Advanced search
Publication Cover
Molecular and Cellular Biology Volume 24, 2004 - Issue 23
Submit an article Journal homepage
16
Views
73
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways

Angelique Whitehurst1 Department of Pharmacology
,
Melanie H. Cobb1 Department of PharmacologyCorrespondence[email protected] [email protected]
&
Michael A. White2 Cell Biology, UT Southwestern Medical Center, Dallas, TexasCorrespondence[email protected] [email protected]
Pages 10145-10150 | Received 30 Mar 2004, Accepted 02 Sep 2004, Published online: 27 Mar 2023

Citations (73)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Yanshuang Wang, Su Luo, Dafang Zhang, Xiaobo Qu & Yinfeng Tan. (2017) Sika pilose antler type I collagen promotes BMSC differentiation via the ERK1/2 and p38-MAPK signal pathways. Pharmaceutical Biology 55:1, pages 2196-2204.
Read now
Sam Jacob, Yong Zhu, Sven Asmussen, Hiroshi Ito, David N. Herndon, Perenlei Enkhbaatar, Hal K. Hawkins & Robert A. Cox. (2014) Tiotropium bromide suppresses smoke inhalation and burn injury-induced ERK 1/2 and SMAD 2/3 signaling in sheep bronchial submucosal glands. Toxicology Mechanisms and Methods 24:4, pages 250-258.
Read now
Jeffrey P. MacKeigan, Leon O. Murphy, Christopher A. Dimitri & John Blenis. (2005) Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells. Molecular and Cellular Biology 25:11, pages 4676-4682.
Read now

Articles from other publishers (70)

Franck Talmont, Elodie Mitri, Christine Dozier, Arnaud Besson, Olivier Cuvillier & Anastassia Hatzoglou. (2022) Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts. Cancers 14:7, pages 1661.
Crossref
Neetu Saini & Apurva Sarin. (2021) Spatial regulation and generation of diversity in signaling pathways. Journal of Biosciences 46:1.
Crossref
Zheng Bao, Xue Wang, Yuhong Li & Fumin Feng. (2020) Vitamin D Alleviates Cognitive Dysfunction by Activating the VDR/ERK1/2 Signaling Pathway in an Alzheimer’s Disease Mouse Model. Neuroimmunomodulation 27:4, pages 178-185.
Crossref
Aaron Vazquez-Jimenez & Jesus Rodriguez-Gonzalez. (2019) On Information Extraction and Decoding Mechanisms Improved by Noisy Amplification in Signaling Pathways. Scientific Reports 9:1.
Crossref
Taylor M. Courtney & Alexander Deiters. (2019) Optical control of protein phosphatase function. Nature Communications 10:1.
Crossref
Harry Nunns & Lea Goentoro. (2018) Signaling pathways as linear transmitters. eLife 7.
Crossref
Jean Bigeard & Heribert Hirt. (2018) Nuclear Signaling of Plant MAPKs. Frontiers in Plant Science 9.
Crossref
Bhaswar Ghosh, Uddipan Sarma, Victor Sourjik & Stefan Legewie. (2018) Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades. Biophysical Journal 114:1, pages 223-236.
Crossref
Yuki Shindo, Kazunari Iwamoto, Kazunari Mouri, Kayo Hibino, Masaru Tomita, Hidetaka Kosako, Yasushi Sako & Koichi Takahashi. (2016) Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling. Nature Communications 7:1.
Crossref
Yuki SHINDO, Hidetaka KOSAKO, Yasushi SAKO & Koichi TAKAHASHI. (2016) Analog-to-digital Conversion in the Cellular Signaling System. Seibutsu Butsuri 56:6, pages 334-336.
Crossref
Bomyi Lim, Carmeline J. Dsilva, Thomas J. Levario, Hang Lu, Trudi Schüpbach, Ioannis G. Kevrekidis & Stanislav Y. Shvartsman. (2015) Dynamics of Inductive ERK Signaling in the Drosophila Embryo. Current Biology 25:13, pages 1784-1790.
