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Jessica A. Neal, Seiji Sugiman-Marangos, Pamela VanderVere-Carozza, Mike Wagner, John Turchi, Susan P. Lees-Miller, Murray S. Junop & Katheryn Meek. (2014) Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation. Molecular and Cellular Biology 34:12, pages 2162-2175.
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Berina Eppink, Przemek M. Krawczyk, Jan Stap & Roland Kanaar. (2012) Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia 28:6, pages 509-517.
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Jessica A. Neal, Van Dang, Pauline Douglas, Marc S. Wold, Susan P. Lees-Miller & Katheryn Meek. (2011) Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation
. Molecular and Cellular Biology 31:8, pages 1719-1733.
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Anthony J. Davis, Sairei So & David J. Chen. (2010) Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle 9:13, pages 2529-2536.
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Ping-Kun Zhou, Yi Sun & Jing An. (2009) Interaction between viral proteins and hosts and its disturbance in the cellular responses to ionising radiation. International Journal of Radiation Biology 85:7, pages 587-597.
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Katheryn Meek, Pauline Douglas, Xiaoping Cui, Qi Ding & Susan P. Lees-Miller. (2007) trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining. Molecular and Cellular Biology 27:10, pages 3881-3890.
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Pauline Douglas, Xiaoping Cui, Wesley D. Block, Yaping Yu, Shikha Gupta, Qi Ding, Ruiqiong Ye, Nick Morrice, Susan P. Lees-Miller & Katheryn Meek. (2007) The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain. Molecular and Cellular Biology 27:5, pages 1581-1591.
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Articles from other publishers (180)
Ren-Yan Li, Dan Yang, Yan-Ji He, Yong Zhou, Cheng-Cheng Li, Lian-Bing Li, Ming-Xing Liao, Zhong-Liang Deng, Le-Tian Zhao, Tian-Feng Zhang, Yong Luo, Ying-Xiong Wang & Yan-Fei Gao. (2023) Heavy metal ions exchange driven protein phosphorylation cascade functions in genomic instability in spermatocytes and male infertility. Nucleic Acids Research 51:7, pages 3150-3165.
Crossref
Crossref
Christopher J. Buehl, Noah J. Goff, Steven W. Hardwick, Martin Gellert, Tom L. Blundell, Wei Yang, Amanda K. Chaplin & Katheryn Meek. (2023) Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. Molecular Cell 83:5, pages 698-714.e4.
Crossref
Crossref
Shikang Liang & Tom L. Blundell. (2023) Human DNA-dependent protein kinase activation mechanism. Nature Structural & Molecular Biology 30:2, pages 140-147.
Crossref
Crossref
Sushmitha Sriramulu, Shivani Thoidingjam, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas & Shyam Nyati. (2023) Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside. Biomedicine & Pharmacotherapy 158, pages 114126.
Crossref
Crossref
Huaping Xiao, Fanghua Li, Emil Mladenov, Aashish Soni, Veronika Mladenova, Bing Pan, Rositsa Dueva, Martin Stuschke, Beate Timmermann & George Iliakis. (2022) Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Cells 11:13, pages 2099.
Crossref
Crossref
Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Linda Jillianne Tsai, Ragini Bhargava & Jeremy M. Stark. (2022) The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened. Nature Communications 13:1.
Crossref
Crossref
Zongpei Guo, Ping-Kun Zhou & Teng Ma. (2022) DNA-PKcs post-translational modifications and associated diseases. Genome Instability & Disease 3:3, pages 136-143.
Crossref
Crossref
Jiang-Dong Sui, Zheng Tang, Benjamin P.C. Chen, Ping Huang, Meng-Qi Yang, Nuo-Han Wang, Hao-Nan Yang, Hong-Lei Tu, Qing-Ming Jiang, Jing Zhang, Ying Wang & Yong-Zhong Wu. (2022) Protein Phosphatase 2A–Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping. Molecular Cancer Research 20:4, pages 583-595.
