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Hadi Khalil, Nieves Peltzer, Joël Walicki, Jiang-Yan Yang, Gilles Dubuis, Noémie Gardiol, Werner Held, Paul Bigliardi, Benjamin Marsland, Lucas Liaudet & Christian Widmann. (2012) Caspase-3 Protects Stressed Organs against Cell Death. Molecular and Cellular Biology 32:22, pages 4523-4533.
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Andre Bernards & Jeffrey Settleman. (2005) GAPs in growth factor signalling. Growth Factors 23:2, pages 143-149.
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Articles from other publishers (66)
Charis Putinski & Lynn A. Megeney. 2022. Biochemistry of Apoptosis and Autophagy. Biochemistry of Apoptosis and Autophagy
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Hua He, Jingjing Huang, Sufang Wu, Shiyao Jiang, Lu Liang, Yueying Liu, Wenbing Liu, Li Xie, Yongguang Tao, Yiqun Jiang & Li Cong. (2021) The roles of GTPase-activating proteins in regulated cell death and tumor immunity. Journal of Hematology & Oncology 14:1.
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Michiel van der Vlist, M. Inês Pascoal Ramos, Lucas L. van den HoogenSanne Hiddingh, Laura M. Timmerman, Titus A. P. de HondEllen D. Kaan, Maarten van der KroefRobert Jan Lebbink, Florence M. A. Peters, William Khoury-Hanold, Ruth Fritsch-StorkTimothy R. D. J. Radstake & Linde Meyaard. (2021) Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Science Signaling 14:704.
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María del Carmen Conde-Rubio, Roman Mylonas & Christian Widmann. (2021) The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Cell Death Discovery 7:1.
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Junfang Yan, Yi Xie, Jing Si, Lu Gan, Hongyan Li, Chao Sun, Cuixia Di, Jinhua Zhang, Guomin Huang, Xuetian Zhang & Hong Zhang. (2021) Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling. International Journal of Molecular Sciences 22:2, pages 817.
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Yichun Xie, Yiyi Zhong, Jinhui Chang & Hoi Shan Kwan. (2021) Chromosome-level de novo assembly of Coprinopsis cinerea A43mut B43mut pab1-1 #326 and genetic variant identification of mutants using Nanopore MinION sequencing. Fungal Genetics and Biology 146, pages 103485.
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Xinli An, Zekun Wei, Botian Ran, Hao Tian, Hongyu Gu, Yan Liu, Hongjuan Cui & Shunqin Zhu. (2020) Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry 20:17, pages 2114-2124.
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Adi Zheng, Nadja Chevalier, Margot Calderoni, Gilles Dubuis, Olivier Dormond, Panos G. Ziros, Gerasimos P. Sykiotis & Christian Widmann. (2019) CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma. Oncotarget 10:66, pages 7058-7070.
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Janis J. Noonan, Monika Jarzabek, Frank A. Lincoln, Brenton L. Cavanagh, Arhona R. Pariag, Viktorija Juric, Leonie S. Young, Keith L. Ligon, Hanne Jahns, Daniella Zheleva, Jochen H. M. Prehn, Markus Rehm, Annette T. Byrne & Brona M. Murphy. (2019) Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma. Cancers 11:12, pages 2005.
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Charis Putinski, Mohammad Abdul‐Ghani, Steve Brunette, Patrick G. Burgon & Lynn A. Megeney. (2018) Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy. Journal of the American Heart Association 7:23.
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Mohamed Eldeeb, Richard Fahlman, Mansoore Esmaili & Mohamed Ragheb. (2018) Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells. International Journal of Molecular Sciences 19:11, pages 3414.
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Riley Kellermeyer, Leah Heydman, Grant Mastick & Thomas Kidd. (2018) The Role of Apoptotic Signaling in Axon Guidance. Journal of Developmental Biology 6:4, pages 24.
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Mary Chacko Sunitha, Radhakrishnan Dhanyakrishnan, Bhaskara PrakashKumar & Kottayath Govindan Nevin. (2018) p-Coumaric acid mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy. Biomedicine & Pharmacotherapy 102, pages 823-832.
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Güliz Vanli, Christine Sempoux & Christian Widmann. (2017) The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice. Molecular Carcinogenesis 56:6, pages 1680-1684.
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Philip E. Lapinski, Beth A. Lubeck, Di Chen, Abbas Doosti, Scott D. Zawieja, Michael J. Davis & Philip D. King. (2017) RASA1 regulates the function of lymphatic vessel valves in mice. Journal of Clinical Investigation 127:7, pages 2569-2585.
