34
Views
62
CrossRef citations to date
0
Altmetric
Gene Expression

Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation

, , , , , & show all
Pages 9910-9919 | Received 30 Dec 2004, Accepted 08 Aug 2005, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Jian-Min Lv, Lu Chen, Yi Gao, Hai Huang, Xiu-Wu Pan, Xi Liu, Ming Chen, Fa-Jun Qu, Lin Li, Jun-Kai Wang, Xin-Gang Cui & Dan-Feng Xu. (2018) PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation. OncoTargets and Therapy 11, pages 5797-5809.
Read now
Jianing Zhong, Ji Liao, Xin Liu, Pei Wang, Jinping Liu, Wenya Hou, Bingtao Zhu, Lu Yao, Jinsheng Wang, Jing Li, Jeremy M. Stark, Yuntao Xie & Xingzhi Xu. (2011) Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle 10:9, pages 1411-1419.
Read now
Junjie Feng, Timothy Wakeman, Sheila Yong, Xiaohua Wu, Sally Kornbluth & Xiao-Fan Wang. (2009) Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress. Molecular and Cellular Biology 29:21, pages 5696-5709.
Read now
Xi Tang, Zhou-guang Hui, Xiao-li Cui, Renu Garg, Michael B. Kastan & Bo Xu. (2008) A Novel ATM-Dependent Pathway Regulates Protein Phosphatase 1 in Response to DNA Damage. Molecular and Cellular Biology 28:8, pages 2559-2566.
Read now
Zheng Fu, Katherine A. Larson, Raghu K. Chitta, Sirlester A. Parker, Benjamin E. Turk, Matthew W. Lawrence, Philipp Kaldis, Konstantin Galaktionov, Steven M. Cohn, Jeffrey Shabanowitz, Donald F. Hunt & Thomas W. Sturgill. (2006) Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase. Molecular and Cellular Biology 26:22, pages 8639-8654.
Read now
Van Leung-Pineda, Christine E. Ryan & Helen Piwnica-Worms. (2006) Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit. Molecular and Cellular Biology 26:20, pages 7529-7538.
Read now

Articles from other publishers (56)

Hengheng Zhang, Qiuyue Zhang, Jiaqi Tu, Qidong You & Lei Wang. (2023) Dual function of protein phosphatase 5 (PPP5C): An emerging therapeutic target for drug discovery. European Journal of Medicinal Chemistry 254, pages 115350.
Crossref
Ren-Yan Li, Dan Yang, Yan-Ji He, Yong Zhou, Cheng-Cheng Li, Lian-Bing Li, Ming-Xing Liao, Zhong-Liang Deng, Le-Tian Zhao, Tian-Feng Zhang, Yong Luo, Ying-Xiong Wang & Yan-Fei Gao. (2023) Heavy metal ions exchange driven protein phosphorylation cascade functions in genomic instability in spermatocytes and male infertility. Nucleic Acids Research 51:7, pages 3150-3165.
Crossref
Maru Jaime-Garza, Carlos A. Nowotny, Daniel Coutandin, Feng Wang, Mariano Tabios & David A. Agard. (2023) Hsp90 provides a platform for kinase dephosphorylation by PP5. Nature Communications 14:1.
Crossref
Edit Ábrahám, Zsuzsánna Réthi-Nagy, Péter Vilmos, Rita Sinka & Zoltán Lipinszki. (2023) Plk4 Is a Novel Substrate of Protein Phosphatase 5. International Journal of Molecular Sciences 24:3, pages 2033.
Crossref
Kalil Batnini, Thibault Houles, Olivier Kirsh, Stanislas Du Manoir, Mehdi Zaroual, Hélène Delpech, Chloé Fallet, Matthieu Lacroix, Laurent Le Cam, Charles Theillet, Claude Sardet & Geneviève Rodier. (2022) Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer. International Journal of Molecular Sciences 23:16, pages 9217.
Crossref
Sara M. Fielder, Jill A. Rosenfeld, Lindsay C. Burrage, Lisa Emrick, Seema Lalani, Ruben Attali, Joshua N. Bembenek, Hieu Hoang, Dustin Baldridge, Gary A. Silverman, Tim Schedl & Stephen C. Pak. (2022) Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay. Molecular Genetics and Metabolism 136:1, pages 65-73.
Crossref
Joachim Neumann, Peter Boknik, Uwe Kirchhefer & Ulrich Gergs. (2021) The role of PP5 and PP2C in cardiac health and disease. Cellular Signalling 85, pages 110035.
