Advanced search
Publication Cover
Molecular and Cellular Biology Volume 24, 2004 - Issue 4
Submit an article Journal homepage
30
Views
59
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Actin Cytoskeleton Regulates Calcium Dynamics and NFAT Nuclear Duration

Fabiola V. RivasDepartment of Pathology, Department of Medicine, and Ben May Institute, The University of Chicago, Chicago, Illinois60637
,
James P. O'KeefeDepartment of Pathology, Department of Medicine, and Ben May Institute, The University of Chicago, Chicago, Illinois60637
,
Maria-Luisa AlegreDepartment of Pathology, Department of Medicine, and Ben May Institute, The University of Chicago, Chicago, Illinois60637
&
Thomas F. GajewskiDepartment of Pathology, Department of Medicine, and Ben May Institute, The University of Chicago, Chicago, Illinois60637Correspondence[email protected]
Pages 1628-1639 | Received 19 Jun 2003, Accepted 18 Nov 2003, Published online: 27 Mar 2023

Citations (59)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Jeffrey C. Nolz, Ricardo B. Medeiros, Jason S. Mitchell, Peimin Zhu, Bruce D. Freedman, Yoji Shimizu & Daniel D. Billadeau. (2007) WAVE2 Regulates High-Affinity Integrin Binding by Recruiting Vinculin and Talin to the Immunological Synapse. Molecular and Cellular Biology 27:17, pages 5986-6000.
Read now
Janna Dejmek, Annette Säfholm, Christian Kamp Nielsen, Tommy Andersson & Karin Leandersson. (2006) Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells. Molecular and Cellular Biology 26:16, pages 6024-6036.
Read now

Articles from other publishers (57)

Nayoung Kim, Eunbi Yi, Soon Jae Kwon, Hyo Jin Park, Hyung-Joon Kwon & Hun Sik Kim. (2022) Filamin A Is Required for NK Cell Cytotoxicity at the Expense of Cytokine Production via Synaptic Filamentous Actin Modulation. Frontiers in Immunology 12.
Crossref
NOUR HIJAZI, DON C. ROCKEY & ZENGDUN SHI. (2022) The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis. BIOCELL 46:9, pages 2003-2007.
Crossref
Raanan Greenman, Yoav Pizem, Maya Haus-Cohen, Guy Horev, Galit Denkberg, Shai Shen-Orr, Jacob Rubinstein & Yoram Reiter. (2021) Phenotypic Models of CAR T-Cell Activation Elucidate the Pivotal Regulatory Role of CAR Downmodulation. Molecular Cancer Therapeutics 20:5, pages 946-957.
Crossref
Marta Mastrogiovanni, Marie Juzans, Andrés Alcover & Vincenzo Di Bartolo. (2020) Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions. Frontiers in Cell and Developmental Biology 8.
Crossref
Qasim Alhadidi & Zahoor A. Shah. (2017) Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NF-κB and JAK–STAT Pathway. Molecular Neurobiology 55:2, pages 1676-1691.
Crossref
Marianela G. Dalghi, Mariela Ferreira-Gomes, Nicolás Montalbetti, Alexandre Simonin, Emanuel E. Strehler, Matthias A. Hediger & Juan Pablo Rossi. (2017) Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:8, pages 1413-1424.
Crossref
Elana Ben-Akiva, Randall A. Meyer, David R. Wilson & Jordan J. Green. (2017) Surface engineering for lymphocyte programming. Advanced Drug Delivery Reviews 114, pages 102-115.
Crossref
Arvind Kumar Sinha, Pradeep Singh, Anand Prakash, Dharm Pal, Anuradha Dube & Awanish Kumar. (2017) Putative Drug and Vaccine Target Identification in Leishmania donovani Membrane Proteins Using Naïve Bayes Probabilistic Classifier. IEEE/ACM Transactions on Computational Biology and Bioinformatics 14:1, pages 204-211.
Crossref
Patricia Hernández-Ortiz & Eduardo A. Espeso. (2017) Spatiotemporal dynamics of the calcineurin target CrzA. Cellular Signalling 29, pages 168-180.
Crossref
Jonathan Pabon, Man Kit Law & Avery August. 2017. Drebrin. Drebrin 281 290 .
Bo-Hong Lin, Ming-Hsuan Tsai, Chong-Kuei Lii & Tsu-Shing Wang. (2016) IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells. Environmental Toxicology 31:11, pages 1293-1306.
