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Molecular and Cellular Biology Volume 24, 2004 - Issue 23
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Cell Growth and Development

Genetic Interaction between Rb and K-ras in the Control of Differentiation and Tumor Suppression

Chiaki Takahashi1 Department of Medical Oncology, Dana Farber Cancer Institute;2 Department of Medicine;3 Department of Molecular Oncology and 21st Century Center of Excellence, Kyoto University Graduate School of Medicine, Kyoto, Japan
,
Bernardo Contreras1 Department of Medical Oncology, Dana Farber Cancer Institute;2 Department of Medicine
,
Roderick T. Bronson4 Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts;5 Rodent Histopathology Core
,
Massimo Loda1 Department of Medical Oncology, Dana Farber Cancer Institute;6 Department of Pathology, Harvard Medical School
&
Mark E. Ewen1 Department of Medical Oncology, Dana Farber Cancer Institute;2 Department of MedicineCorrespondence[email protected]
Pages 10406-10415 | Received 12 Apr 2004, Accepted 02 Sep 2004, Published online: 27 Mar 2023

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Awad Shamma, Misa Suzuki, Naoyuki Hayashi, Masahiko Kobayashi, Nobunari Sasaki, Takumi Nishiuchi, Yuichiro Doki, Takahiro Okamoto, Susumu Kohno, Hayato Muranaka, Shunsuke Kitajima, Ken-ichi Yamamoto & Chiaki Takahashi. (2013) ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation. Molecular and Cellular Biology 33:16, pages 3113-3124.
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Poppy P. Fotiadou, Chiaki Takahashi, Hasan N. Rajabi & Mark E. Ewen. (2007) Wild-Type NRas and KRas Perform Distinct Functions during Transformation. Molecular and Cellular Biology 27:19, pages 6742-6755.
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Nam-Sung Moon, Luisa Di Stefano & Nicholas Dyson. (2006) A Gradient of Epidermal Growth Factor Receptor Signaling Determines the Sensitivity of rbf1 Mutant Cells to E2F-Dependent Apoptosis. Molecular and Cellular Biology 26:20, pages 7601-7615.
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Articles from other publishers (26)

