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Molecular and Cellular Biology Volume 25, 2005 - Issue 12
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Signal Transduction

Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA

Kausik Chakrabarti1 University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut06030-4301
,
Rong Lin1 University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut06030-4301
,
Noraisha I. Schiller1 University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut06030-4301
,
Yanping Wang1 University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut06030-4301
,
David Koubi2 Laboratoire de Biologie Moleculaire de la Cellule, UMR 5161 CNRS, INRA U1237, Ecole Normale Supérieure de Lyon, IFR 128 “BioSciences Lyon-Gerland,”69364Lyoncedex 07, France
,
Ying-Xin Fan3 Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland20892
,
Brian B. Rudkin2 Laboratoire de Biologie Moleculaire de la Cellule, UMR 5161 CNRS, INRA U1237, Ecole Normale Supérieure de Lyon, IFR 128 “BioSciences Lyon-Gerland,”69364Lyoncedex 07, France
,
Gibbes R. Johnson3 Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland20892
&
Martin R. Schiller1 University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Ave., Farmington, Connecticut06030-4301Correspondence[email protected]
 show all
Pages 5106-5118 | Received 30 Jun 2004, Accepted 10 Mar 2005, Published online: 27 Mar 2023

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Chunhui Li, James I. S. MacDonald, Asghar Talebian, Jennifer Leuenberger, Claudia Seah, Stephen H. Pasternak, Stephen W. Michnick & Susan O. Meakin. (2016) Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. Molecular and Cellular Biology 36:20, pages 2596-2611.
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Michael J. Van Kanegan & Stefan Strack. (2009) The Protein Phosphatase 2A Regulatory Subunits B′β and B′δ Mediate Sustained TrkA Neurotrophin Receptor Autophosphorylation and Neuronal Differentiation. Molecular and Cellular Biology 29:3, pages 662-674.
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Articles from other publishers (37)

Euan Parnell, Roos A. Voorn, M. Dolores Martin-de-Saavedra, Daniel D. Loizzo, Marc Dos Santos & Peter Penzes. (2022) A developmental delay linked missense mutation in Kalirin-7 disrupts protein function and neuronal morphology. Frontiers in Molecular Neuroscience 15.
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Zhengzhi Liu, Lynette B Naler, Yan Zhu, Chengyu Deng, Qiang Zhang, Bohan Zhu, Zirui Zhou, Mimosa Sarma, Alexander Murray, Hehuang Xie & Chang Lu. (2022) nMOWChIP-seq: low-input genome-wide mapping of non-histone targets. NAR Genomics and Bioinformatics 4:2.
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Arne W. Mould, Noura Al-Juffali, Annette von Delft, Paul E. Brennan & Elizabeth M. Tunbridge. (2021) Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia. CNS Drugs 36:1, pages 1-16.
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Suzuna Go, Hisaka Kurita, Manami Hatano, Kana Matsumoto, Hina Nogawa, Masatake Fujimura, Masatoshi Inden & Isao Hozumi. (2021) DNA methyltransferase- and histone deacetylase-mediated epigenetic alterations induced by low-level methylmercury exposure disrupt neuronal development. Archives of Toxicology 95:4, pages 1227-1239.
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Euan Parnell, Lauren P. Shapiro, Roos A. Voorn, Marc P. Forrest, Hiba A. Jalloul, Daniel D. Loizzo & Peter Penzes. (2021) KALRN: A central regulator of synaptic function and synaptopathies. Gene 768, pages 145306.
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Adelaide Tousley, Maria Iuliano, Elizabeth Weisman, Ellen Sapp, Ningzhe Zhang, Petr Vodicka, Jonathan Alexander, Hubert Aviolat, Leah Gatune, Patrick Reeves, Xueyi Li, Anastasia Khvorova, Lisa M. Ellerby, Neil Aronin, Marian DiFiglia & Kimberly B. Kegel-Gleason. (2019) Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease. Journal of Huntington's Disease 8:1, pages 53-69.
