11
Views
66
CrossRef citations to date
0
Altmetric
Signal Transduction

Chk1-Dependent S-M Checkpoint Delay in Vertebrate Cells Is Linked to Maintenance of Viable Replication Structures

, &
Pages 563-574 | Received 27 Jul 2004, Accepted 15 Oct 2004, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Margarethe Draga, Elizabeth B. Madgett, Cassandra J. Vandenberg, David du Plessis, Aisling Kaufmann, Petra Werler, Prasun Chakraborty, Noel F. Lowndes & Kevin Hiom. (2015) BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells. Molecular and Cellular Biology 35:22, pages 3829-3840.
Read now
Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis & Carl G Maki. (2014) Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer Biology & Therapy 15:12, pages 1600-1612.
Read now
Rosaria Chilà, Cinzia Celenza, Monica Lupi, Giovanna Damia & Laura Carrassa. (2013) Chk1-Mad2 interaction. Cell Cycle 12:7, pages 1083-1090.
Read now
Stephan Gasser. (2007) DNA damage response and development of targeted cancer treatments. Annals of Medicine 39:6, pages 457-464.
Read now
Eva Petermann, Apolinar Maya-Mendoza, George Zachos, David A. F. Gillespie, Dean A. Jackson & Keith W. Caldecott. (2006) Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase. Molecular and Cellular Biology 26:8, pages 3319-3326.
Read now
Ji Zhang, Shideng Bao, Ryohei Furumai, Katerina S. Kucera, Ambereen Ali, Nicolas M. Dean & Xiao-Fan Wang. (2005) Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation. Molecular and Cellular Biology 25:22, pages 9910-9919.
Read now

Articles from other publishers (60)

Martin Fischer, Amy E. Schade, Timothy B. Branigan, Gerd A. Müller & James A. DeCaprio. (2022) Coordinating gene expression during the cell cycle. Trends in Biochemical Sciences 47:12, pages 1009-1022.
Crossref
Urvashi Garg, Anurag Chaudhary & Shobhit Kumar. (2022) Nanoformulations of Anti-cancer Agents: Present Status & Future Directions. Current Nanomedicine 12:3, pages 179-190.
Crossref
Chenxia Ding, Benyu Su, Qiaoling Li, Wenwen Ding, Guochao Liu, Zuchao Cai, Fengmei Zhang, David Lim & Zhihui Feng. (2022) Histone deacetylase inhibitor 2-hexyl-4-pentynoic acid enhances hydroxyurea therapeutic effect in triple-negative breast cancer cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 873, pages 503422.
Crossref
Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman & Thomas D. Friedrich. (2021) Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection. Viruses 13:7, pages 1353.
Crossref
Timothy B. Branigan, David Kozono, Amy E. Schade, Peter Deraska, Hembly G. Rivas, Larissa Sambel, Hunter D. Reavis, Geoffrey I. Shapiro, Alan D. D’Andrea & James A. DeCaprio. (2021) MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Reports 34:9, pages 108808.
Crossref
Debjani Pal, Adrian E. Torres, Benjamin R. Stromberg, Abbey L. Messina, Andrew S. Dickson, Kuntal De, Belinda Willard, Monica Venere & Matthew K. Summers. (2020) Chk1-mediated phosphorylation of Cdh1 promotes the SCFβTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression. Cell Death & Disease 11:4.
Crossref
Michalis Fragkos, Viviana Barra, Tom Egger, Benoit Bordignon, Delphine Lemacon, Valeria Naim & Arnaud Coquelle. (2019) Dicer prevents genome instability in response to replication stress. Oncotarget 10:43, pages 4407-4423.
Crossref
Xuanrong Sun, Longchao Zhang, Mengshi Gao, Xiangjie Que, Chenfeng Zhou, Dabu Zhu & Yue Cai. (2019) Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a P53-Independent Pathway. Molecules 24:3, pages 624.
Crossref
Debjani Pal & Matthew K. Summers. 2018. Ubiquitination Governing DNA Repair - Implications in Health and Disease. Ubiquitination Governing DNA Repair - Implications in Health and Disease.
