Advanced search
Publication Cover
Molecular and Cellular Biology Volume 25, 2005 - Issue 22
Submit an article Journal homepage
18
Views
57
CrossRef citations to date
0
Altmetric
Signal Transduction

Mixed-Disulfide Folding Intermediates between Thyroglobulin and Endoplasmic Reticulum Resident Oxidoreductases ERp57 and Protein Disulfide Isomerase

Bruno Di Jeso1 Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze MFN, Università degli Studi di Lecce, Centro Ecotekne, 73100Lecce, Italy
,
Young-nam Park2 Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, 1500 W. Medical Ctr. Dr., Ann Arbor, Michigan48109
,
Luca Ulianich3 Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R. “G. Salvatore” e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli “Federico II,”Napoli, Italy
,
A. Sonia Treglia1 Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze MFN, Università degli Studi di Lecce, Centro Ecotekne, 73100Lecce, Italy
,
Malene L. Urbanas4 Faculty of Life Sciences, University of Manchester, Smith Building, Oxford Road, ManchesterM13 9PT, United Kingdom
,
Stephen High4 Faculty of Life Sciences, University of Manchester, Smith Building, Oxford Road, ManchesterM13 9PT, United Kingdom
&
Peter Arvan2 Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, 1500 W. Medical Ctr. Dr., Ann Arbor, Michigan48109Correspondence[email protected]
 show all
Pages 9793-9805 | Received 19 Feb 2005, Accepted 29 Aug 2005, Published online: 27 Mar 2023

Citations (57)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Anish Sharda & Bruce Furie. (2018) Regulatory role of thiol isomerases in thrombus formation. Expert Review of Hematology 11:5, pages 437-448.
Read now

Articles from other publishers (56)

Xiaohan Zhang, Crystal Young, Yoshiaki Morishita, Kookjoo Kim, Omer O. Kabil, Oliver B. Clarke, Bruno Di Jeso & Peter Arvan. (2022) Defective Thyroglobulin: Cell Biology of Disease. International Journal of Molecular Sciences 23:21, pages 13605.
Crossref
Cintia E. Citterio, Carina M. Rivolta & Héctor M. Targovnik. (2021) Structure and genetic variants of thyroglobulin: Pathophysiological implications. Molecular and Cellular Endocrinology 528, pages 111227.
Crossref
Madison T. Wright, Logan Kouba & Lars Plate. (2021) Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis. Molecular & Cellular Proteomics 20, pages 100008.
Crossref
Tadashi Suzuki & Haruhiko Fujihira. 2021. Comprehensive Glycoscience. Comprehensive Glycoscience 1 28 .
Luca Ulianich, Paola Mirra, Corrado Garbi, Gaetano Calì, Domenico Conza, Antonella Sonia Treglia, Alessandro Miraglia, Dario Punzi, Claudia Miele, Gregory Alexander Raciti, Francesco Beguinot, Eduardo Consiglio & Bruno Di Jeso. (2020) The Pervasive Effects of ER Stress on a Typical Endocrine Cell: Dedifferentiation, Mesenchymal Shift and Antioxidant Response in the Thyrocyte. Frontiers in Endocrinology 11.
Crossref
Yair Argon, Sophie E. Bresson, Michal T. Marzec & Adda Grimberg. (2020) Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production. Cells 9:8, pages 1844.
Crossref
Cintia E. Citterio, Sofia Siffo, Christian M. Moya, Mauricio Gomes Pio, Maricel F. Molina, Karen G. Scheps, Osvaldo A. Rey, Peter Arvan, Carina M. Rivolta & Héctor M. Targovnik. (2020) p.L571P in the linker domain of rat thyroglobulin causes intracellular retention. Molecular and Cellular Endocrinology 505, pages 110719.
Crossref
Wenqing Yang, Yang Xiang, Hongmei Zhang, Zhongyan Shan, Jing Li & Weiping Teng. (2020) The role of protein disulphide-isomerase A3 as autoantigen in the pathogenesis of autoimmune thyroiditis and related brain damage in adult mice. Clinical Immunology 212, pages 108350.
Crossref
Héctor M. Targovnik, Karen G. Scheps & Carina M. Rivolta. (2020) Defects in protein folding in congenital hypothyroidism. Molecular and Cellular Endocrinology 501, pages 110638.
