Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 14
Submit an article Journal homepage
70
Views
176
CrossRef citations to date
0
Altmetric
Gene Expression

Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-κB and AP-1

Heping Yang1 Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California90033
,
Nathaniel Magilnick1 Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California90033
,
Candy Lee2 Department of Pathology, University of California, Irvine, Irvine, California92697
,
Denise Kalmaz1 Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California90033
,
Xiaopeng Ou1 Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California90033
,
Jefferson Y. Chan2 Department of Pathology, University of California, Irvine, Irvine, California92697
&
Shelly C. Lu1 Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California90033Correspondence[email protected]
 show all
Pages 5933-5946 | Received 20 Aug 2004, Accepted 12 Apr 2005, Published online: 27 Mar 2023

Citations (176)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

M. Yang, R. Chen, Y. D. Song, Y. M. Zhou, Q. Liu & S. Zhuang. (2022) Effects of dietary betaine supplementation on growth performance, meat quality, muscle fatty acid composition and antioxidant ability in slow-growing broiler chickens. British Poultry Science 63:3, pages 351-359.
Read now
Michelle Vaz, Narsa Machireddy, Ashley Irving, Haranatha R. Potteti, Karinne Chevalier, Dhananjaya Kalvakolanu & Sekhar P. Reddy. (2012) Oxidant-Induced Cell Death and Nrf2-Dependent Antioxidative Response Are Controlled by Fra-1/AP-1. Molecular and Cellular Biology 32:9, pages 1694-1709.
Read now
Irene Bobilev, Victoria Novik, Itai Levi, Ofer Shpilberg, Joseph Levy, Yoav Sharoni, George P. Studzinski & Michael Danilenko. (2011) The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells . Cancer Biology & Therapy 11:3, pages 317-329.
Read now
Shruti Singh, Sonal Vrishni, Brijesh K. Singh, Irfan Rahman & Poonam Kakkar. (2010) Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radical Research 44:11, pages 1267-1288.
Read now
Wei Yan, Han-dong Wang, Lin Zhu, Xiao-mei Feng, Liang Qiao, Wei Jin & Ke Tang. (2008) Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain Injury 22:10, pages 802-810.
Read now
W. B. Mattes, K. K. Daniels, M. Summan, Z. A. Xu & D. L. Mendrick. (2006) Tissue and species distribution of the glutathione pathway transcriptome. Xenobiotica 36:10-11, pages 1081-1121.
Read now

Articles from other publishers (170)

Bingqing Wang, Yue Wang, Jing Zhang, Chang Hu, Jun Jiang, Yiming Li & ZhiYong Peng. (2023) ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Archives of Toxicology 97:6, pages 1439-1451.
Crossref
Chengtao Ni, Qing Ye, Xiaodan Mi, Dian Jiao, Shuangshuang Zhang, Ruidong Cheng, Zhanglu Fang, Marong Fang & Xiangming Ye. (2023) Resveratrol inhibits ferroptosis via activating NRF2 / GPX4 pathway in mice with spinal cord injury . Microscopy Research and Technique.
Crossref
Aryatara Shakya, Nicholas W. McKee, Matthew Dodson, Eli Chapman & Donna D. Zhang. (2023) Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response. Molecules and Cells 46:3, pages 165-175.
Crossref
He Cuiping, Zhao Na, Hu Limei, Tianli Tang, Yufeng Yang & Nie Xiangping. (2023) Assessment of ecotoxicity effects of aspirin on non-target organism (Daphnia magna) via analysis of the responses of oxidative stress, DNA methylation-related genes expressions and life traits changes. Ecotoxicology 32:2, pages 137-149.
Crossref
Xixiang Tang, Jinli Wang, Hanna E. Abboud, Yanming Chen, Joshua J. Wang & Sarah X. Zhang. (2023) Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetes 72:1, pages 112-125.
Crossref
Ahmad Salimi, Zhaleh Jamali & Leila Rezaie Shirmard. 2023. Molecular Nutrition and Mitochondria. Molecular Nutrition and Mitochondria 461 500 .
Wenwen Wang, Jing Hu, Zhengyi Fu, Gang Yu & Zhenhua Ma. (2022) Daily Rhythmicity of Hepatic Rhythm, Lipid Metabolism and Immune Gene Expression of Mackerel Tuna (Euthynnus affinis) under Different Weather. Journal of Marine Science and Engineering 10:12, pages 2028.
Crossref
Bing Yang, Xi Yang, Xumei Tan, Liqing Lu, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Ting Liu & Heping Yang. (2022) Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease. Canadian Journal of Gastroenterology and Hepatology 2022, pages 1-18.
Crossref
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran & Anupam Agarwal. (2022) Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1. Antioxidants 11:10, pages 1888.
Crossref
Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou & Liming Mao. (2022) Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets. Biomedicine & Pharmacotherapy 153, pages 113524.
Crossref
Jingyi Chen, Guiying Li, Hang Yu, Hongli Liu & Taicheng An. (2022) The respiratory cytotoxicity of typical organophosphorus flame retardants on five different respiratory tract cells: Which are the most sensitive one?. Environmental Pollution 307, pages 119564.
Crossref
Kai Yin, Dongxu Wang, Hongjing Zhao, Yu Wang, Yue Zhang, Yachen Liu, Baoying Li & Mingwei Xing. (2022) Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis. Environmental Pollution 307, pages 119449.
Crossref
Norifumi Iseda, Shinji Itoh, Katsuya Toshida, Takahiro Tomiyama, Akinari Morinaga, Masahiro Shimokawa, Tomonari Shimagaki, Huanlin Wang, Takeshi Kurihara, Takeo Toshima, Yoshihiro Nagao, Noboru Harada, Tomoharu Yoshizumi & Masaki Mori. (2022) Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma. Cancer Science 113:7, pages 2272-2287.
Crossref
Qin Jiang, Ye Zhao, Xiao-Qiu Zhou, Xiao-Yun Wu, Shang-Xiao Xu, Lin Feng, Yang Liu, Wei-Dan Jiang, Pei Wu, Juan Zhao & Jun Jiang. (2021) Effects of dietary tryptophan on muscle growth, protein synthesis and antioxidant capacity in hybrid catfish Pelteobagrus vachelli♀ × Leiocassis longirostris♂ . British Journal of Nutrition 127:12, pages 1761-1773.
