Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 14
Submit an article Journal homepage
55
Views
124
CrossRef citations to date
0
Altmetric
Gene Expression

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases

Ajay KumarProgram in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts02115
,
Zhiyong LinProgram in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts02115
,
Sucharita SenBanerjeeProgram in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts02115
&
Mukesh K. JainProgram in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts02115Correspondence[email protected]
Pages 5893-5903 | Received 09 Dec 2004, Accepted 07 Apr 2005, Published online: 27 Mar 2023

Citations (124)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Hiroyuki Nakajima & Naoki Mochizuki. (2017) Flow pattern-dependent endothelial cell responses through transcriptional regulation. Cell Cycle 16:20, pages 1893-1901.
Read now
Gwenaele Garin & Bradford C. Berk. (2006) Flow-Mediated Signaling Modulates Endothelial Cell Phenotype. Endothelium 13:6, pages 375-384.
Read now

Articles from other publishers (122)

Lihua Wang, Bingyue Wang, Lan Jia, Haibo Yu, Zhe Wang, Fang Wei & Aili Jiang. (2023) Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions. Open Life Sciences 18:1.
Crossref
Zexu Shen, Yun Bei, Haoran Lin, Taofeng Wei, Yunjian Dai, Yangmin Hu, Chao Zhang & Haibin Dai. (2023) The role of class IIa histone deacetylases in regulating endothelial function. Frontiers in Physiology 14.
Crossref
Jiaojiao Wang, Zhiping Liu, Jing Lu, Jiami Zou, Weile Ye, Hong Li, Si Gao & Peiqing Liu. (2023) SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3). Biochemical Pharmacology 209, pages 115439.
Crossref
Mostafa Samak, Andreas Kues, Diana Kaltenborn, Lina Klösener, Matthias Mietsch, Giulia Germena & Rabea Hinkel. (2023) Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes. International Journal of Molecular Sciences 24:3, pages 2482.
Crossref
Brian G. Coon, Sushma Timalsina, Matteo Astone, Zhen W. Zhuang, Jennifer Fang, Jinah Han, Jurgen Themen, Minhwan Chung, Young Joo Yang-Klingler, Mukesh Jain, Karen K. Hirschi, Ai Yamamato, Louis-Eric Trudeau, Massimo Santoro & Martin A. Schwartz. (2022) A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells. Journal of Cell Biology 221:7.
Crossref
Nada M. Kamel, Dalia M. El-Tanbouly, Dalaal M. Abdallah & Helmy M. Sayed. (2022) PAR1, a therapeutic target for remote lung injury associated with hind limb ischemia/reperfusion: ERK5/KLF2-dependent lung capillary barrier preservation. Chemico-Biological Interactions 354, pages 109809.
Crossref
Hanqiang Deng, Elizabeth MinNicolas Baeyens, Brian G. CoonRui HuZhen W. ZhuangMinghao Chen, Billy HuangTitilayo AfolabiGeorgia ZarkadaAngela Acheampong, Kathleen McEnteeAnne EichmannFang Liu, Bing Su, Michael Simons & Martin A. Schwartz. (2021) Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling. Proceedings of the National Academy of Sciences 118:37.
Crossref
Suowen Xu, Yujie Liu, Yu Ding, Sihui Luo, Xueying Zheng, Xiumei Wu, Zhenghong Liu, Iqra Ilyas, Suyu Chen, Shuxin Han, Peter J. Little, Mukesh K. Jain & Jianping Weng. (2021) The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal Transduction and Targeted Therapy 6:1.
Crossref
Cleide Angolano, Elzbieta Kaczmarek, Sanah Essayagh, Soizic Daniel, Lynn Y. Choi, Brian Tung, Gabriel Sauvage, Andy Lee, Franciele C. Kipper, Maria B. Arvelo, Herwig P. Moll & Christiane Ferran. (2021) A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation. Frontiers in Cardiovascular Medicine 8.
Crossref
Salina Nicoleau, Adam Fellows & Beata Wojciak-Stothard. (2021) Role of Krüppel-like factors in pulmonary arterial hypertension. The International Journal of Biochemistry & Cell Biology 134, pages 105977.
Crossref
Chi Chen, Jingyan Chen, Xuefei Tao, Minghuan Fu, Biao Cheng & Xiaohan Chen. (2021) Activation of GPR30 with G1 inhibits oscillatory shear stress-induced adhesion of THP-1 monocytes to HAECs by increasing KLF2. Aging 13:8, pages 11942-11953.
