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Molecular and Cellular Biology Volume 25, 2005 - Issue 12
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Gene Expression

The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

Roy Drissen1 Department of Cell Biology
,
Marieke von Lindern2 Department of Hematology Erasmus MC, 3000 DRRotterdam, The Netherlands
,
Andrea Kolbus3 Institute of Molecular Pathology, A-1030Vienna, Austria
,
Siska Driegen1 Department of Cell Biology
,
Peter Steinlein3 Institute of Molecular Pathology, A-1030Vienna, Austria
,
Hartmut Beug3 Institute of Molecular Pathology, A-1030Vienna, Austria
,
Frank Grosveld1 Department of Cell Biology
&
Sjaak PhilipsenCorrespondence[email protected]
 show all
Pages 5205-5214 | Received 11 Jan 2005, Accepted 21 Mar 2005, Published online: 27 Mar 2023

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Alister P. W. Funnell, Ka Sin Mak, Natalie A. Twine, Gregory J. Pelka, Laura J. Norton, Tania Radziewic, Melinda Power, Marc R. Wilkins, Kim S. Bell-Anderson, Stuart T. Fraser, Andrew C. Perkins, Patrick P. Tam, Richard C. M. Pearson & Merlin Crossley. (2013) Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing. Molecular and Cellular Biology 33:15, pages 2976-2987.
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Yvette Y. Yien & James J. Bieker. (2013) EKLF/KLF1, a Tissue-Restricted Integrator of Transcriptional Control, Chromatin Remodeling, and Lineage Determination. Molecular and Cellular Biology 33:1, pages 4-13.
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Alister P. W. Funnell, Laura J. Norton, Ka Sin Mak, Jon Burdach, Crisbel M. Artuz, Natalie A. Twine, Marc R. Wilkins, Carl A. Power, Tzong-Tyng Hung, José Perdomo, Philip Koh, Kim S. Bell-Anderson, Stuart H. Orkin, Stuart T. Fraser, Andrew C. Perkins, Richard C. M. Pearson & Merlin Crossley. (2012) The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology 32:16, pages 3281-3292.
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Christopher J. Pang, Wafaa Lemsaddek, Yousef N. Alhashem, Cornelius Bondzi, Latasha C. Redmond, Nicolas Ah-Son, Catherine I. Dumur, Kellie J. Archer, Jack L. Haar, Joyce A. Lloyd & Marie Trudel. (2012) Krüppel-Like Factor 1 (KLF1), KLF2, and Myc Control a Regulatory Network Essential for Embryonic Erythropoiesis. Molecular and Cellular Biology 32:13, pages 2628-2644.
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Susanna Porcu, Maria F. Manchinu, Maria F. Marongiu, Valeria Sogos, Daniela Poddie, Isadora Asunis, Loredana Porcu, Maria G. Marini, Paolo Moi, Antonio Cao, Frank Grosveld & Maria S. Ristaldi. (2011) Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis. Molecular and Cellular Biology 31:19, pages 4144-4154.
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Miroslawa Siatecka, Felix Lohmann, Sujin Bao & James J. Bieker. (2010) EKLF Directly Activates the p21WAF1/CIP1 Gene by Proximal Promoter and Novel Intronic Regulatory Regions during Erythroid Differentiation. Molecular and Cellular Biology 30:11, pages 2811-2822.
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Andre M. Pilon, Murat O. Arcasoy, Holly K. Dressman, Serena E. Vayda, Yelena D. Maksimova, Jose I. Sangerman, Patrick G. Gallagher & David M. Bodine. (2008) Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2. Molecular and Cellular Biology 28:24, pages 7394-7401.
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Tanushri Sengupta, Ken Chen, Eric Milot & James J. Bieker. (2008) Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the β-Globin Locus. Molecular and Cellular Biology 28:20, pages 6160-6170.
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Pieter Fokko van Loo, Edris A. F. Mahtab, Lambertus J. Wisse, Jun Hou, Frank Grosveld, Guntram Suske, Sjaak Philipsen & Adriana C. Gittenberger-de Groot. (2007) Transcription Factor Sp3 Knockout Mice Display Serious Cardiac Malformations. Molecular and Cellular Biology 27:24, pages 8571-8582.
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Miroslawa Siatecka, Li Xue & James J. Bieker. (2007) Sumoylation of EKLF Promotes Transcriptional Repression and Is Involved in Inhibition of Megakaryopoiesis. Molecular and Cellular Biology 27:24, pages 8547-8560.
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Alister P. W. Funnell, Christopher A. Maloney, Lucinda J. Thompson, Janelle Keys, Michael Tallack, Andrew C. Perkins & Merlin Crossley. (2007) Erythroid Krüppel-Like Factor Directly Activates the Basic Krüppel-Like Factor Gene in Erythroid Cells. Molecular and Cellular Biology 27:7, pages 2777-2790.
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Andre M. Pilon, Douglas G. Nilson, Dewang Zhou, Jose Sangerman, Tim M. Townes, David M. Bodine & Patrick G. Gallagher. (2006) Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice. Molecular and Cellular Biology 26:11, pages 4368-4377.
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