Crossref
Caroline Molinaro, Alain Martoriati & Katia Cailliau. (2021) Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies. Cancers 13:15, pages 3819.
Crossref
Riva ShmulevichValery Krizhanovsky. (2021) Cell Senescence, DNA Damage, and Metabolism. Antioxidants & Redox Signaling 34:4, pages 324-334.
Crossref
Rebecca A. Sager, Natela Dushukyan, Mark Woodford & Mehdi Mollapour. (2020) Structure and function of the co-chaperone protein phosphatase 5 in cancer. Cell Stress and Chaperones 25:3, pages 383-394.
Crossref
Adrián Campos & Andrés Clemente-Blanco. (2020) Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. International Journal of Molecular Sciences 21:2, pages 446.
Crossref
Jie Zhang, Zhenglong Wang, Nemat O. Keyhani, Guoxiong Peng, Kai Jin & Yuxian Xia. (2019) The protein phosphatase gene MaPpt1 acts as a programmer of microcycle conidiation and a negative regulator of UV-B tolerance in Metarhizium acridum. Applied Microbiology and Biotechnology 103:3, pages 1351-1362.
Crossref
Jun Wang, Tao Shen, Wuqiang Zhu, Longyu Dou, Hao Gu, Lingling Zhang, Zhenyun Yang, Hanying Chen, Qi Zhou, Edwin R. Sánchez, Loren J. Field, Lindsey D. Mayo, Zhongwen Xie, Deyong Xiao, Xia Lin, Weinian Shou & Weidong Yong. (2018) Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice. Journal of Biological Chemistry 293:47, pages 18218-18229.
Crossref
Chao-Yuan Huang, Feng-Shu Hsieh, Cheng-Yi Wang, Li-Ju Chen, Shih-Shin Chang, Ming-Hsien Tsai, Man-Hsin Hung, Chiung-Wen Kuo, Chi-Ting Shih, Tzu-I Chao & Kuen-Feng Chen. (2018) Palbociclib enhances radiosensitivity of hepatocellular carcinoma and cholangiocarcinoma via inhibiting ataxia telangiectasia–mutated kinase–mediated DNA damage response. European Journal of Cancer 102, pages 10-22.
Crossref
Songli Zhu, Laura A. Fisher, Tadayoshi Bessho & Aimin Peng. (2017) Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining. Nucleic Acids Research 45:18, pages 10583-10594.
Crossref
Feng-Shu Hsieh, Man-Hsin Hung, Cheng-Yi Wang, Yen-Lin Chen, Yung-Jen Hsiao, Ming-Hsien Tsai, Jia-Rong Li, Li-Ju Chen, Chih-Ting Shih, Tzu-I Chao & Kuen-Feng Chen. (2017) Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation. Lung Cancer 112, pages 81-89.
Crossref
Yao-Li Chen, Man-Hsin Hung, Pei-Yi Chu, Tzu-I Chao, Ming-Hsien Tsai, Li-Ju Chen, Yung-Jen Hsiao, Chih-Ting Shih, Feng-Shu Hsieh & Kuen-Feng Chen. (2017) Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase. Biochemical Pharmacology 138, pages 49-60.
Crossref
Arpita De, Manoswini Chakrabarti, Ilika Ghosh & Anita Mukherjee. (2016) Evaluation of genotoxicity and oxidative stress of aluminium oxide nanoparticles and its bulk form in Allium cepa. The Nucleus 59:3, pages 219-225.
Crossref
Yunhua Liu, Yujing Li & Xiongbin Lu. (2016) Regulators in the DNA damage response. Archives of Biochemistry and Biophysics 594, pages 18-25.
Crossref
Maristella De Cicco, Munirah Rahim & Sonja Dames. (2015) Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting. Membranes 5:4, pages 553-575.
Crossref
Jianwei Wang, Jinhui Zhu, Mingjun Dong, Hua Yu, Xiaoyu Dai & Keqiang Li. (2015) Inhibition of protein phosphatase 5 (PP5) suppresses survival and growth of colorectal cancer cells. Biotechnology and Applied Biochemistry 62:5, pages 621-627.
Crossref
Xinglong Zhi, Hongqi Zhang, Chuan He, Yukui Wei, Lisong Bian & Guilin Li. (2015) Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma. Cellular and Molecular Neurobiology 35:5, pages 669-677.
Crossref
Indra A. Shaltiel, Lenno Krenning, Wytse Bruinsma & René H. Medema. (2015) The same, only different – DNA damage checkpoints and their reversal throughout the cell cycle. Journal of Cell Science.