Crossref
David R. SweetMukesh K. Jain. (2021) Safeguarding the Vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology 41:3, pages 1124-1126.
Crossref
Yao Wei Lu, Nina MartinoBrennan D. Gerlach, John M. Lamar, Peter A. VincentAlejandro P. Adam & John J. Schwarz. (2021) MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program. Arteriosclerosis, Thrombosis, and Vascular Biology 41:3, pages 1105-1123.
Crossref
Heming Ma, Xu Liu, Mingyuan Zhang & Junqi Niu. (2021) Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms. Molecular Biology Reports 48:3, pages 2803-2815.
Crossref
Hanna M. Peacock, Margo Daems & Elizabeth A. V. Jones. 2021. Vascular Mechanobiology in Physiology and Disease. Vascular Mechanobiology in Physiology and Disease 127 166 .
Rosa María Tordera & María Cortés-Erice. 2021. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 1 47 .
Francesco Ferraro, Francesca Patella, Joana R. Costa, Robin Ketteler, Janos Kriston‐Vizi & Daniel F. Cutler. (2020) Modulation of endothelial organelle size as an antithrombotic strategy. Journal of Thrombosis and Haemostasis 18:12, pages 3296-3308.
Crossref
David R. Sweet, Neelakantan T. Vasudevan, Liyan Fan, Chloe E. Booth, Komal S. Keerthy, Xudong Liao, Vinesh Vinayachandran, Yoichi Takami, Derin Tugal, Nikunj Sharma, E. Ricky Chan, Lilei Zhang, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Panjamaporn Sangwung, Lalitha Nayak, Paul Holvoet, Keiichiro Matoba, Yuan Lu, Guangjin Zhou & Mukesh K. Jain. (2020) Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation. Nature Communications 11:1.
Crossref
Marta Roche-Molina, Bryn Hardwick, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M. Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A. Palma, Borja Ibanez, Grahame Mckenzie & Juan A. Bernal. (2020) The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis. Scientific Reports 10:1.
Crossref
Ratan Sadhukhan, Justin W. C. Leung, Sarthak Garg, Kimberly J. Krager, Alena V. Savenka, Alexei G. Basnakian & Rupak Pathak. (2020) Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Scientific Reports 10:1.
Crossref
Suowen Xu. (2020) Therapeutic potential of blood flow mimetic compounds in preventing endothelial dysfunction and atherosclerosis. Pharmacological Research 155, pages 104737.
Crossref
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins & Beata Wojciak-Stothard. (2020) Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nature Communications 11:1.
Crossref
K. T. Turpaev. (2020) Transcription Factor KLF2 and Its Role in the Regulation of Inflammatory Processes. Biochemistry (Moscow) 85:1, pages 54-67.
Crossref
Chang Xue, Xiaohui Liu, Bin Wen, Ruimeng Yang, Shuo Gao, Jiong Tao & Jun Zhou. (2019) Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c. Frontiers in Cell and Developmental Biology 7.
Crossref
Zhongzhong Liu, Chin-hui Lai, Xingjian Zhang, Jun Luo, Xiaoying Huang, Xiao Qi, Wei Wang, Zibiao Zhong, Fan Xiaoli, Ling Li, Yan Xiong, Norbert Senninger, Yanfeng Wang, Qifa Ye & Shaojun Ye. (2019) Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats. Clinics and Research in Hepatology and Gastroenterology 43:2, pages 171-178.
Crossref
Katharine R. Clapham, Inderjit Singh, Isabella S. Capuano, Sudarshan Rajagopal & Hyung J. Chun. (2019) MEF2 and the Right Ventricle: From Development to Disease. Frontiers in Cardiovascular Medicine 6.
Crossref
Himavanth Gatla, Nethaji Muniraj, Prashanth Thevkar, Siddhartha Yavvari, Sahithi Sukhavasi & Monish Makena. (2019) Regulation of Chemokines and Cytokines by Histone Deacetylases and an Update on Histone Decetylase Inhibitors in Human Diseases. International Journal of Molecular Sciences 20:5, pages 1110.
Crossref
Hong Wu, Xinzhou Wang, Shuibo Gao, Liping Dai, Haibin Tong, Haixia Gao, Zhen Lei, Yongjun Han, Zhentao Wang, Lihua Han & Dake Qi. (2019) Yiqi-Huoxue Granule (YQHX) Downregulates Prothrombotic Factors by Modulating KLF2 and NF- κ B in HUVECs following LPS Stimulation . Oxidative Medicine and Cellular Longevity 2019, pages 1-10.
