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Signal Transduction

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

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Pages 10407-10418 | Received 28 Jul 2005, Accepted 14 Sep 2005, Published online: 27 Mar 2023

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Kristy R. Howell & Amanda J. Law. (2020) Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development. Schizophrenia Research 217, pages 95-104.
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Simone F. GlaserAndreas W. HeumüllerLukas TomborPatrick Hofmann, Marion Muhly-ReinholzAriane FischerStefan GüntherKaroline E. KokotHitoshi OkadaDavid HasselSandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley AbplanalpDavid JohnJes-Niels BoeckelStefanie Dimmeler. (2020) The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proceedings of the National Academy of Sciences 117:8, pages 4180-4187.
Crossref
Taojian Tu, Jingyu Chen, Lulu Chen & Bangyan L. Stiles. (2020) Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions. Cold Spring Harbor Perspectives in Medicine 10:1, pages a036301.
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Crossref
Nico Hinz & Manfred Jücker. (2019) Distinct functions of AKT isoforms in breast cancer: a comprehensive review. Cell Communication and Signaling 17:1.
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Juwen C. DuBois, Alex K. Ray, Ross C. Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan & Bridget Shafit-Zagardo. (2019) Akt3-Mediated Protection Against Inflammatory Demyelinating Disease. Frontiers in Immunology 10.
Crossref
MacRae F. Linton, Javid J. Moslehi & Vladimir R. Babaev. (2019) Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis. International Journal of Molecular Sciences 20:11, pages 2703.
Crossref
Joan Sanchez-Gurmaches, Camila Martinez Calejman, Su Myung Jung, Huawei Li & David A. Guertin. (2019) Brown fat organogenesis and maintenance requires AKT1 and AKT2. Molecular Metabolism 23, pages 60-74.
Crossref
Vladimir R. Babaev, Lei Ding, Youmin Zhang, James M. May, Stephen A. RamseyKasey C. Vickers & MacRae F. Linton. (2019) Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice . Arteriosclerosis, Thrombosis, and Vascular Biology 39:2, pages 156-169.
Crossref
Elizabeth Michele Davies, Rajendra Gurung, Kai Qin Le & Christina Anne Mitchell. (2019) Effective angiogenesis requires regulation of phosphoinositide signaling. Advances in Biological Regulation 71, pages 69-78.
Crossref
Colin J. Dinsmore & Philippe Soriano. (2018) MAPK and PI3K signaling: At the crossroads of neural crest development. Developmental Biology 444, pages S79-S97.
Crossref
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Crossref
Nobuki Moriya & Mitsunori Miyazaki. (2018) Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314:5, pages R741-R751.
Crossref
Klaudia Szymonowicz, Sebastian Oeck, Nathalie Malewicz & Verena Jendrossek. (2018) New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. Cancers 10:3, pages 78.
Crossref
Katie Weihbrecht, Wesley A. Goar, Calvin S. Carter, Val C. Sheffield & Seongjin Seo. (2018) Genotypic and phenotypic characterization of the Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model. PLOS ONE 13:2, pages e0192755.
Crossref
Camille L. Duran, David W. Howell, Jui M. Dave, Rebecca L. Smith, Melanie E. Torrie, Jeffrey J. Essner & Kayla J. Bayless. 2011. Comprehensive Physiology. Comprehensive Physiology 153 235 .
Peter Rotwein. (2017) Variation in Akt protein kinases in human populations. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 313:6, pages R687-R692.
Crossref
Josien Levenga, Helen Wong, Ryan A Milstead, Bailey N Keller, Lauren E LaPlante & Charles A Hoeffer. (2017) AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. eLife 6.
Crossref
Ouyang Chen, Zhiyong Cao, He Li, Zhouheng Ye, Rongjia Zhang, Ning Zhang, Junlong Huang, Ting Zhang, Liping Wang, Ling Han, Wenwu Liu & Xuejun Sun. (2017) High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway. Scientific Reports 7:1.
