Molecular and Cellular Biology, Volume 25, Issue 12 (2005)

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Molecular and Cellular Biology, Volume 25, Issue 12 (2005)

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Gene Expression

Article
Proximity of the U12 snRNA with both the 5′ Splice Site and the Branch Point during Early Stages of Spliceosome Assembly
Mikko J. Frilander & Xiaojuan Meng
Pages: 4813-4825
Published online: 27 Mar 2023
AbstractforProximity of the U12 snRNA with both the 5′ Splice Site and the Branch Point during Early Stages of Spliceosome Assembly | Full Text | References | PDF (647.7 KB) | Supplemental
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Article
Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells
Cecilia Proietti, Mariana Salatino, Cinthia Rosemblit, Romina Carnevale, Adalí Pecci, Alberto R. Kornblihtt, Alfredo A. Molinolo, Isabel Frahm, Eduardo H. Charreau, Roxana Schillaci & Patricia V. Elizalde
Pages: 4826-4840
Published online: 27 Mar 2023
AbstractforProgestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells | Full Text | References | PDF (424.5 KB)
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Article
Modulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways
Cheol Yi Hong, Ji Ho Suh, Kabsun Kim, Eun-Yeung Gong, Sung Ho Jeon, Myunggon Ko, Rho Hyun Seong, Hyuk Bang Kwon & Keesook Lee
Pages: 4841-4852
Published online: 27 Mar 2023
AbstractforModulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways | Full Text | References | PDF (506.7 KB)
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Article
Differential Requirement of SAGA Subunits for Mot1p and Taf1p Recruitment in Gene Activation
Chris J. C. van Oevelen, Hetty A. A. M. van Teeffelen & H. T. Marc Timmers
Pages: 4863-4872
Published online: 27 Mar 2023
AbstractforDifferential Requirement of SAGA Subunits for Mot1p and Taf1p Recruitment in Gene Activation | Full Text | References | PDF (502.3 KB) | Supplemental
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Article
The GI-GPx Gene Is a Target for Nrf2
Antje Banning, Stefanie Deubel, Dirk Kluth, Zewen Zhou & Regina Brigelius-Flohé
Pages: 4914-4923
Published online: 27 Mar 2023
AbstractforThe GI-GPx Gene Is a Target for Nrf2 | Full Text | References | PDF (343 KB)
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Article
The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II
Armelle Yart, Matthias Gstaiger, Christiane Wirbelauer, Maria Pecnik, Dimitrios Anastasiou, Daniel Hess & Wilhelm Krek
Pages: 5052-5060
Published online: 27 Mar 2023
AbstractforThe HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II | Full Text | References | PDF (521.9 KB)
  • 51 Views
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Article
XIC Is Required for Siamois Activity and Dorsoanterior Development
Lauren Snider & Stephen J. Tapscott
Pages: 5061-5072
Published online: 27 Mar 2023
AbstractforXIC Is Required for Siamois Activity and Dorsoanterior Development | Full Text | References | PDF (543.2 KB)
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Article
Connexin 40, a Target of Transcription Factor Tbx5, Patterns Wrist, Digits, and Sternum
Anne Pizard, Patrick G. Burgon, David L. Paul, Benoit G. Bruneau, Christine E. Seidman & J. G. Seidman
Pages: 5073-5083
Published online: 27 Mar 2023
AbstractforConnexin 40, a Target of Transcription Factor Tbx5, Patterns Wrist, Digits, and Sternum | Full Text | References | PDF (1.2 MB)
  • 27 Views
  • 30 CrossRef citations
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Article
Oct-3/4 Maintains the Proliferative Embryonic Stem Cell State via Specific Binding to a Variant Octamer Sequence in the Regulatory Region of the UTF1 Locus
Masazumi Nishimoto, Satoru Miyagi, Toshiyuki Yamagishi, Takehisa Sakaguchi, Hitoshi Niwa, Masami Muramatsu & Akihiko Okuda
Pages: 5084-5094
Published online: 27 Mar 2023