Sanjay Kumar Bharti, Joshua A Sommers, Sanket Awate, Marina A Bellani, Irfan Khan, Lynda Bradley, Graeme A King, Yeonee Seol, Venkatasubramanian Vidhyasagar, Yuliang Wu, Takuye Abe, Koji Kobayashi, Kazuo Shin-ya, Hiroyuki Kitao, Marc S Wold, Dana Branzei, Keir C Neuman & Robert M BroshJrJr. (2018) A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair. Nucleic Acids Research 46:12, pages 6238-6256.
Crossref
David A. Gillespie. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy 209 240 .
Suthakar Ganapathy, Johan B Fagman, Ling Shen, Tianqi Yu, Xiaodong Zhou, Wei Dai, Alexandros Makriyannis & Changyan Chen. (2016) Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C . Oncotarget 7:51, pages 84326-84337.
Crossref
Veronique A. J. Smits & David A. Gillespie. (2015) DNA damage control: regulation and functions of checkpoint kinase 1. FEBS Journal 282:19, pages 3681-3692.
Crossref
Pedro Zuazua-Villar, Anil Ganesh, Geraldine Phear, Mary E. Gagou & Mark Meuth. (2015) Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Research, pages gkv835.
Crossref
Eun-Yeung Gong, Veronique A. J. Smits, Felipe Fumagallo, Desiree Piscitello, Nick Morrice, Raimundo Freire & David A. Gillespie. (2015) KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage. Scientific Reports 5:1.
Crossref
Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti & Pier Paolo Pandolfi. (2015) Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis . Cancer Discovery 5:5, pages 550-563.
Crossref
Xiangzi Han, Franklin Mayca Pozo, Jacob N. Wisotsky, Benlian Wang, James W. Jacobberger & Youwei Zhang. (2015) Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation. Journal of Biological Chemistry 290:19, pages 12370-12378.
Crossref
Giorgia Basile, Giuseppe Leuzzi, Pietro Pichierri & Annapaola Franchitto. (2014) Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress. Nucleic Acids Research 42:20, pages 12628-12639.
Crossref
Lorena Taricani, Frances Shanahan, Maria-Christina Malinao, Maribel Beaumont & David Parry. (2014) A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells. PLoS ONE 9:11, pages e111714.
Crossref
Jacob G. Jansen, Piya Temviriyanukul, Niek Wit, Frédéric Delbos, Claude-Agnès Reynaud, Heinz Jacobs & Niels de Wind. (2014) Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light. Nucleic Acids Research 42:17, pages 11071-11082.
Crossref
Xiaoyun Yang, Wei Xu, Zuowei Hu, Yaou Zhang & Naihan Xu. (2014) Chk1 is required for the metaphase–anaphase transition via regulating the expression and localization of Cdc20 and Mad2. Life Sciences 106:1-2, pages 12-18.
Crossref
P Zuazua-Villar, R Rodriguez, M E Gagou, P A Eyers & M Meuth. (2014) DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. Cell Death & Disease 5:5, pages e1253-e1253.
Crossref
Hongpeng He, Mei-Chin Lee, Li-Ling Zheng, Lei ZhengYan Luo. (2013) Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes. Bioscience Reports 33:2.
Crossref
Heather J. Landau, Samuel C. McNeely, Jayasree S. Nair, Raymond L. Comenzo, Takashi Asai, Hillel Friedman, Suresh C. Jhanwar, Stephen D. Nimer & Gary K. Schwartz. (2012) The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53 -Mutated Multiple Myeloma Cells . Molecular Cancer Therapeutics 11:8, pages 1781-1788.
Crossref
Karen Finn, Noel Francis Lowndes & Muriel Grenon. (2011) Eukaryotic DNA damage checkpoint activation in response to double-strand breaks. Cellular and Molecular Life Sciences 69:9, pages 1447-1473.
Crossref
Jun Wu, Guozheng Lai, Feng Wan, Zhengzheng Xiao, Lingcheng Zeng, Xiongwei Wang, Fei Ye & Ting Lei. (2012) Knockdown of Checkpoint Kinase 1 Is Associated with the Increased Radiosensitivity of Glioblastoma Stem-Like Cells. The Tohoku Journal of Experimental Medicine 226:4, pages 267-274.