Crossref
Xian Qiao, Rui Su, Yang Wang, Ruijun Wang, Ting Yang, Xiaokai Li, Wei Chen, Shiyang He, Yu Jiang, Qiwu Xu, Wenting Wan, Yaolei Zhang, Wenguang Zhang, Jiang Chen, Bin Liu, Xin Liu, Yixing Fan, Duoyuan Chen, Huaizhi Jiang, Dongming Fang, Zhihong Liu, Xiaowen Wang, Yanjun Zhang, Danqing Mao, Zhiying Wang, Ran Di, Qianjun Zhao, Tao Zhong, Huanming Yang, Jian Wang, Wen Wang, Yang Dong, Xiaoli Chen, Xun Xu & Jinquan Li. (2017) Genome-wide Target Enrichment-aided Chip Design: a 66 K SNP Chip for Cashmere Goat. Scientific Reports 7:1.
Crossref
Yixuan Zhang & Hua Cai. (2017) Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad. Trends in Cardiovascular Medicine 27:6, pages 394-396.
Crossref
Bhumika Wadhwa, Ubaid Makhdoomi, Ram Vishwakarma & Fayaz Malik. (2017) Protein kinase B. Anti-Cancer Drugs 28:6, pages 569-580.
Crossref
Qi Wang, Xinyu Chen & Nissim Hay. (2017) Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). British Journal of Cancer 117:2, pages 159-163.
Crossref
Beata Aleksiūnienė, Rugilė Matulevičiūtė, Aušra Matulevičienė, Birutė Burnytė, Natalija Krasovskaja, Laima Ambrozaitytė, Violeta Mikštienė, Vaidas Dirsė, Algirdas Utkus & Vaidutis Kučinskas. (2017) Opposite chromosome constitutions due to a familial translocation t(1;21)(q43;q22) in 2 cousins with development delay and congenital anomalies. Medicine 96:16, pages e6521.
Crossref
Shuang Chen, Yunzhang Liu, Xiaozhi Rong, Yun Li, Jianfeng Zhou & Ling Lu. (2017) Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish. Frontiers in Endocrinology 8.
Crossref
Yuka Morioka, Jin-Min Nam & Takashi Ohashi. (2017) Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation. PLOS ONE 12:2, pages e0171503.
Crossref
Dawei Zhang, Jing Wang, Chi Zhou & Wuhan Xiao. (2017) Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mechanisms of Development 143, pages 42-52.
Crossref
Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian & Young Tang. (2017) Akt3 is responsible for the survival and proliferation of embryonic stem cells. Biology Open.
Crossref
Alberto Álvarez-Aznar, Lars Muhl & Konstantin Gaengel. 2017. Protein Kinases in Development and Disease. Protein Kinases in Development and Disease 433 482 .
Zeyan LiHui WangQian WangJinhao Sun. (2016) Buyang Huanwu Decoction Vigorously Rescues PC12 Cells Against 6-OHDA-Induced Neurotoxicity via Akt/GSK3β Pathway Based on Serum Pharmacology Methodology. Rejuvenation Research 19:6, pages 467-477.
Crossref
Nicolle M. Linnerth-Petrik, Lisa A. Santry, Roger Moorehead, Manfred Jücker, Sarah K. Wootton & Jim Petrik. (2016) Akt isoform specific effects in ovarian cancer progression. Oncotarget 7:46, pages 74820-74833.
Crossref
Jason S. L. Yu & Wei Cui. (2016) Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination. Development 143:17, pages 3050-3060.
Crossref
Shuangshuang Lu, Pan Du, Congjia Shan, Yaohe Wang, Changsheng Ma & Jianzeng Dong. (2016) Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. Biochemical and Biophysical Research Communications 478:4, pages 1726-1731.
Crossref
G Hua, C He, X Lv, L Fan, C Wang, S W Remmenga, K J Rodabaugh, L Yang, S M Lele, P Yang, A R Karpf, J S Davis & C Wang. (2016) The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription. Cell Death & Disease 7:7, pages e2297-e2297.
Crossref
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Crossref
J. Richard Brewer, Pierre Mazot & Philippe Soriano. (2016) Genetic insights into the mechanisms of Fgf signaling. Genes & Development 30:7, pages 751-771.
Crossref
Matthew J. Eramo & Christina A. Mitchell. (2016) Regulation of PtdIns(3,4,5) P 3/Akt signalling by inositol polyphosphate 5-phosphatases . Biochemical Society Transactions 44:1, pages 240-252.
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Wei Yu, Wenliang Zha, Zhiqiang Ke, Qing Min, Cairong Li, Huirong Sun & Chao Liu. (2016) Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway. Journal of Diabetes Research 2016, pages 1-11.