AbstractforOct-3/4 Maintains the Proliferative Embryonic Stem Cell State via Specific Binding to a Variant Octamer Sequence in the Regulatory Region of the UTF1 Locus | Full Text | References | PDF (750.7 KB)
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Article
Combination of hTERT and bmi-1, E6, or E7 Induces Prolongation of the Life Span of Bone Marrow Stromal Cells from an Elderly Donor without Affecting Their Neurogenic Potential
Taisuke Mori, Tohru Kiyono, Hideaki Imabayashi, Yukiji Takeda, Kohei Tsuchiya, Shunichirou Miyoshi, Hatsune Makino, Kenji Matsumoto, Hirohisa Saito, Satoshi Ogawa, Michiie Sakamoto, Jun-Ichi Hata & Akihiro Umezawa
Pages: 5183-5195
Published online: 27 Mar 2023
AbstractforCombination of hTERT and bmi-1, E6, or E7 Induces Prolongation of the Life Span of Bone Marrow Stromal Cells from an Elderly Donor without Affecting Their Neurogenic Potential | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiae
Nicole A. Doudican, Binwei Song, Gerald S. Shadel & Paul W. Doetsch
Pages: 5196-5204
Published online: 27 Mar 2023
AbstractforOxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiae | Full Text | References | PDF (288.5 KB)
  • 56 Views
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Article
The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability
Roy Drissen, Marieke von Lindern, Andrea Kolbus, Siska Driegen, Peter Steinlein, Hartmut Beug, Frank Grosveld & Sjaak Philipsen
Pages: 5205-5214
Published online: 27 Mar 2023
AbstractforThe Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability | Full Text | References | PDF (596.2 KB)
  • 23 Views
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Article
Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo
E. Delabesse, S. Ogilvy, M. A. Chapman, S. G. Piltz, B. Gottgens & A. R. Green
Pages: 5215-5225
Published online: 27 Mar 2023
AbstractforTranscriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo | Full Text | References | PDF (715.1 KB)
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Signal Transduction

Article
Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling
Brooke M. Emerling, Leonidas C. Platanias, Emma Black, Angel R. Nebreda, Roger J. Davis & Navdeep S. Chandel
Pages: 4853-4862
Published online: 27 Mar 2023
AbstractforMitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling | Full Text | References | PDF (446.6 KB)
  • 77 Views
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Article
Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases
Tomas Brdicka, Theresa A. Kadlecek, Jeroen P. Roose, Alexander W. Pastuszak & Arthur Weiss
Pages: 4924-4933
Published online: 27 Mar 2023
AbstractforIntramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases | Full Text | References | PDF (413.1 KB)
  • 42 Views
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Article
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
Minrong Ai, Sheri L. Holmen, Wim Van Hul, Bart O. Williams & Matthew L. Warman
Pages: 4946-4955
Published online: 27 Mar 2023
AbstractforReduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling | Full Text | References | PDF (466.9 KB)
  • 56 Views
  • 205 CrossRef citations
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Article
RelA/p65 Regulation of IκBβ
Erin Hertlein, Jingxin Wang, Katherine J. Ladner, Nadine Bakkar & Denis C. Guttridge
Pages: 4956-4968
Published online: 27 Mar 2023
AbstractforRelA/p65 Regulation of IκBβ | Full Text | References | PDF (779 KB)
  • 19 Views
  • 24 CrossRef citations
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Article
CCT Chaperonin Complex Is Required for the Biogenesis of Functional Plk1
Xiaoqi Liu, Chin-Yo Lin, Ming Lei, Shi Yan, Tianhua Zhou & Raymond L. Erikson
Pages: 4993-5010
Published online: 27 Mar 2023
AbstractforCCT Chaperonin Complex Is Required for the Biogenesis of Functional Plk1 | Full Text | References | PDF (2.2 MB) | Supplemental
  • 32 Views
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Article