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NEYLIANE F.G. DOS SANTOS, RAFAEL F. SILVA, MARCELA M.P.L. PINTO, EDVANE B. DA SILVA, DEBORAH R. TASAT & ADEMIR AMARAL. (2017) Active caspase-3 expression levels as bioindicator of individual radiosensitivity. Anais da Academia Brasileira de Ciências 89:1 suppl, pages 649-659.
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Pelagia Tsoutsou, Alessandro Annibaldi, David Viertl, Jonathan Ollivier, Franz Buchegger, Marie-Catherine Vozenin, Jean Bourhis, Christian Widmann & Oscar Matzinger. (2017) TAT-RasGAP317–326 Enhances Radiosensitivity of Human Carcinoma Cell Lines In Vitro and In Vivo through Promotion of Delayed Mitotic Cell Death. Radiation Research 187:5, pages 562.
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A.A. Yakovlev, A.A. Lyzhin, O.P. Aleksandrova, L.G. Khaspekov & N.V. Gulyaeva. (2016) Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage. Biomeditsinskaya Khimiya 62:6, pages 656-663.
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Adam M. Hanif, Moon K. Kim, Joel G. Thomas, Vincent T. Ciavatta, Micah Chrenek, John R. Hetling & Machelle T. Pardue. (2016) Whole-eye electrical stimulation therapy preserves visual function and structure in P23H-1 rats. Experimental Eye Research 149, pages 75-83.
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Evangelos Giampazolias & Stephen W.G. Tait. (2016) Mitochondria and the hallmarks of cancer. FEBS Journal 283:5, pages 803-814.
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Catherine Dabrowska, Mingli Li & Yun Fan. 2016. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy
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Katia Cailliau, Arlette Lescuyer, Anne-Françoise Burnol, Álvaro Cuesta-Marbán, Christian Widmann & Edith Browaeys-Poly. (2015) RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3. Journal of Biological Chemistry 290:32, pages 19653-19665.
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A. A. Yakovlev & N. V. Gulyaeva. (2015) Possible role of proteases in preconditioning of brain cells to pathological conditions. Biochemistry (Moscow) 80:2, pages 163-171.
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Christine Neumann, Mei Bigliardi-Qi, Christian Widmann & Paul L. Bigliardi. (2015) The δ-Opioid Receptor Affects Epidermal Homeostasis via ERK-Dependent Inhibition of Transcription Factor POU2F3. Journal of Investigative Dermatology 135:2, pages 471-480.
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Hadi Khalil, Noureddine Loukili, Alexandre Regamey, Alvaro Cuesta-Marban, Elettra Santori, Marcel Huber & Christian Widmann. (2015) The caspase-3/p120 RasGAP module generates a NF-κB repressor in response to cellular stress. Journal of Cell Science.
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Güliz Vanli, Nieves Peltzer, Gilles Dubuis & Christian Widmann. (2014) The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity. Cellular Signalling 26:12, pages 2992-2997.
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David Barras, Nadja Chevalier, Vincent Zoete, Rosemary Dempsey, Karine Lapouge, Monilola A. Olayioye, Olivier Michielin & Christian Widmann. (2014) A WXW Motif Is Required for the Anticancer Activity of the TAT-RasGAP317–326 Peptide. Journal of Biological Chemistry 289:34, pages 23701-23711.
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David Barras, Girieca Lorusso, Benoît Lhermitte, David Viertl, Curzio Rüegg & Christian Widmann. (2014) Fragment N2, a caspase‐3‐generated RasGAP fragment, inhibits breast cancer metastatic progression. International Journal of Cancer 135:1, pages 242-247.
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Hao Zhang, Shenghua Zhang, Hongwei He, Caixia Zhang, Yi Chen, Dongke Yu, Jianhua Chen & Rongguang Shao. (2014) RasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells. Acta Pharmaceutica Sinica B 4:2, pages 128-134.
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Hadi Khalil, Mathieu J.M. Bertrand, Peter Vandenabeele & Christian Widmann. (2014) Caspase-3 and RasGAP: a stress-sensing survival/demise switch. Trends in Cell Biology 24:2, pages 83-89.
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Julien Puyal, Jannick Pétremand, Gilles Dubuis, Coralie Rummel & Christian Widmann. (2013) HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality. Molecular and Cellular Endocrinology 381:1-2, pages 291-301.
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Jiao Zhang, Xin Wang, Wenjing Cui, Wenwen Wang, Huamei Zhang, Lu Liu, Zicheng Zhang, Zheng Li, Guoguang Ying, Ning Zhang & Binghui Li. (2013) Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage. Nature Communications 4:1.
