krüger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush, Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schröder, Peter Rehling, Marco Henneke, Susann Boretius, A. Alia, Oliver Wirths, Andre Fischer, Christine Stadelmann, Stefan Nessler & Jutta Gärtner. (2021) Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nature Communications 12:1.
Crossref
Isabelle Couillin & Nicolas Riteau. (2021) STING Signaling and Sterile Inflammation. Frontiers in Immunology 12.
Crossref
Ryan J. Shirey, Lewis D. Turner, Luke L. Lairson & Kim D. Janda. (2021) Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen. Bioorganic & Medicinal Chemistry Letters 49, pages 128293.
Crossref
Adrian M. Baris, Eugenia Fraile-Bethencourt & Sudarshan Anand. (2021) Nucleic Acid Sensing in the Tumor Vasculature. Cancers 13:17, pages 4452.
Crossref
Audrey M. Hagiwara, Richard E. Moore, Daniel J. Wallace, Mariko Ishimori & Caroline A. Jefferies. (2021) Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosus. Rheumatology and Immunology Research 2:3, pages 173-184.
Crossref
Wanyu Bai, Guangchao Zhu, Jiejie Xu, Pingyue Chen, Feilong Meng, Hongman Xue, Chun Chen & Junchao Dong. (2021) The 3′-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Reports 36:13, pages 109756.
Crossref
Bianca B. Jütte, Calvin Krollmann, Kevin Cieslak, Ruth-Miriam Koerber, Peter Boor, Claus M. Graef, Eva Bartok, Mirko Wagner, Thomas Carell, Jennifer Landsberg, Pia Aymans, Jörg Wenzel, Peter Brossart & Lino L. Teichmann. (2021) Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. iScience 24:8, pages 102833.
Crossref
Ana Gázquez-Gutiérrez, Jeroen Witteveldt, Sara R. Heras & Sara Macias. (2021) Sensing of transposable elements by the antiviral innate immune system. RNA 27:7, pages 735-752.
Crossref
Jasmine Y. Serpen, Stephen T. Armenti & Lev Prasov. (2021) Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders. Journal of Ophthalmology 2021, pages 1-19.
Crossref
Hong Cai, Xin Liu, Feng Zhang, Qiu-Ying Han, Zhao-Shan Liu, Wen Xue, Zeng-Lin Guo, Jiang-Man Zhao, Li-Ming Sun, Na Wang, Jie Mao, Kun He, Tian Xia, Yuan Chen, Liang Chen, Ai-Ling Li, Tao Zhou, Xue-Min Zhang, Wei-Hua Li & Tao Li. (2021) G3BP1 Inhibition Alleviates Intracellular Nucleic Acid–Induced Autoimmune Responses. The Journal of Immunology 206:10, pages 2453-2467.
Crossref
Loïs Bolko, Wei Jiang, Nozomu Tawara, Océane Landon‐Cardinal, Céline Anquetil, Olivier Benveniste & Yves Allenbach. (2021) The role of interferons type I, II and III in myositis: A review. Brain Pathology 31:3.
Crossref
Qiuya Yu, Lei Chu, Yongxing Li, Quanyi Wang, Juanjuan Zhu, Chen Wang & Shufang Cui. (2021) miR-23a/b suppress cGAS-mediated innate and autoimmunity. Cellular & Molecular Immunology 18:5, pages 1235-1248.
Crossref
Lei Chu, Chenhui Li, Yongxing Li, Qiuya Yu, Huansha Yu, Chunhui Li, Wei Meng, Juanjuan Zhu, Quanyi Wang, Chen Wang & Shufang Cui. (2021) Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response. Frontiers in Immunology 12.
Crossref
Wayne O. Hemphill, Sean R. Simpson, Mingyong Liu, Freddie R. SalsburyJrJr, Thomas Hollis, Jason M. Grayson & Fred W. Perrino. (2021) TREX1 as a Novel Immunotherapeutic Target. Frontiers in Immunology 12.
Crossref
Hideo Onizawa, Hiroki Kato, Hiroyuki Kimura, Tomoo Kudo, Nobumasa Soda, Shota Shimizu, Masahide Funabiki, Yusuke Yagi, Yuji Nakamoto, Josef Priller, Ryuta Nishikomori, Toshio Heike, Nan Yan, Tohru Tsujimura, Tsuneyo Mimori & Takashi Fujita. (2021) Aicardi–Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5. International Immunology 33:4, pages 225-240.
Crossref
Pauline Santa, Anne Garreau, Lee Serpas, Amandine Ferriere, Patrick Blanco, Chetna Soni & Vanja Sisirak. (2021) The Role of Nucleases and Nucleic Acid Editing Enzymes in the Regulation of Self-Nucleic Acid Sensing. Frontiers in Immunology 12.
Crossref
Motahareh Sheikh-Hosseini, Mohammad Moarefzadeh, Hamideh Alavi-Moghaddam & Saeid Morovvati. (2020) A Novel Mutation in Aicardi–Goutières' Syndrome: A Case Report. Journal of Pediatric Neurology 19:01, pages 050-053.
Crossref
Holly A. Rutherford, Paul R. Kasher & Noémie Hamilton. (2021) Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy. Frontiers in Immunology 11.
Crossref
Justine Lagisquet, Kilian Zuber & Thomas Gramberg. (2021) Recognize Yourself—Innate Sensing of Non-LTR Retrotransposons. Viruses 13:1, pages 94.
Crossref
David Hunt. 2021. Systemic Lupus Erythematosus. Systemic Lupus Erythematosus 341 348 .