Crossref
Liang Feng, Peng Sun, Zhiyu Li, Ming Liu & Shibo Sun. (2014) Knockdown of PPP5C Inhibits Growth of Hepatocellular Carcinoma Cells In Vitro. Applied Biochemistry and Biotechnology 175:1, pages 526-534.
Crossref
Masaoki Kawasumi, James E. Bradner, Nicola Tolliday, Renee Thibodeau, Heather Sloan, Kay M. Brummond & Paul Nghiem. (2014) Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity. Cancer Research 74:24, pages 7534-7545.
Crossref
Kangdi Hu, Wanjie Li, Jiaxin Gao, Qizheng Liu, Haitao Wang, Yue Wang & Jianli Sang. (2014) Role of Ppt1 in multiple stress responses in Candida albicans. Chinese Science Bulletin 59:31, pages 4060-4068.
Crossref
Henrik Ortsäter, Nina Grankvist, Richard E Honkanen & Åke Sjöholm. (2014) Protein phosphatases in pancreatic islets. Journal of Endocrinology 221:3, pages R121-R144.
Crossref
Matthew D. Mazalouskas, Raquel Godoy-Ruiz, David J. Weber, Danna B. Zimmer, Richard E. Honkanen & Brian E. Wadzinski. (2014) Small G Proteins Rac1 and Ras Regulate Serine/Threonine Protein Phosphatase 5 (PP5)·Extracellular Signal-Regulated Kinase (ERK) Complexes Involved in the Feedback Regulation of Raf1. Journal of Biological Chemistry 289:7, pages 4219-4232.
Crossref
Mengmeng Zhang, S. D. Yogesha, Joshua E. Mayfield, Gordon N. Gill & Yan Zhang. (2013) Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS Journal 280:19, pages 4739-4760.
Crossref
O. M. Malanchuk, G. V. Ovcharenko, I. O. Tykhonkova, O. S. Khoma, U. V. Chorna, M. P. Rubak & S. S. Palchevskyy. (2013) Generation of monoclonal antibody against protein phosphatase 5. Biopolymers and Cell 29:2, pages 136-142.
Crossref
David L. Bruce, Thomas Macartney, Weidong Yong, Weinian Shou & Gopal P. Sapkota. (2012) Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor‐β pathway. Cellular Signalling 24:11, pages 1999-2006.
Crossref
Lauren Amable, Nina Grankvist, Jason W. Largen, Henrik Ortsäter, Åke Sjöholm & Richard E. Honkanen. (2011) Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1). Journal of Biological Chemistry 286:47, pages 40413-40422.
Crossref
Dong-Hyun Lee & Dipanjan Chowdhury. (2011) What goes on must come off: phosphatases gate-crash the DNA damage response. Trends in Biochemical Sciences 36:11, pages 569-577.
Crossref
Bryan M. Ham. 2011. Proteomics of Biological Systems. Proteomics of Biological Systems 147 180 .
Bo Liu & XingZhi Xu. (2011) Serine/threonine protein phosphatases in DNA damage response. Chinese Science Bulletin 56:30.
Crossref
Dana V. Skarra, Marilyn Goudreault, Hyungwon Choi, Michael Mullin, Alexey I. Nesvizhskii, Anne-Claude Gingras & Richard E. Honkanen. (2011) Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. PROTEOMICS 11:8, pages 1508-1516.
Crossref
Yoonsung Kang, Hyang-Min Cheong, Jung-Hee Lee, Peter I. Song, Kwang-Ho Lee, Sang-Yong Kim, Jae Yeoul Jun & Ho Jin You. (2011) Protein phosphatase 5 is necessary for ATR-mediated DNA repair. Biochemical and Biophysical Research Communications 404:1, pages 476-481.
Crossref
Chiao Yun LinBertrand Chin-Ming Tan, Hsuan LiuChii-Jiun Shih, Kun-Yi Chien, Chih-Li Lin & Benjamin Yat-Ming Yung. (2010) Dephosphorylation of Nucleophosmin by PP1β Facilitates pRB Binding and Consequent E2F1-dependent DNA Repair. Molecular Biology of the Cell 21:24, pages 4409-4417.
Crossref
A Peng & J L Maller. (2010) Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene 29:45, pages 5977-5988.
Crossref
Charmian Cher, Marie-Helene Tremblay, Jack R. Barber, Shi Chung Ng & Bin Zhang. (2009) Identification of Chaulmoogric Acid as a Small Molecule Activator of Protein Phosphatase 5. Applied Biochemistry and Biotechnology 160:5, pages 1450-1459.