Crossref
Alexander T. Piala, John M. Humphreys & Elizabeth J. Goldsmith. (2014) MAP Kinase Modules: The Excursion Model and the Steps that Count. Biophysical Journal 107:9, pages 2006-2015.
Crossref
Ruth Nussinov & Chung-Jung Tsai. (2014) Free Energy Diagrams for Protein Function. Chemistry & Biology 21:3, pages 311-318.
Crossref
John M. Humphreys, Alexander T. Piala, Radha Akella, Haixia He & Elizabeth J. Goldsmith. (2013) Precisely Ordered Phosphorylation Reactions in the p38 Mitogen-activated Protein (MAP) Kinase Cascade. Journal of Biological Chemistry 288:32, pages 23322-23330.
Crossref
Bomyi LimNúria SamperHang LuChristine Rushlow, Gerardo Jiménez & Stanislav Y. Shvartsman. (2013) Kinetics of gene derepression by ERK signaling. Proceedings of the National Academy of Sciences 110:25, pages 10330-10335.
Crossref
Sang-Ryul Lee, Jennifer A. Rutan, Andrew J. Monteith, Shannon Z. Jones, Sun Ah Kang, Kristen N. Krum, Michelle A. Kilmon, Jose R. Roques, Nikki J. Wagner, Stephen H. Clarke & Barbara J. Vilen. (2012) Receptor Cross-Talk Spatially Restricts p-ERK during TLR4 Stimulation of Autoreactive B Cells. The Journal of Immunology 189:8, pages 3859-3868.
Crossref
Christopher J. Caunt, Rebecca M. Perett, Robert C. Fowkes & Craig A. McArdle. (2012) Mechanisms of GnRH-Induced Extracellular Signal-Regulated Kinase Nuclear Localization. PLoS ONE 7:7, pages e40077.
Crossref
Christopher J. CauntCraig A. McArdle. (2012) ERK phosphorylation and nuclear accumulation: insights from single-cell imaging. Biochemical Society Transactions 40:1, pages 224-229.
Crossref
Ping Liu, Ioannis G. Kevrekidis & Stanislav Y. Shvartsman. (2011) Substrate-Dependent Control of ERK Phosphorylation Can Lead to Oscillations. Biophysical Journal 101:11, pages 2572-2581.
Crossref
Kazuhiro Aoki, Masashi Yamada, Katsuyuki Kunida, Shuhei YasudaMichiyuki Matsuda. (2011) Processive phosphorylation of ERK MAP kinase in mammalian cells. Proceedings of the National Academy of Sciences 108:31, pages 12675-12680.
Crossref
A. M. Bersani, E. Bersani & L. Mastroeni. (2010) Modeling the action of drugs on cellular enzymes by means of optimal control techniques. Journal of Mathematical Chemistry 49:3, pages 776-795.
Crossref
Ellen C. O'Shaughnessy, Santhosh Palani, James J. Collins & Casim A. Sarkar. (2011) Tunable Signal Processing in Synthetic MAP Kinase Cascades. Cell 144:1, pages 119-131.
Crossref
Oliver E. SturmRichard OrtonJoan GrindlayMarc BirtwistleVladislav VyshemirskyDavid GilbertMuffy CalderAndrew PittBoris KholodenkoWalter Kolch. (2010) The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier. Science Signaling 3:153.
Crossref
Christopher J. Caunt & Craig A. McArdle. (2010) Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. Journal of Cell Science 123:24, pages 4310-4320.
Crossref
Stephen P. Armstrong, Christopher J. Caunt, Robert C. Fowkes, Krasimira Tsaneva-Atanasova & Craig A. McArdle. (2010) Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling. Journal of Biological Chemistry 285:32, pages 24360-24371.