Crossref
Fang Ma, Zhe Liu, Jinqiang Huang, Yongjuan Li, Yujun Kang, Xiaoxia Liu & Jianfu Wang. (2019) High-throughput sequencing reveals microRNAs in response to heat stress in the head kidney of rainbow trout (Oncorhynchus mykiss). Functional & Integrative Genomics 19:5, pages 775-786.
Crossref
Cintia E. Citterio, Héctor M. Targovnik & Peter Arvan. (2019) The role of thyroglobulin in thyroid hormonogenesis. Nature Reviews Endocrinology 15:6, pages 323-338.
Crossref
Carrie R. Sowers, Rong Wang, Rebecca A. Bourne, Barbara C. McGrath, Jingjie Hu, Sarah C. Bevilacqua, James C. Paton, Adrienne W. Paton, Sophie Collardeau-Frachon, Marc Nicolino & Douglas R. Cavener. (2018) The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones. Journal of Biological Chemistry 293:14, pages 5134-5149.
Crossref
Robert B. Freedman, Jasmine L. Desmond, Lee J. Byrne, Jack W. Heal, Mark J. Howard, Narinder Sanghera, Kelly L. Walker, A. Katrine Wallis, Stephen A. Wells, Richard A. Williamson & Rudolf A. Römer. (2017) ‘Something in the way she moves’: The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1865:11, pages 1383-1394.
Crossref
Guojun Shi, Diane Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess & Ling Qi. (2017) ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. Journal of Clinical Investigation 127:10, pages 3897-3912.
Crossref
Amy E. M. Beedle, Marc Mora, Steven Lynham, Guillaume Stirnemann & Sergi Garcia-Manyes. (2017) Tailoring protein nanomechanics with chemical reactivity. Nature Communications 8:1.
Crossref
Michele Longo, Rosa Spinelli, Vittoria D'Esposito, Federica Zatterale, Francesca Fiory, Cecilia Nigro, Gregory A. Raciti, Claudia Miele, Pietro Formisano, Francesco Beguinot & Bruno Di Jeso. (2016) Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:6, pages 1146-1156.
Crossref
Bruno Di JesoPeter Arvan. (2016) Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology. Endocrine Reviews 37:1, pages 2-36.
Crossref
Sol SchulmanPavan BendapudiAnish ShardaVivien ChenLola Bellido-MartinReema JasujaBarbara C. FurieRobert FlaumenhaftBruce Furie. (2016) Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxidants & Redox Signaling 24:1, pages 1-15.
Crossref
H. P. Gaide ChevronnayV. JanssensP. Van Der SmissenX. H. LiaoY. AbidN. NevoC. AntignacS. RefetoffS. Cherqui, C. E. PierreuxP. J. Courtoy. (2015) A Mouse Model Suggests Two Mechanisms for Thyroid Alterations in Infantile Cystinosis: Decreased Thyroglobulin Synthesis Due to Endoplasmic Reticulum Stress/Unfolded Protein Response and Impaired Lysosomal Processing. Endocrinology 156:6, pages 2349-2364.
Crossref
Sonam Parakh & Julie D. Atkin. (2015) Novel roles for protein disulphide isomerase in disease states: a double edged sword?. Frontiers in Cell and Developmental Biology 3.
Crossref
Murli Manohar, Huma Khan, Vijay Kumar Sirohi, Vinita Das, Anjoo Agarwal, Amita Pandey, Waseem Ahmad Siddiqui & Anila Dwivedi. (2014) Alteration in Endometrial Proteins during Early- and Mid-Secretory Phases of the Cycle in Women with Unexplained Infertility. PLoS ONE 9:11, pages e111687.
Crossref
Bruno Di Jeso, Yoshiaki Morishita, Antonella S. Treglia, Dario D. Lofrumento, Giuseppe Nicolardi, Francesco Beguinot, Aaron P. Kellogg & Peter Arvan. (2014) Transient Covalent Interactions of Newly Synthesized Thyroglobulin with Oxidoreductases of the Endoplasmic Reticulum. Journal of Biological Chemistry 289:16, pages 11488-11496.
Crossref
Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie & Huey-Jen Tsay. (2013) Cysteine-rich domain of scavenger receptor AI modulates the efficacy of surface targeting and mediates oligomeric Aβ internalization. Journal of Biomedical Science 20:1.