Crossref
W.X. Gladys Ang, Alison M. Church, Mike Kulis, Hae Woong Choi, A. Wesley Burks & Soman N. Abraham. (2016) Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. Journal of Clinical Investigation 126:11, pages 4103-4118.
Crossref
Pauline Gosselin, Gianpaolo Rando, Fabienne Fleury-Olela & Ueli Schibler. (2016) Unbiased identification of signal-activated transcription factors by barcoded synthetic tandem repeat promoter screening (BC-STAR-PROM). Genes & Development 30:16, pages 1895-1907.
Crossref
Catherine A Hartzell, Katarzyna I Jankowska, Janis K Burkhardt & Richard S Lewis. (2016) Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse. eLife 5.
Crossref
William A. Comrie & Janis K. Burkhardt. (2016) Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse. Frontiers in Immunology 7.
Crossref
Eugénie Ansseau, Jocelyn O. Eidahl, Céline Lancelot, Alexandra Tassin, Christel Matteotti, Cassandre Yip, Jian Liu, Baptiste Leroy, Céline Hubeau, Cécile Gerbaux, Samuel Cloet, Armelle Wauters, Sabrina Zorbo, Pierre Meyer, Isabelle Pirson, Dalila Laoudj-Chenivesse, Ruddy Wattiez, Scott Q. Harper, Alexandra Belayew & Frédérique Coppée. (2016) Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. PLOS ONE 11:1, pages e0146893.
Crossref
Emanuel E. Strehler. 2016. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases 63 80 .
Rumiko Ono, Tsuneyasu Kaisho & Takashi Tanaka. (2015) PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm. Scientific Reports 5:1.
Crossref
Mankit Law, YongChan Lee, J. Luis Morales, Gang Ning, Weishan Huang, Jonathan Pabon, Arun K. Kannan, Ah-Reum Jeong, Amie Wood, Chavez Carter, Sonia Mohinta, Jihong Song & Avery August. (2015) Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses. The Journal of Immunology 195:2, pages 426-430.
Crossref
Xiaowei ShaoQingsen LiAlex MogilnerAlexander D. BershadskyG. V. Shivashankar. (2015) Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim. Proceedings of the National Academy of Sciences 112:20.
Crossref
Vinicius Cotta-de-Almeida, Loïc Dupré, Delphine Guipouy & Zilton Vasconcelos. (2015) Signal Integration during T Lymphocyte Activation and Function: Lessons from the Wiskott–Aldrich Syndrome. Frontiers in Immunology 6.
Crossref
Keiichiro Matoba, Daiji Kawanami, Masami Tsukamoto, Jun Kinoshita, Tomoko Ito, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Noriyuki Murai, Senya Matsufuji & Kazunori Utsunomiya. (2014) Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells. American Journal of Physiology-Renal Physiology 307:5, pages F571-F580.
Crossref
Ebrahim Mostafavi, Arash Aghajani Nargesi, Zaniar Ghazizadeh, Mehrdad Larry, Roya Horabad Farahani, Afsaneh Morteza, Alireza Esteghamati, Claude Vigneron & Manouchehr Nakhjavani. (2014) The Degree of Resistance of Erythrocyte Membrane Cytoskeletal Proteins to Supra-Physiologic Concentrations of Calcium: An In Vitro Study. The Journal of Membrane Biology 247:8, pages 695-701.
Crossref
Noah Joseph, Barak Reicher & Mira Barda-Saad. (2014) The calcium feedback loop and T cell activation: How cytoskeleton networks control intracellular calcium flux. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:2, pages 557-568.
Crossref
Sudha Kumari, Silvia Curado, Viveka Mayya & Michael L. Dustin. (2014) T cell antigen receptor activation and actin cytoskeleton remodeling. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:2, pages 546-556.
Crossref
Frederick L. Locke, Yuan-yuan Zha, Yan Zheng, Gregory Driessens & Thomas F. Gajewski. (2013) Conditional Deletion of PTEN in Peripheral T Cells Augments TCR-Mediated Activation but Does Not Abrogate CD28 Dependency or Prevent Anergy Induction. The Journal of Immunology 191:4, pages 1677-1685.
Crossref
Roddy S. O’Connor, Xueli Hao, Keyue Shen, Keenan Bashour, Tatiana Akimova, Wayne W. Hancock, Lance C. Kam & Michael C. Milone. (2012) Substrate Rigidity Regulates Human T Cell Activation and Proliferation. The Journal of Immunology 189:3, pages 1330-1339.