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Megan B. Miller, Yan Yan, Kazuya Machida, Drew D. Kiraly, Aaron D. Levy, Yi I. Wu, TuKiet T. Lam, Thomas Abbott, Anthony J. Koleske, Betty A. Eipper & Richard E. Mains. (2017) Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 8:7, pages 1554-1569.
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Mayuresh A. Sarangdhar, Divya Chaubey, Abhishek Bhatt, Monisha KM, Manish Kumar, Shashi Ranjan & Beena Pillai. (2017) A Novel Long Non-coding RNA, durga Modulates Dendrite Density and Expression of kalirin in Zebrafish. Frontiers in Molecular Neuroscience 10.
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Yan Yan, Betty A. Eipper & Richard E. Mains. (2016) Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching. Neuropharmacology 107, pages 227-238.
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Rafael Dominik Fritz & Olivier Pertz. (2016) The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Research 5, pages 749.
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Erkan Kiris, Ting Wang, Sudhirkumar Yanpallewar, Susan G. Dorsey, Jodi Becker, Sina Bavari, Mary Ellen Palko, Vincenzo Coppola & Lino Tessarollo. (2014) TrkA In Vivo Function Is Negatively Regulated by Ubiquitination . The Journal of Neuroscience 34:11, pages 4090-4098.
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C.F. Zhao, Y. Liu, Y.L. Ni, J.W. Yang, H.D. Hui, Z.B. Sun & S.J. Liu. (2013) SCIRR39 Promotes Neurite Extension via RhoA in NGF-Induced PC12 Cells. Developmental Neuroscience 35:5, pages 373-383.
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Asghar Talebian, Kim Robinson-Brookes, James I. S. MacDonald & Susan O. Meakin. (2012) Ras Guanine Nucleotide Releasing Factor 1 (RasGrf1) Enhancement of Trk Receptor-Mediated Neurite Outgrowth Requires Activation of Both H-Ras and Rac. Journal of Molecular Neuroscience 49:1, pages 38-51.
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Yu-Chun Tsai, Olaf Riess, Anne S. Soehn & Huu Phuc Nguyen. (2012) The Guanine Nucleotide Exchange Factor Kalirin-7 Is a Novel Synphilin-1 Interacting Protein and Modifies Synphilin-1 Aggregate Transport and Formation. PLoS ONE 7:12, pages e51999.
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Prashant Mandela, Maya Yankova, Lisa H Conti, Xin-Ming Ma, James Grady, Betty A Eipper & Richard E Mains. (2012) Kalrnplays key roles within and outside of the nervous system. BMC Neuroscience 13:1.
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N. Fernàndez-Castillo, M. J. Orejarena, M. Ribasés, E. Blanco, M. Casas, P. Robledo, R. Maldonado & B. Cormand. (2012) Active and passive MDMA (‘ecstasy’) intake induces differential transcriptional changes in the mouse brain. Genes, Brain and Behavior 11:1, pages 38-51.
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M E Cahill, K A Jones, I Rafalovich, Z Xie, C S Barros, U Müller & P Penzes. (2011) Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition. Molecular Psychiatry 17:1, pages 99-107.
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Richard E Mains, Drew D Kiraly, Jodi E Eipper-Mains, Xin-Ming Ma & Betty A Eipper. (2011) Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. BMC Neuroscience 12:1.
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Megan E. Rudock, Amanda. J. Cox, Julie T. Ziegler, Allison B. Lehtinen, Jessica J. Connelly, Barry I. Freedman, J. Jeffrey Carr, Carl D. Langefeld, Elizabeth R. Hauser, Benjamin D. Horne & Donald W. Bowden. (2011) Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the diabetes heart study. Genes & Genomics 33:5, pages 483-490.
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Drew D. Kiraly, Fouad Lemtiri-Chlieh, Eric S. Levine, Richard E. Mains & Betty A. Eipper. (2011) Kalirin Binds the NR2B Subunit of the NMDA Receptor, Altering Its Synaptic Localization and Function. The Journal of Neuroscience 31:35, pages 12554-12565.
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Xin-Ming Ma, Jian-Ping Huang, Eun-Ji Kim, Qing Zhu, George A. Kuchel, Richard E. Mains & Betty A. Eipper. (2011) Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons. Hippocampus 21:6, pages 661-677.