Crossref
Rui Yan, Matijs van Meurs, Eliane R. Popa, Ranran Li, Peter J. Zwiers, Jan G. Zijlstra, Jill Moser & Grietje Molema. (2019) Early Heterogenic Response of Renal Microvasculature to Hemorrhagic Shock/Resuscitation and the Influence of NF-κB Pathway Blockade. Shock 51:2, pages 200-212.
Crossref
Jianghua Zheng, Kai Chen, Yanbin Zhu, Haifei Wang, Zhilong Chen, Xi Yong, Hongshun Yin, Jingquan Chen, Kun Lai & Yujuan Liu. (2019) The neurokinin-1 receptor antagonist aprepitant ameliorates oxidized LDL-induced endothelial dysfunction via KLF2. Molecular Immunology 106, pages 29-35.
Crossref
Siva Kumar Panguluri. 2019. Coronary and Cardiothoracic Critical Care. Coronary and Cardiothoracic Critical Care 322 345 .
Xinxing Zhu, Jiang Du, Jinjin Yu, Rui Guo, Yanyan Feng, Liang Qiao, Zhihao Xu, Fen Yang, Genshen Zhong, Fulong Liu, Fangfang Cheng, Maoping Chu & Juntang Lin. (2019) LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop. Journal of Molecular and Cellular Cardiology 126, pages 60-69.
Crossref
Caroline CaraduThierry CouffinhalCandice ChapoulySarah GuimbalPierre-Louis HollierEric DucasseAlessandra Bura-RivièreMathilde DuboisAlain-Pierre GadeauMarie-Ange Renault. (2018) Restoring Endothelial Function by Targeting Desert Hedgehog Downstream of Klf2 Improves Critical Limb Ischemia in Adults. Circulation Research 123:9, pages 1053-1065.
Crossref
Peta Bradbury, Daniela Traini, Alaina J. Ammit, Paul M. Young & Hui Xin Ong. (2018) Repurposing of statins via inhalation to treat lung inflammatory conditions. Advanced Drug Delivery Reviews 133, pages 93-106.
Crossref
Meng Li, Betty C.A.M. van Esch, Gerry T.M. Wagenaar, Johan Garssen, Gert Folkerts & Paul A.J. Henricks. (2018) Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. European Journal of Pharmacology 831, pages 52-59.
Crossref
Hairong Chu, Hong Li, Xiumei Guan, Hong Yan, Xiaoyun Zhang, Xiaodong Cui, Xin Li & Min Cheng. (2018) Resveratrol protects late endothelial progenitor cells from TNF-α-induced inflammatory damage by upregulating Kr�ppel-like factor-2. Molecular Medicine Reports.
Crossref
Keith Saum, Begoña Campos, Diego Celdran‐Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy‐Chaudhury & A. Phillip OwensIII PhDIII PhD. (2018) Uremic Advanced Glycation End Products and Protein‐Bound Solutes Induce Endothelial Dysfunction Through Suppression of Krüppel‐Like Factor 2. Journal of the American Heart Association 7:1.
Crossref
Prerana Jha & Hiranmoy Das. (2017) KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation. International Journal of Molecular Sciences 18:11, pages 2383.
Crossref
Eugene Chang, Lalitha Nayak & Mukesh K. Jain. (2017) Krüppel-like factors in endothelial cell biology. Current Opinion in Hematology 24:3, pages 224-229.
Crossref
Christina A. Eichstaedt, Jie Song, Rebecca Rodríguez Viales, Zixuan Pan, Nicola Benjamin, Christine Fischer, Marius M. Hoeper, Silvia Ulrich, Katrin Hinderhofer & Ekkehard Grünig. (2017) First identification of Krüppel-like factor 2 mutation in heritable pulmonary arterial hypertension . Clinical Science 131:8, pages 689-698.
Crossref
Jack E. Teasdale, Georgina G. J. Hazell, Alasdair M. G. Peachey, Graciela B. Sala-Newby, Charles C. T. Hindmarch, Tristan R. McKay, Mark Bond, Andrew C. Newby & Stephen J. White. (2017) Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells. Scientific Reports 7:1.
Crossref
Siva Kumar Panguluri. 2017. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research 93 116 .