Crossref
Crossref
Alessia Anastasia, Giulia Dellavedova, Antonio Ramos-Montoya, Neil James, Giovanna Chiorino, Massimo Russo, Hana Baakza, Joanne Wilson, Carmen Ghilardi, Elaine B. Cadogan, Raffaella Giavazzi & Maria Rosa Bani. (2022) The DNA-PK Inhibitor AZD7648 Sensitizes Patient-Derived Ovarian Cancer Xenografts to Pegylated Liposomal Doxorubicin and Olaparib Preventing Abdominal Metastases. Molecular Cancer Therapeutics 21:4, pages 555-567.
Crossref
Crossref
Emanuela Dylgjeri & Karen E. Knudsen. (2022) DNA-PKcs: A Targetable Protumorigenic Protein Kinase. Cancer Research 82:4, pages 523-533.
Crossref
Crossref
Hajnalka Laura Pálinkás, Lőrinc Pongor, Máté Balajti, Ádám Nagy, Kinga Nagy, Angéla Békési, Giampaolo Bianchini, Beáta G. Vértessy & Balázs Győrffy. (2022) Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer. International Journal of Molecular Sciences 23:2, pages 633.
Crossref
Crossref
Lan Liu, Xuemin Chen, Jun Li, Huaibin Wang, Christopher J. Buehl, Noah J. Goff, Katheryn Meek, Wei Yang & Martin Gellert. (2022) Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Molecular Cell 82:1, pages 177-189.e4.
Crossref
Crossref
Michael Hausmann, Georg Hildenbrand & Götz Pilarczyk. 2022. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
3
34
.
Elena K. Zaharieva, Megumi Sasatani & Kenji Kamiya. (2021) Kinetics of DNA Repair Under Chronic Irradiation at Low and Medium Dose Rates in Repair Proficient and Repair Compromised Normal Fibroblasts. Radiation Research 197:4.
Crossref
Crossref
Manni Wang, Siyuan Chen, Yuquan Wei & Xiawei Wei. (2021) DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer. Acta Pharmaceutica Sinica B 11:12, pages 3935-3949.
Crossref
Crossref
Michal Hammel & John A. Tainer. (2021)
X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for
DNA
double‐strand break repair impacting cell and cancer biology
. Protein Science 30:9, pages 1735-1756.
Crossref
Crossref
Shikang Liang, Amanda K. Chaplin, Antonia Kefala Stavridi, Robert Appleby, Ales Hnizda & Tom L. Blundell. (2021) Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM. Progress in Biophysics and Molecular Biology 163, pages 60-73.
Crossref
Crossref
James P. Lees-Miller, Alexander Cobban, Panagiotis Katsonis, Albino Bacolla, Susan E. Tsutakawa, Michal Hammel, Katheryn Meek, Dave W. Anderson, Olivier Lichtarge, John A. Tainer & Susan P. Lees-Miller. (2021) Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Progress in Biophysics and Molecular Biology 163, pages 87-108.
Crossref
Crossref
Michal Hammel, Daniel J. Rosenberg, Jan Bierma, Gregory L. Hura, Roopa Thapar, Susan P. Lees-Miller & John A. Tainer. (2021) Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Progress in Biophysics and Molecular Biology 163, pages 74-86.
Crossref
Crossref
Siyu Chen, James P. Lees-Miller, Yuan He & Susan P. Lees-Miller. (2021) Structural insights into the role of DNA-PK as a master regulator in NHEJ. Genome Instability & Disease 2:4, pages 195-210.
Crossref
Crossref
Aya Kurosawa. (2021) Autophosphorylation and Self-Activation of DNA-Dependent Protein Kinase. Genes 12:7, pages 1091.
Crossref
Crossref
Benjamin M. StinsonJoseph J. Loparo. (2021) Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway. Annual Review of Biochemistry 90:1, pages 137-164.
Crossref
Crossref
Ajay Kumar Sharma, Priyanka Shaw, Aman Kalonia, M.H. Yashavarddhan, Pankaj Chaudhary, Arpana Vibhuti & Sandeep Kumar Shukla. 2021. DNA - Damages and Repair Mechanisms. DNA - Damages and Repair Mechanisms.
Jin-Ho Lee & Michael Hausmann. 2021. DNA - Damages and Repair Mechanisms. DNA - Damages and Repair Mechanisms.