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Akihiro Goto, Mikio Hoshino, Michiyuki Matsuda & Takeshi Nakamura. (2011) Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP–treated PC12D cells. Molecular Biology of the Cell 22:10, pages 1780-1790.
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Derek C. Prosser, Duvinh Tran, Allana Schooley, Beverly Wendland & Johnny K. Ngsee. (2010) A Novel, Retromer-Independent Role for Sorting Nexins 1 and 2 in RhoG-Dependent Membrane Remodeling. Traffic 11:10, pages 1347-1362.
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Xiaonan Xin, Chana A Rabiner, Richard E Mains & Betty A Eipper. (2009) Kalirin12 interacts with dynamin. BMC Neuroscience 10:1.
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L. Ulmann, J.-L. Rodeau, L. Danoux, J.-L. Contet-Audonneau, G. Pauly & R. Schlichter. (2009) Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron–keratinocyte coculture model. Neuroscience 159:2, pages 514-525.
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Anthony W. Harrington, Qi Ming Li, Chhavy Tep, Jong Bae Park, Zhigang He & Sung Ok Yoon. (2008) The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule Neurons. Journal of Biological Chemistry 283:36, pages 24690-24697.
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Peter Penzes, Michael E. Cahill, Kelly A. Jones & Deepak P. Srivastava. (2008) Convergent CaMK and RacGEF signals control dendritic structure and function. Trends in Cell Biology 18:9, pages 405-413.
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Małgorzata Beręsewicz, Joanna E. Kowalczyk & Barbara Zabłocka. (2008) Kalirin-7, a Protein Enriched in Postsynaptic Density, is Involved in Ischemic Signal Transduction. Neurochemical Research 33:9, pages 1789-1794.
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Xiaonan Xin, Yanping Wang, Xin-ming Ma, Panteleimon Rompolas, Henry T. Keutmann, Richard E. Mains & Betty A. Eipper. (2008) Regulation of Kalirin by Cdk5. Journal of Cell Science 121:15, pages 2601-2611.
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Francesco Ferraro, Xin-Ming Ma, Jacqueline A. Sobota, Betty A. Eipper & Richard E. Mains. (2007) Kalirin/Trio Rho Guanine Nucleotide Exchange Factors Regulate a Novel Step in Secretory Granule Maturation. Molecular Biology of the Cell 18:12, pages 4813-4825.
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Francisca C. Bronfman, Claudia A. Escudero, Joachim Weis & Alex Kruttgen. (2007) Endosomal transport of neurotrophins: Roles in signaling and neurodegenerative diseases. Developmental Neurobiology 67:9, pages 1183-1203.
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Peter Griac. (2007) Sec14 related proteins in yeast. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1771:6, pages 737-745.
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Simona Baldassa, Nerina Gnesutta, Umberto Fascio, Emmapaola Sturani & Renata Zippel. (2007) SCLIP, a Microtubule-destabilizing Factor, Interacts with RasGRF1 and Inhibits Its Ability to Promote Rac Activation and Neurite Outgrowth. Journal of Biological Chemistry 282:4, pages 2333-2345.
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Martin R. Schiller. (2006) Coupling receptor tyrosine kinases to Rho GTPases—GEFs what's the link. Cellular Signalling 18:11, pages 1834-1843.
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Martin R. Schiller, Kausik Chakrabarti, Glenn F. King, Noraisha I. Schiller, Betty A. Eipper & Mark W. Maciejewski. (2006) Regulation of RhoGEF Activity by Intramolecular and Intermolecular SH3 Domain Interactions. Journal of Biological Chemistry 281:27, pages 18774-18786.
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WeiGang Duan, LiXin Sun, Jun Liu, XuDong Wu, LuYong Zhang & Ming Yan. (2006) Establishment and Application of a High Throughput Model for Rho Kinase Inhibitors Screening Based on Fluorescence Polarization. Biological and Pharmaceutical Bulletin 29:6, pages 1138-1142.
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Cheng-Gee Koh. (2006) Rho GTPases and Their Regulators in Neuronal Functions and Development. Neurosignals 15:5, pages 228-237.
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