Crossref
Fuxuan Wang, Shu Xiao, Yang Zhang, Yuehuan Zhang, Ying Liu, Yan Yan, Zhiming Xiang & Ziniu Yu. (2015) ChAkt1 involvement in orchestrating the immune and heat shock responses in Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish & Shellfish Immunology 47:2, pages 1015-1023.
Crossref
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Maren G. Dietrich, Richard A. Zuellig, Giatgen A. Spinas, Roger Lehmann, Oliver Tschopp & Markus Niessen. (2015) Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. Experimental Cell Research 338:1, pages 82-88.
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Lauren M. Hare, Quenten Schwarz, Sophie Wiszniak, Rajendra Gurung, Karen G. Montgomery, Christina A. Mitchell & Wayne A. Phillips. (2015) Heterozygous expression of the oncogenic Pik3caH1047R mutation during murine development results in fatal embryonic and extraembryonic defects. Developmental Biology 404:1, pages 14-26.
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Noemi RotllanAmarylis C. WanschelAna Fernández-HernandoAlessandro G. SalernoStefan OffermannsWilliam C. SessaCarlos Fernández-Hernando. (2015) Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis. Circulation Research 116:11, pages 1744-1752.
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Yves Brand, Soledad Levano, Vesna Radojevic, Arianne Monge Naldi, Cristian Setz, Allen F. Ryan, Kwang Pak, Brian A. Hemmings & Daniel Bodmer. (2015) All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear. PLOS ONE 10:3, pages e0121599.
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Richa Arya & Kristin White. (2015) Cell death in development: Signaling pathways and core mechanisms. Seminars in Cell & Developmental Biology 39, pages 12-19.
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Dayu Gai, Eric Haan, Matthew Scholar, Jillian Nicholl & Sui Yu. (2015) Phenotypes of AKT3 deletion: A case report and literature review . American Journal of Medical Genetics Part A 167:1, pages 174-179.
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Güliz Vanli, Nieves Peltzer, Gilles Dubuis & Christian Widmann. (2014) The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity. Cellular Signalling 26:12, pages 2992-2997.
Crossref
Kai Xu, Pengda Liu & Wenyi Wei. (2014) mTOR signaling in tumorigenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:2, pages 638-654.
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François Fabi & Eric Asselin. (2014) Expression, activation, and role of AKT isoforms in the uterus. REPRODUCTION 148:5, pages R85-R95.
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Monica Y. LeeAmelia K. LucianoEric AckahJuan Rodriguez-Vita, Tara A. Bancroft, Anne EichmannMichael SimonsThemis R. Kyriakides, Manuel Morales-Ruiz & William C. Sessa. (2014) Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proceedings of the National Academy of Sciences 111:35, pages 12865-12870.
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Xin Qi, Jingyue Xu, Pengyu Gu, Xiao Yang & Xiang Gao. (2014) PTEN in smooth muscle cells is essential for colonic immune homeostasis. The International Journal of Biochemistry & Cell Biology 53, pages 108-114.
Crossref
Lifang Ma, Jiayi Wang, Jiafei Lin, Qiuhui Pan, Yongchun Yu & Fenyong Sun. (2014) Cluster of Differentiation 166 (CD166) Regulated by Phosphatidylinositide 3-Kinase (PI3K)/AKT Signaling to Exert Its Anti-apoptotic Role via Yes-associated Protein (YAP) in Liver Cancer. Journal of Biological Chemistry 289:10, pages 6921-6933.
Crossref
Vinodkumar B. PillaiNagalingam R. SundaresanMahesh P. Gupta. (2014) Regulation of Akt Signaling by Sirtuins. Circulation Research 114:2, pages 368-378.
Crossref
Hideki Hayashi. 2014. Neuroprotection and Neuroregeneration for Retinal Diseases. Neuroprotection and Neuroregeneration for Retinal Diseases 25 41 .
Christine Schramm, Michelle A. Edwards & Maike Krenz. (2013) New Approaches to Prevent LEOPARD Syndrome-associated Cardiac Hypertrophy by Specifically Targeting Shp2-dependent Signaling. Journal of Biological Chemistry 288:25, pages 18335-18344.
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Lei Peng, Dexiao Zhu, Xiaowen Feng, Haiman Dong, Qingwei Yue, Jing Zhang, Qing Gao, Jing Hao, Xingzhen Zhang, Zengxun Liu & Jinhao Sun. (2013) Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophrenia Research 147:1, pages 14-23.
