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Molecular and Cellular Biology Volume 25, 2005 - Issue 22
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Signal Transduction

TRAF6 Is Required for TRAF2-Dependent CD40 Signal Transduction in Nonhemopoietic Cells

Clare C. Davies1 Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TA, United Kingdom
,
Tak W. Mak2 Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, University of Toronto, Toronto, CanadaM5G 2C1
,
Lawrence S. Young1 Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TA, United Kingdom
&
Aristides G. Eliopoulos1 Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, BirminghamB15 2TA, United Kingdom;3 University of Crete Medical School, Molecular and Cellular Biology Laboratory, Heraklion71003, GreeceCorrespondence[email protected]
Pages 9806-9819 | Received 03 May 2005, Accepted 23 Aug 2005, Published online: 27 Mar 2023

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Aristides Moschonas, Maria Kouraki, Pauline G. Knox, Efstathia Thymiakou, Dimitris Kardassis & Aristides G. Eliopoulos. (2008) CD40 Induces Antigen Transporter and Immunoproteasome Gene Expression in Carcinomas via the Coordinated Action of NF-κB and of NF-κB-Mediated De Novo Synthesis of IRF-1. Molecular and Cellular Biology 28:20, pages 6208-6222.
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Meizhen Zhang, Chenghao Shen, Haiying Liang, Yuyuan Wu & Bidan Liang. (2023) Molecular cloning and function of two tumor necrosis factor receptor-associated factors genes (TRAF2 and TRAF4) from Pinctada fucata martensii. Frontiers in Marine Science 9.
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Camilla Palumbo, Alice Mecchia, Alessio Bocedi, Katia Aquilano, Daniele Lettieri-Barbato, Marco Rosina, Almerinda Di Venere, Carlo Rodolfo & Anna Maria Caccuri. (2022) Revisited role of TRAF2 and TRAF2 C-terminal domain in endoplasmic reticulum stress-induced autophagy in HAP1 leukemia cells. The International Journal of Biochemistry & Cell Biology 145, pages 106193.
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Maria Vougioukalaki, Konstantina Georgila, Emmanouil I. Athanasiadis & Aristides G. Eliopoulos. (2022) Cell adhesion tunes inflammatory TPL2 kinase signal transduction. Cellular and Molecular Life Sciences 79:3.
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Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec & Aymen I. Idris. (2022) Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis. Biochemical Pharmacology 195, pages 114869.
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Julia Busch, Rita Moreno, Laureano de la Vega, Vera Vivian Saul, Susanne Bacher, Felix von Zweydorf, Marius Ueffing, Axel Weber, Christian Johannes Gloeckner, Uwe Linne, Michael Kracht & Michael Lienhard Schmitz. (2021) TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks. Cancers 13:14, pages 3618.
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Jiawei Jiang, Jinlong Zhang, Chunshuai Wu, Chu Chen, Guofeng Bao, Guanhua Xu, Pengfei Xue, Yong Zhou, Yuyu Sun & Zhiming Cui. (2021) Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis. Molecular and Cellular Biochemistry 476:4, pages 1929-1938.
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Duygu KIRKIK, Faruk Berat AKÇEŞME & Sevgi KALKANLI. (2020) Detection of CD40 polymorphisms and investigation of their relationship with possible diseases by bioinformatics methodsBiyoinformatik yöntemler yardımıyla, CD40 polimorfizmlerinin tespiti ve olası hastalıklarla ilişkinin araştırılması. Journal of Medicine and Palliative Care 1:4, pages 83-92.
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Debanjan Mukhopadhyay, Lamba Omar Sangaré, Laurence Braun, Mohamed‐Ali Hakimi & Jeroen PJ Saeij. (2020) Toxoplasma GRA 15 limits parasite growth in IFN γ‐activated fibroblasts through TRAF ubiquitin ligases . The EMBO Journal 39:10.
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Cheryl S Sultan, Michael Weitnauer, Martin Turinsky, Thorsten Kessler, Maik Brune, Christian A Gleissner, Florian Leuschner, Andreas H Wagner & Markus Hecker. (2020) Functional association of a CD40 gene single-nucleotide polymorphism with the pathogenesis of coronary heart disease. Cardiovascular Research 116:6, pages 1214-1225.
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Taha Elmetwali, Asmaa Salman, Wenbin Wei, Syed A. Hussain, Lawrence S. Young & Daniel H. Palmer. (2020) CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. Scientific Reports 10:1.
