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Molecular and Cellular Biology Volume 24, 2004 - Issue 7
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Transcriptional Regulation

Functional Analysis of the Mad1-mSin3A Repressor-Corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response

Shaun M. Cowley1 Fred Hutchinson Cancer Research Center, Seattle, Washington98109
,
Richard S. Kang2 Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois60208
,
John V. Frangioni3 Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Jason J. Yada1 Fred Hutchinson Cancer Research Center, Seattle, Washington98109
,
Alec M. DeGrand3 Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Ishwar Radhakrishnan2 Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois60208
&
Robert N. Eisenman1 Fred Hutchinson Cancer Research Center, Seattle, Washington98109Correspondence[email protected]
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Pages 2698-2709 | Received 12 Aug 2003, Accepted 22 Dec 2003, Published online: 27 Mar 2023

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Shaun M. Cowley, Brian M. Iritani, Susan M. Mendrysa, Tina Xu, Pei Feng Cheng, Jason Yada, H. Denny Liggitt & Robert N. Eisenman. (2005) The mSin3A Chromatin-Modifying Complex Is Essential for Embryogenesis and T-Cell Development. Molecular and Cellular Biology 25:16, pages 6990-7004.
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Articles from other publishers (26)

Nisha Rani Dahiya, Boris A. Leibovitch, Rama Kadamb, Nidhi Bansal & Samuel Waxman. (2022) The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells. Cells 11:7, pages 1179.
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Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver & Birthe B. Kragelund. (2021) Connecting the αα-hubs: same fold, disordered ligands, new functions. Cell Communication and Signaling 19:1.
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Katrine Bugge, Lasse Staby, Edoardo Salladini, Rasmus G. Falbe-Hansen, Birthe B. Kragelund & Karen Skriver. (2021) αα-Hub domains and intrinsically disordered proteins: A decisive combo. Journal of Biological Chemistry 296, pages 100226.
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Philipp Raffeiner, Jonathan R. Hart, Daniel García-CaballeroLiron Bar-PeledMarc S. Weinberg & Peter K. Vogt. (2020) An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation. Proceedings of the National Academy of Sciences 117:12, pages 6571-6579.
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Grace E. AdamsAditya ChandruShaun M. Cowley. (2018) Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex. Biochemical Journal 475:24, pages 3921-3932.
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Aditya Chandru, Neil Bate, Geerten W. Vuister & Shaun M. Cowley. (2018) Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain. Scientific Reports 8:1.
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Fugui Zhu, Qianshu Zhu, Dan Ye, Qingquan Zhang, Yiwei Yang, Xudong Guo, Zhenping Liu, Zeyidan Jiapaer, Xiaoping Wan, Guiying Wang, Wen Chen, Songcheng Zhu, Cizhong Jiang, Weiyang Shi & Jiuhong Kang. (2018) Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Research 46:12, pages 6026-6040.
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Gwo-Jen Liaw. (2016) Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation. Scientific Reports 6:1.
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Tauheed Hasan & Daman Saluja. 2015. Proteostasis and Chaperone Surveillance. Proteostasis and Chaperone Surveillance 3 24 .
Shereen Jamaladdin, Richard D. W. Kelly, Laura O’Regan, Oliver M. Dovey, Grace E. Hodson, Christopher J. Millard, Nicola Portolano, Andrew M. Fry, John W. R. Schwabe & Shaun M. Cowley. (2014) Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proceedings of the National Academy of Sciences 111:27, pages 9840-9845.
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Juanita L. Merchant. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 3 42 .