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Xiangqi Wu, Yunshan Cao, Junwei Nie, Hailang Liu, Shuangshuang Lu, Xiaoshan Hu, Jingai Zhu, Xia Zhao, Jiandong Chen, Xiaohu Chen, Zhongzhou Yang & Xinli Li. (2013) Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice. The American Journal of Pathology 182:6, pages 2005-2014.
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E.A. Ostrakhovitch & O.A. Semenikhin. (2013) The role of redox environment in neurogenic development. Archives of Biochemistry and Biophysics 534:1-2, pages 44-54.
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Nicole M. Mackey-Lawrence, Xiaoti Guo, Daniel E. Sturdevant, Kimmo Virtaneva, Matthew M. Hernandez, Eric Houpt, Alan Sher, Stephen F. Porcella & William A. PetriJr.Jr.. (2013) Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome following Infection with Entamoeba histolytica. Infection and Immunity 81:5, pages 1460-1470.
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Annabelle Veillette, Kathy Grenier, Kevin Brasseur, Guylaine Fréchette-Frigon, Valérie Leblanc, Sophie Parent & Eric Asselin. (2013) Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium1. Biology of Reproduction 88:3.
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Yi-Chuan Cheng, Fu-Yu Hsieh, Ming-Chang Chiang, Paul J. Scotting, Hung-Yu Shih, Sheng-Jia Lin, Hui-Lan Wu & Han-Ting Lee. (2013) Akt1 Mediates Neuronal Differentiation in Zebrafish via a Reciprocal Interaction with Notch Signaling. PLoS ONE 8:1, pages e54262.
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Ichiro Shiojima, Stephan Schiekofer, Jochen G. Schneider, Kurt Belisle, Kaori Sato, Martin Andrassy, Gennaro Galasso & Kenneth Walsh. (2012) Short-Term Akt Activation in Cardiac Muscle Cells Improves Contractile Function in Failing Hearts. The American Journal of Pathology 181:6, pages 1969-1976.
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Suma P. Kunuthur, Mihaela M. Mocanu, Brian A. Hemmings, Derek J. Hausenloy & Derek M. Yellon. (2012) The Akt1 isoform is an essential mediator of ischaemic preconditioning. Journal of Cellular and Molecular Medicine 16:8, pages 1739-1749.
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Min Jin, Xiaolan Du & Lin Chen. (2013) Cross‐talk between FGF and other cytokine signalling pathways during endochondral bone development. Cell Biology International 36:8, pages 691-696.
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Jianling Xie & Terence P. Herbert. (2011) The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes. Cellular and Molecular Life Sciences 69:8, pages 1289-1304.
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Sung Tae Kim, Kenan Omurtag & Kelle H. Moley. (2012) Decreased Spermatogenesis, Fertility, and Altered Slc2A Expression in Akt1−/− and Akt2−/− Testes and Sperm. Reproductive Sciences 19:1, pages 31-42.
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Ruomin Di, Xiangqi Wu, Zai Chang, Xia Zhao, Qiuting Feng, Shuangshuang Lu, Qing Luan, Brian A. Hemmings, Xinli Li & Zhongzhou Yang. (2011) S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochemical Journal 441:1, pages 199-207.
Crossref
Li-Jun Yao, James A. McCormick, Jian Wang, Katherine Y. Yang, Atif Kidwai, Gian Luca Colussi, Krishna M. Boini, Morris J. Birnbaum, Florian Lang, Michael S. German & David Pearce. (2011) Novel Role for SGK3 in Glucose Homeostasis Revealed in SGK3/Akt2 Double-Null Mice. Molecular Endocrinology 25:12, pages 2106-2118.
Crossref
Rachel S. Lee, Colin M. House, Briony E. Cristiano, Ross D. Hannan, Richard B. Pearson & Katherine M. Hannan. (2011) Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity . Enzyme Research 2011, pages 1-18.
Crossref
Mark A. Sussman, Mirko Völkers, Kimberlee Fischer, Brandi Bailey, Christopher T. Cottage, Shabana Din, Natalie Gude, Daniele Avitabile, Roberto Alvarez, Balaji Sundararaman, Pearl Quijada, Matt Mason, Mathias H. Konstandin, Amy Malhowski, Zhaokang Cheng, Mohsin Khan & Michael McGregor. (2011) Myocardial AKT: The Omnipresent Nexus. Physiological Reviews 91:3, pages 1023-1070.