Mindy S. Lo. 2021. Systemic Lupus Erythematosus. Systemic Lupus Erythematosus 97 104 .
Dinah M. Duarte, Maria Beatriz da Silva Lima & Bruno Sepodes. (2020) The translational value of animal models in orphan medicines designations for rare paediatric neurological diseases. Regulatory Toxicology and Pharmacology 118, pages 104810.
Crossref
Ruihua Ma, Tatiana P. Ortiz Serrano, Jennifer Davis, Andrew D. Prigge & Karen M. Ridge. (2020) The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease. The FASEB Journal 34:10, pages 13156-13170.
Crossref
Sean R. Simpson, Wayne O. Hemphill, Teesha Hudson & Fred W. Perrino. (2020) TREX1 – Apex predator of cytosolic DNA metabolism. DNA Repair 94, pages 102894.
Crossref
Arthid Thim-uam, Thaneas Prabakaran, Mookmanee Tansakul, Jiradej Makjaroen, Piriya Wongkongkathep, Naphat Chantaravisoot, Thammakorn Saethang, Asada Leelahavanichkul, Thitima Benjachat, Søren R. Paludan, Trairak Pisitkun & Prapaporn Pisitkun. (2020) STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation. iScience 23:9, pages 101530.
Crossref
Yixuan Liu, Nanyang Xiao, Hekang Du, Meng Kou, Lili Lin, Min Huang, Sitong Zhang, Shan Xu, Daliang Li & Qi Chen. (2020) Celastrol ameliorates autoimmune disorders in Trex1-deficient mice. Biochemical Pharmacology 178, pages 114090.
Crossref
Eileen A. Moran & Susan R. Ross. (2020) Insights into Sensing of Murine Retroviruses. Viruses 12:8, pages 836.
Crossref
Eva Bartok & Gunther Hartmann. (2020) Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids. Immunity 53:1, pages 54-77.
Crossref
Clara Forrer Charlier & Rodrigo A. P. Martins. (2020) Protective Mechanisms Against DNA Replication Stress in the Nervous System. Genes 11:7, pages 730.
Crossref
Caroline Wiser, Byungil Kim, Jessica Vincent & Manuel Ascano. (2020) Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells. Scientific Reports 10:1.
Crossref
Si’Ana A. Coggins, Bijan Mahboubi, Raymond F. Schinazi & Baek Kim. (2020) SAMHD1 Functions and Human Diseases. Viruses 12:4, pages 382.
Crossref
Yinling Han, Lin Chen, Huiwen Liu, Zhangchu Jin, Yinfang Wu, Yanping Wu, Wen Li, Songmin Ying, Zhihua Chen, Huahao Shen & Fugui Yan. (2020) Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation. The Journal of Immunology 204:6, pages 1437-1447.
Crossref
Junzhong Lai, Xuan Luo, Shuoran Tian, Xing Zhang, Shanlu Huang, Hanze Wang, Qiumei Li, Shaoli Cai & Qi Chen. (2020) Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation. Frontiers in Pharmacology 11.
Crossref
Vladislav Pokatayev, Kun Yang, Xintao Tu, Nicole Dobbs, Jianjun Wu, Robert G. Kalb & Nan Yan. (2020) Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nature Immunology 21:2, pages 158-167.
Crossref
Sean R. Simpson, Stephen L. Rego, Scott E. Harvey, Mingyong Liu, Wayne O. Hemphill, Rajkumar Venkatadri, Rahul Sharma, Jason M. Grayson & Fred W. Perrino. (2020) T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity. The Journal of Immunology 204:2, pages 348-359.
Crossref
Ruoyu Zhou, Xiaoli Xie, Xinbo Li, Ziyi Qin, Chuanyu Wei, Jing Liu & Ying Luo. (2020) The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseases. Infection, Genetics and Evolution 77, pages 104094.
Crossref
Jürgen Arnhold. 2020. Cell and Tissue Destruction. Cell and Tissue Destruction 155 203 .
Eloisa Arbustini, Nupoor Narula, Lorenzo Giuliani & Alessandro Di Toro. 2020. Myocarditis. Myocarditis 45 89 .
Alida L. P. Caforio, Renzo Marcolongo, Anna Baritussio, Loira Leoni, Chun-Yan Cheng & Sabino Iliceto. 2020. Myocarditis. Myocarditis 195 221 .
Vassilis L. Souliotis, Nikolaos I. Vlachogiannis, Maria Pappa, Alexandra Argyriou, Panagiotis A. Ntouros & Petros P. Sfikakis. (2019) DNA Damage Response and Oxidative Stress in Systemic Autoimmunity. International Journal of Molecular Sciences 21:1, pages 55.
Crossref
Kerstin Nündel & Ann Marshak-Rothstein. (2019) The role of nucleic acid sensors and type I IFNs in patient populations and animal models of autoinflammation. Current Opinion in Immunology 61, pages 74-79.
Crossref
Sha-Sha Tao, Guo-Cui Wu, Qin Zhang, Tian-Ping Zhang, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye. (2019) TREX1 As a Potential Therapeutic Target for Autoimmune and Inflammatory Diseases. Current Pharmaceutical Design 25:30, pages 3239-3247.
Crossref
Holly A. Rutherford & Noémie Hamilton. (2019) Animal models of leukodystrophy: a new perspective for the development of therapies. The FEBS Journal 286:21, pages 4176-4191.
Crossref
Nobumasa Soda, Nobuhiro Sakai, Hiroki Kato, Masamichi Takami & Takashi Fujita. (2019) Singleton-Merten Syndrome–like Skeletal Abnormalities in Mice with Constitutively Activated MDA5. The Journal of Immunology 203:5, pages 1356-1368.