Crossref
Jing Su, Qin Zhao, Zhuangzhuang Zheng, Huanhuan Wang, Chenbin Bian, Lingbin Meng, Ying Xin & Xin Jiang. (2022) Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy. Antioxidants 11:5, pages 921.
Crossref
Chi Qu, Yang Peng & Shengchun Liu. (2022) Ferroptosis Biology and Implication in Cancers. Frontiers in Molecular Biosciences 9.
Crossref
Simona Granata, Valentina Votrico, Federica Spadaccino, Valeria Catalano, Giuseppe Stefano Netti, Elena Ranieri, Giovanni Stallone & Gianluigi Zaza. (2022) Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants. Antioxidants 11:4, pages 769.
Crossref
Shiyao Sui, Shouping Xu & Da Pang. (2022) Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression. Pharmacology & Therapeutics 232, pages 107992.
Crossref
Shanshan Ran, Xin Gao, Mingxiao Ma, Jingyi Zhang, Sheng Li, Mengyao Zhang & Shugang Li. (2022) NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway. Ecotoxicology and Environmental Safety 234, pages 113380.
Crossref
Benedikt Rauscher, William F Mueller, Sandra Clauder-Münster, Petra Jakob, M Saiful Islam, Han Sun, Sonja Ghidelli-Disse, Markus Boesche, Marcus Bantscheff, Hannah Pflaumer, Paul Collier, Bettina Haase, Songjie Chen, Rene Hoffman, Guangwen Wang, Vladimir Benes, Gerard Drewes, Michael Snyder & Lars M Steinmetz. (2022) Patient-derived gene and protein expression signatures of NGLY1 deficiency. The Journal of Biochemistry 171:2, pages 187-199.
Crossref
Yi-Tian Ying, Jing Yang, Xun Tan, Rui Liu, Ying Zhuang, Jia-Xue Xu & Wei-Jia Ren. (2021) Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response. Cells 10:12, pages 3426.
Crossref
Jing Lu, Yanan Zhao, Meitong Liu, Jianing Lu & Shuang Guan. (2021) Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis. Food & Function 12:20, pages 9583-9606.
Crossref
Reziyamu Wufuer, Zhuo Fan, Keli Liu & Yiguo Zhang. (2021) Differential Yet Integral Contributions of Nrf1 and Nrf2 in the Human HepG2 Cells on Antioxidant Cytoprotective Response against Tert-Butylhydroquinone as a Pro-Oxidative Stressor. Antioxidants 10:10, pages 1610.
Crossref
K E Hupfeld, H W Hyatt, P Alvarez Jerez, M Mikkelsen, C J Hass, R A E Edden, R D Seidler & E C Porges. (2021) In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility. Cerebral Cortex 31:10, pages 4576-4594.
Crossref
Suping Ren, Yiying Bian, Yongyong Hou, Zhendi Wang, Zhuo Zuo, Zhiyuan Liu, Yue Teng, Jingqi Fu, Huihui Wang, Yuanyuan Xu, Qiang Zhang, Yanyan Chen & Jingbo Pi. (2021) The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models. Redox Biology 44, pages 102015.
Crossref
David G. GennertRachel C. LynnJeff M. GranjaEvan W. WeberMaxwell R. MumbachYang ZhaoZhana Duren, Elena SotilloWilliam J. Greenleaf, Wing H. Wong, Ansuman T. SatpathyCrystal L. Mackall & Howard Y. Chang. (2021) Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. Proceedings of the National Academy of Sciences 118:30.
Crossref
Lina Wang, Yibing Chen, Yanjun Mi, Jianghua Qiao, Huan Jin, Juntao Li, Zhenduo Lu, Qiming Wang & Zhengzhi Zou. (2021) ATF2 inhibits ani-tumor effects of BET inhibitor in a negative feedback manner by attenuating ferroptosis. Biochemical and Biophysical Research Communications 558, pages 216-223.
Crossref
Jianhui Ji, Fashui Hong, Yingjun Zhou, Tingwu Liu, Dongxue Fan, Xingxiang Zhang, Yutian Lu, Lingling Jiang, Xiaomei Wang & Chen Wang. (2020) Molecular mechanisms associated with oxidative damage in the mouse testis induced by LaCl 3 . Environmental Toxicology 36:3, pages 408-416.
Crossref
Jie Cheng, Tao Xu, Chuanhui Xun, Hailong Guo, Rui Cao, Shutao Gao & Weibin Sheng. (2021) Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway. Life Sciences 266, pages 118905.
Crossref
Yang Liu, Fengchao Lang & Chunzhang Yang. (2021) NRF2 in human neoplasm: Cancer biology and potential therapeutic target. Pharmacology & Therapeutics 217, pages 107664.
Crossref
Rui-Feng Fan, Zi-Fa Li, Dong Zhang & Zhen-Yong Wang. (2020) Involvement of Nrf2 and mitochondrial apoptotic signaling in trehalose protection against cadmium-induced kidney injury. Metallomics 12:12, pages 2098-2107.
Crossref
Sarmistha Saha, Brigitta Buttari, Emiliano Panieri, Elisabetta Profumo & Luciano Saso. (2020) An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules 25:22, pages 5474.
Crossref
Luís M. Félix, Ana Luzio, Ana Santos, Luís M. Antunes, Ana M. Coimbra & Ana M. Valentim. (2020) MS-222 induces biochemical and transcriptional changes related to oxidative stress, cell proliferation and apoptosis in zebrafish embryos. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 237, pages 108834.
Crossref
Yuyang Liu, Thomas Burton, Benjamin Saul Rayner, Patrick T. San Gabriel, Han Shi, Mary El Kazzi, XiaoSuo Wang, Joanne M. Dennis, Gulfam Ahmad, Angie L. Schroder, Antony Gao, Paul Kenneth Witting & Belal Chami. (2020) The role of sodium thiocyanate supplementation during dextran sodium sulphate-stimulated experimental colitis. Archives of Biochemistry and Biophysics 692, pages 108490.
