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Signal Transduction

Regulation of Apoptotic c-Jun N-Terminal Kinase Signaling by a Stabilization-Based Feed-Forward Loop

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Pages 9949-9959 | Received 09 Aug 2005, Accepted 23 Aug 2005, Published online: 27 Mar 2023

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Norman J. Kennedy & Roger J. Davis. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 1315 1328 .
Nicolas Bisson & Thomas Moss. (2009) Mlk2. AfCS-Nature Molecule Pages.
Crossref
Nicolas Bisson & Thomas Moss. (2009) Mlk1. AfCS-Nature Molecule Pages.
Crossref
Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Alisan Kahraman, Sean P. Garrison, Gerard P. Zambetti, Michael R. Charlton & Gregory J. Gores. (2009) JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis. Journal of Biological Chemistry 284:39, pages 26591-26602.
Crossref
Andrew A Sproul, Zhiheng Xu, Michael Wilhelm, Stephen Gire & Lloyd A Greene. (2009) Cbl negatively regulates JNK activation and cell death. Cell Research 19:8, pages 950-961.
Crossref
Jean-Philippe Couture & Richard Blouin. (2009) DLK. AfCS-Nature Molecule Pages.
Crossref
Jennifer TaylorKwan-Ho Chung, Claudia FigueroaJonathan ZurawskiHeather M. DicksonE. J. BraceAdam W. AveryDavid L. Turner & Anne B. Vojtek. (2008) The Scaffold Protein POSH Regulates Axon Outgrowth. Molecular Biology of the Cell 19:12, pages 5181-5192.
Crossref
Hai-Xuan Qiao, Chan-Juan Hao, Yan Li, Xin He, Ri-Sheng Chen, Jie Cui, Zhi-Heng Xu & Wei Li. (2008) JNK activation mediates the apoptosis of xCT-deficient cells. Biochemical and Biophysical Research Communications 370:4, pages 584-588.
Crossref
Shujing Liu, Mei Yu, Ying He, Lin Xiao, Fang Wang, Changcheng Song, Shuhan Sun, Changquan Ling & Zhiheng Xu. (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47:6, pages 1964-1973.
Crossref
Silke Plaumann, Roland Blume, Svenja Börchers, Hans Jürgen Steinfelder, Willhart Knepel & Elke Oetjen. (2008) Activation of the Dual-Leucine-Zipper-Bearing Kinase and Induction of β-Cell Apoptosis by the Immunosuppressive Drug Cyclosporin A. Molecular Pharmacology 73:3, pages 652-659.
Crossref
María J. Muñoz-Alonso, Laura González-Santiago, Natasha Zarich, Teresa Martínez, Enrique Alvarez, José María Rojas & Alberto Muñoz. (2008) Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH 2 -Terminal Kinase Activation in Human Melanoma Cells . Journal of Pharmacology and Experimental Therapeutics 324:3, pages 1093-1101.
Crossref
Yiming Sun, Tao Yang & Zhiheng Xu. (2007) The JNK Pathway and Neuronal Migration. Journal of Genetics and Genomics 34:11, pages 957-965.
Crossref
Traci R. Lyons, Jackie Thorburn, Philip W. Ryan, Andrew Thorburn, Steven M. Anderson & C. Kenneth Kassenbrock. (2007) Regulation of the Pro-apoptotic Scaffolding Protein POSH by Akt. Journal of Biological Chemistry 282:30, pages 21987-21997.
Crossref
Jie CUI, Ming ZHANG, Yong-qing ZHANG & Zhi-heng XU. (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacologica Sinica 28:5, pages 601-608.
Crossref
Michael Wilhelm, Zhiheng Xu, Nickolay V. Kukekov, Stephen Gire & Lloyd A. Greene. (2007) Proapoptotic Nix Activates the JNK Pathway by Interacting with POSH and Mediates Death in a Parkinson Disease Model. Journal of Biological Chemistry 282:2, pages 1288-1295.
Crossref
Jason DeFuria, Po Chen & Thomas B. Shea. (2006) Divergent effects of the MEKK-1/JNK pathway on NB2a/d1 differentiation: Some activity is required for outgrowth and stabilization of neurites but overactivation inhibits both phenomena. Brain Research 1123:1, pages 20-26.
Crossref
Karen Schachter, Geou-Yarh Liou, Yan Du & Kathleen Gallo. (2006) Mlk3. AfCS-Nature Molecule Pages.
Crossref
Karen A. Schachter, Yan Du, Anning Lin & Kathleen A. Gallo. (2006) Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains. Journal of Biological Chemistry 281:28, pages 19134-19144.
Crossref
Nickolay V. Kukekov, Zhiheng Xu & Lloyd A. Greene. (2006) Direct Interaction of the Molecular Scaffolds POSH and JIP Is Required for Apoptotic Activation of JNKs. Journal of Biological Chemistry 281:22, pages 15517-15524.
Crossref
Zhiheng Xu, Andrew Sproul, Wenyi Wang, Nikolay Kukekov & Lloyd A. Greene. (2006) Siah1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. Journal of Biological Chemistry 281:1, pages 303-312.
Crossref
Zhiheng Xu & Lloyd A. Greene. 2006. Regulators and Effectors of Small GTPases: Rho Family. Regulators and Effectors of Small GTPases: Rho Family 479 489 .

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