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Molecular and Cellular Biology Volume 24, 2004 - Issue 4
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Cell Growth and Development

Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression

Brendan J. Jenkins1 Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology LaboratoryCorrespondence[email protected]
,
Dianne Grail1 Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory
,
Melissa Inglese1 Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory
,
Cathy Quilici1 Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory
,
Steven Bozinovski2 Pharmacology Department, University of Melbourne, Parkville, Victoria, Australia
,
Peter Wong3 The Walter and Eliza Hall Institute for Medical Research
&
Matthias Ernst1 Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory
 show all
Pages 1453-1463 | Received 21 May 2003, Accepted 07 Nov 2003, Published online: 27 Mar 2023

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Cédric Rébé, Frédérique Végran, Hélène Berger & François Ghiringhelli. (2013) STAT3 activation. JAK-STAT 2:1.
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Hua Yu Ling, Zhong Yang, Pan Jun Wang, Yu Sun, Song Guang Ju, Jun Li & Jin Xiang Fu. (2022) Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway. Chemico-Biological Interactions 352, pages 109779.
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Toshio Hirano. (2021) IL-6 in inflammation, autoimmunity and cancer. International Immunology 33:3, pages 127-148.
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Jianhong Ge, Hongqian Chu, Qianqian Xiao, Weidong Hao, Jing Shang, Tong Zhu, Zhaogang Sun & Xuetao Wei. (2021) BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells☆. Environmental Pollution 273, pages 116452.
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Kristina Ritter, Jasmin Rousseau & Christoph Hölscher. (2020) The Role of gp130 Cytokines in Tuberculosis. Cells 9:12, pages 2695.
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Shinwan Kany, Jan Tilmann Vollrath & Borna Relja. (2019) Cytokines in Inflammatory Disease. International Journal of Molecular Sciences 20:23, pages 6008.
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Rébé & Ghiringhelli. (2019) STAT3, a Master Regulator of Anti-Tumor Immune Response. Cancers 11:9, pages 1280.
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Jennifer K. Dowling, Michelle D. Tate, Sarah Rosli, Nollaig M. Bourke, Natalie Bitto, Mario A. Lauterbach, Shane Cheung, Thomas Ve, Bostjan Kobe, Douglas Golenbock & Ashley Mansell. (2019) The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses. The Journal of Immunology 202:8, pages 2384-2396.
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Masaaki Murakami, Daisuke Kamimura & Toshio Hirano. (2019) Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines. Immunity 50:4, pages 812-831.
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Sunyoung Ham, Luize G. Lima, Edna Pei Zhi Chai, Alexandra Muller, Richard J. Lobb, Sophie Krumeich, Shu Wen Wen, Adrian P. Wiegmans & Andreas Möller. (2018) Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling. Frontiers in Immunology 9.
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Koji Akita, Kikuo Isoda, Yayoi Sato-Okabayashi, Tomoyasu Kadoguchi, Kenichi Kitamura, Fumie Ohtomo, Kazunori Shimada & Hiroyuki Daida. (2017) An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice. Frontiers in Cardiovascular Medicine 4.
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Rocio RojoClare PridansDavid Langlais & David A. Hume. (2017) Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clinical Science 131:16, pages 2161-2182.
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Michael Tang, Jun Diao & Mark S. Cattral. (2016) Molecular mechanisms involved in dendritic cell dysfunction in cancer. Cellular and Molecular Life Sciences 74:5, pages 761-776.
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Christopher A Hunter & Simon A Jones. (2015) IL-6 as a keystone cytokine in health and disease. Nature Immunology 16:5, pages 448-457.
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Martin Pal, Mark A Febbraio & Martin Whitham. (2014) From cytokine to myokine: the emerging role of interleukin‐6 in metabolic regulation. Immunology & Cell Biology 92:4, pages 331-339.
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Elizabeth CsaszarWeijia Wang, Tatiana Usenko, Wenlian Qiao, Colleen DelaneyIrwin D. BernsteinPeter W. Zandstra. (2014) Blood stem cell fate regulation by Delta-1–mediated rewiring of IL-6 paracrine signaling. Blood 123:5, pages 650-658.
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Claire J Greenhill, Jodee Gould, Matthias Ernst, Andrew Jarnicki, Paul J Hertzog, Ashley Mansell & Brendan J Jenkins. (2011) LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling. Immunology & Cell Biology 90:5, pages 559-563.
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Maria M. Costa, Tanja Maehr, Patricia Diaz-Rosales, Christopher J. Secombes & Tiehui Wang. (2011) Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: Effects on macrophage growth and antimicrobial peptide gene expression. Molecular Immunology 48:15-16, pages 1903-1916.
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Jürgen Scheller, Athena Chalaris, Dirk Schmidt-Arras & Stefan Rose-John. (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:5, pages 878-888.