Crossref
Shuangshuang Lu, Junwei Nie, Qing Luan, Qiuting Feng, Qi Xiao, Zai Chang, Congjia Shan, Daniel Hess, Brian A. Hemmings & Zhongzhou Yang. (2011) Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling. PLoS ONE 6:4, pages e19251.
Crossref
Anne-Marie Fortier, Eric Asselin & Monique Cadrin. (2011) Functional specificity of Akt isoforms in cancer progression. BioMolecular Concepts 2:1-2, pages 1-11.
Crossref
Nissim Hay. (2011) Akt isoforms and glucose homeostasis – the leptin connection. Trends in Endocrinology & Metabolism 22:2, pages 66-73.
Crossref
Luc Furic, Mark Livingstone, Ivan Topisirovic & Nahum Sonenberg. 2011. Insulin Resistance and Cancer. Insulin Resistance and Cancer 181 192 .
Stacey A. Santi, Alison C. Douglas & Hoyun Lee. (2010) The Akt isoforms, their unique functions and potential as anticancer therapeutic targets. BioMolecular Concepts 1:5-6, pages 389-401.
Crossref
Justin R Siebert, Frank A Middleton & Dennis J Stelzner. (2010) Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury. BMC Neuroscience 11:1.
Crossref
Brennan T. Harmon, Stephanie A. Devaney, Heather Gordish-Dressman, Erica K. Reeves, Po Zhao, Joseph M. Devaney & Eric P. Hoffman. (2010) Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome. Human Genetics 128:6, pages 635-645.
Crossref
Zai Chang, Qin Zhang, Qiuting Feng, Jie Xu, Teng Teng, Qing Luan, Congjia Shan, Yali Hu, Brian A. Hemmings, Xiang Gao & Zhongzhou Yang. (2010) Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Developmental Biology 347:2, pages 384-391.
Crossref
Fei Zhou, Zai Chang, Luqing Zhang, Young-Kwon Hong, Bin Shen, Bo Wang, Fan Zhang, Guangming Lu, Denis Tvorogov, Kari Alitalo, Brian A. Hemmings, Zhongzhou Yang & Yulong He. (2010) Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development. The American Journal of Pathology 177:4, pages 2124-2133.
Crossref
Chien-Chung Chen, Robert B Boxer, Douglas B Stairs, Carla P Portocarrero, Rachel H Horton, James V Alvarez, Morris J Birnbaum & Lewis A Chodosh. (2010) Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Research 12:5.
Crossref
Katrien Vandoorne, Jeremy Magland, Vicki Plaks, Amnon Sharir, Elazar Zelzer, Felix Wehrli, Brian A. Hemmings, Alon Harmelin & Michal Neeman. (2010) Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene-dosage-dependent manner: In vivo and ex vivo MRI. Magnetic Resonance in Medicine 64:1, pages 54-64.
Crossref
Marisa M. JuntillaVineet D. PatilMarco CalamitoRohan P. JoshiMorris J. Birnbaum & Gary A. Koretzky. (2010) AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood 115:20, pages 4030-4038.
Crossref
Atsushi Fukai, Naohiro Kawamura, Taku Saito, Yasushi Oshima, Toshiyuki Ikeda, Fumitaka Kugimiya, Akiro Higashikawa, Fumiko Yano, Naoshi Ogata, Kozo Nakamura, Ung-Il Chung & Hiroshi Kawaguchi. (2010) Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions. Arthritis & Rheumatism 62:3, pages 826-836.
Crossref
Caitlin Brown, Jessica LaRocca, Jodie Pietruska, Melissa Ota, Linnea Anderson, Stuart Duncan Smith, Paula Weston, Teresa Rasoulpour & Mary L. Hixon. (2010) Subfertility Caused by Altered Follicular Development and Oocyte Growth in Female Mice Lacking PKBalpha/Akt11. Biology of Reproduction 82:2, pages 246-256.
Crossref
Tove Kirkegaard, Caroline J Witton, Joanne Edwards, Kirsten Vang Nielsen, Linda Boye Jensen, Fiona M Campbell, Timothy G Cooke & John M S Bartlett. (2010) Molecular alterations in AKT1 , AKT2 and AKT3 detected in breast and prostatic cancer by FISH . Histopathology 56:2, pages 203-211.