Crossref
Sergio de Frutos, Juan Manuel Ramiro Diaz, Carlos H. Nitta, Mingma L. Sherpa & Laura V. Gonzalez Bosc. (2011) Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. American Journal of Physiology-Cell Physiology 301:2, pages C441-C450.
Crossref
Sandra V. Verstraeten, Gerardo G. Mackenzie & Patricia I. Oteiza. (2010) The plasma membrane plays a central role in cells response to mechanical stress. Biochimica et Biophysica Acta (BBA) - Biomembranes 1798:9, pages 1739-1749.
Crossref
H Boukerche, H Aissaoui, C Prévost, H Hirbec, S K Das, Z-Z Su, D Sarkar & P B Fisher. (2010) Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-κB. Oncogene 29:21, pages 3054-3066.
Crossref
Alexander KeremJun YinStephanie M. KaestleJulia HoffmannAxel M. SchoeneBaljit SinghHermann KuppeMathias M. BorstWolfgang M. Kuebler. (2010) Lung Endothelial Dysfunction in Congestive Heart Failure. Circulation Research 106:6, pages 1103-1116.
Crossref
Jill M. Schartner, William T. Simonson, Sarah A. Wernimont, Lauren M. Nettenstrom, Anna Huttenlocher & Christine M. Seroogy. (2009) Gene Related to Anergy in Lymphocytes (GRAIL) Expression in CD4+ T Cells Impairs Actin Cytoskeletal Organization during T Cell/Antigen-presenting Cell Interactions. Journal of Biological Chemistry 284:50, pages 34674-34681.
Crossref
Stéphane Bécart & Amnon Altman. (2009) SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca 2+ signaling in T cells . Immunological Reviews 232:1, pages 319-333.
Crossref
Gaelle Kustermans, Jacques Piette & Sylvie Legrand-Poels. (2008) Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction. Biochemical Pharmacology 76:11, pages 1310-1322.
Crossref
Gaelle Kustermans, Nadia El Mjiyad, Julie Horion, Nathalie Jacobs, Jacques Piette & Sylvie Legrand-Poels. (2008) Actin cytoskeleton differentially modulates NF-κB-mediated IL-8 expression in myelomonocytic cells. Biochemical Pharmacology 76:10, pages 1214-1228.
Crossref
Bénédicte Mugnier, Béatrice Nal, Christophe Verthuy, Claude Boyer, David Lam, Lionel Chasson, Vincent Nieoullon, Geneviève Chazal, Xiao-Jun Guo, Hai-Tao He, Dominique Rueff-Juy, Andrés Alcover & Pierre Ferrier. (2008) Coronin-1A Links Cytoskeleton Dynamics to TCRαβ-Induced Cell Signaling. PLoS ONE 3:10, pages e3467.
Crossref
Sandeepa M. Eswarappa, Vidhi Pareek & Dipshikha Chakravortty. (2008) Role of actin cytoskeleton in LPS-induced NF-κB activation and nitric oxide production in murine macrophages. Innate Immunity 14:5, pages 309-318.
Crossref
Janis K. BurkhardtEsteban CarrizosaMeredith H. Shaffer. (2008) The Actin Cytoskeleton in T Cell Activation. Annual Review of Immunology 26:1, pages 233-259.
Crossref
Timothy S. Gomez & Daniel D. Billadeau. 2008. 1 64 .
Constantinos Petrovas, Yvonne M. Mueller, Guibin Yang, Susan R. Altork, Jeffrey M. Jacobson, Peter G. Pitsakis, Karam C. Mounzer, John D. Altman & Peter D. Katsikis. (2007) Actin integrity is indispensable for CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells. Apoptosis 12:12, pages 2175-2186.
Crossref
Jeffrey C. Nolz, Martin E. Fernandez-Zapico & Daniel D. Billadeau. (2007) TCR/CD28-Stimulated Actin Dynamics Are Required for NFAT1-Mediated Transcription of c- rel Leading to CD28 Response Element Activation . The Journal of Immunology 179:2, pages 1104-1112.
Crossref
Fabeha Fazal, Mohd Minhajuddin, Kaiser M. Bijli, James L. McGrath & Arshad Rahman. (2007) Evidence for Actin Cytoskeleton-dependent and -independent Pathways for RelA/p65 Nuclear Translocation in Endothelial Cells. Journal of Biological Chemistry 282:6, pages 3940-3950.
