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Molecular and Cellular Biology Volume 25, 2005 - Issue 13
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Signal Transduction

Mutations in Proline 82 of p53 Impair Its Activation by Pin1 and Chk2 in Response to DNA Damage

Michael Berger1 Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem91120, Israel
,
Nathalie Stahl1 Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem91120, Israel
,
Giannino Del Sal2 Laboratorio Nazionale CIB, AREA Science Park, Padriciano 99, and Dipartimento di Biochimica Biofisica Chimica delle Macromolecole, Via L. Giorgeri 1, 34023Trieste, Italy
&
Ygal Haupt1 Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem91120, IsraelCorrespondence[email protected]
Pages 5380-5388 | Received 10 Feb 2005, Accepted 30 Mar 2005, Published online: 27 Mar 2023

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Morris Nechama, Chien-Ling Lin & Joel D. Richter. (2013) An Unusual Two-Step Control of CPEB Destruction by Pin1. Molecular and Cellular Biology 33:1, pages 48-58.
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Nicolas L Young, Mariana D Plazas-Mayorca & Benjamin A Garcia. (2010) Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Review of Proteomics 7:1, pages 79-92.
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Franck Toledo, Crystal J. Lee, Kurt A. Krummel, Luo-Wei Rodewald, Chung-Wen Liu & Geoffrey M. Wahl. (2007) Mouse Mutants Reveal that Putative Protein Interaction Sites in the p53 Proline-Rich Domain Are Dispensable for Tumor Suppression. Molecular and Cellular Biology 27:4, pages 1425-1432.
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Articles from other publishers (49)

Yumi Hoshino & Takafumi Uchida. (2022) Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes. Cells 11:23, pages 3772.
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David Hoyos, Benjamin Greenbaum & Arnold J. Levine. (2022) The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein. Cell Death & Differentiation 29:5, pages 938-945.
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Mareike Seelinger, Caroline Krogh Søgaard & Marit Otterlei. (2020) The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on the DNA Lesion Type. Biomolecules 10:3, pages 463.
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Li Li, Zijun Su, Zhimin Zou, Hongping Tan, Daozhang Cai, Lei Su & Zhengtao Gu. (2019) Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress. Cell Death & Disease 10:2.
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Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Chiara Cremolini, Sara Lonardi, Francesca Bergamo, Yang Ning, Noriko Yamamoto, Satoshi Okazaki, Martin D. Berger, Yuji Miyamoto, Roel GopezJr.Jr., Afsaneh Barzi, Toshiharu Yamaguchi, Sebastian Stintzing, Volker Heinemann, Fotios Loupakis, Alfredo Falcone & Heinz-Josef Lenz. (2018) Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. The Pharmacogenomics Journal 18:5, pages 623-632.
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Eric R. Wolf, Ciarán P. McAtarsney, Kristin E. BredholdAmber M. Kline & Lindsey D. Mayo. (2018) Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK. Science Signaling 11:524.
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Lu Yang, Yun Li, Arup Bhattacharya & Yuesheng Zhang. (2017) PEPD is a pivotal regulator of p53 tumor suppressor. Nature Communications 8:1.
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Katherine Baran, Mao Yang, Christopher P Dillon, Leona L Samson & Douglas R Green. (2017) The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage. Cell Death & Differentiation 24:11, pages 1925-1936.
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Danielly C.F. Costa, Guilherme A.P. de Oliveira, Elio A. Cino, Iaci N. Soares, Luciana P. Rangel & Jerson L. Silva. (2016) Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?. Cold Spring Harbor Perspectives in Biology 8:10, pages a023614.
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Savita Srinivasa, Xuan Ding & Juergen Kast. (2015) Formaldehyde cross-linking and structural proteomics: Bridging the gap. Methods 89, pages 91-98.
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Fiamma Mantovani, Alessandro Zannini, Alessandra Rustighi & Giannino Del Sal. (2015) Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:10, pages 2048-2060.
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David W. Meek. (2015) Regulation of the p53 response and its relationship to cancer. Biochemical Journal 469:3, pages 325-346.
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Anna Comel, Giovanni Sorrentino, Valeria Capaci & Giannino Del Sal. (2014) The cytoplasmic side of p53's oncosuppressive activities. FEBS Letters 588:16, pages 2600-2609.
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Tilman Polonio-Vallon, Daniel Krüger & Thomas G. Hofmann. (2014) ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair. Frontiers in Oncology 4.
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Thuy-Ai Nguyen, Daniel Menendez, Michael A. Resnick & Carl W. Anderson. (2014) Mutant TP53 Posttranslational Modifications: Challenges and Opportunities. Human Mutation 35:6, pages 738-755.
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Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt & Ygal Haupt. 2014. Mutant p53 and MDM2 in Cancer. Mutant p53 and MDM2 in Cancer 161 186 .
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LU ZHOU, BYUNG-HYUN PARK, JONG HYUK PARK, KYU YUN JANG, HO SUNG PARK, SAJEEV WAGLE, KWANG-BOK LEE & JUNG RYUL KIM. (2012) Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells. Oncology Reports 29:1, pages 193-198.
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Kyu-Sung Choi, Ji Yeon Kim, Seo-Kyung Lim, Yong Won Choi, Young Hwa Kim, So Young Kang, Tae Jun Park & In Kyoung Lim. (2012) TIS21/BTG2/PC3 accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2T68–p53S20 pathway. DNA Repair 11:12, pages 965-975.
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Tao Liu, Yu Liu, Hung-Ying Kao & Dehua Pei. (2010) Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1. Journal of Medicinal Chemistry 53:6, pages 2494-2501.
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Jiin-Tarng Wang, Shin-Lian Doong, Shu-Chun Teng, Chung-Pei Lee, Ching-Hwa Tsai & Mei-Ru Chen. (2009) Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway. Journal of Virology 83:4, pages 1856-1869.
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E. V. Spitsina, N. Yu. Yakunina, D. A. Chudakova, A. G. Nikitin, G. N. Svetlova, T. N. Soluyanova, I. A. Strokov & V. V. Nosikov. (2007) The association of the TP53 polymorphisms Pro72Arg and C(−594)CC with diabetic polyneuropathy in Russian Muscovites with type 1 diabetes mellitus. Molecular Biology 41:6, pages 901-905.
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Fiamma Mantovani, Francesca Tocco, Javier Girardini, Paul Smith, Milena Gasco, Xin Lu, Tim Crook & Giannino Del Sal. (2007) The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nature Structural & Molecular Biology 14:10, pages 912-920.
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