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Molecular and Cellular Biology Volume 25, 2005 - Issue 21
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Gene Expression

Transforming Growth Factor β2 Is a Neuronal Death-Inducing Ligand for Amyloid-β Precursor Protein

Yuichi Hashimoto1 Department of Pharmacology
,
Tomohiro Chiba1 Department of Pharmacology
,
Marina Yamada1 Department of Pharmacology;2 Department of Anatomy, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan
,
Mikiro Nawa1 Department of Pharmacology;2 Department of Anatomy, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan
,
Kohsuke Kanekura1 Department of Pharmacology
,
Hiroaki Suzuki1 Department of Pharmacology;2 Department of Anatomy, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan
,
Kenzo Terashita1 Department of Pharmacology
,
Sadakazu Aiso2 Department of Anatomy, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan
,
Ikuo Nishimoto1 Department of Pharmacology
&
Masaaki Matsuoka1 Department of PharmacologyCorrespondence[email protected]
 show all
Pages 9304-9317 | Received 27 May 2005, Accepted 09 Aug 2005, Published online: 27 Mar 2023

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Yuichi Hashimoto, Takahiko Umahara, Haruo Hanyu, Toshihiko Iwamoto & Masaaki Matsuoka. (2017) Calmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer’s disease patients with apolipoprotein E4; a pilot study using postmortem samples. Neurological Research 39:9, pages 767-772.
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Atsushi Noguchi, Mikiro Nawa, Sadakazu Aiso, Koichi Okamoto & Masaaki Matsuoka. (2010) Transforming Growth Factor β2 Level is Elevated in Neurons of Alzheimer's Disease Brains. International Journal of Neuroscience 120:3, pages 168-175.
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Articles from other publishers (32)