Crossref
Yuntao Xia, Charlotte R. Pfeifer, Kuangzheng Zhu, Jerome Irianto, Dazhen Liu, Kalia Pannell, Emily J. Chen, Lawrence J. Dooling, Michael P. Tobin, Mai Wang, Irena L. Ivanovska, Lucas R. Smith, Roger A. Greenberg & Dennis E. Discher. (2019) Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. Journal of Cell Biology 218:8, pages 2545-2563.
Crossref
Chetna Soni & Boris Reizis. (2019) Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects. Frontiers in Immunology 10.
Crossref
Vijay Kumar. (2019) A STING to inflammation and autoimmunity. Journal of Leukocyte Biology 106:1, pages 171-185.
Crossref
Keith B. Elkon. (2019) Aspirin meets cGAS. Nature Reviews Rheumatology 15:5, pages 254-255.
Crossref
Phillip K. West, Barney Viengkhou, Iain L. Campbell & Markus J. Hofer. (2019) Microglia responses to interleukin‐6 and type I interferons in neuroinflammatory disease. Glia.
Crossref
Anne Louise Hansen, Kojiro Mukai, Francisco J. Schopfer, Tomohiko Taguchi & Christian K. Holm. (2019) STING palmitoylation as a therapeutic target. Cellular & Molecular Immunology 16:3, pages 236-241.
Crossref
Jiang Dai, Yi-Jiao Huang, Xinhua He, Ming Zhao, Xinzheng Wang, Zhao-Shan Liu, Wen Xue, Hong Cai, Xiao-Yan Zhan, Shao-Yi Huang, Kun He, Hongxia Wang, Na Wang, Zhihong Sang, Tingting Li, Qiu-Ying Han, Jie Mao, Xinwei Diao, Nan Song, Yuan Chen, Wei-Hua Li, Jiang-Hong Man, Ai-Ling Li, Tao Zhou, Zheng-Gang Liu, Xue-Min Zhang & Tao Li. (2019) Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell 176:6, pages 1447-1460.e14.
Crossref
Bruna Prati, Walason da Silva Abjaude, Lara Termini, Mirian Morale, Suellen Herbster, Adhemar Longatto-Filho, Rafaella Almeida Lima Nunes, Lizeth Carolina Córdoba Camacho, Silvia Helena Rabelo-Santos, Luiz Carlos Zeferino, Francisco Aguayo & Enrique Boccardo. (2019) Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo. Scientific Reports 9:1.
Crossref
Zhao-Shan Liu, Hong Cai, Wen Xue, Miao Wang, Tian Xia, Wan-Jin Li, Jia-Qing Xing, Ming Zhao, Yi-Jiao Huang, Shuai Chen, Sheng-Ming Wu, Xinzheng Wang, Xin Liu, Xue Pang, Zi-Yu Zhang, Tingting Li, Jiang Dai, Fangting Dong, Qing Xia, Ai-Ling Li, Tao Zhou, Zheng-gang Liu, Xue-Min Zhang & Tao Li. (2018) G3BP1 promotes DNA binding and activation of cGAS. Nature Immunology 20:1, pages 18-28.
Crossref
Wayne O. Hemphill & Fred W. Perrino. 2019. DNA Sensors and Inflammasomes. DNA Sensors and Inflammasomes 109 133 .
Terry Medler, Jaina M. Patel, Alejandro Alice, Jason R. Baird, Hong-Ming Hu & Michael J. Gough. 2019. Nucleic Acid Sensing and Immunity, Part A. Nucleic Acid Sensing and Immunity, Part A 173 214 .
Shibani Mukherjee, Salim Abdisalaam, Souparno Bhattacharya, Kalayarasan Srinivasan, Debapriya Sinha & Aroumougame Asaithamby. 2019. DNA Repair. DNA Repair 297 324 .
Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley & Yukio Kawahara. (2018) ADAR 1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity . EMBO reports 19:12.
Crossref
Gianluca Storci, Sabrina De Carolis, Fabiola Olivieri & Massimiliano Bonafè. (2018) Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging. Seminars in Immunology 40, pages 6-16.
Crossref
Parul H. Kothari, Grant R. Kolar, Joanna C. Jen, Rula Hajj-Ali, Paula Bertram, Robert E. Schmidt & John P. Atkinson. (2018) TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia. Brain Pathology 28:6, pages 806-821.
Crossref
Jie An, Joshua J. Woodward, Weinan Lai, Mark Minie, Xizhang Sun, Lena Tanaka, Jessica M. Snyder, Tomikazu Sasaki & Keith B. Elkon. (2018) Inhibition of Cyclic GMP-AMP Synthase Using a Novel Antimalarial Drug Derivative in Trex1 -Deficient Mice . Arthritis & Rheumatology 70:11, pages 1807-1819.
Crossref
Sebastiano La Maestra, Guido Frosina, Rosanna T. Micale, Chiara D’Oria, Silvano Garibaldi, Antonio Daga, Alessandra Pulliero & Alberto Izzotti. (2018) Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. Drug Delivery and Translational Research 8:5, pages 1345-1354.
Crossref
Amanda L. Gavin, Deli Huang, Christoph Huber, Annica Mårtensson, Virginie Tardif, Patrick D. Skog, Tanya R. Blane, Therese C. Thinnes, Kent Osborn, Hayley S. Chong, Farnaz Kargaran, Phoebe Kimm, Armen Zeitjian, Rachel L. Sielski, Megan Briggs, Sebastian R. Schulz, Alessandro Zarpellon, Benjamin Cravatt, Ee Shan Pang, John Teijaro, Juan Carlos de la Torre, Meredith O’Keeffe, Hubertus Hochrein, Markus Damme, Luc Teyton, Brian R. Lawson & David Nemazee. (2018) PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nature Immunology 19:9, pages 942-953.