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Nieves Peltzer, Güliz Vanli, Jiang-Yan Yang & Christian Widmann. (2013) Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection. PLoS ONE 8:6, pages e68123.
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Hadi Khalil, Nathalie Rosenblatt, Lucas Liaudet & Christian Widmann. (2012) The role of endogenous and exogenous RasGAP-derived fragment N in protecting cardiomyocytes from peroxynitrite-induced apoptosis. Free Radical Biology and Medicine 53:4, pages 926-935.
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Robert S. de Wijn, Charlène E.U. Oduber, Corstiaan C. Breugem, Marielle Alders, Raoul C.M. Hennekam & Chantal M.A.M. van der Horst. (2012) Phenotypic variability in a family with capillary malformations caused by a mutation in the RASA1 gene. European Journal of Medical Genetics 55:3, pages 191-195.
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Hao Zhang, Shenghua Zhang, Hongwei He, Wuli Zhao, Kaihuan Ren, Jianhua Chen & Rong-guang Shao. (2011) RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-κB in colon carcinoma HCT116 cells. Cancer Letters 308:1, pages 62-70.
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Natasa Bulat, Evrim Jaccard, Nieves Peltzer, Hadi Khalil, Jiang-Yan Yang, Gilles Dubuis & Christian Widmann. (2011) RasGAP-Derived Fragment N Increases the Resistance of Beta Cells towards Apoptosis in NOD Mice and Delays the Progression from Mild to Overt Diabetes. PLoS ONE 6:7, pages e22609.
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Jung-Hyun Shim, Zheng-Yuan Su, Jung-Il Chae, Dong Joon Kim, Feng Zhu, Wei-Ya Ma, Ann M. Bode, Chung S. Yang & Zigang Dong. (2010) Epigallocatechin Gallate Suppresses Lung Cancer Cell Growth through Ras–GTPase-Activating Protein SH3 Domain-Binding Protein 1. Cancer Prevention Research 3:5, pages 670-679.
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Jiang-Yan YangJöel WalickiEvrim JaccardGilles DubuisNatasa BulatJean-Pierre HornungBernard ThorensChristian Widmann. (2009) Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes. Diabetes 58:11, pages 2596-2606.
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Natasa Bulat & Christian Widmann. (2009) Caspase substrates and neurodegenerative diseases. Brain Research Bulletin 80:4-5, pages 251-267.
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S. Lesven & V. Kerlan. (2009) Apoptose et cellule β : de la physiologie au diabète. D’après la conférence de Christian Widmann (Lausanne), Congrès de l’ALFEDIAM, 26 mars 2008. Annales d'Endocrinologie 70:4, pages 261-262.
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Yael Feinstein-Rotkopf & Eli Arama. (2009) Can’t live without them, can live with them: roles of caspases during vital cellular processes. Apoptosis 14:8, pages 980-995.
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Alessandro Annibaldi, David Michod, Linda Vanetta, Steeve Cruchet, Pascal Nicod, Gilles Dubuis, Christelle Bonvin & Christian Widmann. (2009) Role of the sub-cellular localization of RasGAP fragment N2 for its ability to sensitize cancer cells to genotoxin-induced apoptosis. Experimental Cell Research 315:12, pages 2081-2091.
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Perayot Pamonsinlapatham, Réda Hadj-Slimane, Yves Lepelletier, Barbara Allain, Mirco Toccafondi, Christiane Garbay & Françoise Raynaud. (2009) P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling. Biochimie 91:3, pages 320-328.
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Kurt F. Hauser, Yun Kyung Hahn, Valeriya V. Adjan, Shiping Zou, Shreya K. Buch, Avindra Nath, Annadora J. Bruce-Keller & Pamela E. Knapp. (2009) HIV-1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology. Glia 57:2, pages 194-206.
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Perayot Pamonsinlapatham, Brunilde Gril, Sylvie Dufour, Réda Hadj-Slimane, Véronique Gigoux, Stéphanie Pethe, Sébastien L'Hoste, Jacques Camonis, Christiane Garbay, Françoise Raynaud & Michel Vidal. (2008) Capns1, a new binding partner of RasGAP-SH3 domain in K-RasV12 oncogenic cells: Modulation of cell survival and migration. Cellular Signalling 20:11, pages 2119-2126.
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Natasa Bulat & Christian Widmann. (2008)
Generation of a tightly regulated all-
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β cell-specific tetracycline-inducible vector
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D Tulasne & B Foveau. (2007) The shadow of death on the MET tyrosine kinase receptor. Cell Death & Differentiation 15:3, pages 427-434.