Crossref
Tali Gidalevitz, Fred Stevens & Yair Argon. (2013) Orchestration of secretory protein folding by ER chaperones. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:11, pages 2410-2424.
Crossref
Pallav Kosuri, Jorge Alegre-Cebollada, Jason Feng, Anna Kaplan, Alvaro Inglés-Prieto, Carmen L. Badilla, Brent R. Stockwell, Jose M. Sanchez-Ruiz, Arne Holmgren & Julio M. Fernández. (2012) Protein Folding Drives Disulfide Formation. Cell 151:4, pages 794-806.
Crossref
Yoshimi Sato & Kenji Inaba. (2012) Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals. FEBS Journal 279:13, pages 2262-2271.
Crossref
A. Lombardi, L. Ulianich, A. S. Treglia, C. Nigro, L. Parrillo, D. D. Lofrumento, G. Nicolardi, C. Garbi, F. Beguinot, C. Miele & B. Di Jeso. (2011) Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway. Diabetologia 55:1, pages 141-153.
Crossref
Stefan Sonderegger, Joanne Yap, Ellen Menkhorst, Gareth Weston, Peter G. Stanton & Evdokia Dimitriadis. (2011) Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts. Human Reproduction 26:10, pages 2841-2849.
Crossref
Trevor L. Cameron, Katrina M. Bell, Liliana Tatarczuch, Eleanor J. Mackie, M. Helen Rajpar, Ben T. McDermott, Raymond P. Boot-Handford & John F. Bateman. (2011) Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy. PLoS ONE 6:9, pages e24600.
Crossref
Jaemin Lee, Bruno Di Jeso & Peter Arvan. (2011) Maturation of Thyroglobulin Protein Region I. Journal of Biological Chemistry 286:38, pages 33045-33052.
Crossref
L. Ulianich, G. Terrazzano, M. Annunziatella, G. Ruggiero, F. Beguinot & B. Di Jeso. (2011) ER stress impairs MHC Class I surface expression and increases susceptibility of thyroid cells to NK-mediated cytotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:4, pages 431-438.
Crossref
Stefania De Vitis, Antonella Sonia Treglia, Luca Ulianich, Stefano Turco, Giuseppe Terrazzano, Angela Lombardi, Claudia Miele, Corrado Garbi, Francesco Beguinot & Bruno Di Jeso. (2011) Tyr Phosphatase-Mediated P-ERK Inhibition Suppresses Senescence in EIA + v-raf Transformed Cells, Which, Paradoxically, Are Apoptosis-Protected in a MEK-Dependent Manner. Neoplasia 13:2, pages 120-IN6.
Crossref
Martin McLaughlin & Koen Vandenbroeck. (2011) The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?. British Journal of Pharmacology 162:2, pages 328-345.
Crossref
Ryo Ushioda & Kazuhiro Nagata. 2011. The Unfolded Protein Response and Cellular Stress, Part B. The Unfolded Protein Response and Cellular Stress, Part B 235 258 .
Emilia Pedone, Danila Limauro, Katia D’Ambrosio, Giuseppina De Simone & Simonetta Bartolucci. (2010) Multiple catalytically active thioredoxin folds: a winning strategy for many functions. Cellular and Molecular Life Sciences 67:22, pages 3797-3814.
Crossref
Xiaofan Wang, Jaemin Lee, Bruno Di Jeso, A. Sonia Treglia, Davide Comoletti, Noga Dubi, Palmer Taylor & Peter Arvan. (2010) Cis and Trans Actions of the Cholinesterase-like Domain within the Thyroglobulin Dimer. Journal of Biological Chemistry 285:23, pages 17564-17573.
Crossref
Chantal Christis, Asier Fullaondo, Danny Schildknegt, Souren Mkrtchian, Albert J. R. Heck & Ineke Braakman. (2010) Regulated increase in folding capacity prevents unfolded protein stress in the ER. Journal of Cell Science 123:5, pages 787-794.
Crossref
Daorong Feng, Jianwen Wei, Sounak Gupta, Barbara C McGrath & Douglas R Cavener. (2009) Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biology 10:1.
Crossref
Feras HatahetLloyd W. Ruddock. (2009) Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation. Antioxidants & Redox Signaling 11:11, pages 2807-2850.