Crossref
Naihan Xu, Yuanzhi Lao, Yaou Zhang & David A. Gillespie. (2012) Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability. Journal of Oncology 2012, pages 1-15.
Crossref
Xavier FantKumiko SamejimaAna CarvalhoHiromi OgawaZhenjie XuZuojun YueWilliam C. EarnshawSandrine Ruchaud. (2010) Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function. Biochemical Society Transactions 38:6, pages 1655-1659.
Crossref
Eva Petermann & Thomas Helleday. (2010) Pathways of mammalian replication fork restart. Nature Reviews Molecular Cell Biology 11:10, pages 683-687.
Crossref
Francesca Ammazzalorso, Livia Maria Pirzio, Margherita Bignami, Annapaola Franchitto & Pietro Pichierri. (2010) ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery. The EMBO Journal 29:18, pages 3156-3169.
Crossref
Laura Carrassa, Elisa Montelatici, Lorenza Lazzari, Stefano Zangrossi, Matteo Simone, Massimo Broggini & Giovanna Damia. (2010) Role of Chk1 in the differentiation program of hematopoietic stem cells. Cellular and Molecular Life Sciences 67:10, pages 1713-1722.
Crossref
Rebekka A Schwab, Andrew N Blackford & Wojciech Niedzwiedz. (2010) ATR activation and replication fork restart are defective in FANCM-deficient cells. The EMBO Journal 29:4, pages 806-818.
Crossref
Kazumasa Yoshida, Nozomi Sugimoto, Satoko Iwahori, Takashi Yugawa, Mako Narisawa-Saito, Tohru Kiyono & Masatoshi Fujita. (2010) CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. Journal of Cell Science 123:2, pages 225-235.
Crossref
Daniël O. Warmerdam, Roland Kanaar & Veronique A. J. Smits. (2010) Differential Dynamics of ATR-Mediated Checkpoint Regulators. Journal of Nucleic Acids 2010, pages 1-16.
Crossref
Joanne Smith, Lye Mun Tho, Naihan Xu & David A. Gillespie. 2010. 73 112 .
Paula J. Hurley & Fred Bunz. 2009. Checkpoint Controls and Targets in Cancer Therapy. Checkpoint Controls and Targets in Cancer Therapy 27 36 .
Mónica Segurado & José Antonio Tercero. (2009) The S-phase checkpoint: targeting the replication fork. Biology of the Cell 101:11, pages 617-627.
Crossref
Laura Carrassa, Yolanda Sanchez, Eugenio Erba & Giovanna Damia. (2009) U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. Journal of Cellular and Molecular Medicine 13:8a, pages 1565-1576.
Crossref
Laura Carrassa, Yolanda Sanchez, Eugenio Erba & Giovanna Damia. (2009) U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. Journal of Cellular and Molecular Medicine 13:8a, pages 1565-1576.
Crossref
M Walker, E J Black, V Oehler, D A Gillespie & M T Scott. (2009) Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity. Oncogene 28:24, pages 2314-2323.
Crossref
Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska, Joshua D. Parsels, Brian D. Palmer, R. John Booth, William A. Denny, Christine E. Canman, Alan J. Kraker, Theodore S. Lawrence & Jonathan Maybaum. (2009) Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Molecular Cancer Therapeutics 8:1, pages 45-54.
Crossref
Yiduo Hu, Xincheng Lu, Guangjin Zhou, Ellen L. Barnes & Guangbin Luo. (2009) Recql5 Plays an Important Role in DNA Replication and Cell Survival after Camptothecin Treatment. Molecular Biology of the Cell 20:1, pages 114-123.
Crossref
Ryo Sakasai & Randal S. Tibbetts. 2009. The DNA Damage Response: Implications on Cancer Formation and Treatment. The DNA Damage Response: Implications on Cancer Formation and Treatment 81 107 .
Alexis R. Barr, Deborah Zyss & Fanni Gergely. 2009. Mitosis. Mitosis 1 19 .
