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Molecular and Cellular Biology Volume 24, 2004 - Issue 23
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Transcriptional Regulation

Multiple, Distant Gata2 Enhancers Specify Temporally and Tissue-Specific Patterning in the Developing Urogenital System

Melin Khandekar1 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan
,
Norio Suzuki2 Department of Molecular and Developmental Biology, TARA Centre, University of Tsukuba, Tsukuba, Japan
,
Jon Lewton1 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan
,
Masayuki Yamamoto2 Department of Molecular and Developmental Biology, TARA Centre, University of Tsukuba, Tsukuba, Japan
&
James Douglas Engel1 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MichiganCorrespondence[email protected]
Pages 10263-10276 | Received 12 Jun 2004, Accepted 09 Sep 2004, Published online: 27 Mar 2023

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Takashi Moriguchi, Tomofumi Hoshino, Arvind Rao, Lei Yu, Jun Takai, Satoshi Uemura, Kazue Ise, Yasuhiro Nakamura, Kim-Chew Lim, Ritsuko Shimizu, Masayuki Yamamoto & James Douglas Engel. (2018) A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression. Molecular and Cellular Biology 38:21.
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Lei Yu, Takashi Moriguchi, Hiroshi Kaneko, Makiko Hayashi, Atsushi Hasegawa, Masahiro Nezu, Hideyuki Saya, Masayuki Yamamoto & Ritsuko Shimizu. (2017) Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury. Molecular and Cellular Biology 37:22.
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Takashi Moriguchi, Lei Yu, Akihito Otsuki, Keiko Ainoya, Kim-Chew Lim, Masayuki Yamamoto & James Douglas Engel. (2016) Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect. Molecular and Cellular Biology 36:17, pages 2272-2281.
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Takashi Moriguchi, Mikiko Suzuki, Lei Yu, Jun Takai, Kinuko Ohneda & Masayuki Yamamoto. (2015) Progenitor Stage-Specific Activity of a cis-Acting Double GATA Motif for Gata1 Gene Expression. Molecular and Cellular Biology 35:5, pages 805-815.
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Lei Yu, Takashi Moriguchi, Tomokazu Souma, Jun Takai, Hironori Satoh, Naoki Morito, James Douglas Engel & Masayuki Yamamoto. (2014) GATA2 Regulates Body Water Homeostasis through Maintaining Aquaporin 2 Expression in Renal Collecting Ducts. Molecular and Cellular Biology 34:11, pages 1929-1941.
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Keiko Ainoya, Takashi Moriguchi, Shin'ya Ohmori, Tomokazu Souma, Jun Takai, Masanobu Morita, Kelly J. Chandler, Douglas P. Mortlock, Ritsuko Shimizu, James Douglas Engel, Kim-Chew Lim & Masayuki Yamamoto. (2012) UG4 Enhancer-Driven GATA-2 and Bone Morphogenetic Protein 4 Complementation Remedies the CAKUT Phenotype in Gata2 Hypomorphic Mutant Mice. Molecular and Cellular Biology 32:12, pages 2312-2322.
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Sakie Hosoya-Ohmura, Yu-Hsuan Lin, Mary Herrmann, Takashi Kuroha, Arvind Rao, Takashi Moriguchi, Kim-Chew Lim, Tomonori Hosoya & James Douglas Engel. (2011) An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene. Molecular and Cellular Biology 31:9, pages 1894-1904.
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Mikiko Suzuki, Takashi Moriguchi, Kinuko Ohneda & Masayuki Yamamoto. (2009) Differential Contribution of the Gata1 Gene Hematopoietic Enhancer to Erythroid Differentiation. Molecular and Cellular Biology 29:5, pages 1163-1175.
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Ronald L. Chandler, Kelly J. Chandler, Karen A. McFarland & Douglas P. Mortlock. (2007) Bmp2 Transcription in Osteoblast Progenitors Is Regulated by a Distant 3′ Enhancer Located 156.3 Kilobases from the Promoter. Molecular and Cellular Biology 27:8, pages 2934-2951.
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Xiaohong Xu, Michael M. Scott & Evan S. Deneris. (2006) Shared Long-Range Regulatory Elements Coordinate Expression of a Gene Cluster Encoding Nicotinic Receptor Heteromeric Subtypes. Molecular and Cellular Biology 26:15, pages 5636-5649.
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Articles from other publishers (32)

Jun Takai, Takashi Shimada, Tadaho Nakamura, James Douglas Engel & Takashi Moriguchi. (2021) Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance. iScience 24:8, pages 102836.
