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Chromosome Structure and Dynamics

Expression of a Human Cytochrome P450 in Yeast Permits Analysis of Pathways for Response to and Repair of Aflatoxin-Induced DNA Damage

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Pages 5823-5833 | Received 07 Jan 2005, Accepted 25 Apr 2005, Published online: 27 Mar 2023

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Weiya Cao, Pan Yu, KePeng Yang & Dongli Cao. (2022) Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development. Toxicology Mechanisms and Methods 32:6, pages 395-419.
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Martha M. Moore, Rita S. Schoeny, Richard A. Becker, Kimberly White & Lynn H. Pottenger. (2018) Development of an adverse outcome pathway for chemically induced hepatocellular carcinoma: case study of AFB1, a human carcinogen with a mutagenic mode of action. Critical Reviews in Toxicology 48:4, pages 312-337.
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Lynn H. Pottenger, Larry S. Andrews, Ammie N. Bachman, Peter J. Boogaard, Jean Cadet, Michelle R. Embry, Peter B. Farmer, Matthew W. Himmelstein, Annie M. Jarabek, Elizabeth A. Martin, Robert J. Mauthe, Rudranath Persaud, R. Julian Preston, Rita Schoeny, Julie Skare, James A. Swenberg, Gary M. Williams, Errol Zeiger, Fagen Zhang & James H. Kim. (2014) An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Critical Reviews in Toxicology 44:4, pages 348-391.
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Articles from other publishers (27)