Wnt7b Activates Canonical Signaling in Epithelial and Vascular Smooth Muscle Cells through Interactions with Fzd1, Fzd10, and LRP5
Zhishan Wang, Weiguo Shu, Min Min Lu & Edward E. Morrisey
Pages: 5022-5030
Published online: 27 Mar 2023
AbstractforWnt7b Activates Canonical Signaling in Epithelial and Vascular Smooth Muscle Cells through Interactions with Fzd1, Fzd10, and LRP5 | Full Text | References | PDF (1,001.4 KB)
  • 99 Views
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Article
Active Src Elevates the Expression of β-Catenin by Enhancement of Cap-Dependent Translation
Rotem Karni, Yael Gus, Yuval Dor, Oded Meyuhas & Alexander Levitzki
Pages: 5031-5039
Published online: 27 Mar 2023
AbstractforActive Src Elevates the Expression of β-Catenin by Enhancement of Cap-Dependent Translation | Full Text | References | PDF (423.3 KB) | Supplemental
  • 21 Views
  • 53 CrossRef citations
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Article
DNA Topoisomerase I Is a Cofactor for c-Jun in the Regulation of Epidermal Growth Factor Receptor Expression and Cancer Cell Proliferation
Antoine Mialon, Matti Sankinen, Henrik Söderström, Teemu T. Junttila, Tim Holmström, Riku Koivusalo, Anastassios C. Papageorgiou, Randall S. Johnson, Sakari Hietanen, Klaus Elenius & Jukka Westermarck
Pages: 5040-5051
Published online: 27 Mar 2023
AbstractforDNA Topoisomerase I Is a Cofactor for c-Jun in the Regulation of Epidermal Growth Factor Receptor Expression and Cancer Cell Proliferation | Full Text | References | PDF (506.4 KB)
  • 26 Views
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Article
Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA
Kausik Chakrabarti, Rong Lin, Noraisha I. Schiller, Yanping Wang, David Koubi, Ying-Xin Fan, Brian B. Rudkin, Gibbes R. Johnson & Martin R. Schiller
Pages: 5106-5118
Published online: 27 Mar 2023
AbstractforCritical Role for Kalirin in Nerve Growth Factor Signaling through TrkA | Full Text | References | PDF (626.2 KB)
  • 12 Views
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Article
The MEK1 Scaffolding Protein MP1 Regulates Cell Spreading by Integrating PAK1 and Rho Signals
Ashok Pullikuth, Evangeline McKinnon, Hans-Joerg Schaeffer & Andrew D. Catling
Pages: 5119-5133
Published online: 27 Mar 2023
AbstractforThe MEK1 Scaffolding Protein MP1 Regulates Cell Spreading by Integrating PAK1 and Rho Signals | Full Text | References | PDF (1.2 MB)
  • 26 Views
  • 50 CrossRef citations
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Article
High-Level Activation of Cyclic AMP Signaling Attenuates Bone Morphogenetic Protein 2-Induced Sympathoadrenal Lineage Development and Promotes Melanogenesis in Neural Crest Cultures
Ming Ji & Ourania M. Andrisani
Pages: 5134-5145
Published online: 27 Mar 2023
AbstractforHigh-Level Activation of Cyclic AMP Signaling Attenuates Bone Morphogenetic Protein 2-Induced Sympathoadrenal Lineage Development and Promotes Melanogenesis in Neural Crest Cultures | Full Text | References | PDF (658.8 KB)
  • 21 Views
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Article
Overexpression of Glucose-6-Phosphate Dehydrogenase Is Associated with Lipid Dysregulation and Insulin Resistance in Obesity
Jiyoung Park, Ho Kyung Rho, Kang Ho Kim, Sung Sik Choe, Yun Sok Lee & Jae Bum Kim
Pages: 5146-5157
Published online: 27 Mar 2023
AbstractforOverexpression of Glucose-6-Phosphate Dehydrogenase Is Associated with Lipid Dysregulation and Insulin Resistance in Obesity | Full Text | References | PDF (1.1 MB) | Supplemental
  • 87 Views
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Article
The Actin-Binding Protein UNC-115/abLIM Controls Formation of Lamellipodia and Filopodia and Neuronal Morphogenesis in Caenorhabditis elegans
Yieyie Yang & Erik A. Lundquist
Pages: 5158-5170
Published online: 27 Mar 2023
AbstractforThe Actin-Binding Protein UNC-115/abLIM Controls Formation of Lamellipodia and Filopodia and Neuronal Morphogenesis in Caenorhabditis elegans | Full Text | References | PDF (796.6 KB)
  • 12 Views