Zhongzhong Liu, Xingjian Zhang, Qi Xiao, Shaojun Ye, Chin-Hui Lai, Jun Luo, Xiaoying Huang, Wei Wang, Cheng Zeng, Zibiao Zhong, Xiaoli Fan, Zhiping Xia, Yan Xiong, Xinfang Mao, Qifa Ye & Yanfeng Wang. (2017) Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxidative Medicine and Cellular Longevity 2017, pages 1-10.
Crossref
Dimitry A. Chistiakov, Alexander N. Orekhov & Yuri V. Bobryshev. (2017) Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation. International Journal of Cardiology 227, pages 66-82.
Crossref
Kyung-Sun HeoBradford C. BerkJun-ichi Abe. (2016) Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events . Antioxidants & Redox Signaling 25:7, pages 435-450.
Crossref
Rachel D. Simmons, Sandeep Kumar, Salim Raid Thabet, Sanjoli Sur & Hanjoong Jo. (2016) Omics‐based approaches to understand mechanosensitive endothelial biology and atherosclerosis. WIREs Systems Biology and Medicine 8:5, pages 378-401.
Crossref
Ajay Kumar, Catherine Corey, Iain Scott, Sruti Shiva & Jonathan D’Cunha. (2016) Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer. PLOS ONE 11:8, pages e0160783.
Crossref
Rachel D. Simmons, Sandeep Kumar & Hanjoong Jo. (2016) The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches. Archives of Biochemistry and Biophysics 591, pages 111-131.
Crossref
Hsiao-Huei ChenKianoosh KeyhanianXun ZhouRagnar O. VilmundarsonNaif A.M. AlmontashiriShelly A. CruzNihar R. PandeyNida Lerma YapTiffany HoChloe A. StewartHua HuangAswin HariMichele GeoffrionRuth McPhersonKatey J. RaynerAlexandre F.R. Stewart. (2015) IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis. Circulation Research 117:8, pages 671-683.
Crossref
Kohshiro Nakao, Hiroshi Kishi, Fumiharu Imai, Hiroto Suwa, Takashi Hirakawa & Takashi Minegishi. (2015) TNF-α Suppressed FSH-Induced LH Receptor Expression Through Transcriptional Regulation in Rat Granulosa Cells. Endocrinology 156:9, pages 3192-3202.
Crossref
Zhenhua Xu, Takeshi Yoshida, Lijuan Wu, Debasish Maiti, Liudmila Cebotaru & Elia J. Duh. (2015) Transcription Factor MEF2C Suppresses Endothelial Cell Inflammation via Regulation of NF-κB and KLF2. Journal of Cellular Physiology 230:6, pages 1310-1320.
Crossref
Tamaki Kurosawa, Atsushi Yamada, Masamichi Takami, Dai Suzuki, Yoshiro Saito, Katsuhiro Hiranuma, Takuya Enomoto, Naoko Morimura, Matsuo Yamamoto, Takehiko Iijima, Tatsuo Shirota, Hiroyuki Itabe & Ryutaro Kamijo. (2015) Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways. FEBS Open Bio 5:1, pages 303-307.
Crossref
Eros Di Giorgio, Enrico Gagliostro & Claudio Brancolini. (2014) Selective class IIa HDAC inhibitors: myth or reality. Cellular and Molecular Life Sciences 72:1, pages 73-86.
Crossref
TIAN ZHOU, YIMING ZHENG, JUHUI QIU, JIANJUN HU, DAMING SUN, CHAOJUN TANG & GUIXUE WANG. (2014) ENDOTHELIAL MECHANOTRANSDUCTION MECHANISMS FOR VASCULAR PHYSIOLOGY AND ATHEROSCLEROSIS. Journal of Mechanics in Medicine and Biology 14:05, pages 1430006.
Crossref
Il-Sun Kwon, Weiye Wang, Suowen Xu & Zheng-Gen Jin. (2014) Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium. Cardiovascular Research 104:1, pages 127-137.
Crossref
Lawryn H. Kasper, Tomofusa Fukuyama & Paul K. Brindle. (2014) T-Cells Null for the MED23 Subunit of Mediator Express Decreased Levels of KLF2 and Inefficiently Populate the Peripheral Lymphoid Organs. PLoS ONE 9:7, pages e102076.
Crossref
Yi-Zhou JiangJuan M. JiménezKristy OuMargaret E. McCormickLing-Di ZhangPeter F. Davies. (2014) Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo. Circulation Research 115:1, pages 32-43.
Crossref
Cristina M. Alvira. (2014) Nuclear factor‐kappa‐B signaling in lung development and disease: One pathway, numerous functions. Birth Defects Research Part A: Clinical and Molecular Teratology 100:3, pages 202-216.