Crossref
Claire Vanpouille-Box, Sandra Demaria, Silvia C. Formenti & Lorenzo Galluzzi. (2018) Cytosolic DNA Sensing in Organismal Tumor Control. Cancer Cell 34:3, pages 361-378.
Crossref
Anne Louise HansenGregory J. BuchanMichael RühlKojiro MukaiSonia R. SalvatoreEmari OgawaSidsel D. AndersenMarie B. IversenAnne L. ThielkeCamilla GunderstofteMona MotwaniCharlotte T. MøllerAndreas S. JakobsenKatherine A. FitzgeraldJessica RoosRongtuan LinThorsten J. MaierRaphaela Goldbach-ManskyCathrine A. MinerWei QianJonathan J. MinerRachel E. Rigby, Jan Rehwinkel, Martin R. JakobsenHiroyuki AraiTomohiko Taguchi, Francisco J. SchopferDavid OlagnierChristian K. Holm. (2018) Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. Proceedings of the National Academy of Sciences 115:33.
Crossref
Kalpana Mujoo, Clayton R. Hunt, Raj K. Pandita, Mauro Ferrari, Sunil Krishnan, John P. Cooke, Stephen Hahn & Tej K. Pandita. (2018) Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes. Molecular Cancer Research 16:8, pages 1209-1214.
Crossref
George N. Goulielmos, Maria I. Zervou, Vassilis M. Vazgiourakis, Yogita Ghodke-Puranik, Alexandros Garyfallos & Timothy B. Niewold. (2018) The genetics and molecular pathogenesis of systemic lupus erythematosus (SLE) in populations of different ancestry. Gene 668, pages 59-72.
Crossref
Sophie Waldvogel Abramowski, Diderik Tirefort, Pierre Lau, Arthur Guichebaron, Sofiane Taleb, Christine Modoux, Coralie Lemoine Chaduc, Pascale Bruyere Cerdan, Pascale Roux Lombard, Thomas Lecompte & Olivier Preynat‐Seauve. (2018) Cell‐free nucleic acids are present in blood products and regulate genes of innate immune response. Transfusion 58:7, pages 1671-1681.
Crossref
Simone M. Haag, Muhammet F. Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F. Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt & Andrea Ablasser. (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559:7713, pages 269-273.
Crossref
Wei-Wei Luo & Hong-Bing Shu. (2018) Delicate regulation of the cGAS–MITA-mediated innate immune response. Cellular & Molecular Immunology 15:7, pages 666-675.
Crossref
Kuan-Wei Huang, Tung-Chang Liu, Ruei-Yue Liang, Lee-Ya Chu, Hiu-Lo Cheng, Jhih-Wei Chu & Yu-Yuan Hsiao. (2018) Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1. PLOS Biology 16:5, pages e2005653.
Crossref
Sunetra Sase, Asako Takanohashi, Adeline Vanderver & Akshata Almad. (2018) Astrocytes, an active player in Aicardi-Goutières syndrome. Brain Pathology 28:3, pages 399-407.
Crossref
C. Picard & A. Belot. (2018) Les interféronopathies de type I. Mise au point et revue de la littérature. La Revue de Médecine Interne 39:4, pages 271-278.
Crossref
Kareen Bartsch, Markus Damme, Tommy Regen, Lore Becker, Lillian Garrett, Sabine M Hölter, Katharina Knittler, Christopher Borowski, Ari Waisman, Markus Glatzel, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis & Björn Rabe. (2018) RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation. Frontiers in Immunology 9.
Crossref
K.S. Ramos & P. Bojang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 626 643 .
Sandra DemariaClaire Vanpouille-Box. (2017) TREX1 is a checkpoint for innate immune sensing of DNA damage that fosters cancer immune resistance. Emerging Topics in Life Sciences 1:5, pages 509-515.
Crossref
James D. Warner, Ricardo A. Irizarry-Caro, Brock G. Bennion, Teresa L. Ai, Amber M. Smith, Cathrine A. Miner, Tomomi Sakai, Vijay K. Gonugunta, Jianjun Wu, Derek J. Platt, Nan Yan & Jonathan J. Miner. (2017) STING-associated vasculopathy develops independently of IRF3 in mice. Journal of Experimental Medicine 214:11, pages 3279-3292.
Crossref
Martin Achleitner, Martin Kleefisch, Alexander Hennig, Katrin Peschke, Anastasia Polikarpova, Reinhard Oertel, Benjamin Gabriel, Livia Schulze, Dirk Lindeman, Alexander Gerbaulet, Uwe Fiebig, Min Ae Lee-Kirsch, Axel Roers & Rayk Behrendt. (2017) Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs. The Journal of Immunology 199:7, pages 2261-2269.
Crossref
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman & Manuel Ascano. (2017) Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nature Communications 8:1.