Ganesan Senthil Kumar, Tao Xie, Yongbo Zhang & Ishwar Radhakrishnan. (2011) Solution Structure of the mSin3A PAH2–Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S Complex. Journal of Molecular Biology 408:5, pages 987-1000.
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Lulu Farhana, Marcia I. Dawson, Zebin Xia, Amro Aboukameel, Liping Xu, Gang Liu, Jayanta K. Das, James Hatfield, Edi Levi, Ramzi Mohammad & Joseph A. Fontana. (2010) Adamantyl-Substituted Retinoid-Related Molecules Induce Apoptosis in Human Acute Myelogenous Leukemia Cells. Molecular Cancer Therapeutics 9:11, pages 2903-2913.
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Lulu Farhana, Marcia I. Dawson, Liping Xu, Jan-Hermen Dannenberg & Joseph A. Fontana. (2009) SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule–mediated nuclear factor-κB activation, c-Fos/c-Jun expression, and cellular apoptosis. Molecular Cancer Therapeutics 8:6, pages 1625-1635.
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Yi Cai & Allen Laughon. (2009) The Drosophila Smad cofactor Schnurri engages in redundant and synergistic interactions with multiple corepressors. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1789:3, pages 232-245.
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Sarata C. Sahu, Kurt A. Swanson, Richard S. Kang, Kai Huang, Kurt Brubaker, Kathleen Ratcliff & Ishwar Radhakrishnan. (2008) Conserved Themes in Target Recognition by the PAH1 and PAH2 Domains of the Sin3 Transcriptional Corepressor. Journal of Molecular Biology 375:5, pages 1444-1456.
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T. Ohtomo, T. Horii, M. Nomizu, T. Suga & J. Yamada. (2007) Molecular cloning of a structural homolog of YY1AP, a coactivator of the multifunctional transcription factor YY1. Amino Acids 33:4, pages 645-652.
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Lisa Y. Zhao, Aleixo Santiago, Jilin Liu & Daiqing Liao. (2007) Repression of p53-mediated Transcription by Adenovirus E1B 55-kDa Does Not Require Corepressor mSin3A and Histone Deacetylases. Journal of Biological Chemistry 282:10, pages 7001-7010.
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Lulu Farhana, Marcia I. Dawson, Mark Leid, Li Wang, David D. Moore, Gang Liu, Zeben Xia & Joseph A. Fontana. (2007) Adamantyl-Substituted Retinoid-Related Molecules Bind Small Heterodimer Partner and Modulate the Sin3A Repressor. Cancer Research 67:1, pages 318-325.
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Hugo van Ingen, Maria A.H. Baltussen, Jan Aelen & Geerten W. Vuister. (2006) Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B. Journal of Molecular Biology 358:2, pages 485-497.
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Juanita L. Merchant & Longchuan Bai. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 1 30 .
S. Rottmann & B. Lüscher. 2006. The Myc/Max/Mad Transcription Factor Network. The Myc/Max/Mad Transcription Factor Network 63 122 .
Mitsuru Nomura, Hiroko Uda-Tochio, Kiyohito Murai, Nozomu Mori & Yoshifumi Nishimura. (2005) The Neural Repressor NRSF/REST Binds the PAH1 Domain of the Sin3 Corepressor by Using its Distinct Short Hydrophobic Helix. Journal of Molecular Biology 354:4, pages 903-915.
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A. ORIAN, S.S. GREWAL, P.S. KNOEPFLER, B.A. EDGAR, S.M. PARKHURST & R.N. EISENMAN. (2005) Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors. Cold Spring Harbor Symposia on Quantitative Biology 70:0, pages 299-307.
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Claire Dugast-Darzacq, Melinda Pirity, Jennifer K Blanck, Alexis Scherl & Nicole Schreiber-Agus. (2004) Mxi1-SRα: a novel Mxi1 isoform with enhanced transcriptional repression potential. Oncogene 23:55, pages 8887-8899.
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Kurt A Swanson, Paul S Knoepfler, Kai Huang, Richard S Kang, Shaun M Cowley, Carol D Laherty, Robert N Eisenman & Ishwar Radhakrishnan. (2004) HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nature Structural & Molecular Biology 11:8, pages 738-746.
Crossref

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