Crossref
Arturo Solano-Urrusquieta, José A. Morales-González, Graciela E. Castro-Narro, Eira Cerda-Reyes, Perla D. Flores-Rangel & Raul Fierros-Oceguera. (2020) NRF-2 and nonalcoholic fatty liver disease. Annals of Hepatology 19:5, pages 458-465.
Crossref
Stefanie Endesfelder, Evelyn Strauß, Ivo Bendix, Thomas Schmitz & Christoph Bührer. (2020) Prevention of Oxygen-Induced Inflammatory Lung Injury by Caffeine in Neonatal Rats. Oxidative Medicine and Cellular Longevity 2020, pages 1-19.
Crossref
Xuefei Zhang, Lingling Wang, Haixia Li, Lei Zhang, Xiulan Zheng & Wen Cheng. (2020) Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression. Cell Death & Disease 11:7.
Crossref
Shelly C. Lu. (2020) Dysregulation of glutathione synthesis in liver disease. Liver Research 4:2, pages 64-73.
Crossref
Waewaree Boontiam, Chalong Wachirapakorn & Phreerapong Phaengphairee. (2020) Effects of hydrolyzed yeast supplementation on growth performance, immunity, antioxidant capacity, and microbial shedding in weaning pigs. Veterinary World 13:9, pages 1902-1909.
Crossref
Juepu Zhou, Yao Jin, Yuhong Lei, Tianyi Liu, Zheng Wan, Hao Meng & Honglei Wang. (2020) Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases. Neurodegenerative Diseases 20:1, pages 20-34.
Crossref
Erika Ramos‐Tovar & Pablo Muriel. (2019) Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage. Journal of Applied Toxicology 40:1, pages 151-168.
Crossref
Sara A. Wahdan, Samar S. Azab, Doaa A. Elsherbiny & Ebtehal El-Demerdash. (2019) Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade. Naunyn-Schmiedeberg's Archives of Pharmacology 392:11, pages 1331-1345.
Crossref
Ye Zhao, Xiao-yun Wu, Shang-xiao Xu, Jia-yuan Xie, Kai-wen Xiang, Lin Feng, Yang Liu, Wei-dan Jiang, Pei Wu, Juan Zhao, Xiao-qiu Zhou & Jun Jiang. (2019) Dietary tryptophan affects growth performance, digestive and absorptive enzyme activities, intestinal antioxidant capacity, and appetite and GH–IGF axis-related gene expression of hybrid catfish (Pelteobagrus vachelli♀ × Leiocassis longirostris♂). Fish Physiology and Biochemistry 45:5, pages 1627-1647.
Crossref
Vijaya Prakash Krishnan Muthaiah, Tamilselvi Palaniappan, Sridhar Skylab Rajan, Kirubhanand Chandrasekar & Sankar Venkatachalam. (2019) Attenuation of oxidative stress after contusion spinal cord injury through inhibition of Poly ADP Ribose Polymerase involves glutamate cysteine ligase. Process Biochemistry 84, pages 180-185.
Crossref
Yingsong Zhou, Julien S Baker, Xiaoping Chen, Yajun Wang, Haimin Chen, Gareth W Davison & Xiaojun Yan. (2019) High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice. Nutrients 11:6, pages 1244.
Crossref
Matthew Dodson, Raul Castro-Portuguez & Donna D. Zhang. (2019) NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biology 23, pages 101107.
Crossref
Rahul Kumar, Tariq A. Bhat, Elise M. Walsh, Ajay K. Chaudhary, Jordan O'Malley, Johng S. Rhim, Jianmin Wang, Carl D. Morrison, Kristopher Attwood, Wiam Bshara, James L. Mohler, Neelu Yadav & Dhyan Chandra. (2019) Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer . Cancer Research 79:7, pages 1353-1368.
Crossref
Gina Manda, Mihail E. Hinescu, Ionela V. Neagoe, Luis F.V. Ferreira, Rica Boscencu, Paul Vasos, Selma H. Basaga & Antonio Cuadrado. (2019) Emerging Therapeutic Targets in Oncologic Photodynamic Therapy. Current Pharmaceutical Design 24:44, pages 5268-5295.
Crossref
Wuding Hong, Huijuan Kuang, Xingping He, Lin Yang, Pengfei Yang, Bolu Chen, Zoraida Aguilar & Hengyi Xu. (2019) CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway. Nanomaterials 9:2, pages 257.
Crossref
Xingguo Zhu, Aluya R Oseghale, Lopez H Nicole, Biaoru Li & Betty S Pace. (2019) Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease. Experimental Biology and Medicine 244:2, pages 171-182.
Crossref
Mayrel Palestino‐Dominguez, Mario Pelaez‐Luna, Roberto Lazzarini‐Lechuga, Ignacio Rodriguez‐Ochoa, Veronica Souza, Roxana U. Miranda, Benjamín Perez‐Aguilar, Leticia Bucio, Jens U. Marquardt, Luis Enrique Gomez‐Quiroz & Maria Concepcion Gutierrez‐Ruiz. (2018) Recombinant human hepatocyte growth factor provides protective effects in cerulein‐induced acute pancreatitis in mice. Journal of Cellular Physiology 233:12, pages 9354-9364.
Crossref
Azhwar Raghunath, Kiruthika Sundarraj, Raju Nagarajan, Frank Arfuso, Jinsong Bian, Alan P. Kumar, Gautam Sethi & Ekambaram Perumal. (2018) Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox Biology 17, pages 297-314.
Crossref
Vachirapong Sompakdee, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Papavee Samathiwat, Jaroon Wandee & Veerapol Kukongviriyapan. (2018) Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction. Biomedicine & Pharmacotherapy 101, pages 627-634.
Crossref
Lulu Zhou, Hongqiao Zhang, Kelvin J.A. Davies & Henry Jay Forman. (2018) Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biology 14, pages 35-40.
Crossref
Quan-wei Wang, Xiao-feng Yu, Hua-li Xu, Yi-chuan Jiang, Xue-zhong Zhao & Da-yuan Sui. (2018) Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-8.