Crossref
Justin Hall, Amy Brault, Fabien Vincent, Shawn Weng, Hong Wang, Darren Dumlao, Ann Aulabaugh, Dikran Aivazian, Dana Castro, Ming Chen, Jeffrey Culp, Ken Dower, Joseph Gardner, Steven Hawrylik, Douglas Golenbock, David Hepworth, Mark Horn, Lyn Jones, Peter Jones, Eicke Latz, Jing Li, Lih-Ling Lin, Wen Lin, David Lin, Frank Lovering, Nootaree Niljanskul, Ryan Nistler, Betsy Pierce, Olga Plotnikova, Daniel Schmitt, Suman Shanker, James Smith, William Snyder, Timothy Subashi, John Trujillo, Edyta Tyminski, Guoxing Wang, Jimson Wong, Bruce Lefker, Leslie Dakin & Karen Leach. (2017) Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLOS ONE 12:9, pages e0184843.
Crossref
Joan Manils, Heinz Fischer, Joan Climent, Eduard Casas, Celia García-Martínez, Jordi Bas, Supawadee Sukseree, Tanya Vavouri, Francisco Ciruela, Josep Maria de Anta, Erwin Tschachler, Leopold Eckhart & Concepció Soler. (2017) Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses. Scientific Reports 7:1.
Crossref
Alida L.P. Caforio, Yehuda Adler, Carlo Agostini, Yannick Allanore, Aris Anastasakis, Michael Arad, Michael Böhm, Philippe Charron, Perry M. Elliott, Urs Eriksson, Stephan B. Felix, Pablo Garcia-Pavia, Eric Hachulla, Stephane Heymans, Massimo Imazio, Karin Klingel, Renzo Marcolongo, Marco Matucci Cerinic, Antonis Pantazis, Sven Plein, Valeria Poli, Angelos Rigopoulos, Petar Seferovic, Yehuda Shoenfeld, Josè L Zamorano & Ales Linhart. (2017) Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. European Heart Journal 38:35, pages 2649-2662.
Crossref
Yuki Nakaya, Jingtao Lilue, Spyridon Stavrou, Eileen A. Moran & Susan R. Ross. (2017) AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA. mBio 8:4.
Crossref
Kalliopi Stratigi, Ourania Chatzidoukaki & George A. Garinis. (2017) DNA damage-induced inflammation and nuclear architecture. Mechanisms of Ageing and Development 165, pages 17-26.
Crossref
Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L. Kovalchuk, Parul H. Kothari, Charles S. Fermaintt, John P. Atkinson, Fred W. Perrino, Nan Yan & Herbert C. MorseIIIIII. (2017) DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. Journal of Autoimmunity 81, pages 13-23.
Crossref
Peter J. McKinnon. (2017) Genome integrity and disease prevention in the nervous system. Genes & Development 31:12, pages 1180-1194.
Crossref
Tommy E. White, Alberto Brandariz-Nuñez, Alicia Martinez-Lopez, Caitlin Knowlton, Gina Lenzi, Baek Kim, Dmitri Ivanov & Felipe Diaz-Griffero. (2017) A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans. Human Mutation 38:6, pages 658-668.
Crossref
Peng Li, Juan Du, John L. Goodier, Jingwei Hou, Jian Kang, Haig H. KazazianJrJr, Ke Zhao & Xiao-Fang Yu. (2017) Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. Nucleic Acids Research 45:8, pages 4619-4631.
Crossref
Nan Yan. (2017) Immune Diseases Associated with TREX1 and STING Dysfunction. Journal of Interferon & Cytokine Research 37:5, pages 198-206.
Crossref
Birutė Tumienė, Norine Voisin, Eglė Preikšaitienė, Donatas Petroška, Jurgita Grikinienė, Rūta Samaitienė, Algirdas Utkus, Alexandre Reymond & Vaidutis Kučinskas. (2017) Inflammatory myopathy in a patient with Aicardi-Goutières syndrome. European Journal of Medical Genetics 60:3, pages 154-158.
Crossref
G. Hartmann. 2017. 121 169 .
John L. Goodier. (2016) Restricting retrotransposons: a review. Mobile DNA 7:1.
Crossref
Keren Mahlab-Guri, Ilan Asher, Shira Rosenberg-Bezalel, Daniel Elbirt, Michael Burke & Zev M. Sthoeger. (2016) Two case reports of severe myocarditis associated with the initiation of dolutegravir treatment in HIV patients. Medicine 95:47, pages e5465.
Crossref
Anine H. Stam, Parul H. Kothari, Aisha Shaikh, Andreas Gschwendter, Joanna C. Jen, Suzanne Hodgkinson, Todd A. Hardy, Michael Hayes, Peter A. Kempster, Katya E. Kotschet, Ingeborg M. Bajema, Sjoerd G. van Duinen, Marion L. C. Maat-Schieman, Paulus T. V. M. de Jong, Marc D. de Smet, Didi de Wolff-Rouendaal, Greet Dijkman, Nadine Pelzer, Grant R. Kolar, Robert E. Schmidt, JoAnne Lacey, Daniel Joseph, David R. Fintak, M. Gilbert Grand, Elizabeth M. Brunt, Helen Liapis, Rula A. Hajj-Ali, Mark C. Kruit, Mark A. van Buchem, Martin Dichgans, Rune R. Frants, Arn M. J. M. van den Maagdenberg, Joost Haan, Robert W. Baloh, John P. Atkinson, Gisela M. Terwindt & Michel D. Ferrari. (2016) Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations. Brain 139:11, pages 2909-2922.
Crossref
Pengyan Xia, Shuo Wang, Pu Gao, Guangxia Gao & Zusen Fan. (2016) DNA sensor cGAS-mediated immune recognition. Protein & Cell 7:11, pages 777-791.
Crossref
Annika Wylie, Amanda E. Jones & John M. Abrams. (2016) p53 in the game of transposons. BioEssays 38:11, pages 1111-1116.