Crossref
Peter Novodvorsky & Timothy J.A. Chico. 2014. Genetics of Cardiovascular Disease. Genetics of Cardiovascular Disease 155 188 .
José Basílio, Martina Hoeth, Yvonne M. Holper-Schichl, Ulrike Resch, Herbert Mayer, Renate Hofer-Warbinek & Rainer de Martin. (2013) TNFα-induced down-regulation of Sox18 in endothelial cells is dependent on NF-κB. Biochemical and Biophysical Research Communications 442:3-4, pages 221-226.
Crossref
Ajay KumarSantosh KumarAjit VikramTimothy A. HoffmanAsma NaqviChristopher M. LewarchikYoung-Rae KimKaikobad Irani. (2013) Histone and DNA Methylation–Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology 33:8, pages 1936-1942.
Crossref
Lalitha Nayak, Lediana Goduni, Yoichi Takami, Nikunj Sharma, Parul Kapil, Mukesh K. Jain & Ganapati H. Mahabeleshwar. (2013) Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation. The American Journal of Pathology 182:5, pages 1696-1704.
Crossref
Siva K. Panguluri, Jared Tur, Kalyan C. Chapalamadugu, Chris Katnik, Javier Cuevas & Srinivas M. Tipparaju. (2013) MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators. PLoS ONE 8:4, pages e60545.
Crossref
Hae-Young Lee, Seock-Won Youn, Hyun-Jai Cho, Yoo-Wook Kwon, Sae-Won Lee, Sung-Jin Kim, Young-Bae Park, Byung-Hee Oh & Hyo-Soo Kim. (2013) FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Krüppel-like factor 2. Cardiovascular Research 97:1, pages 143-152.
Crossref
B Mills, T Robb & DF Larson. (2012) Intimal hyperplasia: slow but deadly. Perfusion 27:6, pages 520-528.
Crossref
Xinghui Sun & Mark W. Feinberg. (2012) NF-κB and Hypoxia. The American Journal of Pathology 181:5, pages 1513-1517.
Crossref
Alexandre Casta, Hyunmi Kim, Courtney T. Luke, Michael A. Bachelor, Andrew Engelhard, David M. Owens & Angela M. Christiano. (2012) Hairless and NFκB Form a Positive Feedback Loop After UVB and TNFα Stimulation†. Photochemistry and Photobiology 88:5, pages 1173-1183.
Crossref
Moeez G. Rathore, Anne Saumet, Jean-François Rossi, Carine de Bettignies, Denis Tempé, Charles-Henri Lecellier & Martin Villalba. (2012) The NF-κB member p65 controls glutamine metabolism through miR-23a. The International Journal of Biochemistry & Cell Biology 44:9, pages 1448-1456.
Crossref
Ellen L. van Agtmaal, Ruben Bierings, Bieuwke S. Dragt, Thomas A. Leyen, Mar Fernandez-Borja, Anton J. G. Horrevoets & Jan Voorberg. (2012) The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies. PLoS ONE 7:6, pages e38399.
Crossref
Jerry B LingrelRobyn Pilcher-RobertsJoshua E. BasfordPalanikumar ManoharanJon NeumannEddy S. KonaniahRamprasad SrinivasanVladimir Y. BogdanovDavid Y. Hui. (2012) Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases Macrophage and Neutrophil Adhesion and Promotes Atherosclerosis. Circulation Research 110:10, pages 1294-1302.
Crossref
J.S. Marschall, T. Wilhelm, W. Schuh & M. Huber. (2012) MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells. Cellular Signalling 24:4, pages 879-888.
Crossref
Zhuang Wu, Ming-Cheh Liu, Mei Liang & Jian Fu. (2012) Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure. Blood 119:10, pages 2422-2429.
Crossref
Xiao-Qun WangPatrizia NigroCameron WorldKeigi FujiwaraChen YanBradford C. Berk. (2012) Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2. Circulation Research 110:4, pages 560-568.
Crossref
Thomas Helbing, René Rothweiler, Elena Ketterer, Lena Goetz, Jennifer Heinke, Sebastian Grundmann, Daniel Duerschmied, Cam Patterson, Christoph Bode & Martin Moser. (2011) BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium. Blood 118:18, pages 5040-5049.
Crossref
Lalitha NayakZhiyong LinMukesh K. Jain. (2011) “Go With the Flow”: How Krüppel-Like Factor 2 Regulates the Vasoprotective Effects of Shear Stress. Antioxidants & Redox Signaling 15:5, pages 1449-1461.