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Takashi Moriguchi. (2021) Development and Carcinogenesis: Roles of GATA Factors in the Sympathoadrenal and Urogenital Systems. Biomedicines 9:3, pages 299.
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Ellen V. Rothenberg & Berthold Göttgens. (2021) How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson. Current Opinion in Hematology 28:1, pages 1-10.
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Nouraiz Ahmed, Leo Kunz, Philipp S. Hoppe, Dirk Loeffler, Martin Etzrodt, Germán Camargo Ortega, Oliver Hilsenbeck, Konstantinos Anastassiadis & Timm Schroeder. (2020) A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types. Stem Cell Reports 15:2, pages 326-339.
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Ayaka YamaokaMikiko Suzuki, Saori Katayama, Daiki OriharaJames Douglas Engel & Masayuki Yamamoto. (2020) EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. Blood Advances 4:8, pages 1722-1736.
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Ritsuko Shimizu & Masayuki Yamamoto. (2019) Quantitative and qualitative impairments in GATA2 and myeloid neoplasms. IUBMB Life 72:1, pages 142-150.
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Jun Takai, Hiroshi Ohtsu, Atsushi Sato, Satoshi Uemura, Tsutomu Fujimura, Masayuki Yamamoto & Takashi Moriguchi. (2019) Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice. Scientific Reports 9:1.
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Tomofumi Hoshino, Tsumoru Terunuma, Jun Takai, Satoshi Uemura, Yasuhiro Nakamura, Michito Hamada, Satoru Takahashi, Masayuki Yamamoto, James Douglas Engel & Takashi Moriguchi. (2019) Spiral ganglion cell degeneration‐induced deafness as a consequence of reduced GATA factor activity. Genes to Cells 24:8, pages 534-545.
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Elena Martynova, Maxime Bouchard, Linda S. Musil & Ales Cvekl. (2018) Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens. Developmental Dynamics 247:11, pages 1186-1198.
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Veronica Rodriguez-Bravo, Marc Carceles-Cordon, Yujin Hoshida, Carlos Cordon-Cardo, Matthew D. Galsky & Josep Domingo-Domenech. (2016) The role of GATA2 in lethal prostate cancer aggressiveness. Nature Reviews Urology 14:1, pages 38-48.
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Hiromi Yamazaki, Mikiko Suzuki, Akihito Otsuki, Ritsuko Shimizu, Emery H. Bresnick, James Douglas Engel & Masayuki Yamamoto. (2014) A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression. Cancer Cell 25:4, pages 415-427.
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Conall M. O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M. Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A. Catharina Brockhaus, Marcus E. Kleber, Anubha Mahajan, Florian D. Ernst, Vilmundur Gudnason, Lenore J. Launer, Aurelien Mace, Eric Boerwinckle, Dan E. Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J. Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S. Siscovick, Bruce M. Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F. Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M. Brown, Karol Estrada, Jingzhong Ding, Tamara B. Harris, Stefania Bandinelli, Dena Hernandez, Andrew B. Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M. Starr, John C. Chambers, Bernhard O. Boehm, Bernhard R. Winkelmann, Jie Huang, Federico Murgia, Sarah H. Wild, Harry Campbell, Andrew P. Morris, Oscar H. Franco, Albert Hofman, Andre G. Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So–Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, Patricia B. Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D. Spector, Albert V. Smith, Igor Rudan, James F. Wilson, Ozren Polasek, Ian J. Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S. Kooner, Jacqueline C. M. Witteman, Matthias Nauck, W. H. Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S. Fox & Murielle Bochud. (2013) Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations. PLoS Genetics 9:9, pages e1003796.
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Kim-Chew Lim, Tomonori Hosoya, William Brandt, Chia-Jui Ku, Sakie Hosoya-Ohmura, Sally A. Camper, Masayuki Yamamoto & James Douglas Engel. (2012) Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. Journal of Clinical Investigation 122:10, pages 3705-3717.
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Carmen Vicente, Ana Conchillo, María A. García-Sánchez & María D. Odero. (2012) The role of the GATA2 transcription factor in normal and malignant hematopoiesis. Critical Reviews in Oncology/Hematology 82:1, pages 1-17.
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Sumantra Chatterjee, Guillaume Bourque & Thomas Lufkin. (2011) Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes. BMC Developmental Biology 11:1.
