Advanced search
Publication Cover
Molecular and Cellular Biology Volume 24, 2004 - Issue 22
Submit an article Journal homepage
28
Views
67
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Tankyrase Polymerization Is Controlled by Its Sterile Alpha Motif and Poly(ADP-Ribose) Polymerase Domains

Manu De RyckerDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio
&
Carolyn M. PriceDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OhioCorrespondence[email protected]
Pages 9802-9812 | Received 25 Jun 2004, Accepted 28 Aug 2004, Published online: 27 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Susan J. Hsiao, Marc F. Poitras, Brandoch D. Cook, Yie Liu & Susan Smith. (2006) Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping. Molecular and Cellular Biology 26:6, pages 2044-2054.
Read now
Lowenna J. Holt & Roger J. Daly. (2005) Adapter protein connections: The MRL and Grb7 protein families. Growth Factors 23:3, pages 193-201.
Read now

Articles from other publishers (65)

Yoshinori Matsumoto & Robert Rottapel. (2023) PARsylation-mediated ubiquitylation: lessons from rare hereditary disease Cherubism. Trends in Molecular Medicine 29:5, pages 390-405.
Crossref
Jie Zhang, Yuqi Gao, Zipeng Zhang, Jinbo Zhao, Wenshuang Jia, Chengcai Xia, Fugang Wang & Tingting Liu. (2022) Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. Journal of Medicinal Chemistry 65:24, pages 16099-16127.
Crossref
Nisha Pillay, Laura Mariotti, Mariola Zaleska, Oviya Inian, Matthew Jessop, Sam Hibbs, Ambroise Desfosses, Paul C. R. Hopkins, Catherine M. Templeton, Fabienne Beuron, Edward P. Morris & Sebastian Guettler. (2022) Structural basis of tankyrase activation by polymerization. Nature 612:7938, pages 162-169.
Crossref
Sven T. Sowa, Chiara Bosetti, Albert Galera-Prat, Mark S. Johnson & Lari Lehtiö. (2022) An Evolutionary Perspective on the Origin, Conservation and Binding Partner Acquisition of Tankyrases. Biomolecules 12:11, pages 1688.
Crossref
Ping Li, Yushuang Lei, Jia Qi, Wanqin Liu & Kai Yao. (2022) Functional roles of ADP-ribosylation writers, readers and erasers. Frontiers in Cell and Developmental Biology 10.
Crossref
Mingfeng Yu, Yuchao Yang, Matthew Sykes & Shudong Wang. (2022) Small-Molecule Inhibitors of Tankyrases as Prospective Therapeutics for Cancer. Journal of Medicinal Chemistry 65:7, pages 5244-5273.
Crossref
Daniela Muoio, Natalie Laspata & Elise Fouquerel. (2022) Functions of ADP-ribose transferases in the maintenance of telomere integrity. Cellular and Molecular Life Sciences 79:4.
Crossref
Masato Mashimo, Momoko Kita, Arina Uno, Moe Nii, Moe Ishihara, Takuya Honda, Yuka Gotoh-Kinoshita, Atsuo Nomura, Hiroyuki Nakamura, Toshihiko Murayama, Ryoichi Kizu & Takeshi Fujii. (2022) Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of β-Catenin Signaling. International Journal of Molecular Sciences 23:5, pages 2834.
Crossref
Sven T. Sowa & Lari Lehtiö. (2022) The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain. Open Biology 12:3.
Crossref
Felix O. Okunlola, Oluwole B. Akawa, Temitayo I. Subair, Kehinde F. Omolabi & Mahmoud E. S. Soliman. (2021) Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach. Cell Biochemistry and Biophysics 80:1, pages 1-10.
Crossref
Esteban Zamudio-Martinez, Ana Belén Herrera-Campos, Alberto Muñoz, José Manuel Rodríguez-Vargas & F. Javier Oliver. (2021) Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Gleb Simanov, Irene Dang, Artem I. Fokin, Ksenia Oguievetskaia, Valérie Campanacci, Jacqueline Cherfils & Alexis M. Gautreau. (2021) Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex. International Journal of Molecular Sciences 22:8, pages 4115.