Crossref
Elena Zhuravleva, Oliver Tschopp & Brian A. Hemmings. 2010. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases 243 259 .
Elisabeth Fayard, Gongda Xue, Arnaud Parcellier, Lana Bozulic & Brian A. Hemmings. 2011. Phosphoinositide 3-kinase in Health and Disease. Phosphoinositide 3-kinase in Health and Disease 31 56 .
Nadine Cybulski & Michael N. Hall. (2009) TOR complex 2: a signaling pathway of its own. Trends in Biochemical Sciences 34:12, pages 620-627.
Crossref
Veronica Ulici, Katie D. Hoenselaar, Hanga Agoston, David D. McErlain, Joseph Umoh, Subrata Chakrabarti, David W. Holdsworth & Frank Beier. (2009) The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification. Bone 45:6, pages 1133-1145.
Crossref
Theodora M. Mauro, James A. McCormick, Jian Wang, Krishna M. Boini, Leena Ray, Bobby Monks, Morris J. Birnbaum, Florian Lang & David Pearce. (2009) Akt2 and SGK3 are both determinants of postnatal hair follicle development. The FASEB Journal 23:9, pages 3193-3202.
Crossref
Ariadne Androulidaki, Dimitrios Iliopoulos, Alicia Arranz, Christina Doxaki, Steffen Schworer, Vassiliki Zacharioudaki, Andrew N. Margioris, Philip N. Tsichlis & Christos Tsatsanis. (2009) The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs. Immunity 31:2, pages 220-231.
Crossref
Kristen Pollizzi, Izabela Malinowska-Kolodziej, Cheryl Doughty, Charles Betz, Jian Ma, June Goto & David J. Kwiatkowski. (2009) A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Human Molecular Genetics 18:13, pages 2378-2387.
Crossref
Sylvestor A. Moses, M. Ahad Ali, Song Zuohe, Lei Du-Cuny, Li Li Zhou, Robert Lemos, Nathan Ihle, A. Geoffrey Skillman, Shuxing Zhang, Eugene A. Mash, Garth Powis & Emmanuelle J. Meuillet. (2009) In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT . Cancer Research 69:12, pages 5073-5081.
Crossref
Peter Rotwein & Elizabeth M. Wilson. (2009) Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation. Journal of Cellular Physiology 219:2, pages 503-511.
Crossref
Saskia Lippens, Esther Hoste, Peter Vandenabeele, Patrizia Agostinis & Wim Declercq. (2009) Cell death in the skin. Apoptosis 14:4, pages 549-569.
Crossref
G Ragone, A Bresin, F Piermarini, C Lazzeri, M C Picchio, D Remotti, S-M Kang, M D Cooper, C M Croce, M G Narducci & G Russo. (2009) The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen–telogen transition and affects stem-cell marker CD34 expression. Oncogene 28:10, pages 1329-1338.
Crossref
Josef Scheiber, Bin Chen, Mariusz Milik, Sai Chetan K. Sukuru, Andreas Bender, Dmitri Mikhailov, Steven Whitebread, Jacques Hamon, Kamal Azzaoui, Laszlo Urban, Meir Glick, John W. Davies & Jeremy L. Jenkins. (2009) Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis. Journal of Chemical Information and Modeling 49:2, pages 308-317.
Crossref
Sung Ji Yun, David F. Tucker, Eun Kyoung Kim, Min Sung Kim, Kee Hun Do, Jung Min Ha, Sun Young Lee, Jeanho Yun, Chi Dae Kim, Morris J. Birnbaum & Sun Sik Bae. (2009) Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Letters 583:4, pages 685-690.
Crossref
Michael Bieri, Melinda Oroszlan, Christian Zuppinger & Paul J. Mohacsi. (2009) Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway. Molecular Immunology 46:5, pages 866-872.
Crossref
Tohru Kimura & Toru Nakano. 2009. Regulatory Networks in Stem Cells. Regulatory Networks in Stem Cells 309 318 .
Eun Kyoung Kim, David F. Tucker, Sung Ji Yun, Kee Hun Do, Min Sung Kim, Jae Ho Kim, Chi Dae Kim, Morris J. Birnbaum & Sun Sik Bae. (2008) Linker region of Akt1/protein kinase Bα mediates platelet-derived growth factor-induced translocation and cell migration. Cellular Signalling 20:11, pages 2030-2037.