Sumit Rajaura, Pooja Chauhan, Harish Chandra & Nitin Bhardwaj. (2023) Aflatoxin B1 administration induces reactive oxygen species production and apoptosis of erythrocytes in mice. Toxicon 221, pages 106963.
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Lishan Yao, Tao Zhang, Shurui Peng, Dan Xu, Zhenbin Liu, Hongbo Li, Liangbin Hu & Haizhen Mo. (2022) Fe2+ protects postharvest pitaya (Hylocereus undulatus britt) from Aspergillus. flavus infection by directly binding its genomic DNA. Food Chemistry: Molecular Sciences 5, pages 100135.
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Solomon E. Owumi, Chioma E. Irozuru, Uche O. Arunsi, Hammed O. Faleke & Adegboyega K. Oyelere. (2022) Caffeic acid mitigates aflatoxin B1 ‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and the redox‐regulatory systems . Journal of Food Biochemistry 46:5.
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Lihong Jiang, Lei Huang, Jin Cai, Zhinan Xu & Jiazhang Lian. (2020) Functional expression of eukaryotic cytochrome P450s in yeast. Biotechnology and Bioengineering 118:3, pages 1050-1065.
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Michael Fasullo. 2021. Genotoxicity and Mutagenicity - Mechanisms and Test Methods. Genotoxicity and Mutagenicity - Mechanisms and Test Methods.
Nick St. John, Julian Freedland, Henri Baldino, Francis Doyle, Cinzia Cera, Thomas Begley & Michael Fasullo. (2020) Genome Profiling for Aflatoxin B1 Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B1-Associated DNA Damage . G3 Genes|Genomes|Genetics 10:11, pages 3929-3947.
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Simranjeet Singh, Vijay Kumar, Daljeet Singh Dhanjal, Siddharth Thotapalli, Sonali & Joginder Singh. 2020. New and Future Developments in Microbial Biotechnology and Bioengineering. New and Future Developments in Microbial Biotechnology and Bioengineering 301 309 .
Michael Fasullo. 2019. DNA Repair- An Update. DNA Repair- An Update.
Martin Klvana & Urban Bren. (2019) Aflatoxin B1–Formamidopyrimidine DNA Adducts: Relationships between Structures, Free Energies, and Melting Temperatures. Molecules 24:1, pages 150.
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Andreas Zimmermann, Sebastian Hofer, Tobias Pendl, Katharina Kainz, Frank Madeo & Didac Carmona-Gutierrez. (2018) Yeast as a tool to identify anti-aging compounds. FEMS Yeast Research 18:6.
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Toshihiko Eki. (2018) Yeast-based genotoxicity tests for assessing DNA alterations and DNA stress responses: a 40-year overview. Applied Microbiology and Biotechnology 102:6, pages 2493-2507.
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Evelyn Smit, Terezinha Souza, Danyel G.J. Jennen, Jos C.S. Kleinjans & Twan van den Beucken. (2017) Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics. Toxicology 390, pages 74-82.
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Liang Li, Kyle L. Brown, Ruidan Ma & Michael P. Stone. (2015) DNA Sequence Modulates Geometrical Isomerism of the trans -8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B 1 Adduct . Chemical Research in Toxicology 28:2, pages 225-237.
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Ying-Chih Lin, Liang Li, Alena V. Makarova, Peter M. Burgers, Michael P. Stone & R. Stephen Lloyd. (2014) Molecular basis of aflatoxin-induced mutagenesis—role of the aflatoxin B1-formamidopyrimidine adduct. Carcinogenesis 35:7, pages 1461-1468.
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Michael Fasullo, Autumn Smith, Patricia Egner & Cinzia Cera. (2014) Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 761, pages 18-26.
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Xue-Jiao Yang, Hui-Yuan Lu, Zi-Yin Li, Qian Bian, Liang-Lin Qiu, Zhong Li, Qizhan Liu, Jianmin Li, Xinru Wang & Shou-Lin Wang. (2012) Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells. Toxicology 300:3, pages 138-148.
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Renata Matuo, Fabrício G. Sousa, Daniele G. Soares, Diego Bonatto, Jenifer Saffi, Alexandre E. Escargueil, Annette K. Larsen & João Antonio Pêgas Henriques. (2012) Saccharomyces cerevisiae as a model system to study the response to anticancer agents. Cancer Chemotherapy and Pharmacology 70:4, pages 491-502.
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Kerstin Gross-Steinmeyer & David L. Eaton. (2012) Dietary modulation of the biotransformation and genotoxicity of aflatoxin B1. Toxicology 299:2-3, pages 69-79.
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Jolanda S. van Leeuwen, Galvin Vredenburg, Sanja Dragovic, T.F. Jennifer Tjong, J. Chris Vos & Nico P.E. Vermeulen. (2011) Metabolism related toxicity of diclofenac in yeast as model system. Toxicology Letters 200:3, pages 162-168.
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Michael Fasullo, Yifan Chen, William Bortcosh, Minzeng Sun & Patricia A. Egner. (2010) Aflatoxin B 1 -Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae . Journal of Nucleic Acids 2010, pages 1-9.
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Matthew R Northam, Heather A Robinson, Olga V Kochenova & Polina V Shcherbakova. (2010) Participation of DNA Polymerase ζ in Replication of Undamaged DNA in Saccharomyces cerevisiae . Genetics 184:1, pages 27-42.
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Michael Fasullo, Mingzeng Sun & Patricia Egner. (2008) Stimulation of sister chromatid exchanges and mutation by aflatoxin B 1 ‐DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53 , and DUN1 . Molecular Carcinogenesis 47:8, pages 608-615.
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Pascal Pineau, Agnès Marchio, Carlo Battiston, Emilie Cordina, Alessandro Russo, Benoît Terris, Lun-Xiu Qin, Bruno Turlin, Zhao-You Tang, Vincenzo Mazzaferro & Anne Dejean. (2008) Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 653:1-2, pages 6-13.
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Da C. Hao, Pan H. Zhu, Sheng L. Yang & Ling Yang. (2006) Enhanced production of human Cytochrome P450 2C9 by Escherichia coli BL21(DE3)pLysS through the novel use of grey relational analysis and Plackett–Burman design. World Journal of Microbiology and Biotechnology 23:1, pages 71-78.
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Sabrina Peterson, Johanna W. Lampe, Theo K. Bammler, Kerstin Gross-Steinmeyer & David L. Eaton. (2006) Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food and Chemical Toxicology 44:9, pages 1474-1484.
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Leanne L. Bedard & Thomas E. Massey. (2006) Aflatoxin B1-induced DNA damage and its repair. Cancer Letters 241:2, pages 174-183.
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Yingying Guo, Linda L. Breeden, Wenhong Fan, Lue Ping Zhao, David L. Eaton & Helmut Zarbl. (2006) Analysis of cellular responses to aflatoxin B1 in yeast expressing human cytochrome P450 1A2 using cDNA microarrays. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 593:1-2, pages 121-142.
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