Morgan Hepburn, Daniel J. Saltzberg, Linda Lee, Shujuan Fang, Claire Atkinson, Natalie C.J. Strynadka, Andrej Sali, Susan P. Lees-Miller & David C. Schriemer. (2021) The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex. Structure 29:5, pages 467-478.e6.
Crossref
Crossref
Xuemin Chen, Xiang Xu, Yun Chen, Joyce C. Cheung, Huaibin Wang, Jiansen Jiang, Natalia de Val, Tara Fox, Martin Gellert & Wei Yang. (2021) Structure of an activated DNA-PK and its implications for NHEJ. Molecular Cell 81:4, pages 801-810.e3.
Crossref
Crossref
Amanda K. Chaplin, Steven W. Hardwick, Shikang Liang, Antonia Kefala Stavridi, Ales Hnizda, Lee R. Cooper, Taiana Maia De Oliveira, Dimitri Y. Chirgadze & Tom L. Blundell. (2020) Dimers of DNA-PK create a stage for DNA double-strand break repair. Nature Structural & Molecular Biology 28:1, pages 13-19.
Crossref
Crossref
Patryk Moskwa. 2021. Genome Stability. Genome Stability
349
365
.
Ayse Basak Engin & Atilla Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death
71
100
.
Michaela Medová, Matúš Medo, Lusine Hovhannisyan, Carmen Muñoz-Maldonado, Daniel M. Aebersold & Yitzhak Zimmer. (2020) DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions. Pharmacology & Therapeutics 215, pages 107617.
Crossref
Crossref
Xing Bian, Xiaolin Wang, Qiuyan Zhang, Liying Ma, Guozhen Cao, Ao Xu, Jinhua Han, Jun Huang & Wenchu Lin. (2020) The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer. Frontiers in Oncology 10.
Crossref
Crossref
Jessica A. Neal, Krista Dunger, Kelly Geith & Katheryn Meek. (2020) Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks. DNA Repair 94, pages 102925.
Crossref
Crossref
Xiaobin S. Wang, Brian J. Lee & Shan Zha. (2020) The recent advances in non-homologous end-joining through the lens of lymphocyte development. DNA Repair 94, pages 102874.
Crossref
Crossref
Sébastien Britton, Pauline Chanut, Christine Delteil, Nadia Barboule, Philippe Frit & Patrick Calsou. (2020) ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks. Nucleic Acids Research 48:17, pages 9710-9723.
Crossref
Crossref
Katheryn Meek. (2020) Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. Nucleic Acids Research 48:16, pages 9098-9108.
Crossref
Crossref
Jennifer L. CroweXiaobin S. WangZhengping ShaoBrian J. Lee, Verna M. EstesShan Zha. (2020) DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences 117:37, pages 22953-22961.
Crossref
Crossref
Sung-Eun Noh & Yong-Sung Juhnn. (2020) Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells. Scientific Reports 10:1.
Crossref
Crossref
Bailian Cai, Zhiyi Hu, Huanyin Tang, Zhangsen Hu, Zhiyong Mao, Binya Liu, Xiaojun Xu, Ying Jiang & Xiaoping Wan. (2020) Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells. Biomedicine & Pharmacotherapy 129, pages 110427.
Crossref
Crossref
Antonio Carusillo & Claudio Mussolino. (2020) DNA Damage: From Threat to Treatment. Cells 9:7, pages 1665.
Crossref
Crossref
Rui-Xue Huang & Ping-Kun Zhou. (2020) DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduction and Targeted Therapy 5:1.
Crossref
Crossref
Benjamin M. Stinson, Andrew T. Moreno, Johannes C. Walter & Joseph J. Loparo. (2020) A Mechanism to Minimize Errors during Non-homologous End Joining. Molecular Cell 77:5, pages 1080-1091.e8.
Crossref
Crossref
Régine Janel‐Bintz, Lauriane Kuhn, Philippe Frit, Johana Chicher, Jérôme Wagner, Lajos Haracska, Philippe Hammann & Agnès M Cordonnier. (2020) Proteomic Analysis of DNA Synthesis on a Structured DNA Template in Human Cellular Extracts: Interplay Between NHEJ and Replication‐Associated Proteins. PROTEOMICS 20:3-4, pages 1900184.