Crossref
Matthew FosbrinkNwe-Nwe Aye-HanRaymond Cheong, Andre Levchenko & Jin Zhang. (2010) Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proceedings of the National Academy of Sciences 107:12, pages 5459-5464.
Crossref
Elizabeth R. Smith, Kathy Qi Cai, Jennifer L. Smedberg, Melina M. Ribeiro, Malgorzata E. Rula, Carolyn Slater, Andrew K. Godwin & Xiang-Xi Xu. (2010) Nuclear Entry of Activated MAPK Is Restricted in Primary Ovarian and Mammary Epithelial Cells. PLoS ONE 5:2, pages e9295.
Crossref
Xing Yin, Lian Hu, Hao Feng, Lazar Z. Krsmanovic & Kevin J. Catt. (2010) Mechanisms of angiotensin II-induced ERK1/2 activation in fetal cardiomyocytes. Hormone Molecular Biology and Clinical Investigation 2:3.
Crossref
Diane S. Lidke, Fang Huang, Janine N. Post, Bernd Rieger, Julie Wilsbacher, James L. Thomas, Jacques Pouysségur, Thomas M. Jovin & Philippe Lenormand. (2010) ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation. Journal of Biological Chemistry 285:5, pages 3092-3102.
Crossref
Arif Jivan, Aarati Ranganathan & Melanie H. Cobb. 2010. MAP Kinase Signaling Protocols. MAP Kinase Signaling Protocols 273 285 .
Christopher P. Gayer, David H. Craig, Thomas L. Flanigan, Thomas D. Reed, Dean E. Cress & Marc D. Basson. (2010) ERK regulates strain-induced migration and proliferation from different subcellular locations. Journal of Cellular Biochemistry, pages n/a-n/a.
Crossref
Hyun-Jeong Eom & Jinhee Choi. (2009) Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicology in Vitro 23:7, pages 1326-1332.
Crossref
Annayya R. Aroor, Youn Ju Lee & Shivendra D. Shukla. (2009) Activation of MEK 1/2 and p42/44 MAPK by angiotensin II in hepatocyte nucleus and their potentiation by ethanol. Alcohol 43:4, pages 315-322.
Crossref
Sharon A. Matheny & Michael A. White. (2009) Signaling Threshold Regulation by the Ras Effector IMP. Journal of Biological Chemistry 284:17, pages 11007-11011.
Crossref
Alexander M. Berezhkovskii, Mathieu Coppey & Stanislav Y. Shvartsman. (2009) Signaling gradients in cascades of two-state reaction-diffusion systems. Proceedings of the National Academy of Sciences 106:4, pages 1087-1092.
Crossref
Giselle M. Knudsen, Brandon M. Davis, Shirshendu K. Deb, Yvette Loethen, Ravindra Gudihal, Pradeep Perera, Dor Ben-Amotz & V. Jo Davisson. (2008) Quantification of Isotope Encoded Proteins in 2-D Gels Using Surface Enhanced Resonance Raman. Bioconjugate Chemistry 19:11, pages 2212-2220.
Crossref
Satoe Takahashi & Peter M. Pryciak. (2008) Membrane Localization of Scaffold Proteins Promotes Graded Signaling in the Yeast MAP Kinase Cascade. Current Biology 18:16, pages 1184-1191.
Crossref
V. KAPETANIOS, A. C. LAZARIS, P. BOGRIS, S. KOUNELI, A. NONNI, H. ARVANITI, E. KOURI, M. TZAVARA, G. GIANNAKODIMOS, H. KOUTSELINI & E. S. PATSOURIS. (2008) Extracellular regulated kinase-2 immunoreactivity increases in parallel with cervical intraepithelial neoplasia grade in cervical neoplasia. International Journal of Gynecologic Cancer 18:3, pages 540-545.
Crossref
Chiyuan Chen, Robert E. Lewis & Michael A. White. (2008) IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds. Journal of Biological Chemistry 283:19, pages 12789-12796.