Paing Linn, Susumu Kohno, Jindan Sheng, Nilakshi Kulathunga, Hai Yu, Zhiheng Zhang, Dominic Voon, Yoshihiro Watanabe & Chiaki Takahashi. (2021) Targeting RB1 Loss in Cancers. Cancers 13:15, pages 3737.
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Elizabeth G. GrubbsMichelle D. WilliamsPaul ScheetSelina VattathilNancy D. PerrierJeffrey E. LeeRobert F. GagelTao HaiLei FengMaria E. CabanillasGilbert J. Cote. (2016) Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma . Thyroid 26:11, pages 1553-1562.
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Susumu Kohno, Shunsuke Kitajima, Nobunari Sasaki & Chiaki Takahashi. (2016) Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies. World Journal of Stem Cells 8:4, pages 170.
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L Zhu, Z Lu & H Zhao. (2014) Antitumor mechanisms when pRb and p53 are genetically inactivated. Oncogene 34:35, pages 4547-4557.
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Shunsuke Kitajima, Susumu Kohno, Atsushi Kondoh, Nobunari Sasaki, Yuuki Nishimoto, Fengkai Li, Mohammed Salah Abdallah Mohammed, Hayato Muranaka, Naoko Nagatani, Misa Suzuki, Yukiharu Kido & Chiaki Takahashi. (2015) Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells 33:5, pages 1657-1669.
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Hasan N. Rajabi, Chiaki Takahashi & Mark E. Ewen. (2014) Retinoblastoma Protein and MyoD Function Together to Effect the Repression of Fra-1 and in Turn Cyclin D1 during Terminal Cell Cycle Arrest Associated with Myogenesis. Journal of Biological Chemistry 289:34, pages 23417-23427.
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Zhonglei Lu, Frederick Bauzon, Hao Fu, Jinhua Cui, Hongling Zhao, Keiko Nakayama, Keiich I. Nakayama & Liang Zhu. (2014) Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. Nature Communications 5:1.
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Evan J. Molinelli, Anil Korkut, Weiqing Wang, Martin L. Miller, Nicholas P. Gauthier, Xiaohong Jing, Poorvi Kaushik, Qin He, Gordon Mills, David B. Solit, Christine A. Pratilas, Martin Weigt, Alfredo Braunstein, Andrea Pagnani, Riccardo Zecchina & Chris Sander. (2013) Perturbation Biology: Inferring Signaling Networks in Cellular Systems. PLoS Computational Biology 9:12, pages e1003290.
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Karine Pozo, Emely Castro-Rivera, Chunfeng Tan, Florian Plattner, Gert Schwach, Veronika Siegl, Douglas Meyer, Ailan Guo, Justin Gundara, Gabriel Mettlach, Edmond Richer, Jonathan A. Guevara, Li Ning, Anjali Gupta, Guiyang Hao, Li-Huei Tsai, Xiankai Sun, Pietro Antich, Stanley Sidhu, Bruce G. Robinson, Herbert Chen, Fiemu E. Nwariaku, Roswitha Pfragner, James A. Richardson & James A. Bibb. (2013) The Role of Cdk5 in Neuroendocrine Thyroid Cancer. Cancer Cell 24:4, pages 499-511.
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Paola Indovina, Eleonora Marcelli, Nadia Casini, Valeria Rizzo & Antonio Giordano. (2013) Emerging roles of RB family: New defense mechanisms against tumor progression. Journal of Cellular Physiology 228:3, pages 525-535.
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Stanley R G Polley & David S Fay. (2012) A Network of Genes Antagonistic to the LIN-35 Retinoblastoma Protein of Caenorhabditis elegans . Genetics 191:4, pages 1367-1380.
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Chiaki Takahashi, Nobunari Sasaki & Shunsuke Kitajima. (2012) Twists in views on RB functions in cellular signaling, metabolism and stem cells. Cancer Science 103:7, pages 1182-1188.
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Z Ma, Z Liu, R-F Wu & L S Terada. (2010) p66Shc restrains Ras hyperactivation and suppresses metastatic behavior. Oncogene 29:41, pages 5559-5567.
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Jun Liu, Xiao-ju Luo, An-wen Xiong, Zeng-di Zhang, Shen Yue, Ming-sheng Zhu & Steven Y. Cheng. (2010) MicroRNA-214 Promotes Myogenic Differentiation by Facilitating Exit from Mitosis via Down-regulation of Proto-oncogene N-ras. Journal of Biological Chemistry 285:34, pages 26599-26607.
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Hongbo Wang, Frederick Bauzon, Peng Ji, Xiaoliang Xu, Daqian Sun, Joseph Locker, Rani S Sellers, Keiko Nakayama, Keiich I Nakayama, David Cobrinik & Liang Zhu. (2009) Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice. Nature Genetics 42:1, pages 83-88.
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Daniel S. Peeper. (2009) Ras and pRb: The Relationship Gets Yet More Intimate. Cancer Cell 15:4, pages 243-245.
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Awad Shamma, Yujiro Takegami, Takao Miki, Shunsuke Kitajima, Makoto Noda, Takao Obara, Takahiro Okamoto & Chiaki Takahashi. (2009) Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation. Cancer Cell 15:4, pages 255-269.
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V M Ho, B E Schaffer, A N Karnezis, K S Park & J Sage. (2009) The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras. Oncogene 28:10, pages 1393-1399.
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Wendy van Veelen, Carola J.R. van Gasteren, Dennis S. Acton, David S. Franklin, Ruud Berger, Cornelis J.M. Lips & Jo W.M. Höppener. (2008) Synergistic Effect of Oncogenic RET and Loss of p18 on Medullary Thyroid Carcinoma Development . Cancer Research 68:5, pages 1329-1337.
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Aaron M. Bender, Natalia V. Kirienko, Sara K. Olson, Jeffery D. Esko & David S. Fay. (2007) lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Developmental Biology 302:2, pages 448-462.
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Chiaki Takahashi & Mark E. Ewen. (2006) Genetic Interaction between Rb and N- ras : Differentiation Control and Metastasis . Cancer Research 66:19, pages 9345-9348.
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Nady Golestaneh, Yi Tang, Varalakshmi Katuri, Wilma Jogunoori, Lopa Mishra & Bibhuti Mishra. (2006) Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-β adaptor elf mouse brain. Brain Research 1108:1, pages 45-53.
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S X Skapek, Y-R Pan & E Y-H P Lee. (2006) Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene 25:38, pages 5268-5276.
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D W Goodrich. (2006) The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene 25:38, pages 5233-5243.
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Chiaki Takahashi, Bernardo Contreras, Tsuyoshi Iwanaga, Yujiro Takegami, Anke Bakker, Roderick T Bronson, Makoto Noda, Massimo Loda, Jennifer L Hunt & Mark E Ewen. (2005) Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nature Genetics 38:1, pages 118-123.
Crossref
Mark E. Ewen. (2005) Functions of the retinoblastoma protein that contribute to tumor suppression. Drug Discovery Today: Disease Mechanisms 2:2, pages 185-190.
Crossref

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