Crossref
Crossref
Almudena Serrano-Benítez, Felipe Cortés-Ledesma & Jose F. Ruiz. (2020) “An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process. Frontiers in Molecular Biosciences 6.
Crossref
Crossref
Catherine E. Willoughby, Yanyan Jiang, Huw D. Thomas, Elaine Willmore, Suzanne Kyle, Anita Wittner, Nicole Phillips, Yan Zhao, Susan J. Tudhope, Lisa Prendergast, Gesa Junge, Luiza Madia Lourenco, M. Raymond V. Finlay, Paul Turner, Joanne M. Munck, Roger J. Griffin, Tommy Rennison, James Pickles, Celine Cano, David R. Newell, Helen L. Reeves, Anderson J. Ryan & Stephen R. Wedge. (2019) Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. Journal of Clinical Investigation 130:1, pages 258-271.
Crossref
Crossref
Arishya Sharma, Turkeya Alswillah, Isha Kapoor, Pal Debjani, Belinda Willard, Matthew K Summers, Zihua Gong & Alexandru Almasan. (2019) USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells. Nucleic Acids Research.
Crossref
Crossref
Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies & Elaine B. Cadogan. (2019) AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nature Communications 10:1.
Crossref
Crossref
Payel Chatterjee, Michael T. Schweizer, Jared M. Lucas, Ilsa Coleman, Michael D. Nyquist, Sander B. Frank, Robin Tharakan, Elahe Mostaghel, Jun Luo, Colin C. Pritchard, Hung-Ming Lam, Eva Corey, Emmanuel S. Antonarakis, Samuel R. Denmeade & Peter S. Nelson. (2019) Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage. Journal of Clinical Investigation 129:10, pages 4245-4260.
Crossref
Crossref
Ismail S. Mohiuddin & Min H. Kang. (2019) DNA-PK as an Emerging Therapeutic Target in Cancer. Frontiers in Oncology 9.
Crossref
Crossref
Wenxia Jiang, Verna M. Estes, Xiaobin S. Wang, Zhengping Shao, Brian J. Lee, Xiaohui Lin, Jennifer L. Crowe & Shan Zha. (2019) Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination. The Journal of Immunology 203:1, pages 178-187.
Crossref
Crossref
Vazhappilly Cijo George, Shabbir Ahmed Ansari, Vipin Shankar Chelakkot, Ayshwarya Lakshmi Chelakkot, Chaithanya Chelakkot, Varsha Menon, Wafaa Ramadan, Kannatt Radhakrishnan Ethiraj, Raafat El-Awady, Theodora Mantso, Melina Mitsiogianni, Mihalis I. Panagiotidis, Graham Dellaire & H.P. Vasantha Rupasinghe. (2019) DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. Mutation Research/Reviews in Mutation Research 780, pages 92-105.
Crossref
Crossref
Shuang Liu, Yuan Shao, Qi Wang, Yonggong Zhai & Xialu Li. (2018)
Genotoxic stress causes the accumulation of DNA‐dependent protein kinase catalytic subunit phosphorylated at serine 2056 at nuclear speckles and alters pre‐
mRNA
alternative splicing
. FEBS Open Bio 9:2, pages 304-314.
Crossref
Crossref
Rashmi R. Joshi, Sk Imran Ali & Amanda K. Ashley. (2019) DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer. Journal of Nucleic Acids 2019, pages 1-11.
Crossref
Crossref
Benjamin R. Nixon, Sara C. Sebag, Michael S. Glennon, Eric J. Hall, Emily S. Kounlavong, Michael L. Freeman & Jason R. Becker. (2018) Nuclear localized Raf1 isoform alters DNA‐dependent protein kinase activity and the DNA damage response. The FASEB Journal 33:1, pages 1138-1150.
Crossref
Crossref
Jessica A. Neal & Katheryn Meek. (2019) Deciphering phenotypic variance in different models of DNA-PKcs deficiency. DNA Repair 73, pages 7-16.