Crossref
Michael C Lawrence, Arif Jivan, Chunli Shao, Lingling Duan, Daryl Goad, Elma Zaganjor, Jihan Osborne, Kathleen McGlynn, Steve Stippec, Svetlana Earnest, Wei Chen & Melanie H Cobb. (2008) The roles of MAPKs in disease. Cell Research 18:4, pages 436-442.
Crossref
Christopher J. Caunt, Caroline A. Rivers, Becky L. Conway-Campbell, Michael R. Norman & Craig A. McArdle. (2008) Epidermal Growth Factor Receptor and Protein Kinase C Signaling to ERK2. Journal of Biological Chemistry 283:10, pages 6241-6252.
Crossref
Cherry Ballard-Croft, Adam C. Locklar, Byron J. Keith, Robert M. MentzerJrJr & Robert D. Lasley. (2008) Oxidative stress and adenosine A 1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs . American Journal of Physiology-Heart and Circulatory Physiology 294:1, pages H263-H271.
Crossref
Ernest Blackwell, Hye-Jin N Kim & David E Stone. (2007) The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biology 8:1.
Crossref
Youn Ju Lee & Shivendra D. Shukla. (2007) Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde⁎. European Journal of Pharmacology 573:1-3, pages 29-38.
Crossref
Stefan Legewie, Birgit Schoeberl, Nils Blüthgen & Hanspeter Herzel. (2007) Competing Docking Interactions can Bring About Bistability in the MAPK Cascade. Biophysical Journal 93:7, pages 2279-2288.
Crossref
Mustafa N. Yazicioglu, Daryl L. Goad, Aarati Ranganathan, Angelique W. Whitehurst, Elizabeth J. Goldsmith & Melanie H. Cobb. (2007) Mutations in ERK2 Binding Sites Affect Nuclear Entry. Journal of Biological Chemistry 282:39, pages 28759-28767.
Crossref
Tianhai Tian, Angus Harding, Kerry Inder, Sarah Plowman, Robert G. Parton & John F. Hancock. (2007) Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nature Cell Biology 9:8, pages 905-914.
Crossref
Menachem Katz, Ido Amit & Yosef Yarden. (2007) Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1161-1176.
Crossref
James Sinnett-Smith, Elena Zhukova, Osvaldo Rey & Enrique Rozengurt. (2007) Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cells. Journal of Cellular Physiology 211:3, pages 781-790.
Crossref
Hannes L. Ebner, Michael Blatzer, Muhammad Nawaz & Gerhard Krumschnabel. (2007) Activation and nuclear translocation of ERK in response to ligand-dependent and -independent stimuli in liver and gill cells from rainbow trout. Journal of Experimental Biology 210:6, pages 1036-1045.
Crossref
Feng Shi, Yi-Jen Chiu, Youngsun Cho, Tara A. Bullard, Masahiro Sokabe & Keigi Fujiwara. (2007) Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch. Cardiovascular Research 73:4, pages 813-822.
Crossref
Boris N. Kholodenko. 2007. Introduction to Systems Biology. Introduction to Systems Biology 300 318 .
Diane Palmieri, Amina Bouadis, Ruban Ronchetti, Maria J. Merino & Patricia S. Steeg. (2006) Rab11a Differentially Modulates Epidermal Growth Factor-induced Proliferation and Motility in Immortal Breast Cells. Breast Cancer Research and Treatment 100:2, pages 127-137.
Crossref
Frederique Ruf, Myung-June Park, Fernand Hayot, Gang Lin, Badrinath Roysam, Yongchao Ge & Stuart C. Sealfon. (2006) Mixed Analog/Digital Gonadotrope Biosynthetic Response to Gonadotropin-releasing Hormone. Journal of Biological Chemistry 281:41, pages 30967-30978.
Crossref
Kazuhiro Ishiguro, Joe Avruch, Aimee Landry, Shan Qin, Takafumi Ando, Hidemi Goto & Ramnik Xavier. (2006) Nore1B regulates TCR signaling via Ras and Carma1. Cellular Signalling 18:10, pages 1647-1654.