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Harald Wajant & Daniela Siegmund. (2019) TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages. Frontiers in Cell and Developmental Biology 7.
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L Wang, J Ren, G Li, J P Moorman, Z Q Yao & S Ning. (2016) LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required. Oncogene 36:16, pages 2265-2274.
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Xiangyu Yao, Jian Wu, Meng Lin, Wenxiang Sun, Xiao He, Channe Gowda, Silvia Bolland, Carole A. Long, Rongfu Wang & Xin-zhuan Su. (2016) Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model. PLOS Pathogens 12:10, pages e1005930.
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Kristina Seibold & Martin Ehrenschwender. (2015) p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6. Biochemical and Biophysical Research Communications 464:1, pages 330-335.
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Virginia-Maria Vlahava, Aristides G. Eliopoulos & George Sourvinos. (2015) CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism. Cellular Signalling 27:6, pages 1253-1263.
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Katherine C. Bankert, Kyp L. Oxley, Sonja M. Smith, John P. Graham, Mark de Boer, Marielle Thewissen, Peter J. Simons & Gail A. Bishop. (2015) Induction of an Altered CD40 Signaling Complex by an Antagonistic Human Monoclonal Antibody to CD40. The Journal of Immunology 194:9, pages 4319-4327.
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Jose-Andres C. Portillo, Jennifer A. Greene, Isaac Schwartz, Maria Cecilia Subauste & Carlos S. Subauste. (2015) Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells. Immunology 144:1, pages 21-33.
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T Elmetwali, L S Young & D H Palmer. (2014) Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop. Cell Death & Disease 5:5, pages e1213-e1213.
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Sophia Miliara, Kalliopi K. Gkouskou, Tyson V. Sharp & Aristides G. Eliopoulos. (2013) SUMOylation Is Required for Optimal TRAF3 Signaling Capacity. PLoS ONE 8:11, pages e80470.
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Pauline Sebby Ogolla, Jose-Andres C. Portillo, Christine L. White, Krupen Patel, Bruce Lamb, Ganes C. Sen & Carlos S. Subauste. (2013) The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen. PLoS Pathogens 9:8, pages e1003557.
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Daoxia Li, Yingjia Zhong, Yuqiong Zhou, Hong Sun, Xuelian Zheng, Chen Zhao, Youyi Yan, Yong Lin, Linchuan Liao & Xia Wang. (2013) Autocrine TNF-α-mediated NF-κB activation is a determinant for evasion of CD40-induced cytotoxicity in cancer cells. Biochemical and Biophysical Research Communications 436:3, pages 467-472.
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Jun Shen, Yuqi Qiao, Zhihua Ran & Tianrong Wang. (2013) Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease. Mediators of Inflammation 2013, pages 1-8.
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Aristides Moschonas, Marina Ioannou & Aristides G. Eliopoulos. (2012) CD40 Stimulates a “Feed-Forward” NF-κB–Driven Molecular Pathway That Regulates IFN-β Expression in Carcinoma Cells. The Journal of Immunology 188:11, pages 5521-5527.
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Pauline G. Knox, Clare C. Davies, Marina Ioannou & Aristides G. Eliopoulos. (2011) The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. Journal of Cell Biology 192:3, pages 391-399.
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Miwa Sasai, Megumi Tatematsu, Hiroyuki Oshiumi, Kenji Funami, Misako Matsumoto, Shigetsugu Hatakeyama & Tsukasa Seya. (2010) Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway. Molecular Immunology 47:6, pages 1283-1291.
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Wen Zhang, Xuan Zhang, Xiao-li Wu, Liu-sheng He, Xiao-feng Zeng, Amrie C. Grammer & Peter E. Lipsky. (2010) Competition between TRAF2 and TRAF6 Regulates NF-κB Activation in Human B Lymphocytes. Chinese Medical Sciences Journal 25:1, pages 1-12.
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Taha Elmetwali, Lawrence S. Young & Daniel H. Palmer. (2010) CD40 Ligand-Induced Carcinoma Cell Death: A Balance between Activation of TNFR-Associated Factor (TRAF) 3-Dependent Death Signals and Suppression of TRAF6-Dependent Survival Signals. The Journal of Immunology 184:2, pages 1111-1120.
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