Crossref
Joseph W. Zagorski, Alexandra E. Turley, Robert A. Freeborn, Kelly R. VanDenBerg, Heather E. Dover, Brian R. Kardell, Karen T. Liby & Cheryl E. Rockwell. (2018) Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation. Biochemical Pharmacology 147, pages 67-76.
Crossref
Cheng-Kai Wang, Shang-Chih Yang, Shu-Ching Hsu, Fang-Pei Chang, Yu-Tsen Lin, Shang-Fu Chen, Chin-Lun Cheng, Michael Hsiao, Frank Leigh Lu & Jean Lu. (2017) CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells. Free Radical Biology and Medicine 113, pages 439-451.
Crossref
Kelly R. VanDenBerg, Robert A. Freeborn, Sheng Liu, Rebekah C. Kennedy, Joseph W. Zagorski & Cheryl E. Rockwell. (2017) Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2. PLOS ONE 12:10, pages e0185579.
Crossref
Azman Abdullah, Tan Chung Phern, Nur Fatihah Hanis Mohamad Rahim, Nur Izzati Zaharuddin, Nurdayana Maulat Salihin, Ahmad Hilmi Yusof, Kamsiah Jaarin, Yusof Kamisah, Qodriyah Haji Mohd Saad, Nur Azlina Mohd Fahami & Harizz Miszard Radman. (2017) The Effects of Cosmos caudatus (Ulam Raja) on the Levels of Expression of Nrf2 Target Genes in Mice Liver. Journal of Pharmacy and Nutrition Sciences 7:4, pages 147-157.
Crossref
Panfeng Zhao, Xiangshu Piao, Long Pan, Zhikai Zeng, Qingyun Li, Xiao Xu & Hongliang Wang. (2017) Forsythia suspensa extract attenuates lipopolysaccharide-induced inflammatory liver injury in rats via promoting antioxidant defense mechanisms . Animal Science Journal 88:6, pages 873-881.
Crossref
Jamilah Abusarah, Houda Benabdoune, Qin Shi, Bertrand Lussier, Johanne Martel-Pelletier, Michel Malo, Julio C. Fernandes, Fátima Pereira de Souza, Hassan Fahmi & Mohamed Benderdour. (2017) Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis. Journal of Cellular Biochemistry 118:5, pages 1003-1013.
Crossref
Syed Minhaj Uddin Ahmed, Lin Luo, Akhileshwar Namani, Xiu Jun Wang & Xiuwen Tang. (2017) Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:2, pages 585-597.
Crossref
Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer & Thomas Schmitz. (2017) Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International Journal of Molecular Sciences 18:1, pages 187.
Crossref
Likun REN, Chao ZHANG, Li TAO, Jing HAO, Kun TAN, Kai MIAO, Yong YU, Linlin SUI, Zhonghong WU, Jianhui TIAN & Lei AN. (2017) High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development. Journal of Reproduction and Development 63:3, pages 247-261.
Crossref
M. Reyes-Farias, K. Vasquez, F. Fuentes, A. Ovalle-Marin, C. Parra-Ruiz, O. Zamora, M.T. Pino, V. Quitral, P. Jimenez, L. Garcia & D.F. Garcia-Diaz. (2016) Extracts of Chilean native fruits inhibit oxidative stress, inflammation and insulin-resistance linked to the pathogenic interaction between adipocytes and macrophages. Journal of Functional Foods 27, pages 69-83.
Crossref
Si Qin & De-Xing Hou. (2016) Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals. Molecular Nutrition & Food Research 60:8, pages 1731-1755.
Crossref
Hammoudi Alkaissi, Jimmy Ekstrand, Aksa Jawad, Jesper Bo Nielsen, Said Havarinasab, Peter Soderkvist & Per Hultman. (2016) Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Environmental Health Perspectives 124:7, pages 920-926.
Crossref
DIDIER DEQUANTER, MAUREEN VAN DE VELDE, ISABELLE BAR, VINCENT NUYENS, ALEXANDRE ROUSSEAU, NATHALIE NAGY, LUC VANHAMME, MICHEL VANHAEVERBEEK, DANY BROHÉE, PAUL DELRÉE, KARIM BOUDJELTIA, PHILIPPE LOTHAIRE & PIERRICK UZUREAU. (2016) Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncology Letters 11:6, pages 3660-3668.
Crossref
Krit Jaikumkao, Anchalee Pongchaidecha, Nipon Chattipakorn, Varanuj Chatsudthipong, Sasivimon Promsan, Phatchawan Arjinajarn & Anusorn Lungkaphin. (2016) Atorvastatin improves renal organic anion transporter 3 and renal function in gentamicin-induced nephrotoxicity in rats. Experimental Physiology 101:6, pages 743-753.
Crossref
Hyun Min Kim, Jeong Woo Han & Jefferson Y. Chan. (2016) Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation. Gene 584:1, pages 17-25.
Crossref
Yiguo Zhang & Yuancai Xiang. (2016) Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity. Biochemical Journal 473:8, pages 961-1000.
Crossref
Chintan N. Koyani, Kerstin Kitz, Christine Rossmann, Eva Bernhart, Evelyn Huber, Christopher Trummer, Werner Windischhofer, Wolfgang Sattler & Ernst Malle. (2016) Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochemical Pharmacology 104, pages 29-41.
Crossref
Gavin Ferguson & Wallace Bridge. (2016) Glutamate cysteine ligase and the age-related decline in cellular glutathione: The therapeutic potential of γ-glutamylcysteine. Archives of Biochemistry and Biophysics 593, pages 12-23.
Crossref
Agnieszka Gęgotek, Michał Biernacki, Ewa Ambrożewicz, Arkadiusz Surażyński, Adam Wroński & Elżbieta Skrzydlewska. (2016) The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation. Journal of Dermatological Science 81:2, pages 107-117.
Crossref
Janina Dose, Seiichi Matsugo, Haruka Yokokawa, Yutaro Koshida, Shigetoshi Okazaki, Ulrike Seidel, Manfred Eggersdorfer, Gerald Rimbach & Tuba Esatbeyoglu. (2016) Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin. International Journal of Molecular Sciences 17:1, pages 103.