  • 24 CrossRef citations
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Article
Outgrowth of Neurites from NIE-115 Neuroblastoma Cells Is Prevented on Repulsive Substrates through the Action of PAK
Katharine J. M. Marler, Robert Kozma, Sohail Ahmed, Jing-Ming Dong, Christine Hall & Louis Lim
Pages: 5226-5241
Published online: 27 Mar 2023
AbstractforOutgrowth of Neurites from NIE-115 Neuroblastoma Cells Is Prevented on Repulsive Substrates through the Action of PAK | Full Text | References | PDF (1.4 MB)
  • 7 Views
  • 23 CrossRef citations
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Article
Rab3D Regulates a Novel Vesicular Trafficking Pathway That Is Required for Osteoclastic Bone Resorption
Nathan J. Pavlos, Jiake Xu, Dietmar Riedel, Joyce S. G. Yeoh, Steven L. Teitelbaum, John M. Papadimitriou, Reinhard Jahn, F. Patrick Ross & Ming H. Zheng
Pages: 5253-5269
Published online: 27 Mar 2023
AbstractforRab3D Regulates a Novel Vesicular Trafficking Pathway That Is Required for Osteoclastic Bone Resorption | Full Text | References | PDF (2.3 MB) | Supplemental
  • 28 Views
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Article
Conditional Transgenic System for Mouse Aurora A Kinase: Degradation by the Ubiquitin Proteasome Pathway Controls the Level of the Transgenic Protein
Tomokazu Fukuda, Yuji Mishina, Michael P. Walker & Richard P. DiAugustine
Pages: 5270-5281
Published online: 27 Mar 2023
AbstractforConditional Transgenic System for Mouse Aurora A Kinase: Degradation by the Ubiquitin Proteasome Pathway Controls the Level of the Transgenic Protein | Full Text | References | PDF (1,016.7 KB)
  • 14 Views
  • 33 CrossRef citations
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Article
G1/S Cell Cycle Arrest Provides Anoikis Resistance through Erk-Mediated Bim Suppression
Nicole L. Collins, Maurico J. Reginato, Jessica K. Paulus, Dennis C. Sgroi, Joshua LaBaer & Joan S. Brugge
Pages: 5282-5291
Published online: 27 Mar 2023
AbstractforG1/S Cell Cycle Arrest Provides Anoikis Resistance through Erk-Mediated Bim Suppression | Full Text | References | PDF (332.9 KB) | Supplemental
  • 57 Views
  • 104 CrossRef citations
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Article
Involvement of Human MOF in ATM Function
Arun Gupta, Girdhar G. Sharma, Charles S. H. Young, Manjula Agarwal, Edwin R. Smith, Tanya T. Paull, John C. Lucchesi, Kum Kum Khanna, Thomas Ludwig & Tej K. Pandita
Pages: 5292-5305
Published online: 27 Mar 2023
AbstractforInvolvement of Human MOF in ATM Function | Full Text | References | PDF (778.2 KB)
  • 50 Views
  • 180 CrossRef citations
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Mammalian Genetic Models With Minimal Or Complex Phenotypes

Article
MrgX Is Not Essential for Cell Growth and Development in the Mouse
Kaoru Tominaga, Martin M. Matzuk & Olivia M. Pereira-Smith
Pages: 4873-4880
Published online: 27 Mar 2023
AbstractforMrgX Is Not Essential for Cell Growth and Development in the Mouse | Full Text | References | PDF (408.8 KB)
  • 25 Views
  • 12 CrossRef citations
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Article
Normal Sexual Development and Fertility in testatin Knockout Mice
Virpi Töhönen, Jessica Frygelius, Majid Mohammadieh, Ulrik Kvist, Lauri J. Pelliniemi, Kevin O'Brien, Katarina Nordqvist & Anna Wedell
Pages: 4892-4902
Published online: 27 Mar 2023
AbstractforNormal Sexual Development and Fertility in testatin Knockout Mice | Full Text | References | PDF (987.7 KB)
  • 4 Views
  • 11 CrossRef citations
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Article
MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion
Chuan Zhang, Takashi Moriguchi, Miwako Kajihara, Ritsuko Esaki, Ayako Harada, Homare Shimohata, Hisashi Oishi, Michito Hamada, Naoki Morito, Kazuteru Hasegawa, Takashi Kudo, James Douglas Engel, Masayuki Yamamoto & Satoru Takahashi
Pages: 4969-4976
Published online: 27 Mar 2023
AbstractforMafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion | Full Text | References | PDF (573.1 KB)
  • 130 Views
  • 336 CrossRef citations
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Article
Mutation of SENP1/SuPr-2 Reveals an Essential Role for Desumoylation in Mouse Development
Taihei Yamaguchi, Prashant Sharma, Meropi Athanasiou, Amit Kumar, Satoru Yamada & Michael R. Kuehn
Pages: 5171-5182
Published online: 27 Mar 2023
AbstractforMutation of SENP1/SuPr-2 Reveals an Essential Role for Desumoylation in Mouse Development | Full Text | References | PDF (841.3 KB)
  • 11 Views
  • 84 CrossRef citations
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Chromosome Structure and Dynamics

Article
Reduced Genomic Cytosine Methylation and Defective Cellular Differentiation in Embryonic Stem Cells Lacking CpG Binding Protein
Diana L. Carlone, Jeong-Heon Lee, Suzanne R. L. Young, Erika Dobrota, Jill Sergesketter Butler, Joseph Ruiz & David G. Skalnik
Pages: 4881-4891
Published online: 27 Mar 2023
AbstractforReduced Genomic Cytosine Methylation and Defective Cellular Differentiation in Embryonic Stem Cells Lacking CpG Binding Protein | Full Text | References | PDF (423.3 KB)
  • 23 Views
  • 74 CrossRef citations
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Article
Localized Histone Acetylation and Deacetylation Triggered by the Homologous Recombination Pathway of Double-Strand DNA Repair
Beth A. Tamburini & Jessica K. Tyler
Pages: 4903-4913
Published online: 27 Mar 2023
AbstractforLocalized Histone Acetylation and Deacetylation Triggered by the Homologous Recombination Pathway of Double-Strand DNA Repair | Full Text | References | PDF (506.3 KB)
  • 92 Views
  • 226 CrossRef citations
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Article
EBP2 Plays a Key Role in Epstein-Barr Virus Mitotic Segregation and Is Regulated by Aurora Family Kinases
Priya Kapoor, Brigitte D. Lavoie & Lori Frappier
Pages: 4934-4945
Published online: 27 Mar 2023
AbstractforEBP2 Plays a Key Role in Epstein-Barr Virus Mitotic Segregation and Is Regulated by Aurora Family Kinases | Full Text | References | PDF (534.6 KB)
  • 38 Views
  • 59 CrossRef citations
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Article
Mechanism of Aurora-B Degradation and Its Dependency on Intact KEN and A-Boxes: Identification of an Aneuploidy-Promoting Property
Hao G. Nguyen, Dharmaraj Chinnappan, Takeshi Urano & Katya Ravid
Pages: 4977-4992
Published online: 27 Mar 2023
AbstractforMechanism of Aurora-B Degradation and Its Dependency on Intact KEN and A-Boxes: Identification of an Aneuploidy-Promoting Property | Full Text | References | PDF (924.5 KB)
  • 70 Views
  • 111 CrossRef citations
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Article
Trypanosome Telomeres Are Protected by a Homologue of Mammalian TRF2
Bibo Li, Amin Espinal & George A. M. Cross
Pages: 5011-5021
Published online: 27 Mar 2023
AbstractforTrypanosome Telomeres Are Protected by a Homologue of Mammalian TRF2 | Full Text | References | PDF (1 MB)
  • 37 Views
  • 61 CrossRef citations
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Article
SUMO-Dependent Compartmentalization in Promyelocytic Leukemia Protein Nuclear Bodies Prevents the Access of LRH-1 to Chromatin
Angeliki Chalkiadaki & Iannis Talianidis
Pages: 5095-5105
Published online: 27 Mar 2023
AbstractforSUMO-Dependent Compartmentalization in Promyelocytic Leukemia Protein Nuclear Bodies Prevents the Access of LRH-1 to Chromatin | Full Text | References | PDF (971.3 KB)
  • 30 Views
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Intracellular Trafficking

Article
Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin
Carlos M. Farinha & Margarida D. Amaral
Pages: 5242-5252
Published online: 27 Mar 2023
AbstractforMost F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin | Full Text | References | PDF (422.9 KB)
  • 83 Views
  • 140 CrossRef citations
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