Crossref
Crossref
Dmitri Sisario, Simon Memmel, Sören Doose, Julia Neubauer, Heiko Zimmermann, Michael Flentje, Cholpon S. Djuzenova, Markus Sauer & Vladimir L. Sukhorukov. (2018) Nanostructure of DNA repair foci revealed by superresolution microscopy. The FASEB Journal 32:12, pages 6469-6477.
Crossref
Crossref
Amanda W. Rushing, Kimson Hoang, Nicholas Polakowski & Isabelle Lemasson. (2018) The Human T-Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor Attenuates Repair of Double-Stranded DNA Breaks via Nonhomologous End Joining. Journal of Virology 92:15.
Crossref
Crossref
Atif J. Khan, Sarah M. Misenko, Aditya Thandoni, Devora Schiff, Sachin R. Jhawar, Samuel F. Bunting & Bruce G. Haffty. (2018) VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells. Oncotarget 9:40, pages 25833-25841.
Crossref
Crossref
Marek Adamowicz, Fabrizio d’Adda di Fagagna & Jelena Vermezovic. (2018) NOTCH1 modulates activity of DNA-PKcs. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 808, pages 20-27.
Crossref
Crossref
Celine Cano, Suzannah J. Harnor, Elaine Willmore & Stephen R. Wedge. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy
339
357
.
Edward J. Bartlett & Susan P. Lees-Miller. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy
315
338
.
Andris Abramenkovs & Bo Stenerlöw. (2017) Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity. Radiation Research 188:6, pages 677.
Crossref
Crossref
Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan & Alan CM Cheung. (2017) Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution. eLife 6.
Crossref
Crossref
Davide Normanno, Aurélie Négrel, Abinadabe J de Melo, Stéphane Betzi, Katheryn Meek & Mauro Modesti. (2017) Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining. eLife 6.
Crossref
Crossref
Jayme SalsmanGraham Dellaire. (2017) Precision genome editing in the CRISPR era. Biochemistry and Cell Biology 95:2, pages 187-201.
Crossref
Crossref
Guillermo Sastre-Moreno, John M. Pryor, Marta Moreno-Oñate, Andrés M. Herrero-Ruiz, Felipe Cortés-Ledesma, Luis Blanco, Dale A. Ramsden & Jose F. Ruiz. (2017) Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair 51, pages 31-45.
Crossref
Crossref
Lahcen Jaafar, Zhentian Li, Shuyi Li & William S. Dynan. (2017) SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Nucleic Acids Research 45:4, pages 1848-1859.
Crossref
Crossref
Bancinyane L. SibandaDimitri Y. ChirgadzeDavid B. AscherTom L. Blundell. (2017) DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science 355:6324, pages 520-524.
Crossref
Crossref
Hatsumi NagasawaYu-Fen LinTakamitsu A. KatoJohn R. BroganHung-Ying ShihAkihiro Kurimasa, Joel S. BedfordBenjamin P. C. ChenJohn B. Little. (2017) Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells. Radiation Research 187:2, pages 259.
Crossref
Crossref
Chris A. Brosey, Zamal Ahmed, Susan P. Lees-Miller & John A. Tainer. 2017. DNA Repair Enzymes: Structure, Biophysics, and Mechanism. DNA Repair Enzymes: Structure, Biophysics, and Mechanism
417
455
.
Katheryn Meek, Yao Xu, Caleb Bailie, Kefei Yu & Jessica A. Neal. (2016) The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. The Journal of Immunology 197:8, pages 3165-3174.
Crossref
Crossref
Eiichiro Mori, Anthony J. Davis, Masatoshi Hasegawa & David J. Chen. (2016) Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance. Biochemical and Biophysical Research Communications 477:2, pages 235-240.
Crossref
Crossref
Jing Wang, Lina Yin, Junxiang Zhang, Yaping Zhang, Xuxia Zhang, Defang Ding, Yun Gao, Qiang Li & Honghong Chen. (2016) The profiles of gamma-H2AX along with ATM/DNA-PKcs activation in the lymphocytes and granulocytes of rat and human blood exposed to gamma rays. Radiation and Environmental Biophysics 55:3, pages 359-370.