Crossref
Pooja Naik, Ravi K Sajja, Shikha Prasad & Luca Cucullo. (2015) Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line. BMC Neuroscience 16:1.
Crossref
Pei-Ying Zhang. (2015) Polyphenols in Health and Disease. Cell Biochemistry and Biophysics 73:3, pages 649-664.
Crossref
Zhiqin Shi, Yujie Niu, Qian Wang, Lei Shi, Huicai Guo, Yi Liu, Yue Zhu, Shufeng Liu, Chao Liu, Xin Chen & Rong Zhang. (2015) Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo. Journal of Hazardous Materials 298, pages 310-319.
Crossref
Mark E. Hahn, Alicia R. Timme-Laragy, Sibel I. Karchner & John J. Stegeman. (2015) Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radical Biology and Medicine 88, pages 275-289.
Crossref
Magdalena Bugno, Mary Daniel, Nikolai L. Chepelev & William G. Willmore. (2015) Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:10, pages 1260-1276.
Crossref
V. Sánchez-Vallejo, S. Benlloch-Navarro, R. López-Pedrajas, F.J. Romero & M. Miranda. (2015) Neuroprotective actions of progesterone in an in vivo model of retinitis pigmentosa. Pharmacological Research 99, pages 276-288.
Crossref
Ling Niu, Xiu-hua He, Qing-wen Wang, Ming-yu Fu, Feng Xu, Ying Xue, Zhen-zhou Wang & Xin-jiang An. (2015) Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases. Cell Biochemistry and Biophysics 72:2, pages 485-494.
Crossref
D.J.R. Lane, A.M. Merlot, M.L.-H. Huang, D.-H. Bae, P.J. Jansson, S. Sahni, D.S. Kalinowski & D.R. Richardson. (2015) Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:5, pages 1130-1144.
Crossref
Jie Hong, Xiaoyu Pan, Xiaoyang Zhao, Xiaohong Yu, Xuezi Sang, Lei Sheng, Xuecen Wang, Suxin Gui, Qingqing Sun, Ling Wang & Fashui Hong. (2015) Molecular mechanism of oxidative damage of lung in mice following exposure to lanthanum chloride. Environmental Toxicology 30:3, pages 357-365.
Crossref
Yang JiaoSai MaYirong WangJing LiLequn ShanJihua Chen. (2015) Epigallocatechin-3-Gallate Reduces Cytotoxic Effects Caused by Dental Monomers: A Hypothesis. Medical Science Monitor 21, pages 3197-3202.
Crossref
Annadurai Anandhan, Pablo Hernandez-Franco & Rodrigo Franco. 2015. Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2 53 90 .
Bo-hyun Choi, Kyung-Shin Kang & Mi-Kyoung Kwak. (2014) Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease. Molecules 19:8, pages 12727-12759.
Crossref
Tao Jiang, Fei Tian, Hongting Zheng, Samantha A. Whitman, Yifeng Lin, Zhigang Zhang, Nong Zhang & Donna D. Zhang. (2014) Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response. Kidney International 85:2, pages 333-343.
Crossref
L.H. Lash. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Suna Zhou, Wenguang Ye, Qiuju Shao, Mingxin Zhang & Jun Liang. (2013) Nrf2 is a potential therapeutic target in radioresistance in human cancer. Critical Reviews in Oncology/Hematology 88:3, pages 706-715.
Crossref
S Tanigawa, C H Lee, C S Lin, C C Ku, H Hasegawa, S Qin, A Kawahara, Y Korenori, K Miyamori, M Noguchi, L H Lee, Y C Lin, C L Steve Lin, Y Nakamura, C Jin, N Yamaguchi, R Eckner, D-X Hou & K K Yokoyama. (2013) Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death & Disease 4:11, pages e921-e921.
Crossref
Shanshan Pei, Mohammad Minhajuddin, Kevin P. Callahan, Marlene Balys, John M. Ashton, Sarah J. Neering, Eleni D. Lagadinou, Cheryl Corbett, Haobin Ye, Jane L. Liesveld, Kristen M. O'Dwyer, Zheng Li, Lei Shi, Patricia Greninger, Jeffrey Settleman, Cyril Benes, Fred K. Hagen, Joshua Munger, Peter A. Crooks, Michael W. Becker & Craig T. Jordan. (2013) Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells. Journal of Biological Chemistry 288:47, pages 33542-33558.
Crossref
Francisco J. Sánchez-Gómez, Cristina Espinosa-Díez, Megha Dubey, Madhu Dikshit & Santiago Lamas. (2013) S-glutathionylation: relevance in diabetes and potential role as a biomarker. bchm 394:10, pages 1263-1280.
Crossref
Suxin Gui, Bingyan Li, Xiaoyang Zhao, Lei Sheng, Jie Hong, Xiaohong Yu, Xuezi Sang, Qingqing Sun, Yuguan Ze, Ling Wang & Fashui Hong. (2013) Renal Injury and Nrf2 Modulation in Mouse Kidney Following Chronic Exposure to TiO 2 Nanoparticles . Journal of Agricultural and Food Chemistry 61:37, pages 8959-8968.
Crossref
X.-D. Zhao, Y.-T. Zhou & X.-J. Lu. (2013) Sulforaphane enhances the activity of the Nrf2–ARE pathway and attenuates inflammation in OxyHb-induced rat vascular smooth muscle cells. Inflammation Research 62:9, pages 857-863.
Crossref
Yuguan Ze, Lei Zheng, Xiaoyang Zhao, Suxin Gui, Xuezi Sang, Junju Su, Ning Guan, Liyuan Zhu, Lei Sheng, Renping Hu, Jie Cheng, Zhe Cheng, Qingqing Sun, Ling Wang & Fashui Hong. (2013) Molecular mechanism of titanium dioxide nanoparticles-induced oxidative injury in the brain of mice. Chemosphere 92:9, pages 1183-1189.
Crossref
Juhyun Park, Jung-Woo Kang & Sun-Mee Lee. (2013) Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction. European Journal of Pharmacology 707:1-3, pages 61-70.
Crossref
Shelly C. Lu. (2013) Glutathione synthesis. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:5, pages 3143-3153.