Crossref
Daniel Harrision, Polly Gravells, Ruth Thompson & Helen E. Bryant. (2020) Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy. Frontiers in Molecular Biosciences 7.
Crossref
Kameron Azarm & Susan Smith. (2020) Nuclear PARPs and genome integrity. Genes & Development 34:5-6, pages 285-301.
Crossref
Xylia Q. Peters, Thembeka H. Malinga, Clement Agoni, Fisayo A. Olotu & Mahmoud E.S. Soliman. (2020) Zoning in on Tankyrases: A Brief Review on the Past, Present and Prospective Studies. Anti-Cancer Agents in Medicinal Chemistry 19:16, pages 1920-1934.
Crossref
Leeanne McGurk, Olivia Rifai & Nancy M. Bonini. (2020) TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2. Journal of Cell Science.
Crossref
Travis Eisemann & John M. Pascal. (2019) Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity. Cellular and Molecular Life Sciences 77:1, pages 19-33.
Crossref
Katie Pollock, Manjuan Liu, Mariola Zaleska, Mirco Meniconi, Mark Pfuhl, Ian Collins & Sebastian Guettler. (2019) Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase. Scientific Reports 9:1.
Crossref
Travis Eisemann, Marie-France Langelier & John M. Pascal. (2019) Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase. Journal of Biological Chemistry 294:40, pages 14574-14590.
Crossref
Mariola Zaleska, Katie Pollock, Ian Collins, Sebastian Guettler & Mark Pfuhl. (2019) Solution NMR assignment of the ARC4 domain of human tankyrase 2. Biomolecular NMR Assignments 13:1, pages 255-260.
Crossref
Duo Zheng, Wangqing Xie, Li Li, Wenqi Jiang, Yongdong Zou, Chengyao Chiang, Genze Shao & Kaowen Yan. (2019) RXXPEG motif of MERIT40 is required to maintain spindle structure and function through its interaction with Tankyrase1. Cell Biology International 43:2, pages 174-181.
Crossref
Marie-France Langelier, Travis Eisemann, Amanda A Riccio & John M Pascal. (2018) PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification. Current Opinion in Structural Biology 53, pages 187-198.
Crossref
Mi Kim. (2018) Novel insight into the function of tankyrase (Review). Oncology Letters.
Crossref
Chen Fan, Nageswari Yarravarapu, Hua Chen, Ozlem Kulak, Pranathi Dasari, Jeremiah Herbert, Kiyoshi Yamaguchi, Lawrence Lum & Xuewu Zhang. (2018) Regulation of tankyrase activity by a catalytic domain dimer interface. Biochemical and Biophysical Research Communications 503:3, pages 1780-1785.
Crossref
Paul A. DaRosa, Rachel E. Klevit & Wenqing Xu. (2018) S tructural basis for tankyrase‐RNF146 interaction reveals noncanonical tankyrase‐binding motifs . Protein Science 27:6, pages 1057-1067.
Crossref
Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide & Susan Smith. (2017) Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation. Nature Communications 8:1.
Crossref
Laura Mariotti, Katie Pollock & Sebastian Guettler. (2017) Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding. British Journal of Pharmacology 174:24, pages 4611-4636.
Crossref
Tor Espen Thorvaldsen. (2017) Targeting Tankyrase to Fight WNT-dependent Tumours. Basic & Clinical Pharmacology & Toxicology 121:2, pages 81-88.
Crossref
Daichao Xu, Jianping Liu, Tao Fu, Bing Shan, Lihui Qian, Lifeng Pan & Junying Yuan. (2017) USP25 regulates Wnt signaling by controlling the stability of tankyrases. Genes & Development 31:10, pages 1024-1035.
Crossref
Lu Yang, Luxi Sun, Yaqun Teng, Hao Chen, Ying Gao, Arthur S. Levine, Satoshi Nakajima & Li Lan. (2017) Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage. Nucleic Acids Research 45:7, pages 3906-3921.
Crossref
Travis Eisemann, Michael McCauley, Marie-France Langelier, Kushol Gupta, Swati Roy, Gregory D. Van Duyne & John M. Pascal. (2016) Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure 24:10, pages 1679-1692.