Crossref
Kaikobad Irani. (2011) Crippling of Krüppel (-Like Factor 2) by Bad Flow Portends a miRky Day for Endothelial Function. Circulation 124:5, pages 541-543.
Crossref
Wei WuHan XiaoAndrés Laguna-FernandezGuadalupe VillarrealJrJrKuei-Chun WangGreg G. GearyYuzhi ZhangWei-Chi WangHsien-Da HuangJing ZhouYi-Shuan LiShu ChienGuillermo Garcia-CardenaJohn Y.-J. Shyy. (2011) Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation 124:5, pages 633-641.
Crossref
Steffen JustIna M. BergerBenjamin MederJohannes BacksAndreas KellerSabine MarquartKaren FreseEva PatzelGerd-Jörg RauchHugo A. KatusWolfgang Rottbauer. (2011) Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity. Circulation 124:3, pages 324-334.
Crossref
Yan Zhang, Scot J. Matkovich, Xiujun Duan, Abhinav Diwan, Min-Young Kang & Gerald W. DornIIII. (2011) Receptor-independent Protein Kinase Cα (PKCα) Signaling by Calpain-generated Free Catalytic Domains Induces HDAC5 Nuclear Export and Regulates Cardiac Transcription. Journal of Biological Chemistry 286:30, pages 26943-26951.
Crossref
Kristi L. AllenAnne Hamik, Mukesh K. Jain & Keith R. McCrae. (2011) Endothelial cell activation by antiphospholipid antibodies is modulated by Krüppel-like transcription factors. Blood 117:23, pages 6383-6391.
Crossref
Ganapati H. Mahabeleshwar, Daiji Kawanami, Nikunj Sharma, Yoichi Takami, Guangjin Zhou, Hong Shi, Lalitha Nayak, Darwin Jeyaraj, Robert Grealy, Mary White, Ross McManus, Thomas Ryan, Patrick Leahy, Zhiyong Lin, Saptarsi M. Haldar, G. Brandon Atkins, Hector R. Wong, Jerry B. Lingrel & Mukesh K. Jain. (2011) The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity 34:5, pages 715-728.
Crossref
Joseph W. GordonJames A. ShawLorrie A. Kirshenbaum. (2011) Multiple Facets of NF-κB in the Heart. Circulation Research 108:9, pages 1122-1132.
Crossref
M M Chaturvedi, B Sung, V R Yadav, R Kannappan & B B Aggarwal. (2010) NF-κB addiction and its role in cancer: ‘one size does not fit all’. Oncogene 30:14, pages 1615-1630.
Crossref
PAUL R. CLARK, TODD J. JENSEN, MARTIN S. KLUGER, MAURICE MORELOCK, ADEDAYO HANIDU, ZHENHAO QI, REVATI J. TATAKE & JORDAN S. POBER. (2011) MEK5 is Activated by Shear Stress, Activates ERK5 and Induces KLF4 to Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells. Microcirculation 18:2, pages 102-117.
Crossref
Reinier A. Boon, Carmen Urbich, Ariane Fischer, Ruud D. Fontijn, Florian H. Seeger, Masamichi Koyanagi, Anton J.G. Horrevoets & Stefanie Dimmeler. (2011) Krüppel-like factor 2 improves neovascularization capacity of aged proangiogenic cells. European Heart Journal 32:3, pages 371-377.
Crossref
Nadia Cernotta, Andrea Clocchiatti, Cristina Florean & Claudio Brancolini. (2011) Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility. Molecular Biology of the Cell 22:2, pages 278-289.
Crossref
Ajay KumarCuk-Seong KimTimothy A. HoffmanAsma NaqviJeremy DeRiccoSaet-Byel JungZhiyong LinMukesh K. JainKaikobad Irani. (2011) p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2. Arteriosclerosis, Thrombosis, and Vascular Biology 31:1, pages 133-141.
Crossref
Jason C. Wong, Lei Guo, Zhenghong Peng, Weixing Zhang, Nan Zhang, Wayne Lai, Zhenshan Zhang, Chao Zhang, Xiongwen Zhang, Shan Song, Desi Pan, Chuanming Xie, Jia Li, Zhiqing Ning, Xianping Lu, Yun He & Li Chen. (2011) Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy. Bioorganic & Medicinal Chemistry Letters 21:1, pages 110-116.