Crossref
Changcheng Song & Steven G. Kelsen. 2013. Smoking and Lung Inflammation. Smoking and Lung Inflammation 99 127 .
Madhusudhanan Narasimhan, Dhyanesh Patel, Dhanashree Vedpathak, Marylatha Rathinam, George Henderson & Lenin Mahimainathan. (2012) Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells. PLoS ONE 7:12, pages e51111.
Crossref
Jimmy Fourtounis, I-Ming Wang, Marie-Claude Mathieu, David Claveau, Tenneille Loo, Aimee L Jackson, Mette A Peters, Alex G Therien, Yves Boie & Michael A Crackower. (2012) Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene. Respiratory Research 13:1.
Crossref
N. L. Makia, I. Amunom, K. C. Falkner, D. J. Conklin, S. Surapureddi, J. A. Goldstein & R. A. Prough. (2012) Activator Protein-1 Regulation of Murine Aldehyde Dehydrogenase 1a1. Molecular Pharmacology 82:4, pages 601-613.
Crossref
Qingqing Sun, Danlin Tan, Qiuping Zhou, Xiaorun Liu, Zhe Cheng, Gan Liu, Min Zhu, Xuezi Sang, Suxin Gui, Jie Cheng, Renping Hu, Meng Tang & Fashui Hong. (2012) Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles. Journal of Biomedical Materials Research Part A 100A:10, pages 2554-2562.
Crossref
Woojin Jeong, Soo Han Bae, Michel B. Toledano & Sue Goo Rhee. (2012) Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression. Free Radical Biology and Medicine 53:3, pages 447-456.
Crossref
Joo-Young Im, Kang-Woo Lee, Jong-Min Woo, Eunsung Junn & M. Maral Mouradian. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Human Molecular Genetics 21:13, pages 3013-3024.
Crossref
Carlos Perez-SanchezPatricia Ruiz-LimonMaria Angeles AguirreMaria Laura Bertolaccini, Munther A. KhamashtaAntonio Rodriguez-ArizaPedro SeguiEduardo Collantes-EstevezNuria Barbarroja, Husam Khraiwesh, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Francisco VelascoMaria Jose CuadradoChary Lopez-Pedrera. (2012) Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment. Blood 119:24, pages 5859-5870.
Crossref
Ute Boettler, Nadine Volz, Nicole Teller, Larisa M. Haupt, Tamara Bakuradze, Gerhard Eisenbrand, Gerhard Bytof, Ingo Lantz, Lyn R. Griffiths & Doris Marko. (2012) Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?. Molecular Biology Reports 39:6, pages 7155-7162.
Crossref
Weinong Han, Mei Ming, Rui Zhao, Jingbo Pi, Chunli Wu & Yu-Ying He. (2012) Nrf1 CNC-bZIP Protein Promotes Cell Survival and Nucleotide Excision Repair through Maintaining Glutathione Homeostasis. Journal of Biological Chemistry 287:22, pages 18788-18795.
Crossref
Wei Li, Carmina Busu, Magdalena L. Circu & Tak Yee Aw. (2012) Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology: Implications for Brain Homeostasis. International Journal of Cell Biology 2012, pages 1-14.
Crossref
Qiuying Cheng, James L. Kalabus, Jianping Zhang & Javier G. Blanco. (2012) A conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch Nrf2. Biochemical Pharmacology 83:1, pages 139-148.
Crossref
Areum Daseul Kim, Rui Zhang, Kyoung Ah Kang, Ho Jin You & Jin Won Hyun. (2011) Increased Glutathione Synthesis Following Nrf2 Activation by Vanadyl Sulfate in Human Chang Liver Cells. International Journal of Molecular Sciences 12:12, pages 8878-8894.
Crossref
Madhusudhanan Narasimhan, Lenin Mahimainathan, Mary Latha Rathinam, Amanjot Kaur Riar & George I. Henderson. (2011) Overexpression of Nrf2 Protects Cerebral Cortical Neurons from Ethanol-Induced Apoptotic Death. Molecular Pharmacology 80:6, pages 988-999.
Crossref
Hong Lu, Wei Cui & Curtis D. Klaassen. (2011) Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicology and Applied Pharmacology 256:2, pages 122-135.
Crossref
José Pablo Vázquez-Medina, José Guadalupe Soñanez-Organis, Jennifer M. Burns, Tania Zenteno-Savín & Rudy M. Ortiz. (2011) Antioxidant capacity develops with maturation in the deep-diving hooded seal. Journal of Experimental Biology 214:17, pages 2903-2910.
Crossref
Miao Yu, Hui Li, Qiongming Liu, Fang Liu, Liujun Tang, Changyan Li, Yanzhi Yuan, Yiqun Zhan, Wangxiang Xu, Wei Li, Hui Chen, Changhui Ge, Jian Wang & Xiaoming Yang. (2011) Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cellular Signalling 23:5, pages 883-892.
Crossref
Takafumi Suzuki, Jonathan Maher & Masayuki Yamamoto. (2011) Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo . Cancer Research 71:5, pages 1700-1709.
Crossref
Fawzia Bardag-Gorce, Joan Oliva, Andrew Lin, Jun Li, Barbara A. French & Samuel W. French. (2011) Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. Experimental and Molecular Pathology 90:1, pages 123-130.
Crossref
Nobunao WakabayashiStephen L. SlocumJohn J. SkokoSoona ShinThomas W. Kensler. (2010) When NRF2 Talks, Who's Listening?. Antioxidants & Redox Signaling 13:11, pages 1649-1663.
Crossref
Ananta Paine, Britta Eiz-Vesper, Rainer Blasczyk & Stephan Immenschuh. (2010) Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochemical Pharmacology 80:12, pages 1895-1903.
Crossref
Hojin Kim, Yuyeon Jung, Bong Soo Shin, Hyeryeon Kim, Hyunsook Song, Soo Han Bae, Sue Goo Rhee & Woojin Jeong. (2010) Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2. Journal of Biological Chemistry 285:45, pages 34419-34428.