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Shintaro Iwashita & Si-Young Song. (2008) RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions. Molecular BioSystems 4:3, pages 213.
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Philip E. Lapinski, Timothy J. Bauler, Eric J. Brown, Elizabeth D. Hughes, Thomas L. Saunders & Philip D. King. (2007) Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. genesis 45:12, pages 762-767.
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V.V. Adjan, K.F. Hauser, G. Bakalkin, T. Yakovleva, A. Gharibyan, S.W. Scheff & P.E. Knapp. (2007) Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: Differential effects on glia and neurons. Neuroscience 148:3, pages 724-736.
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David Michod & Christian Widmann. (2007) DNA-damage sensitizers: Potential new therapeutical tools to improve chemotherapy. Critical Reviews in Oncology/Hematology 63:2, pages 160-171.
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Krishnaraj Rajalingam, Ralf Schreck, Ulf R. Rapp & Štefan Albert. (2007) Ras oncogenes and their downstream targets. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1177-1195.
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Olivier Pittet, David Petermann, David Michod, Thorsten Krueger, Cai Cheng, Hans-Beat Ris & Christian Widmann. (2007) Effect of the TAT-RasGAP317–326 peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light. Journal of Photochemistry and Photobiology B: Biology 88:1, pages 29-35.
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David Michod & Christian Widmann. (2007) TAT-RasGAP317-326 Requires p53 and PUMA to Sensitize Tumor Cells to Genotoxins. Molecular Cancer Research 5:5, pages 497-507.
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Minako Hashii, Mitsunori Fukuda, Hideki Nomura, Naoko Ito, Hiroto Takahashi, Seisuke Hattori, Katsuhiko Mikoshiba, Makoto Noda & Yoshihiro Higuchi. (2007) Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. Biochemical and Biophysical Research Communications 356:2, pages 374-380.
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Anne E O'Duffy, Yvette M Bordelon & BethAnn McLaughlin. (2006) Killer Proteases and Little Strokes—How the Things that do not Kill You Make You Stronger. Journal of Cerebral Blood Flow & Metabolism 27:4, pages 655-668.
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B Foveau, C Leroy, F Ancot, J Deheuninck, Z Ji, V Fafeur & D Tulasne. (2006) Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor. Cell Death & Differentiation 14:4, pages 752-764.
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Birthe Ross, Ole Kristensen, Dimitri Favre, Joël Walicki, Jette S. Kastrup, Christian Widmann & Michael Gajhede. (2007) High resolution crystal structures of the p120 RasGAP SH3 domain. Biochemical and Biophysical Research Communications 353:2, pages 463-468.
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Pasan Fernando & Lynn A. Megeney. (2006) Is caspase‐dependent apoptosis only cell differentiation taken to the extreme?. The FASEB Journal 21:1, pages 8-17.
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Yue Xu, Sung Ouk Kim, Yilei Li & Jiahuai Han. (2006) Autophagy Contributes to Caspase-independent Macrophage Cell Death. Journal of Biological Chemistry 281:28, pages 19179-19187.
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Jiang-Yan Yang, Joël Walicki, Amar Abderrahmani, Marion Cornu, Gérard Waeber, Bernard Thorens & Christian Widmann. (2005) Expression of an Uncleavable N-terminal RasGAP Fragment in Insulin-secreting Cells Increases Their Resistance toward Apoptotic Stimuli without Affecting Their Glucose-induced Insulin Secretion. Journal of Biological Chemistry 280:38, pages 32835-32842.
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Sophie Launay, Olivier Hermine, Michaëla Fontenay, Guido Kroemer, Eric Solary & Carmen Garrido. (2005) Vital functions for lethal caspases. Oncogene 24:33, pages 5137-5148.
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Jiang-Yan Yang, Joël Walicki, David Michod, Gilles Dubuis & Christian Widmann. (2005) Impaired Akt Activity Down-Modulation, Caspase-3 Activation, and Apoptosis in Cells Expressing a Caspase-resistant Mutant of RasGAP at Position 157. Molecular Biology of the Cell 16:8, pages 3511-3520.
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Guido Kroemer & Seamus J Martin. (2005) Caspase-independent cell death. Nature Medicine 11:7, pages 725-730.
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S. A. Marsh, B. K. Pat, G. C. Gobe & J. S. Coombes. (2005) Evidence for a non-antioxidant, dose-dependent role of α -lipoic acid in caspase-3 and ERK2 activation in endothelial cells. Apoptosis 10:3, pages 657-665.
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