Crossref
Shaolin HeMing LiXuming MaJing LinDazhu Li. (2010) CD4 + CD25 + Foxp3 + Regulatory T Cells Protect the Proinflammatory Activation of Human Umbilical Vein Endothelial Cells . Arteriosclerosis, Thrombosis, and Vascular Biology 30:12, pages 2621-2630.
Crossref
Beth B. McConnell & Vincent W. Yang. (2010) Mammalian Krüppel-Like Factors in Health and Diseases. Physiological Reviews 90:4, pages 1337-1381.
Crossref
Janine Zahlten, Robert Steinicke, Bastian Opitz, Julia Eitel, Philippe Dje N’Guessan, Maya Vinzing, Martin Witzenrath, Bernd Schmeck, Sven Hammerschmidt, Norbert Suttorp & Stefan Hippenstiel. (2010) TLR2- and Nucleotide-Binding Oligomerization Domain 2-Dependent Krüppel-Like Factor 2 Expression Downregulates NF-κB–Related Gene Expression. The Journal of Immunology 185:1, pages 597-604.
Crossref
Yumiko Oishi, Ichiro Manabe, Yasushi Imai, Kazuo Hara, Momoko Horikoshi, Katsuhito Fujiu, Toshihiro Tanaka, Tadanori Aizawa, Takashi Kadowaki & Ryozo Nagai. (2010) Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. The FASEB Journal 24:6, pages 1780-1788.
Crossref
Padmamalini Kannan-Thulasiraman, Darcie D. Seachrist, Ganapati H. Mahabeleshwar, Mukesh K. Jain & Noa Noy. (2010) Fatty Acid-binding Protein 5 and PPARβ/δ Are Critical Mediators of Epidermal Growth Factor Receptor-induced Carcinoma Cell Growth. Journal of Biological Chemistry 285:25, pages 19106-19115.
Crossref
Paul Huang. (2010) HDAC5: going with the flow. Blood 115:14, pages 2728-2729.
Crossref
Weiye Wang, Chang Hoon Ha, Bong Sook Jhun, Chelsea Wong, Mukesh K. Jain & Zheng-Gen Jin. (2010) Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood 115:14, pages 2971-2979.
Crossref
Reinier A. BoonThomas A. LeyenRuud D. FontijnJoost O. FledderusJosefien M. C. BaggenOscar L. VolgerGeerten P. van Nieuw Amerongen & Anton J. G. Horrevoets. (2010) KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium. Blood 115:12, pages 2533-2542.
Crossref
Young-Sook Baek, Stefan Haas, Holger Hackstein, Gregor Bein, Maria Hernandez-Santana, Hans Lehrach, Sascha Sauer & Harald Seitz. (2009) Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunology 10:1.
Crossref
Ajay Kumar, Timothy A. Hoffman, Jeremy DeRicco, Asma Naqvi, Mukesh K. Jain & Kaikobad Irani. (2009) Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc. The FASEB Journal 23:12, pages 4344-4352.
Crossref
Keisuke Sako, Shigetomo Fukuhara, Takashi Minami, Takao Hamakubo, Haihua Song, Tatsuhiko Kodama, Akiyoshi Fukamizu, J. Silvio Gutkind, Gou Young Koh & Naoki Mochizuki. (2009) Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2. Journal of Biological Chemistry 284:9, pages 5592-5601.
Crossref
Pavel Kuneš, Zdeňka Holubcová & Jan Krejsek. (2009) Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall. Acta Medica (Hradec Kralove, Czech Republic) 52:4, pages 135-139.
Crossref
Guillermo García-Cardeña & Guadalupe Villarreal. 2009. The Biology of Krüppel-like Factors. The Biology of Krüppel-like Factors 173 184 .
Judy Enenstein, Liming Milbauer, Evidio Domingo, Alexandra Wells, Mark Roney, Jim Kiley, Peng Wei & Robert P. Hebbel. (2009) Proinflammatory phenotype with imbalance of KLF2 and RelA: Risk of childhood stroke with sickle cell anemia. American Journal of Hematology, pages NA-NA.
Crossref
Pia Larsson, Erik Ulfhammer, Lena Karlsson, Maria Bokarewa, Karin Wåhlander & Sverker Jern. (2008) Effects of IL-1β and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells. Thrombosis Research 123:2, pages 342-351.
Crossref
Victoria Ridger, Rob Krams, Angelo Carpi & Paul C. Evans. (2008) Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update. Biomedicine & Pharmacotherapy 62:8, pages 536-540.