Crossref
Hiroshi Kadokura & Jon Beckwith. (2009) Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel. Cell 138:6, pages 1164-1173.
Crossref
Dong Xu, Ricardo E. Perez, Mohammad H. Rezaiekhaligh, Mohammed Bourdi & William E. Truog. (2009) Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. American Journal of Physiology-Lung Cellular and Molecular Physiology 297:1, pages L44-L51.
Crossref
Jaemin Lee, Xiaofan Wang, Bruno Di Jeso & Peter Arvan. (2009) The Cholinesterase-like Domain, Essential in Thyroglobulin Trafficking for Thyroid Hormone Synthesis, Is Required for Protein Dimerization. Journal of Biological Chemistry 284:19, pages 12752-12761.
Crossref
Prasad Tongaonkar & Michael E. Selsted. (2009) SDF2L1, a Component of the Endoplasmic Reticulum Chaperone Complex, Differentially Interacts with α-, β-, and θ-Defensin Propeptides. Journal of Biological Chemistry 284:9, pages 5602-5609.
Crossref
Chantal Christis, Nicolette H. Lubsen & Ineke Braakman. (2008) Protein folding includes oligomerization - examples from the endoplasmic reticulum and cytosol. FEBS Journal 275:19, pages 4700-4727.
Crossref
Jaemin Lee, Bruno Di Jeso & Peter Arvan. (2008) The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone. Journal of Clinical Investigation 118:8, pages 2950-2958.
Crossref
Christian Appenzeller-Herzog & Lars Ellgaard. (2008) The human PDI family: Versatility packed into a single fold. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:4, pages 535-548.
Crossref
Luca Ulianich, Corrado Garbi, Antonella Sonia Treglia, Dario Punzi, Claudia Miele, Gregory Alexander Raciti, Francesco Beguinot, Eduardo Consiglio & Bruno Di Jeso. (2008) ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. Journal of Cell Science 121:4, pages 477-486.
Crossref
Paul S. Kim, Jaemin Lee, Piyanuch Jongsamak, Shekar Menon, Bailing Li, Shaikh A. Hossain, Jin-Ho Bae, Bhinyo Panijpan & Peter Arvan. (2008) Defective Protein Folding and Intracellular Retention of Thyroglobulin-R19K Mutant as a Cause of Human Congenital Goiter. Molecular Endocrinology 22:2, pages 477-484.
Crossref
Stephan Frey, Martin Haslbeck, Otmar Hainzl & Johannes Buchner. (2008) Synthesis and characterization of a functional intact IgG in a prokaryotic cell-free expression system. bchm 389:1, pages 37-45.
Crossref
Christian Appenzeller-HerzogLars Ellgaard. (2008) In Vivo Reduction-Oxidation State of Protein Disulfide Isomerase: The Two Active Sites Independently Occur in the Reduced and Oxidized Forms . Antioxidants & Redox Signaling 10:1, pages 55-64.
Crossref
Julio J. Caramelo & Armando J. Parodi. (2007) How sugars convey information on protein conformation in the endoplasmic reticulum. Seminars in Cell & Developmental Biology 18:6, pages 732-742.
Crossref
Daniel N. Hebert & Maurizio Molinari. (2007) In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases. Physiological Reviews 87:4, pages 1377-1408.
Crossref
Shekar Menon, Jaemin Lee, William A. Abplanalp, Sung-Eun Yoo, Takashi Agui, Sen-ichi Furudate, Paul S. Kim & Peter Arvan. (2007) Oxidoreductase Interactions Include a Role for ERp72 Engagement with Mutant Thyroglobulin from the rdw/rdw Rat Dwarf. Journal of Biological Chemistry 282:9, pages 6183-6191.
Crossref
Bradley R. Pearse & Daniel N. Hebert. 2007. Molecular Machines Involved in Protein Transport across Cellular Membranes. Molecular Machines Involved in Protein Transport across Cellular Membranes 275 305 .
T. Suzuki, K. Tanabe & Y. Funakoshi. 2007. Comprehensive Glycoscience. Comprehensive Glycoscience 129 149 .
L. DouglasA. DaviesJ. WrattenA.C. Dolphin. (2006) Do voltage-gated calcium channel α2δ subunits require proteolytic processing into α2 and δ to be functional?. Biochemical Society Transactions 34:5, pages 894-898.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.