Crossref
Katrin Peschke, Martin Achleitner, Kathrin Frenzel, Alexander Gerbaulet, Servi Remzi Ada, Nicolas Zeller, Stefan Lienenklaus, Mathias Lesche, Claire Poulet, Ronald Naumann, Andreas Dahl, Ursula Ravens, Claudia Günther, Werner Müller, Klaus-Peter Knobeloch, Marco Prinz, Axel Roers & Rayk Behrendt. (2016) Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity. The Journal of Immunology 197:6, pages 2157-2166.
Crossref
Laura E. Noges, Janice White, John C. Cambier, John W. Kappler & Philippa Marrack. (2016) Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines. The Journal of Immunology 197:4, pages 1221-1230.
Crossref
Rebecca E McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G Rust, Gabriel Balmus, Richard Mott, Jonathan Flint & David J Adams. (2016) A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 Genes|Genomes|Genetics 6:8, pages 2343-2354.
Crossref
Elizabeth E. Gray, Damion Winship, Jessica M. Snyder, Stephanie J. Child, Adam P. Geballe & Daniel B. Stetson. (2016) The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity 45:2, pages 255-266.
Crossref
Arne Klungland & Yun-Gui Yang. (2016) Endogenous DNA Damage and Repair Enzymes. Genomics, Proteomics & Bioinformatics 14:3, pages 122-125.
Crossref
Karen J Mackenzie, Paula Carroll, Laura Lettice, Žygimantė Tarnauskaitė, Kaalak Reddy, Flora Dix, Ailsa Revuelta, Erika Abbondati, Rachel E Rigby, Björn Rabe, Fiona Kilanowski, Graeme Grimes, Adeline Fluteau, Paul S Devenney, Robert E Hill, Martin AM Reijns & Andrew P Jackson. (2016) Ribonuclease H2 mutations induce a cGAS / STING ‐dependent innate immune response . The EMBO Journal 35:8, pages 831-844.
Crossref
Xing Liu & Chen Wang. (2015) The emerging roles of the STING adaptor protein in immunity and diseases . Immunology 147:3, pages 285-291.
Crossref
M J Hofer & I L Campbell. (2016) Immunoinflammatory diseases of the central nervous system - the tale of two cytokines. British Journal of Pharmacology 173:4, pages 716-728.
Crossref
Hiroshi Kobayashi, Toshio Suda & Keiyo Takubo. (2016) How hematopoietic stem/progenitors and their niche sense and respond to infectious stress. Experimental Hematology 44:2, pages 92-100.
Crossref
Masafumi Takahashi. (2016) Innate Immunity and Autoimmune Disease. Nihon Naika Gakkai Zasshi 105:4, pages 747-752.
Crossref
Cécile Picard, Anne-Laure Mathieu, Uzma Hasan, Thomas Henry, Yvan Jamilloux, Thierry Walzer & Alexandre Belot. (2015) Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases. Autoimmunity Reviews 14:12, pages 1147-1153.
Crossref
Maroof Hasan, Nicole Dobbs, Shaheen Khan, Michael A. White, Edward K. Wakeland, Quan-Zhen Li & Nan Yan. (2015) Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. The Journal of Immunology 195:10, pages 4573-4577.
Crossref
Serge M. Candéias & Isabelle Testard. (2015) The many interactions between the innate immune system and the response to radiation. Cancer Letters 368:2, pages 173-178.
Crossref
Daxing GaoTuo LiXiao-Dong LiXiang ChenQuan-Zhen LiMary Wight-Carter & Zhijian J. Chen. (2015) Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proceedings of the National Academy of Sciences 112:42.
Crossref
Sarah McGlasson, Alexa Jury, Andrew Jackson & David Hunt. (2015) Type I interferon dysregulation and neurological disease. Nature Reviews Neurology 11:9, pages 515-523.
Crossref
Tobias Junt & Winfried Barchet. (2015) Translating nucleic acid-sensing pathways into therapies. Nature Reviews Immunology 15:9, pages 529-544.
Crossref
Maroof Hasan, Charles S. Fermaintt, Ningguo Gao, Tomomi Sakai, Takuya Miyazaki, Sixin Jiang, Quan-Zhen Li, John P. Atkinson, Herbert C. MorseIIIIII, Mark A. Lehrman & Nan Yan. (2015) Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity 43:3, pages 463-474.
Crossref
Kazuhiko Nishida, Osamu Yamaguchi & Kinya Otsu. (2015) Degradation systems in heart failure. Journal of Molecular and Cellular Cardiology 84, pages 212-222.
Crossref
Søren R. Paludan. (2015) Activation and Regulation of DNA-Driven Immune Responses. Microbiology and Molecular Biology Reviews 79:2, pages 225-241.
Crossref
Jessica L. GrievesJason M. FyeScott HarveyJason M. Grayson, Thomas Hollis & Fred W. Perrino. (2015) Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proceedings of the National Academy of Sciences 112:16, pages 5117-5122.
Crossref
Eloy Cuadrado, Iliana Michailidou, Emma J. van Bodegraven, Machiel H. Jansen, Jacqueline A. Sluijs, Dirk Geerts, Pierre-Olivier Couraud, Lidia De Filippis, Angelo L. Vescovi, Taco W. Kuijpers & Elly M. Hol. (2015) Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release. The Journal of Immunology 194:8, pages 3623-3633.
Crossref
Gillian I. Rice, Mathieu P. Rodero & Yanick J. Crow. (2015) Human Disease Phenotypes Associated With Mutations in TREX1. Journal of Clinical Immunology 35:3, pages 235-243.