Crossref
Xu-Dong Zhao, Yi-Ting Zhou, Xing Zhang, Xiao-Liang Wang, Wu Qi, Zong Zhuang, Xing-Fen Su & Ji-Xin Shi. (2010) Expression of NF-E2-related factor 2 (Nrf2) in the basilar artery after experimental subarachnoid hemorrhage in rabbits: A preliminary study. Brain Research 1358, pages 221-227.
Crossref
Yiguo Zhang & John D. Hayes. (2010) Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. Biochemical Journal 430:3, pages 497-510.
Crossref
A Meixner, F Karreth, L Kenner, J M Penninger & E F Wagner. (2010) Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death & Differentiation 17:9, pages 1409-1419.
Crossref
Elena K. Braithwaite, Michael D. Mattie & Jonathan H. Freedman. (2010) Activation of metallothionein transcription by 4-hydroxynonenal. Journal of Biochemical and Molecular Toxicology 24:5, pages 330-334.
Crossref
Alvin J.L. Chia, Christopher E. Goldring, Neil R. Kitteringham, Shi Quan Wong, Paul Morgan & B. Kevin Park. (2010) Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB. Biochemical Pharmacology 80:3, pages 410-421.
Crossref
Nobunao WakabayashiSoona ShinStephen L. SlocumElin S. AgostonJunko WakabayashiMi-Kyoung KwakVikas MisraShyam BiswalMasayuki YamamotoThomas W. Kensler. (2010) Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration. Science Signaling 3:130.
Crossref
Michelle A. Schultz, Asim B. Abdel-Mageed & Debasis Mondal. (2010) The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells. Cancers 2:2, pages 1354-1378.
Crossref
Zhimin Peng, Esmond Geh, Liang Chen, Qinghang Meng, Yunxia Fan, Maureen Sartor, Howard G. Shertzer, Zheng-Gang Liu, Alvaro Puga & Ying Xia. (2010) Inhibitor of κB Kinase β Regulates Redox Homeostasis by Controlling the Constitutive Levels of Glutathione. Molecular Pharmacology 77:5, pages 784-792.
Crossref
Heping Yang, Kwangsuk Ko, Meng Xia, Tony W.H. Li, Pilsoo Oh, Jiaping Li & Shelly C. Lu. (2010) Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. Hepatology 51:4, pages 1291-1301.
Crossref
Zhonghua Yan & Ruma Banerjee. (2010) Redox Remodeling as an Immunoregulatory Strategy. Biochemistry 49:6, pages 1059-1066.
Crossref
Jonghyun KimWeirong XingJon Wergedal, Jefferson Y. Chan & Subburaman Mohan. (2010) Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice. Physiological Genomics 40:2, pages 100-110.
Crossref
T. W. Kensler & N. Wakabayashi. (2009) Nrf2: friend or foe for chemoprevention?. Carcinogenesis 31:1, pages 90-99.
Crossref
L.H. Lash. 2010. Comprehensive Toxicology. Comprehensive Toxicology 117 150 .
Jung-Hoon Kang, Seo-Yoon Chang, Hyun-Jong Jang, Jae Min Cho, Dong-Bin Kim, Seong Su Lee, Seung Hyun Ko, Yong-Moon Park, Paul W. Needs, Yang-Hyeok Jo & Myung-Jun Kim. (2009) Quercetin-induced upregulation of human GCLC gene is mediated by cis -regulatory element for early growth response protein-1 (EGR1) in INS-1 beta-cells . Journal of Cellular Biochemistry 108:6, pages 1346-1355.
Crossref
Vesna Petrović, Biljana Buzadžić, Aleksandra Korać, Ana Vasilijević, Aleksandra Janković & Bato Korać. (2009) l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide. Chemico-Biological Interactions 182:2-3, pages 204-212.
Crossref
Jun Chen & Zahir A. Shaikh. (2009) Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells. Toxicology and Applied Pharmacology 241:1, pages 81-89.
Crossref
Hoo-Kyun Choi, Yuba Raj Pokharel, Sung Chul Lim, Hyo-Kyung Han, Chang Seon Ryu, Sang Kyum Kim, Mi Kyong Kwak & Keon Wook Kang. (2009) Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression. Toxicology and Applied Pharmacology 240:3, pages 377-384.
Crossref
Yvonne D. Hoang, Brooke N. Nakamura & Ulrike Luderer. (2009) Follicle-Stimulating Hormone and Estradiol Interact to Stimulate Glutathione Synthesis in Rat Ovarian Follicles and Granulosa Cells1. Biology of Reproduction 81:4, pages 636-646.
Crossref
Muyao Li, Jen-Fu Chiu, Anne Kelsen, Shelly C. Lu & Naomi K. Fukagawa. (2009) Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene ( GCLC ) . Journal of Cellular Biochemistry 107:5, pages 944-954.
Crossref
James A. Thompson, Collin C. White, David P. Cox, Jefferson Y. Chan, Terrance J. Kavanagh, Nelson Fausto & Christopher C. Franklin. (2009) Distinct Nrf1/2-independent mechanisms mediate As3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes. Free Radical Biology and Medicine 46:12, pages 1614-1625.
Crossref
Heping Yang, Komal Ramani, Meng Xia, Kwang Suk Ko, Tony W.H. Li, Pilsoo Oh, Jiaping Li & Shelly C. Lu. (2009) Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications. Hepatology 49:6, pages 1982-1991.
Crossref
Soo Han BaeHyun Ae WooSu Haeng SungHye Eun LeeSe Kyoung LeeIn Sup KilSue Goo Rhee. (2009) Induction of Sulfiredoxin via an Nrf2-Dependent Pathway and Hyperoxidation of Peroxiredoxin III in the Lungs of Mice Exposed to Hyperoxia . Antioxidants & Redox Signaling 11:5, pages 937-948.
Crossref
Miriam M. Cortese-Krott, Christoph V. Suschek, Wiebke Wetzel, Klaus-Dietrich Kröncke & Victoria Kolb-Bachofen. (2009) Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione. American Journal of Physiology-Cell Physiology 296:4, pages C811-C820.
Crossref
Yiguo ZhangJohn M. LucocqJohn D. Hayes. (2009) The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochemical Journal 418:2, pages 293-310.