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Claire J. Greenhill, Stefan Rose-John, Rami Lissilaa, Walter Ferlin, Matthias Ernst, Paul J. Hertzog, Ashley Mansell & Brendan J. Jenkins. (2011) IL-6 Trans -Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3 . The Journal of Immunology 186:2, pages 1199-1208.
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Natalie A. Sims & Nicole C. Walsh. (2010) GP130 cytokines and bone remodelling in health and disease. BMB Reports 43:8, pages 513-523.
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Natalie A. Sims. (2009) gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice. Molecular and Cellular Endocrinology 310:1-2, pages 30-39.
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Violeta Chitu, Polly J. Ferguson, Rosalie de Bruijn, Annette J. Schlueter, Luis A. Ochoa, Thomas J. Waldschmidt, Yee-Guide Yeung & E. Richard Stanley. (2009) Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood 114:12, pages 2497-2505.
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Emily Hams, Chantal S. Colmont, Vincent Dioszeghy, Victoria J. Hammond, Ceri A. Fielding, Anwen S. Williams, Minoru Tanaka, Atsushi Miyajima, Philip R. Taylor, Nicholas Topley & Simon A. Jones. (2008) Oncostatin M Receptor-β Signaling Limits Monocytic Cell Recruitment in Acute Inflammation. The Journal of Immunology 181:3, pages 2174-2180.
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Matthias Ernst, Meri Najdovska, Dianne Grail, Therese Lundgren-May, Michael Buchert, Hazel Tye, Vance B. Matthews, Jane Armes, Prithi S. Bhathal, Norman R. Hughes, Eric G. Marcusson, James G. Karras, Songqing Na, Jonathon D. Sedgwick, Paul J. Hertzog & Brendan J. Jenkins. (2008) STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. Journal of Clinical Investigation.
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J. Sainz, E. Pérez, S. Gómez-Lopera, E. López-Fernández, L. Moratalla, S. Oyonarte & M. Jurado. (2008) Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients. Cytokine 41:3, pages 268-278.
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Kristy A. HoranKen-ichi WatanabeAnne M. KongCharles G. BaileyJohn E. J. Rasko, Takehiko Sasaki & Christina A. Mitchell. (2007) Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood 110:13, pages 4480-4491.
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Brendan J. JenkinsAndrew W. RobertsClaire J. GreenhillMeri NajdovskaTherese Lundgren-MayLorraine RobbDianne GrailMatthias Ernst. (2006) Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood 109:6, pages 2380-2388.
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Malavika Bhattacharya, Namrata Ojha, Sunil Solanki, Chinmay K Mukhopadhyay, Richa Madan, Nitin Patel, Ganga Krishnamurthy, Senthil Kumar, Sandip K Basu & Amitabha Mukhopadhyay. (2006) IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. The EMBO Journal 25:12, pages 2878-2888.
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Ceri A. Fielding, Rachel M. McLoughlin, Chantal S. Colmont, Marina Kovaleva, Dean A. Harris, Stefan Rose-John, Nicholas Topley & Simon A. Jones. (2005) Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation. The Journal of Immunology 175:6, pages 4024-4029.
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Simon A. Jones. (2005) Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6. The Journal of Immunology 175:6, pages 3463-3468.
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Brendan J Jenkins, Dianne Grail, Thao Nheu, Meri Najdovska, Bo Wang, Paul Waring, Melissa Inglese, Rachel M McLoughlin, Simon A Jones, Nicholas Topley, Heinz Baumann, Louise M Judd, Andrew S Giraud, Alex Boussioutas, Hong-Jian Zhu & Matthias Ernst. (2005) Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nature Medicine 11:8, pages 845-852.
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Rachel M. McLoughlin, Brendan J. Jenkins, Dianne Grail, Anwen S. Williams, Ceri A. Fielding, Clare R. Parker, Matthias Ernst, Nicholas Topley & Simon A. Jones. (2005) IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences 102:27, pages 9589-9594.
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Brendan J. JenkinsAndrew W. RobertsMeri NajdovskaDianne GrailMatthias Ernst. (2005) The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood 105:9, pages 3512-3520.
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Simon A. Jones, Peter J. Richards, Jürgen Scheller & Stefan Rose-John. (2005) Review: IL-6 Transsignaling: The In Vivo Consequences . Journal of Interferon & Cytokine Research 25:5, pages 241-253.
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Geoffrey Gersuk, Atsunobu Hiraoka & Kieren A. Marr. (2005) Human monocytes differentiate into macrophages under the influence of human KPB-M15 conditioned medium. Journal of Immunological Methods 299:1-2, pages 99-106.
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Jin-Man Kim, Hyunsoo Kim, Soon Bok Kwon, Soo Young Lee, Sung-Chang Chung, Dae-Won Jeong & Byung-Moo Min. (2004) Intracellular glutathione status regulates mouse bone marrow monocyte-derived macrophage differentiation and phagocytic activity. Biochemical and Biophysical Research Communications 325:1, pages 101-108.
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Natalie A. Sims, Brendan J. Jenkins, Julian M.W. Quinn, Akira Nakamura, Markus Glatt, Matthew T. Gillespie, Matthias Ernst & T. John Martin. (2004) Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. Journal of Clinical Investigation 113:3, pages 379-389.
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