Crossref
Timothy S. Gomez, Karan Kumar, Ricardo B. Medeiros, Yoji Shimizu, Paul J. Leibson & Daniel D. Billadeau. (2007) Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse. Immunity 26:2, pages 177-190.
Crossref
Joanne E. Wood, Helga Schneider & Christopher E. Rudd. (2006) TcR and TcR-CD28 Engagement of Protein Kinase B (PKB/AKT) and Glycogen Synthase Kinase-3 (GSK-3) Operates Independently of Guanine Nucleotide Exchange Factor VAV-1. Journal of Biological Chemistry 281:43, pages 32385-32394.
Crossref
Claudia Haller, Susanne Rauch, Nico Michel, Sebastian Hannemann, Maik J. Lehmann, Oliver T. Keppler & Oliver T. Fackler. (2006) The HIV-1 Pathogenicity Factor Nef Interferes with Maturation of Stimulatory T-lymphocyte Contacts by Modulation of N-Wasp Activity. Journal of Biological Chemistry 281:28, pages 19618-19630.
Crossref
Sašo Čemerski & Andrey Shaw. (2006) Immune synapses in T-cell activation. Current Opinion in Immunology 18:3, pages 298-304.
Crossref
Guido H. Wabnitz, Gabriele Nebl, Martin Klemke, Andreas J. Schröder & Yvonne Samstag. (2006) Phosphatidylinositol 3-Kinase Functions as a Ras Effector in the Signaling Cascade That Regulates Dephosphorylation of the Actin-Remodeling Protein Cofilin after Costimulation of Untransformed Human T Lymphocytes. The Journal of Immunology 176:3, pages 1668-1674.
Crossref
Sarah Russell & Jane Oliaro. (2006) Compartmentalization in T‐cell signalling: Membrane microdomains and polarity orchestrate signalling and morphology. Immunology & Cell Biology 84:1, pages 107-113.
Crossref
Elena M Gallo, Kirsten Canté-Barrett & Gerald R Crabtree. (2005) Lymphocyte calcium signaling from membrane to nucleus. Nature Immunology 7:1, pages 25-32.
Crossref
Jeffrey C. Nolz, Timothy S. Gomez, Peimin Zhu, Shuixing Li, Ricardo B. Medeiros, Yoji Shimizu, Janis K. Burkhardt, Bruce D. Freedman & Daniel D. Billadeau. (2006) The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation. Current Biology 16:1, pages 24-34.
Crossref
Soon Youn Jeong, Sun Young Shin, Han-Seop Kim, Chang-Dae Bae, Dae-Yong Uhm, Myung-Kyu Park & Sungkwon Chung. (2006) Regulation of magnesium-inhibited cation current by actin cytoskeleton rearrangement. Biochemical and Biophysical Research Communications 339:3, pages 810-815.
Crossref
Shengli Hao & Avery August. (2005) Actin Depolymerization Transduces the Strength of B-Cell Receptor Stimulation. Molecular Biology of the Cell 16:5, pages 2275-2284.
Crossref
Gaelle KUSTERMANS, Jamel EL BENNA, Jacques PIETTE & Sylvie LEGRAND-POELS. (2005) Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway. Biochemical Journal 387:2, pages 531-540.
Crossref
Ariel Quintana, D�sir�e Griesemer, Eva C. Schwarz & Markus Hoth. (2004) Calcium-dependent activation of T-lymphocytes. Pfl�gers Archiv - European Journal of Physiology 450:1, pages 1-12.
Crossref
Yvonne Samstag & Gabriele Nebl. (2005) Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes. Advances in Enzyme Regulation 45:1, pages 52-62.
Crossref
Angel L. Armesilla, Judith C. Williams, Mamta H. Buch, Adam Pickard, Michael Emerson, Elizabeth J. Cartwright, Delvac Oceandy, Michele D. Vos, Sheona Gillies, Geoffrey J. Clark & Ludwig Neyses. (2004) Novel Functional Interaction between the Plasma Membrane Ca2+ Pump 4b and the Proapoptotic Tumor Suppressor Ras-associated Factor 1 (RASSF1). Journal of Biological Chemistry 279:30, pages 31318-31328.
Crossref
James P. O'Keefe, Kelly Blaine, Maria-Luisa Alegre & Thomas F. Gajewski. (2004) Formation of a central supramolecular activation cluster is not required for activation of naive CD8 + T cells . Proceedings of the National Academy of Sciences 101:25, pages 9351-9356.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.