Crossref
Ioanna G. Maroulakou, William Oemler, Stephen P. Naber, Ina Klebba, Charlotte Kuperwasser & Philip N. Tsichlis. (2008) Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. Journal of Cellular Physiology 217:2, pages 468-477.
Crossref
Michael Degtyarev, Ann De Mazière, Christine Orr, Jie Lin, Brian B. Lee, Janet Y. Tien, Wei W. Prior, Suzanne van Dijk, Hong Wu, Daniel C. Gray, David P. Davis, Howard M. Stern, Lesley J. Murray, Klaus P. Hoeflich, Judith Klumperman, Lori S. Friedman & Kui Lin. (2008) Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. The Journal of Cell Biology 183:1, pages 101-116.
Crossref
Oliver Renner, Carmen Blanco-Aparicio & Amancio Carnero. (2008) Genetic modelling of the PTEN/AKT pathway in cancer research. Clinical and Translational Oncology 10:10, pages 618-627.
Crossref
R Endersby & S J Baker. (2008) PTEN signaling in brain: neuropathology and tumorigenesis. Oncogene 27:41, pages 5416-5430.
Crossref
Sung-Ji Yun, Eun-Kyoung Kim, David F. Tucker, Chi Dae Kim, Morris J. Birnbaum & Sun Sik Bae. (2008) Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα. Biochemical and Biophysical Research Communications 371:1, pages 138-143.
Crossref
Chris O’Neill. (2008) The potential roles for embryotrophic ligands in preimplantation embryo development. Human Reproduction Update 14:3, pages 275-288.
Crossref
Shingo Hara, Koh-ichi Nakashiro, Hiroyuki Goda & Hiroyuki Hamakawa. (2008) Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. Biochemical and Biophysical Research Communications 370:1, pages 123-128.
Crossref
Anjali K. Nath, Rachel M. Brown, Michael Michaud, M. Rocio Sierra-Honigmann, Michael Snyder & Joseph A. Madri. (2008) Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. The Journal of Cell Biology 181:2, pages 367-380.
Crossref
N Byts, A Samoylenko, T Fasshauer, M Ivanisevic, L Hennighausen, H Ehrenreich & A-L Sirén. (2008) Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. Cell Death & Differentiation 15:4, pages 783-792.
Crossref
Lana Bozulic, Banu Surucu, Debby Hynx & Brian A. Hemmings. (2008) PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival. Molecular Cell 30:2, pages 203-213.
Crossref
Heather J. Evans-AndersonChristina M. AlfieriKatherine E. Yutzey. (2008) Regulation of Cardiomyocyte Proliferation and Myocardial Growth During Development by FOXO Transcription Factors. Circulation Research 102:6, pages 686-694.
Crossref
Carmen SegrellesMarta MoralCorina LorzMirentxu SantosJerry LuJosé Luis Cascallana, M. Fernanda LaraSteve CarbajalAna Belén Martínez-CruzRamón García-EscuderoLinda BeltranJosé C. Segovia, Ana Bravo, John DiGiovanniJesús M. Paramio. (2008) Constitutively Active Akt Induces Ectodermal Defects and Impaired Bone Morphogenetic Protein Signaling. Molecular Biology of the Cell 19:1, pages 137-149.
Crossref
Carmen Segrelles, Jerry Lu, Brian Hammann, Mirentxu Santos, Marta Moral, José Luis Cascallana, M. Fernanda Lara, Okkyung Rho, Steve Carbajal, Jeanine Traag, Linda Beltrán, Ana Belén Martínez-Cruz, Ramón García-Escudero, Corina Lorz, Sergio Ruiz, Ana Bravo, Jesús M. Paramio & John DiGiovanni. (2007) Deregulated Activity of Akt in Epithelial Basal Cells Induces Spontaneous Tumors and Heightened Sensitivity to Skin Carcinogenesis. Cancer Research 67:22, pages 10879-10888.
Crossref
L. Elghazi, L. Rachdi, A. J. Weiss, C. Cras-Méneur & E. Bernal-Mizrachi. (2007) Regulation of ?-cell mass and function by the Akt/protein kinase B signalling pathway. Diabetes, Obesity and Metabolism 9:s2, pages 147-157.