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Maximilian Haeussler & Jean-Stéphane Joly. (2011) When needles look like hay: How to find tissue-specific enhancers in model organism genomes. Developmental Biology 350:2, pages 239-254.
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Sumantra Chatterjee & Thomas Lufkin. (2011) Fishing for function: zebrafish BAC transgenics for functional genomics. Molecular BioSystems 7:8, pages 2345.
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ARVIND RAO, DAVID J. STATES, ALFRED O. HEROIIIIII & JAMES DOUGLAS ENGEL. (2011) UNDERSTANDING DISTAL TRANSCRIPTIONAL REGULATION FROM SEQUENCE, EXPRESSION AND INTERACTOME PERSPECTIVES. Journal of Bioinformatics and Computational Biology 08:02, pages 219-246.
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Takashi Moriguchi, Mikiko Suzuki, James Douglas Engel & Masayuki Yamamoto. 2010. Hematopoietic Stem Cell Biology. Hematopoietic Stem Cell Biology 117 142 .
Daisuke Nozawa, Norio Suzuki, Maki Kobayashi-Osaki, Xiaoqing Pan, James Douglas Engel & Masayuki Yamamoto. (2009) GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain . Genes to Cells 14:5, pages 569-582.
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David Grote, Sami Kamel Boualia, Abdallah Souabni, Calli Merkel, Xuan Chi, Frank Costantini, Thomas Carroll & Maxime Bouchard. (2008) Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction. PLoS Genetics 4:12, pages e1000316.
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ARVIND RAO, ALFRED O. HEROIIIIII, DAVID J. STATES & JAMES DOUGLAS ENGEL. (2011) USING DIRECTED INFORMATION TO BUILD BIOLOGICALLY RELEVANT INFLUENCE NETWORKS. Journal of Bioinformatics and Computational Biology 06:03, pages 493-519.
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William Brandt, Melin Khandekar, Norio Suzuki, Masayuki Yamamoto, Kim-Chew Lim & James Douglas Engel. (2008) Defining the Functional Boundaries of the Gata2 Locus by Rescue with a Linked Bacterial Artificial Chromosome Transgene. Journal of Biological Chemistry 283:14, pages 8976-8983.
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Tomofumi Hoshino, Ritsuko Shimizu, Shinya Ohmori, Masumi Nagano, Xiaoqing Pan, Osamu Ohneda, Melin Khandekar, Masayuki Yamamoto, Kim-Chew Lim & James Douglas Engel. (2008) Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes to Cells 13:2, pages 159-170.
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Zhongan Yang, Hong Jiang, Fang Zhao, Deepa B Shankar, Kathleen M Sakamoto, Michael Q Zhang & Shuo Lin. (2007) A highly conserved regulatory element controls hematopoietic expression of GATA-2in zebrafish. BMC Developmental Biology 7:1.
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Xiaochun Long & Joseph M. Miano. (2007) Remote Control of Gene Expression. Journal of Biological Chemistry 282:22, pages 15941-15945.
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Melin KhandekarWilliam BrandtYinghui ZhouSusan DagenaisThomas W. GloverNorio SuzukiRitsuko ShimizuMasayuki YamamotoKim-Chew LimJames Douglas Engel. (2007) A Gata2 intronic enhancer confers its pan-endothelia-specific regulation . Development 134:9, pages 1703-1712.
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Arvind Rao, Alfred O. Hero III, David J. States & James Douglas Engel. (2007) Inferring Time-Varying Network Topologies from Gene Expression Data. EURASIP Journal on Bioinformatics and Systems Biology 2007, pages 1-12.
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Arvind Rao, Alfred O. Hero III, David J. States & James Douglas Engel. (2007) Motif Discovery in Tissue-Specific Regulatory Sequences Using Directed Information. EURASIP Journal on Bioinformatics and Systems Biology 2007, pages 1-13.
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Susan L. Hasegawa, Takashi Moriguchi, Arvind Rao, Takashi Kuroha, James Douglas Engel & Kim-Chew Lim. (2007) Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer. Developmental Biology 301:2, pages 568-577.
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Peter Fraser & James Douglas Engel. (2006) Constricting restricted transcription: the (actively?) shrinking web. Genes & Development 20:11, pages 1379-1383.
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Norio SuzukiOsamu OhnedaNaoko MinegishiMitsuo Nishikawa, Takayuki Ohta, Satoru TakahashiJames Douglas Engel & Masayuki Yamamoto. (2006) Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche . Proceedings of the National Academy of Sciences 103:7, pages 2202-2207.
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