Crossref
Paul R. Kasher, Emma M. Jenkinson, Valérie Briolat, David Gent, Catherine Morrissey, Leo A. H. Zeef, Gillian I. Rice, Jean-Pierre Levraud & Yanick J. Crow. (2015) Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome . The Journal of Immunology 194:6, pages 2819-2825.
Crossref
Hiroyasu Konno & Glen N. Barber. (2014) The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease. Microbes and Infection 16:12, pages 998-1001.
Crossref
Jeonghyun Ahn & Glen N Barber. (2014) Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease. Current Opinion in Immunology 31, pages 121-126.
Crossref
Jeonghyun Ahn, Phillip Ruiz & Glen N. Barber. (2014) Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING. The Journal of Immunology 193:9, pages 4634-4642.
Crossref
Takuya Miyazaki, Yong-Soo Kim, Jeongheon Yoon, Hongsheng Wang, Teruhiko Suzuki & Herbert C. MorseIIIIII. (2014) The 3′–5′ DNA Exonuclease TREX1 Directly Interacts with Poly(ADP-ribose) Polymerase-1 (PARP1) during the DNA Damage Response. Journal of Biological Chemistry 289:47, pages 32548-32558.
Crossref
Yuk Yuen Lan, Diana Londoño, Richard Bouley, Michael S. Rooney & Nir Hacohen. (2014) Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy. Cell Reports 9:1, pages 180-192.
Crossref
Shivani Srivastava, Lisa K. Koch & Daniel J. Campbell. (2014) IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN–Dependent Inflammatory Disease. The Journal of Immunology 193:6, pages 2733-2742.
Crossref
Grant R. Kolar, Parul H. Kothari, Negar Khanlou, Joanna C. Jen, Robert E. Schmidt & Harry V. Vinters. (2014) Neuropathology and Genetics of Cerebroretinal Vasculopathies. Brain Pathology 24:5, pages 510-518.
Crossref
Olivier Demaria, Jeremy Di Domizio & Michel Gilliet. (2014) Immune sensing of nucleic acids in inflammatory skin diseases. Seminars in Immunopathology 36:5, pages 519-529.
Crossref
Shreeram C. NallarDhan V. Kalvakolanu. (2014) Interferons, Signal Transduction Pathways, and the Central Nervous System. Journal of Interferon & Cytokine Research 34:8, pages 559-576.
Crossref
Lihua Shi, Zhe Zhang, Angela M. Yu, Wei Wang, Zhi Wei, Ehtisham Akhter, Kelly Maurer, Patrícia Costa Reis, Li Song, Michelle Petri & Kathleen E. Sullivan. (2014) The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs. PLoS ONE 9:5, pages e93846.
Crossref
Nadine Althof, Stephanie Harkins, Christopher C. Kemball, Claudia T. Flynn, Mehrdad Alirezaei & J. Lindsay Whitton. (2014) In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease . Journal of Virology 88:9, pages 5087-5099.
Crossref
Hannah E Volkman & Daniel B Stetson. (2014) The enemy within: endogenous retroelements and autoimmune disease. Nature Immunology 15:5, pages 415-422.
Crossref
Jonathan J Miner & Michael S Diamond. (2014) MDA5 and autoimmune disease. Nature Genetics 46:5, pages 418-419.
Crossref
Katrin Peschke, Franziska Friebe, Nick Zimmermann, Tom Wahlicht, Tina Schumann, Martin Achleitner, Nicole Berndt, Hella Luksch, Rayk Behrendt, Min Ae Lee-Kirsch, Axel Roers & Claudia Günther. (2014) Deregulated Type I IFN Response in TREX1-Associated Familial Chilblain Lupus. Journal of Investigative Dermatology 134:5, pages 1456-1459.
Crossref
Anne Joutel. 2014. Cerebral Small Vessel Disease. Cerebral Small Vessel Disease 64 81 .
. 2014. Cerebral Small Vessel Disease. Cerebral Small Vessel Disease 1 116 .
Jiaxi Wu & Zhijian J. Chen. (2014) Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids. Annual Review of Immunology 32:1, pages 461-488.
Crossref
Jonathan J. Miner & Alfred H.J. Kim. (2014) Cardiac Manifestations of Systemic Lupus Erythematosus. Rheumatic Disease Clinics of North America 40:1, pages 51-60.
Crossref
Glen N. Barber. (2014) STING-dependent cytosolic DNA sensing pathways. Trends in Immunology 35:2, pages 88-93.
Crossref
Gabriel Balmus & Rebecca E McIntyre. (2014) Genetic screens in mice for genome integrity maintenance and cancer predisposition. Current Opinion in Genetics & Development 24, pages 1-7.
Crossref
Surya Pandey & Taro Kawai. 2014. Biological DNA Sensor. Biological DNA Sensor 103 132 .
Glen N. Barber. 2014. Biological DNA Sensor. Biological DNA Sensor 67 81 .
Selma Pereira-Lopes, Teja Celhar, Gloria Sans-Fons, Maria Serra, Anna-Marie Fairhurst, Jorge Lloberas & Antonio Celada. (2013) The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation. The Journal of Immunology 191:12, pages 6128-6135.
Crossref
R. Brad Jones, Haihan Song, Yang Xu, Keith E. Garrison, Anton A. Buzdin, Naveed Anwar, Diana V. Hunter, Shariq Mujib, Vesna Mihajlovic, Eric Martin, Erika Lee, Monika Kuciak, Rui André Saraiva Raposo, Ardalan Bozorgzad, Duncan A. Meiklejohn, Lishomwa C. Ndhlovu, Douglas F. Nixon & Mario A. Ostrowski. (2013) LINE-1 Retrotransposable Element DNA Accumulates in HIV-1-Infected Cells. Journal of Virology 87:24, pages 13307-13320.