Crossref
Yan Li, Vashe Chandrakanthan, Margot L. Day & Chris O'Neill. (2007) Direct Evidence for the Action of Phosphatidylinositol (3,4,5)-Trisphosphate-Mediated Signal Transduction in the 2-Cell Mouse Embryo1. Biology of Reproduction 77:5, pages 813-821.
Crossref
Elisabeth Fayard, Jason Gill, Magdalena Paolino, Debby Hynx, Georg A. Holländer & Brian A. Hemmings. (2007) Deletion of PKBα/Akt1 Affects Thymic Development. PLoS ONE 2:10, pages e992.
Crossref
K Murayama, T Kimura, M Tarutani, M Tomooka, R Hayashi, M Okabe, K Nishida, S Itami, I Katayama & T Nakano. (2007) Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors. Oncogene 26:33, pages 4882-4888.
Crossref
David A. Guertin & David M. Sabatini. (2007) Defining the Role of mTOR in Cancer. Cancer Cell 12:1, pages 9-22.
Crossref
B. Dummler & B.A. Hemmings. (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochemical Society Transactions 35:2, pages 231-235.
Crossref
Prashanth T. Bhaskar & Nissim Hay. (2007) The Two TORCs and Akt. Developmental Cell 12:4, pages 487-502.
Crossref
Elizabeth M. Wilson & Peter Rotwein. (2007) Selective Control of Skeletal Muscle Differentiation by Akt1. Journal of Biological Chemistry 282:8, pages 5106-5110.
Crossref
Ioanna G. Maroulakou, William Oemler, Stephen P. Naber & Philip N. Tsichlis. (2007) Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice. Cancer Research 67:1, pages 167-177.
Crossref
Briony E. Cristiano, Joanna C. Chan, Katherine M. Hannan, Nicole A. Lundie, Nelly J. Marmy-Conus, Ian G. Campbell, Wayne A. Phillips, Melissa Robbie, Ross D. Hannan & Richard B. Pearson. (2006) A Specific Role for AKT3 in the Genesis of Ovarian Cancer through Modulation of G2-M Phase Transition. Cancer Research 66:24, pages 11718-11725.
Crossref
Ichiro Shiojima & Kenneth Walsh. (2006) Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes & Development 20:24, pages 3347-3365.
Crossref
David A. Guertin, Deanna M. Stevens, Carson C. Thoreen, Aurora A. Burds, Nada Y. Kalaany, Jason Moffat, Michael Brown, Kevin J. Fitzgerald & David M. Sabatini. (2006) Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1. Developmental Cell 11:6, pages 859-871.
Crossref
Wen-Sung LaiBin XuKoen G. C. WestphalMarta PaterliniBerend OlivierPaul Pavlidis, Maria KarayiorgouJoseph A. Gogos. (2006) Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proceedings of the National Academy of Sciences 103:45, pages 16906-16911.
Crossref
QUN LI & JUN REN. (2006) CARDIAC OVEREXPRESSION OF METALLOTHIONEIN RESCUES CHRONIC ALCOHOL INTAKE-INDUCED CARDIOMYOCYTE DYSFUNCTION: ROLE OF AKT, MAMMALIAN TARGET OF RAPAMYCIN AND RIBOSOMAL P70S6 KINASE. Alcohol and Alcoholism 41:6, pages 585-592.
Crossref
Neil J. Freedman & Geoffrey S. Ginsburg. (2006) Novel—and “Neu”—Therapeutic Possibilities for Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.. Journal of the American College of Cardiology 48:7, pages 1448-1450.
Crossref
Chiyo Shiota, Jeong-Taek Woo, Jill Lindner, Kathy D. Shelton & Mark A. Magnuson. (2006) Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability. Developmental Cell 11:4, pages 583-589.
Crossref
Teresa Rasoulpour, Kathryn DiPalma, Branko Kolvek & Mary Hixon. (2006) Akt1 Suppresses Radiation-Induced Germ Cell Apoptosis in Vivo. Endocrinology 147:9, pages 4213-4221.
Crossref
J. K. Crean, F. Furlong, D. Mitchell, E. Mcardle, C. Godson, F. Martin, J. K. Crean, F. Furlong, D. Mitchell, E. Mcardle, C. Godson & F. Martin. (2006) Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B‐mediated phosphorylation and cytoplasmic translocation of p27 Kip‐1 . The FASEB Journal 20:10, pages 1712-1714.
Crossref

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