Crossref
Amanda A. Riccio, Michael McCauley, Marie-France Langelier & John M. Pascal. (2016) Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling. Structure 24:9, pages 1573-1581.
Crossref
Paul A. DaRosa, Sergey Ovchinnikov, Wenqing Xu & Rachel E. Klevit. (2016) Structural insights into SAM domain-mediated tankyrase oligomerization. Protein Science 25:9, pages 1744-1752.
Crossref
Nina Marie Pedersen, Tor Espen Thorvaldsen, Sebastian Wolfgang Schultz, Eva Maria Wenzel & Harald Stenmark. (2016) Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity. PLOS ONE 11:8, pages e0160507.
Crossref
Laura Mariotti, Catherine M. Templeton, Michael Ranes, Patricia Paracuellos, Nora Cronin, Fabienne Beuron, Edward Morris & Sebastian Guettler. (2016) Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling. Molecular Cell 63:3, pages 498-513.
Crossref
Estefania Martino-Echarri, Mariana G. Brocardo, Kate M. Mills & Beric R. Henderson. (2016) Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta. PLOS ONE 11:3, pages e0150484.
Crossref
Linlin Zhong, Yun Ding, Gautam Bandyopadhyay, Jo Waaler, Emma Börgeson, Susan Smith, Mingchen Zhang, Susan A. Phillips, Sepi Mahooti, Sushil K. Mahata, Jianhua Shao, Stefan Krauss & Nai-Wen Chi. (2015) The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia 59:3, pages 582-591.
Crossref
Tor Espen Thorvaldsen, Nina Marie Pedersen, Eva M. Wenzel, Sebastian W. Schultz, Andreas Brech, Knut Liestøl, Jo Waaler, Stefan Krauss & Harald Stenmark. (2015) Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes. Molecular Cancer Research 13:11, pages 1487-1501.
Crossref
Susan Smith. 2015. PARP Inhibitors for Cancer Therapy. PARP Inhibitors for Cancer Therapy 79 97 .
XIAOHONG TIAN, WEIJIAN HOU, SHULING BAI, JUN FAN, HAO TONG & YU BAI. (2014) XAV939 promotes apoptosis in a neuroblastoma cell line via telomere shortening. Oncology Reports 32:5, pages 1999-2006.
Crossref
Mariann Bienz. (2014) Signalosome assembly by domains undergoing dynamic head-to-tail polymerization. Trends in Biochemical Sciences 39:10, pages 487-495.
Crossref
Andreas M. Grabrucker. (2013) A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders. Developmental Neurobiology 74:2, pages 136-146.
Crossref
Teemu Haikarainen, Mohit Narwal, Päivi Joensuu & Lari Lehtiö. (2013) Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Medicinal Chemistry Letters 5:1, pages 18-22.
Crossref
Tobias Karlberg, Marie-France Langelier, John M. Pascal & Herwig Schüler. (2013) Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Molecular Aspects of Medicine 34:6, pages 1088-1108.
Crossref
Lari Lehtiö, Nai-Wen Chi & Stefan Krauss. (2013) Tankyrases as drug targets. FEBS Journal 280:15, pages 3576-3593.
Crossref
Andrew Voronkov, Daniel D. Holsworth, Jo Waaler, Steven R. Wilson, Bie Ekblad, Harmonie Perdreau-Dahl, Huyen Dinh, Gerard Drewes, Carsten Hopf, Jens P. Morth & Stefan Krauss. (2013) Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor. Journal of Medicinal Chemistry 56:7, pages 3012-3023.
Crossref
Seamus MorroneZhihong ChengRandall T. Moon, Feng Cong & Wenqing Xu. (2012) Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proceedings of the National Academy of Sciences 109:5, pages 1500-1505.
Crossref
Mary Jane Knight, Catherine Leettola, Mari Gingery, Hao Li & James U. Bowie. (2011) A human sterile alpha motif domain polymerizome. Protein Science 20:10, pages 1697-1706.
Crossref
Marinella G. Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N. Sandoval, Peter S. Liu, Sheila Bheddah, Janet Tao, Jennie R. Lill, Jo-Anne Hongo, David Davis, Donald S. Kirkpatrick, Paul Polakis & Mike Costa. (2011) Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling. PLoS ONE 6:7, pages e22595.