Crossref
Baiqiu Wang, Saptarsi M. Haldar, Yuan Lu, Osama A. Ibrahim, Sudeshna Fisch, Susan Gray, Andrew Leask & Mukesh K. Jain. (2008) The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. Journal of Molecular and Cellular Cardiology 45:2, pages 193-197.
Crossref
Bingying Xu, Jane Chiu, Biao Feng, Shali Chen & Subrata Chakrabarti. (2008) PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. Diabetes/Metabolism Research and Reviews 24:5, pages 404-412.
Crossref
Milene T. Saavedra, Abby D. Patterson, James West, Scott H. Randell, David W. Riches, Ken C. Malcolm, Carlyne D. Cool, Jerry A. Nick & Charles A. Dinarello. (2008) Abrogation of Anti-Inflammatory Transcription Factor LKLF in Neutrophil-Dominated Airways. American Journal of Respiratory Cell and Molecular Biology 38:6, pages 679-688.
Crossref
Guang-Hui Liu, Jing Qu & Xun Shen. (2008) NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:5, pages 713-727.
Crossref
Chang-Hoon WooTetsuro ShishidoCarolyn McClainJae Hyang LimJian-Dong LiJay YangChen YanJun-ichi Abe. (2008) Extracellular Signal-Regulated Kinase 5 SUMOylation Antagonizes Shear Stress–Induced Antiinflammatory Response and Endothelial Nitric Oxide Synthase Expression in Endothelial Cells. Circulation Research 102:5, pages 538-545.
Crossref
Bradford C. Berk. (2008) Atheroprotective Signaling Mechanisms Activated by Steady Laminar Flow in Endothelial Cells. Circulation 117:8, pages 1082-1089.
Crossref
Jinghai Wu, Cynthia S. Bohanan, Jon C. Neumann & Jerry B. Lingrel. (2008) KLF2 Transcription Factor Modulates Blood Vessel Maturation through Smooth Muscle Cell Migration. Journal of Biological Chemistry 283:7, pages 3942-3950.
Crossref
Bianca C. W. Groenendijk, Kim Van der Heiden, Beerend P. Hierck & Robert E. Poelmann. (2007) The Role of Shear Stress on ET-1, KLF2, and NOS-3 Expression in the Developing Cardiovascular System of Chicken Embryos in a Venous Ligation Model. Physiology 22:6, pages 380-389.
Crossref
Farah D. Lubin & J. David Sweatt. (2007) The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories. Neuron 55:6, pages 942-957.
Crossref
G. Brandon AtkinsMukesh K. Jain. (2007) Role of Krüppel-Like Transcription Factors in Endothelial Biology. Circulation Research 100:12, pages 1686-1695.
Crossref
Eoin O'Grady, Heidi Mulcahy, Claire Adams, John P. Morrissey & Fergal O'Gara. (2007) Manipulation of host Kruppel-like factor (KLF) function by exotoxins from diverse bacterial pathogens. Nature Reviews Microbiology 5:5, pages 337-341.
Crossref
Neil D. Perkins. (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nature Reviews Molecular Cell Biology 8:1, pages 49-62.
Crossref
Katie Schumm, Sonia Rocha, Jorge Caamano & Neil D Perkins. (2006) Regulation of p53 tumour suppressor target gene expression by the p52 NF-κB subunit. The EMBO Journal 25:20, pages 4820-4832.
Crossref
Justin P. Huddleson, Nisar Ahmad & Jerry B. Lingrel. (2006) Up-regulation of the KLF2 Transcription Factor by Fluid Shear Stress Requires Nucleolin. Journal of Biological Chemistry 281:22, pages 15121-15128.
Crossref
Zhiyong LinAnne HamikRajan JainAjay KumarMukesh K. Jain. (2006) Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Thrombin-Mediated Endothelial Activation. Arteriosclerosis, Thrombosis, and Vascular Biology 26:5, pages 1185-1185.
Crossref
Hiranmoy DasAjay KumarZhiyong LinWillmar D. Patino, Paul M. Hwang, Mark W. FeinbergPradip K. Majumder & Mukesh K. Jain. (2006) Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proceedings of the National Academy of Sciences 103:17, pages 6653-6658.
Crossref
P. Libby, M. Aikawa & M. K. Jain. 2006. The Vascular Endothelium II. The Vascular Endothelium II 285 306 .
Mukesh K. Jain & Paul M. Ridker. (2005) Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms. Nature Reviews Drug Discovery 4:12, pages 977-987.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.