Crossref
Sarantis Polychronopoulos, Mihalis Verykokakis, Mustafa N. Yazicioglu, Maria Sakarellos-Daitsiotis, Melanie H. Cobb & George Mavrothalassitis. (2006) The Transcriptional ETS2 Repressor Factor Associates with Active and Inactive Erks through Distinct FXF Motifs. Journal of Biological Chemistry 281:35, pages 25601-25611.
Crossref
Cherry Ballard-Croft, Adam C. Locklar, Gentian Kristo & Robert D. Lasley. (2006) Regional myocardial ischemia-induced activation of MAPKs is associated with subcellular redistribution of caveolin and cholesterol. American Journal of Physiology-Heart and Circulatory Physiology 291:2, pages H658-H667.
Crossref
Vivek K. Mutalik & K.V. Venkatesh. (2006) Effect of the MAPK cascade structure, nuclear translocation and regulation of transcription factors on gene expression. Biosystems 85:2, pages 144-157.
Crossref
Aarati Ranganathan, Mustafa N. Yazicioglu & Melanie H. Cobb. (2006) The Nuclear Localization of ERK2 Occurs by Mechanisms Both Independent of and Dependent on Energy. Journal of Biological Chemistry 281:23, pages 15645-15652.
Crossref
Leon O. Murphy & John Blenis. (2006) MAPK signal specificity: the right place at the right time. Trends in Biochemical Sciences 31:5, pages 268-275.
Crossref
Xuejun Tian & Larry A. Feig. (2006) Age-dependent Participation of Ras-GRF Proteins in Coupling Calcium-permeable AMPA Glutamate Receptors to Ras/Erk Signaling in Cortical Neurons. Journal of Biological Chemistry 281:11, pages 7578-7582.
Crossref
Boris N. Kholodenko. (2006) Cell-signalling dynamics in time and space. Nature Reviews Molecular Cell Biology 7:3, pages 165-176.
Crossref
Christopher J. Caunt, Ann R. Finch, Kathleen R. Sedgley, Lisa Oakley, Louis M. Luttrell & Craig A. McArdle. (2006) Arrestin-mediated ERK Activation by Gonadotropin-releasing Hormone Receptors. Journal of Biological Chemistry 281:5, pages 2701-2710.
Crossref
Ming Zhao, Richard G. DiScipio, Antonia G. Wimmer & Ingrid U. Schraufstatter. (2006) Regulation of CXCR4-Mediated Nuclear Translocation of Extracellular Signal-Related Kinases 1 and 2. Molecular Pharmacology 69:1, pages 66-75.
Crossref
Kari Callaway, Mark A. Rainey & Kevin N. Dalby. (2005) Quantifying ERK2–protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1754:1-2, pages 316-323.
Crossref
Miki Ebisuya, Kunio Kondoh & Eisuke Nishida. (2005) The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. Journal of Cell Science 118:14, pages 2997-3002.
Crossref
Andrew N. Coogan & Hugh D. Piggins. (2005) Dark pulse suppression of P-ERK and c-Fos in the hamster suprachiasmatic nuclei. European Journal of Neuroscience 22:1, pages 158-168.
Crossref
Michael C. Lawrence, Kathleen McGlynn, Byung-Hyun Park & Melanie H. Cobb. (2005) ERK1/2-dependent Activation of Transcription Factors Required for Acute and Chronic Effects of Glucose on the Insulin Gene Promoter. Journal of Biological Chemistry 280:29, pages 26751-26759.
Crossref
Angus Harding, Tianhai Tian, Elizabeth Westbury, Ester Frische & John F. Hancock. (2005) Subcellular Localization Determines MAP Kinase Signal Output. Current Biology 15:9, pages 869-873.
Crossref
Walter Kolch, Muffy Calder & David Gilbert. (2005) When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Letters 579:8, pages 1891-1895.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.