Crossref
Natalie N. Sidorova, Svetlana Yu. Kurchashova, Tural Ya. Yarahmedov, Rustam H. Ziganshin & Alexander N. Kuimov. (2011) Poly(ADP-ribosyl)ation of mannose-binding lectin out of human kidney cells. Molecular and Cellular Biochemistry 352:1-2, pages 231-238.
Crossref
Kaori Hatsugai, Tomokazu Ohishi, Yoshikazu Sugimoto & Hiroyuki Seimiya. (2010) Tankyrase-1 assembly to large protein complexes blocks its telomeric function. FEBS Letters 584:18, pages 3885-3890.
Crossref
Chong Li, Tan Li & Zhong-li Zhan. (2010) Experimental research of tankyrase 1 antisense oligodeoxynucleotides on the proliferation of lung cancer cell nodules. Clinical Oncology and Cancer Research 7:3, pages 181-186.
Crossref
Charles White, Steve N. Gagnon, Jean-François St-Laurent, Catherine Gravel, Léa-Isabelle Proulx & Serge Desnoyers. (2008) The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes. Molecular and Cellular Biochemistry 324:1-2, pages 73-83.
Crossref
Yuriy V. Shebzukhov, Inna N. Lavrik, Julia Karbach, Svetlana V. Khlgatian, Ekaterina P. Koroleva, Pavel V. Belousov, Kirill N. Kashkin, Alexander Knuth, Elke Jager, Nai-Wen Chi, Dmitry V. Kuprash & Sergei A. Nedospasov. (2007) Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. Cancer Immunology, Immunotherapy 57:6, pages 871-881.
Crossref
Lari Lehtiö, Ruairi Collins, Susanne van den Berg, Andreas Johansson, Lars-Göran Dahlgren, Martin Hammarström, Thomas Helleday, Lovisa Holmberg-Schiavone, Tobias Karlberg & Johan Weigelt. (2008) Zinc Binding Catalytic Domain of Human Tankyrase 1. Journal of Molecular Biology 379:1, pages 136-145.
Crossref
N. N. Sidorova, A. O. Fadeev & A. N. Kuimov. (2011) Isolation and physicochemical properties of tankyrase of human embryonic kidney cells of line 293. Biochemistry (Moscow) 73:3, pages 289-295.
Crossref
Yukiko Muramatsu, Hidetoshi Tahara, Taeko Ono, Takashi Tsuruo & Hiroyuki Seimiya. (2008) Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation. Experimental Cell Research 314:5, pages 1115-1124.
Crossref
Susan J. Hsiao & Susan Smith. (2008) Tankyrase function at telomeres, spindle poles, and beyond. Biochimie 90:1, pages 83-92.
Crossref
Yukiko Muramatsu, Tomokazu Ohishi, Michiko Sakamoto, Takashi Tsuruo & Hiroyuki Seimiya. (2007) Cross-species difference in telomeric function of tankyrase 1. Cancer Science 98:6, pages 850-857.
Crossref
Tomokazu Ohishi, Takashi Tsuruo & Hiroyuki Seimiya. 2007. Telomerase Inhibition. Telomerase Inhibition 133 146 .
Tsung-Yin J. YehTobias N. Meyer, Catherine Schwesinger, Zhi-Yang TsunRay M. LeeNai-Wen Chi. (2006) Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell–cell contact and protein poly(ADP-ribosyl)ation. Biochemical Journal 399:3, pages 415-425.
Crossref
Eckart D. Gundelfinger, Tobias M. Boeckers, Marisa K. Baron & James U. Bowie. (2006) A role for zinc in postsynaptic density asSAMbly and plasticity?. Trends in Biochemical Sciences 31:7, pages 366-373.
Crossref
H Seimiya. (2006) The telomeric PARP, tankyrases, as targets for cancer therapy. British Journal of Cancer 94:3, pages 341-345.
Crossref
William ChangJasmin N. DynekSusan Smith. (2005) NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochemical Journal 391:2, pages 177-184.
Crossref
Shiao Li Oei, Claudia Keil & Mathias Ziegler. (2005) Poly(ADP-ribosylation) and genomic stability. Biochemistry and Cell Biology 83:3, pages 263-269.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.