Crossref
Bryan M. Ham, Hemalatha Jayachandran, Feng Yang, Navdeep Jaitly, Ashoka D. Polpitiya, Matthew E. Monroe, Ling Wang, Rui Zhao, Samuel O. Purvine, Eric A. Livesay, David G. CampIIII, Sandra Rossie & Richard D. Smith. (2009) Novel Ser/Thr Protein Phosphatase 5 (PP5) Regulated Targets during DNA Damage Identified by Proteomics Analysis. Journal of Proteome Research 9:2, pages 945-953.
Crossref
Andrew J. Ramsey, Lance C. RussellMichael Chinkers. (2009) C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins. Biochemical Journal 423:3, pages 411-419.
Crossref
Jamie L. McConnell & Brian E. Wadzinski. (2009) Targeting Protein Serine/Threonine Phosphatases for Drug Development. Molecular Pharmacology 75:6, pages 1249-1261.
Crossref
Yoonsung Kang, Jung-Hee Lee, Nguyen Ngoc Hoan, Hong-Moon Sohn, In-Youb Chang & Ho Jin You. (2009) Protein Phosphatase 5 Regulates the Function of 53BP1 after Neocarzinostatin-induced DNA Damage. Journal of Biological Chemistry 284:15, pages 9845-9853.
Crossref
Karlene A. Cimprich & David Cortez. (2008) ATR: an essential regulator of genome integrity. Nature Reviews Molecular Cell Biology 9:8, pages 616-627.
Crossref
Teresa Golden, Mark Swingle & Richard E. Honkanen. (2008) The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer and Metastasis Reviews 27:2, pages 169-178.
Crossref
Teresa Golden, Ileana V. Aragon, Beth Rutland, J. Allan Tucker, Lalita A. Shevde, Rajeev S. Samant, Guofei Zhou, Lauren Amable, Danalea Skarra & Richard E. Honkanen. (2008) Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1782:4, pages 259-270.
Crossref
M F Lavin. (2007) ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene 26:56, pages 7749-7758.
Crossref
Li NiMark S. SwingleAustin C. BourgeoisRichard E. Honkanen. (2007) High Yield Expression of Serine/Threonine Protein Phosphatase Type 5, and a Fluorescent Assay Suitable for Use in the Detection of Catalytic Inhibitors. ASSAY and Drug Development Technologies 5:5, pages 645-654.
Crossref
Hirokazu Fukuda, Naoto Tsuchiya, Kaori Hara-Fujita, Sachiyo Takagi, Minako Nagao & Hitoshi Nakagama. (2007) Induction of abnormal nuclear shapes in two distinct modes by overexpression of serine/threonine protein phosphatase 5 in Hela cells. Journal of Cellular Biochemistry 101:2, pages 321-330.
Crossref
Weidong Yong, Shideng Bao, Hanying Chen, Dapei Li, Edwin R. Sánchez & Weinian Shou. (2007) Mice Lacking Protein Phosphatase 5 Are Defective in Ataxia Telangiectasia Mutated (ATM)-mediated Cell Cycle Arrest. Journal of Biological Chemistry 282:20, pages 14690-14694.
Crossref
Daniel Stauffer, Bill Chang, Jing Huang, Andrew Dunn & Mathew Thayer. (2007) p300/CREB-binding Protein Interacts with ATR and Is Required for the DNA Replication Checkpoint. Journal of Biological Chemistry 282:13, pages 9678-9687.
Crossref
Ge Li, Robert T. Elder, Kefeng Qin, Hyeon Ung Park, Dong Liang & Richard Y. Zhao. (2007) Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1. Journal of Biological Chemistry 282:10, pages 7287-7298.
Crossref
Naoyuki Okita, Yuki Kudo & Sei-ichi Tanuma. (2007) Checkpoint Kinase 1 Is Cleaved in a Caspase-Dependent Pathway during Genotoxic Stress-Induced Apoptosis. Biological and Pharmaceutical Bulletin 30:2, pages 359-362.
Crossref
Isabelle M. Mansuy & Shirish Shenolikar. (2006) Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory. Trends in Neurosciences 29:12, pages 679-686.
Crossref
Carrie L. Partch, Katherine F. Shields, Carol L. Thompson, Christopher P. Selby & Aziz Sancar. (2006) Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. Proceedings of the National Academy of Sciences 103:27, pages 10467-10472.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.