Crossref
M A Lee-Kirsch, C Wolf & C Günther. (2014) Aicardi–Goutières syndrome: a model disease for systemic autoimmunity. Clinical and Experimental Immunology 175:1, pages 17-24.
Crossref
R Behrendt & A Roers. (2014) Mouse models for Aicardi–Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunity. Clinical and Experimental Immunology 175:1, pages 9-16.
Crossref
Hiroyuki Nakayama & Kinya Otsu. (2013) Translation of hemodynamic stress to sterile inflammation in the heart. Trends in Endocrinology & Metabolism 24:11, pages 546-553.
Crossref
Björn Rabe. (2013) Aicardi–Goutières syndrome: clues from the RNase H2 knock-out mouse. Journal of Molecular Medicine 91:11, pages 1235-1240.
Crossref
Clinton D. Orebaugh, Jason M. Fye, Scott Harvey, Thomas Hollis, John C. Wilkinson & Fred W. Perrino. (2013) The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination. Journal of Biological Chemistry 288:40, pages 28881-28892.
Crossref
Nadine Gehrke, Christina Mertens, Thomas Zillinger, Jörg Wenzel, Tobias Bald, Sabine Zahn, Thomas Tüting, Gunther Hartmann & Winfried Barchet. (2013) Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing. Immunity 39:3, pages 482-495.
Crossref
Swati Sathe. (2013) Migraine and Neurogenetic Disorders. Current Pain and Headache Reports 17:9.
Crossref
Rayk Behrendt, Tina Schumann, Alexander Gerbaulet, Laura A. Nguyen, Nadja Schubert, Dimitra Alexopoulou, Ursula Berka, Stefan Lienenklaus, Katrin Peschke, Kathrin Gibbert, Sabine Wittmann, Dirk Lindemann, Siegfried Weiss, Andreas Dahl, Ronald Naumann, Ulf Dittmer, Baek Kim, Werner Mueller, Thomas Gramberg & Axel Roers. (2013) Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response. Cell Reports 4:4, pages 689-696.
Crossref
Maja T. Tomicic, Dorthe Aasland, Teodora Nikolova, Bernd Kaina & Markus Christmann. (2013) Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:8, pages 1832-1843.
Crossref
Jan Rehwinkel, Jonathan Maelfait, Anne Bridgeman, Rachel Rigby, Bruce Hayward, Rachel A Liberatore, Paul D Bieniasz, Greg J Towers, Luis F Moita, Yanick J Crow, David T Bonthron & Caetano Reis e Sousa. (2013) SAMHD1-dependent retroviral control and escape in mice. The EMBO Journal 32:18, pages 2454-2462.
Crossref
Kouji Kobiyama, Nao Jounai, Taiki Aoshi, Miyuki Tozuka, Fumihiko Takeshita, Cevayir Coban & Ken Ishii. (2013) Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination. Vaccines 1:3, pages 278-292.
Crossref
Bing-Wen Soong, Yi-Chu Liao, Pang-Hsien Tu, Pei-Chien Tsai, I-Hui Lee, Chih-Ping Chung & Yi-Chung Lee. (2013) A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. Journal of the Chinese Medical Association 76:6, pages 319-324.
Crossref
Markus J. Hofer & Iain L. Campbell. (2013) Type I interferon in neurological disease—The devil from within. Cytokine & Growth Factor Reviews 24:3, pages 257-267.
Crossref
Andrea Ablasser, Carola Hertrich, Ruth Waßermann & Veit Hornung. (2013) Nucleic acid driven sterile inflammation. Clinical Immunology 147:3, pages 207-215.
Crossref
Maninjay K. Atianand & Katherine A. Fitzgerald. (2013) Molecular Basis of DNA Recognition in the Immune System. The Journal of Immunology 190:5, pages 1911-1918.
Crossref
Tomas Lindahl. (2013) My Journey to DNA Repair. Genomics, Proteomics & Bioinformatics 11:1, pages 2-7.
Crossref
Nadia Barizzone, Sara Monti, Simona Mellone, Michela Godi, Maurizio Marchini, Raffaella Scorza, Maria G. Danieli & Sandra D’Alfonso. (2013) Rare Variants in the TREX1 Gene and Susceptibility to Autoimmune Diseases . BioMed Research International 2013, pages 1-6.
Crossref
Eloy Cuadrado, Machiel H. Jansen, Jasper Anink, Lidia De Filippis, Angelo L. Vescovi, Colin Watts, Eleonora Aronica, Elly M. Hol & Taco W. Kuijpers. (2013) Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi–Goutières syndrome. Brain 136:1, pages 245-258.
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Alexandre Belot & Rolando Cimaz. (2012) Monogenic forms of systemic lupus erythematosus: new insights into SLE pathogenesis. Pediatric Rheumatology 10:1.
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Penelope A. Mason & Lynne S. Cox. (2011) The role of DNA exonucleases in protecting genome stability and their impact on ageing. AGE 34:6, pages 1317-1340.
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Hyon Ju Park & John P. Atkinson. (2012) Autoimmunity: Homeostasis of Innate Immunity Gone Awry. Journal of Clinical Immunology 32:6, pages 1148-1152.
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Paola G Bronson, Christina Chaivorapol, Ward Ortmann, Timothy W Behrens & Robert R Graham. (2012) The genetics of type I interferon in systemic lupus erythematosus. Current Opinion in Immunology 24:5, pages 530-537.
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