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Signal Transduction

The Ubiquitously Expressed Csk Adaptor Protein Cbp Is Dispensable for Embryogenesis and T-Cell Development and Function

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Pages 10533-10542 | Received 26 Aug 2005, Accepted 15 Sep 2005, Published online: 27 Mar 2023

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Lubica Draberova, Viktor Bugajev, Lucie Potuckova, Ivana Halova, Monika Bambouskova, Iva Polakovicova, Ramnik J. Xavier, Brian Seed & Petr Draber. (2014) Transmembrane Adaptor Protein PAG/CBP Is Involved in both Positive and Negative Regulation of Mast Cell Signaling. Molecular and Cellular Biology 34:23, pages 4285-4300.
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Marie-José Bijlmakers. (2009) Protein acylation and localization in T cell signaling (Review). Molecular Membrane Biology 26:1-2, pages 93-103.
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Dominique Davidson, Burkhart Schraven & André Veillette. (2007) PAG-Associated FynT Regulates Calcium Signaling and Promotes Anergy in T Lymphocytes. Molecular and Cellular Biology 27:5, pages 1960-1973.
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Torkel Vang, Ana V. Miletic, Nunzio Bottini & Tomas Mustelin. (2007) Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity 40:6, pages 453-461.
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Marianne Strazza, Emily K. Moore, Kieran Adam, Inbar Azoulay-Alfaguter & Adam Mor. (2022) Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth. Molecular Therapy - Methods & Clinical Development 27, pages 380-390.
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Wen Lu, Katarzyna M. Skrzypczynska & Arthur Weiss. (2021) Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway. Proceedings of the National Academy of Sciences 118:43.
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Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Kieran Adam & Adam Mor. (2021) Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells. Communications Biology 4:1.
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Anand Sripada, Kapil Sirohi, Lidia Michalec, Lei Guo, Jerome T. McKay, Sangya Yadav, Mukesh Verma, James Good, Donald Rollins, Magdalena M. Gorska & Rafeul Alam. (2021) Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLOS Biology 19:3, pages e3001063.
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Sabrina Simoncelli, Juliette Griffié, David J. Williamson, Jack Bibby, Cara Bray, Rose Zamoyska, Andrew P. Cope & Dylan M. Owen. (2020) Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation. Cell Reports 33:12, pages 108523.
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Wei Wu, Qiuping Zhou, Takeya Masubuchi, Xiaoshan Shi, Hua Li, Xinyi Xu, Min Huang, Li Meng, Xing He, Hengyu Zhu, Shuaixin Gao, Nan Zhang, Ruirui Jing, Jie Sun, Haopeng Wang, Enfu Hui, Catherine Chiulan Wong & Chenqi Xu. (2020) Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell 182:4, pages 855-871.e23.
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Md Ashik Ullah, Cristina T. Vicente, Natasha Collinson, Bodie Curren, Md Al Amin Sikder, Ismail Sebina, Jennifer Simpson, Antiopi Varelias, Jonathan A. Lindquist, Manuel A. R. Ferreira & Simon Phipps. (2019) PAG1 limits allergen‐induced type 2 inflammation in the murine lung. Allergy 75:2, pages 336-345.
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Sitaram, Uyemura, Malarkannan & Riese. (2019) Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity. International Journal of Molecular Sciences 20:23, pages 5821.
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Sigrid S. Skånland & Kjetil Taskén. (2019) Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling. The Journal of Immunology 203:4, pages 1055-1063.
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Carine M. Gonçalves, Sónia N. Henriques, Rita F. Santos & Alexandre M. Carmo. (2018) CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation. Frontiers in Immunology 9.
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Alan Baer, Winston Colon-Moran, Jinhua Xiang, Jack T. Stapleton & Nirjal Bhattarai. (2017) Src-family kinases negatively regulate NFAT signaling in resting human T cells. PLOS ONE 12:10, pages e0187123.
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Janice H.C. Plani-Lam, Neli S. Slavova-Azmanova, Nicole Kucera, Alison Louw, Jiulia Satiaputra, Peter Singer, Kong-Peng Lam, Margaret L. Hibbs & Evan Ingley. (2017) Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity. Experimental Hematology 46, pages 70-82.e10.
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Dominique Davidson, Ming-Chao Zhong, Pier Paolo Pandolfi, Silvia Bolland, Ramnik J. Xavier, Brian Seed, Xin Li, Hua Gu & André Veillette. (2016) The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors. Cell Reports 17:10, pages 2776-2788.
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Matous Hrdinka, Kritika Sudan, Sissy Just, Ales Drobek, Ondrej Stepanek, Dirk Schlüter, Dirk Reinhold, Bryen A. Jordan, Patricia Gintschel, Burkhart Schraven & Michael R. Kreutz. (2016) Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice. PLOS ONE 11:9, pages e0162863.
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Guillaume Voisinne, Antonio García‐Blesa, Karima Chaoui, Frédéric Fiore, Elise Bergot, Laura Girard, Marie Malissen, Odile Burlet‐Schiltz, Anne Gonzalez de Peredo, Bernard Malissen & Romain Roncagalli. (2016) Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD 5 as a key regulator of TCR ‐induced ubiquitylation . Molecular Systems Biology 12:7.
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Kavita Reginald, Karima Chaoui, Romain Roncagalli, Mathilde Beau, Marisa Goncalves Menoita, Bernard Monsarrat, Odile Burlet-Schiltz, Marie Malissen, Anne Gonzalez de Peredo & Bernard Malissen. (2015) Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells. The Journal of Immunology 195:11, pages 5472-5481.
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