Dorota Rybaczek, Aneta Żabka, Anna Pastucha & Janusz Maszewski. (2008) Various chemical agents can induce premature chromosome condensation in Vicia faba. Acta Physiologiae Plantarum 30:5, pages 663-672.
Crossref
Monica Ganzinelli, Laura Carrassa, Francesca Crippa, Michele Tavecchio, Massimo Broggini & Giovanna Damia. (2008) Checkpoint Kinase 1 Down-Regulation by an Inducible Small Interfering RNA Expression System Sensitized In vivo Tumors to Treatment with 5-Fluorouracil . Clinical Cancer Research 14:16, pages 5131-5141.
Crossref
Karlene A. Cimprich & David Cortez. (2008) ATR: an essential regulator of genome integrity. Nature Reviews Molecular Cell Biology 9:8, pages 616-627.
Crossref
Jennifer Scorah, Meng-Qiu Dong, John R. YatesIIIIII, Mary Scott, David Gillespie & Clare H. McGowan. (2008) A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function. Journal of Biological Chemistry 283:25, pages 17250-17259.
Crossref
Xiaohong H. Yang, Bunsyo Shiotani, Marie Classon & Lee Zou. (2008) Chk1 and Claspin potentiate PCNA ubiquitination. Genes & Development 22:9, pages 1147-1152.
Crossref
Dmitri Churikov & Carolyn M Price. (2007) Pot1 and cell cycle progression cooperate in telomere length regulation. Nature Structural & Molecular Biology 15:1, pages 79-84.
Crossref
Berndt Müller, Jane Blackburn, Carmen Feijoo, Xiujie Zhao & Carl Smythe. (2007) DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. Journal of Cell Biology 179:7, pages 1385-1398.
Crossref
Apolinar Maya-Mendoza, Eva Petermann, David A F Gillespie, Keith W Caldecott & Dean A Jackson. (2007) Chk1 regulates the density of active replication origins during the vertebrate S phase. The EMBO Journal 26:11, pages 2719-2731.
Crossref
Emer Bourke, Helen Dodson, Andreas Merdes, Lorraine Cuffe, George Zachos, Mark Walker, David Gillespie & Ciaran G Morrison. (2007) DNA damage induces Chk1‐dependent centrosome amplification. EMBO reports 8:6, pages 603-609.
Crossref
George Zachos, Elizabeth J. Black, Mark Walker, Mary T. Scott, Paola Vagnarelli, William C. Earnshaw & David A.F. Gillespie. (2007) Chk1 Is Required for Spindle Checkpoint Function. Developmental Cell 12:2, pages 247-260.
Crossref
Cynthia de la Fuente, Madhur V Gupta, Zachary Klase, Katharine Strouss, Patrick Cahan, Timothy McCaffery, Anthony Galante, Patricia Soteropoulos, Anne Pumfery, Masahiro Fujii & Fatah Kashanchi. (2006) Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. Retrovirology 3:1.
Crossref
H M R Robinson, R Jones, M Walker, G Zachos, R Brown, J Cassidy & D A F Gillespie. (2006) Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene 25:39, pages 5359-5369.
Crossref
S G Durkin, M F Arlt, N G Howlett & T W Glover. (2006) Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 25:32, pages 4381-4388.
Crossref
Gemma K. Alderton, Laura Galbiati, Elen Griffith, Katharina H. Surinya, Heidemarie Neitzel, Andrew P. Jackson, Penny A. Jeggo & Mark O'Driscoll. (2006) Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nature Cell Biology 8:7, pages 725-733.
Crossref
Ryan D Bomgarden, Patrick J Lupardus, Deena V Soni, Muh-Ching Yee, James M Ford & Karlene A Cimprich. (2006) Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling. The EMBO Journal 25:11, pages 2605-2614.
Crossref
Eisuke Itakura, Isao Sawada & Akira Matsuura. (2005) Dimerization of the ATRIP Protein through the Coiled-Coil Motif and Its Implication to the Maintenance of Stalled Replication Forks. Molecular Biology of the Cell 16:12, pages 5551-5562.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.