Hamid Mostafavi Abdolmaleky, Marian Martin, Jin-Rong Zhou & Sam Thiagalingam. (2023) Epigenetic Alterations of Brain Non-Neuronal Cells in Major Mental Diseases. Genes 14:4, pages 896.
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Ly Porosk, Heleri Heike Härk, Renata Naporano Bicev, Ilja Gaidutšik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva & Ülo Langel. (2023) Aggregation Limiting Cell-Penetrating Peptides Derived from Protein Signal Sequences. International Journal of Molecular Sciences 24:5, pages 4277.
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Grant Pfundstein, Alexander G. Nikonenko & Vladimir Sytnyk. (2022) Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology. Frontiers in Cell and Developmental Biology 10.
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Vladimir Khavinson, Natalia Linkova, Ekaterina Kozhevnikova & Svetlana Trofimova. (2020) EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease. Molecules 26:1, pages 159.
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Emilie Dorard, Stéphanie Chasseigneaux, Lucie Gorisse-Hussonnois, Cédric Broussard, Thierry Pillot & Bernadette Allinquant. (2017) Soluble Amyloid Precursor Protein Alpha Interacts with alpha3-Na, K-ATPAse to Induce Axonal Outgrowth but Not Neuroprotection: Evidence for Distinct Mechanisms Underlying these Properties. Molecular Neurobiology 55:7, pages 5594-5610.
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Laura Tapella, Matteo Cerruti, Isabella Biocotino, Alessio Stevano, Francesca Rocchio, Pier Luigi Canonico, Mariagrazia Grilli, Armando A. Genazzani & Dmitry Lim. (2018) TGF-β2 and TGF-β3 from cultured β-amyloid-treated or 3xTg-AD-derived astrocytes may mediate astrocyte-neuron communication. European Journal of Neuroscience 47:3, pages 211-221.
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Joyce R. Chong, Yuek Ling Chai, Jasinda H. Lee, David Howlett, Johannes Attems, Clive G. Ballard, Dag Aarsland, Paul T. Francis, Christopher P. Chen & Mitchell K.P. Lai. (2017) Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer’s Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load. Journal of Alzheimer's Disease 56:1, pages 157-166.
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Yuichi Hashimoto, Yuka Toyama, Shinya Kusakari, Mikiro Nawa & Masaaki Matsuoka. (2016) An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. Journal of Biological Chemistry 291:23, pages 12282-12293.
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Iryna Leshchyns’ka & Vladimir Sytnyk. (2016) Synaptic Cell Adhesion Molecules in Alzheimer’s Disease. Neural Plasticity 2016, pages 1-9.
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Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Léa Huguet, Lucie Gorisse-Hussonnois, Stéphanie Chasseigneaux & Bernadette Allinquant. (2015) PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons. BMC Neuroscience 16:1.
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Alexei Kurakin & Dale E. Bredesen. (2015) Dynamic self-guiding analysis of Alzheimer's disease. Oncotarget 6:16, pages 14092-14122.
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Silvia Bolognin, Erika Lorenzetto, Giovanni Diana & Mario Buffelli. (2014) The Potential Role of Rho GTPases in Alzheimer's Disease Pathogenesis. Molecular Neurobiology 50:2, pages 406-422.
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Yuichi Hashimoto & Masaaki Matsuoka. (2014) A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity. Journal of Neurochemistry 130:2, pages 291-300.
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Michèle G. DuVal, Matthew J. H. Gilbert, D. Ezekiel Watson, Tanja C. Zerulla, Keith B. Tierney & W. Ted Allison. (2014) Growth Differentiation Factor 6 As a Putative Risk Factor in Neuromuscular Degeneration. PLoS ONE 9:2, pages e89183.
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Elena Anahi Bignante, Florencia Heredia, Gerardo Morfini & Alfredo Lorenzo. (2013) Amyloid β precursor protein as a molecular target for amyloid β–induced neuronal degeneration in Alzheimer's disease. Neurobiology of Aging 34:11, pages 2525-2537.
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Heidemarie Gast, Sonja Gordic, Saskia Petrzilka, Martin Lopez, Andreas Müller, Anton Gietl, Christoph Hock, Thomas Birchler & Adriano Fontana. (2012) Transforming growth factor-beta inhibits the expression of clock genes. Annals of the New York Academy of Sciences 1261:1, pages 79-87.
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Nobuyuki Tachi, Yuichi Hashimoto & Masaaki Matsuoka. (2012) MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. Biochemical Journal 442:2, pages 413-422.
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Jose Miguel Rubio-Perez & Juana Maria Morillas-Ruiz. (2012) A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines. The Scientific World Journal 2012, pages 1-15.
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Stéphanie Briand, Patricia Facchinetti, Christine Clamagirand, Alexandra Madeira, Jean-Michel Pommet, Sanjay W. Pimplikar & Bernadette Allinquant. (2011) PAT1 induces cell death signal and SET mislocalization into the cytoplasm by increasing APP/APLP2 at the cell surface. Neurobiology of Aging 32:6, pages 1099-1113.
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Eun Kyung Kim & Eui-Ju Choi. (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802:4, pages 396-405.
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Nobuyuki Tachi, Yuichi Hashimoto, Mikiro Nawa & Masaaki Matsuoka. (2010) TAG-1 is an inhibitor of TGFβ2-induced neuronal death via amyloid β precursor protein. Biochemical and Biophysical Research Communications 394:1, pages 119-125.
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Francisco Sola Vigo, Gabriela Kedikian, Lorena Heredia, Florencia Heredia, Alberto Díaz Añel, Alberto Luis Rosa & Alfredo Lorenzo. (2009) Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation. Neurobiology of Aging 30:9, pages 1379-1392.
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Yuichi Hashimoto, Megumi Kurita, Sadakazu Aiso, Ikuo Nishimoto & Masaaki Matsuoka. (2009) Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130. Molecular Biology of the Cell 20:12, pages 2864-2873.
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P.D. Maldonado, E. Molina-Jijón, J. Villeda-Hernández, S. Galván-Arzate, A. Santamaría & J. Pedraza-Chaverrí. (2009) NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: Protective role of apocynin. Journal of Neuroscience Research, pages NA-NA.
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Jae Woong Lee, Yong Kyung Lee, Dong Yeon Yuk, Dong Young Choi, Sang Bae Ban, Ki Wan Oh & Jin Tae Hong. (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. Journal of Neuroinflammation 5:1.
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Pirooz Eslami, Ming F. Johnson, Ellen Terzakaryan, Carolyn Chew & Marni E. Harris-White. (2008) TGFβ2-induced changes in LRP-1/TβR-V and the impact on lysosomal Aβ uptake and neurotoxicity. Brain Research 1241, pages 176-187.
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C. Hoareau, V. Borrell, E. Soriano, M.O. Krebs, A. Prochiantz & B. Allinquant. (2008) Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons. Neurobiology of Aging 29:4, pages 542-553.
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Rachael L. Neve & Donna L. McPhie. (2007) Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772:4, pages 430-437.
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Tomohiro Chiba, Ikuo Nishimoto, Sadakazu Aiso & Masaaki Matsuoka. (2007) Neuroprotection against neurodegenerative diseases. Molecular Neurobiology 35:1, pages 55-84.
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Masaaki Matsuoka, Yuichi Hashimoto, Sadakazu Aiso & Ikuo Nishimoto. (2006) Humanin and Colivelin: Neuronal-Death-Suppressing Peptides for Alzheimer's Disease and Amyotrophic Lateral Sclerosis. CNS Drug Reviews 12:2, pages 113-122.
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Yuichi Hashimoto, Mikiro Nawa, Tomohiro Chiba, Sadakazu Aiso, Ikuo Nishimoto & Masaaki Matsuoka. (2006) Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β. Journal of Neuroscience Research 83:6, pages 1039-1047.
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C. M. Sondag & C. K. Combs. (2006) Amyloid precursor protein cross-linking stimulates beta amyloid production and pro-inflammatory cytokine release in monocytic lineage cells. Journal of Neurochemistry 97:2, pages 449-461.
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