Crossref
Saibal K. Biswas & Irfan Rahman. (2009) Environmental toxicity, redox signaling and lung inflammation: The role of glutathione. Molecular Aspects of Medicine 30:1-2, pages 60-76.
Crossref
Shelly C. Lu. (2009) Regulation of glutathione synthesis. Molecular Aspects of Medicine 30:1-2, pages 42-59.
Crossref
Vincent Paupe, Emmanuel P. Dassa, Sergio Goncalves, Françoise Auchère, Maria Lönn, Arne Holmgren & Pierre Rustin. (2009) Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia. PLoS ONE 4:1, pages e4253.
Crossref
William Langston, Magdalena L. Circu & Tak Yee Aw. (2008) Insulin stimulation of γ-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose. Free Radical Biology and Medicine 45:11, pages 1591-1599.
Crossref
Joshua B. Owen, Wycliffe O. Opii, Charles Ramassamy, William M. Pierce & D. Allan Butterfield. (2008) Proteomic analysis of brain protein expression levels in NF-κβ p50 −/− homozygous knockout mice. Brain Research 1240, pages 22-30.
Crossref
Saibal Biswas & Irfan Rahman. 2008. Dietary Modulation of Cell Signaling Pathways. Dietary Modulation of Cell Signaling Pathways.
Clare Bates CongdonH. Rex GaskinsGerardo M. NavaCarolyn Mattingly. (2008) It's not junk!. ACM SIGEVOlution 3:3, pages 5-16.
Crossref
Yan Ding, Kyu Jin Choi, Jin Hwan Kim, Xuezhe Han, Yuji Piao, Jin-Hyun Jeong, Wonchae Choe, Insug Kang, Joohun Ha, Henry Jay Forman, Jinhwa Lee, Kyung-Sik Yoon & Sung Soo Kim. (2008) Endogenous Hydrogen Peroxide Regulates Glutathione Redox via Nuclear Factor Erythroid 2-Related Factor 2 Downstream of Phosphatidylinositol 3-Kinase during Muscle Differentiation. The American Journal of Pathology 172:6, pages 1529-1541.
Crossref
Miriam M. Cortese, Christoph V. Suschek, Wiebke Wetzel, Klaus-D. Kröncke & Victoria Kolb-Bachofen. (2008) Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis. Free Radical Biology and Medicine 44:12, pages 2002-2012.
Crossref
Guang-Hui Liu, Jing Qu & Xun Shen. (2008) NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:5, pages 713-727.
Crossref
Aruna Kode, Saravanan Rajendrasozhan, Samuel Caito, Se-Ran Yang, Ian L. Megson & Irfan Rahman. (2008) Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 294:3, pages L478-L488.
Crossref
Heping Yang, Ainhoa Iglesias Ara, Nathaniel Magilnick, Meng Xia, Komal Ramani, Hui Chen, Taunia D. Lee, José M. Mato & Shelly C. Lu. (2008) Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells. Gastroenterology 134:1, pages 281-291.
Crossref
Heping Yang, Nathaniel Magilnick, Meng Xia & Shelly C. Lu. (2008) Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent. Experimental Cell Research 314:2, pages 398-412.
Crossref
M. Rosario Hernandez & Bin Liu. 2008. Mechanisms of the Glaucomas. Mechanisms of the Glaucomas 363 391 .
William O. Osburn, Baktiar Karim, Patrick M. Dolan, Guosheng Liu, Masayuki Yamamoto, David L. Huso & Thomas W. Kensler. (2007) Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2‐deficient mice upon dextran sulfate treatment. International Journal of Cancer 121:9, pages 1883-1891.
Crossref
Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine & Nathan J. Cherrington. (2007) Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. Journal of Biochemical and Molecular Toxicology 21:4, pages 216-220.
Crossref
Weirong Xing, Anny Singgih, Anil Kapoor, Catrina M. Alarcon, David J. Baylink & Subburaman Mohan. (2007) Nuclear Factor-E2-related Factor-1 Mediates Ascorbic Acid Induction of Osterix Expression via Interaction with Antioxidant-Responsive Element in Bone Cells. Journal of Biological Chemistry 282:30, pages 22052-22061.
Crossref
Feng-Ming Ho, Hao-Cheng Kang, Sho-Tone Lee, Yee Chao, You-Ci Chen, Li-Jiau Huang & Wan-Wan Lin. (2007) The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells. Biochemical Pharmacology 74:2, pages 298-308.
Crossref
Lauren M. Aleksunes & José E. Manautou. (2016) Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease. Toxicologic Pathology 35:4, pages 459-473.
Crossref
Gary D. Minsavage & James F. DillmanIIIIII. (2007) Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor κB Responses and Cell Death Are Altered by Caffeic Acid Phenethyl Ester: A Potential Role for Antioxidant/Electrophilic Response-Element Signaling. Journal of Pharmacology and Experimental Therapeutics 321:1, pages 202-212.
Crossref
Thomas D. Hock, Karen Liby, Marcienne M. Wright, Sean McConnell, Marina Schorpp-Kistner, Thomas M. Ryan & Anupam Agarwal. (2007) JunB and JunD Regulate Human Heme Oxygenase-1 Gene Expression in Renal Epithelial Cells. Journal of Biological Chemistry 282:9, pages 6875-6886.
Crossref
Thomas W. KenslerNobunao WakabayashiShyam Biswal. (2007) Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway. Annual Review of Pharmacology and Toxicology 47:1, pages 89-116.
Crossref
Neville Grant. (2007) The role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: Thyroid hormone as an antioxidant. Medical Hypotheses 68:3, pages 641-649.
Crossref
Irfan Rahman, Saibal K. Biswas & Paul A. Kirkham. (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochemical Pharmacology 72:11, pages 1439-1452.
Crossref
V. V. Lyakhovich, V. A. Vavilin, N. K. Zenkov & E. B. Menshchikova. (2006) Active defense under oxidative stress. The antioxidant responsive element. Biochemistry (Moscow) 71:9, pages 962-974.
Crossref
Olga A. Agapova, Paul L. Kaufman & M. Rosario Hernandez. (2006) Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma. Experimental Eye Research 82:6, pages 1053-1059.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.