Crossref
Crossref
Viviane Silva, Florian Lafont, Houda Benhelli-Mokrani, Magali Breton, Philippe Hulin, Thomas Chabot, François Paris, Vehary Sakanyan & Fabrice Fleury. (2016) Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. International Journal of Molecular Sciences 17:5, pages 703.
Crossref
Crossref
Anna UrygaKelly GrayMartin Bennett. (2016) DNA Damage and Repair in Vascular Disease. Annual Review of Physiology 78:1, pages 45-66.
Crossref
Crossref
P. Moskwa. 2016. Genome Stability. Genome Stability
321
336
.
Shaliny Ramachandran & Alberto Martin. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology
134
143
.
Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma & Gaëlle Legube. (2015) Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. Cell Reports 13:8, pages 1598-1609.
Crossref
Crossref
Daniela A. Dungl, Elaina N. Maginn & Euan A. Stronach. (2015) Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy. Frontiers in Oncology 5.
Crossref
Crossref
Xue-Song Liu, Gurushankar Chandramouly, Emilie Rass, Yinghua Guan, Guocan Wang, Robin M. Hobbs, Anbazhagan Rajendran, Anyong Xie, Jagesh V. Shah, Anthony J. Davis, Ralph Scully, Andrea Lunardi & Pier Paolo Pandolfi. (2015) LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nature Communications 6:1.
Crossref
Crossref
Hiroki Sato, Misako Yoneda, Reiko Honma, Fusako Ikeda, Shinya Watanabe & Chieko Kai. (2015) Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities. Journal of Virology 89:19, pages 9709-9718.
Crossref
Crossref
Payel Chatterjee, Gaurav S. Choudhary, Turkeyah Alswillah, Xiahui Xiong, Warren D. Heston, Cristina Magi-Galluzzi, Junran Zhang, Eric A. Klein & Alexandru Almasan. (2015) The TMPRSS2–ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition. Molecular Cancer Therapeutics 14:8, pages 1896-1906.
Crossref
Crossref
Islam Shamima Keka, Mohiuddin, Yuko Maede, Md Maminur Rahman, Tetsushi Sakuma, Masamitsu Honma, Takashi Yamamoto, Shunichi Takeda & Hiroyuki Sasanuma. (2015) Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Research 43:13, pages 6359-6372.
Crossref
Crossref
Jinho Heo, Jing Li, Matthew Summerlin, Annette Hays, Sachin Katyal, Peter J. McKinnon, Karin C. Nitiss, John L. Nitiss & Leslyn A. Hanakahi. (2015) TDP1 promotes assembly of non-homologous end joining protein complexes on DNA. DNA Repair 30, pages 28-37.
Crossref
Crossref
IAN M. CARTWRIGHT, JUSTIN J. BELL, JUNKO MAEDA, MATTHEW D. GENET, ASHLEY ROMERO, YOSHIHIRO FUJII, AKIRA FUJIMORI, HISASHI KITAMUTA, TADASHI KAMADA, DAVID J. CHEN & TAKAMITSU A. KATO. (2015) Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity. Oncology Letters 9:4, pages 1621-1627.
Crossref
Crossref
Wenxia Jiang, Jennifer L. Crowe, Xiangyu Liu, Satoshi Nakajima, Yunyue Wang, Chen Li, Brian J. Lee, Richard L. Dubois, Chao Liu, Xiaochun Yu, Li Lan & Shan Zha. (2015) Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Molecular Cell 58:1, pages 172-185.
Crossref
Crossref
Nicholas Jette & Susan P. Lees-Miller. (2015) The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Progress in Biophysics and Molecular Biology 117:2-3, pages 194-205.
Crossref
Crossref
Alexander G. Goglia, Robert Delsite, Antonio N. Luz, David Shahbazian, Ahmed F. Salem, Ranjini K. Sundaram, Jeanne Chiaravalli, Petrus J. Hendrikx, Jennifer A. Wilshire, Maria Jasin, Harriet M. Kluger, J. Fraser Glickman, Simon N. Powell & Ranjit S. Bindra. (2015) Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors. Molecular Cancer Therapeutics 14:2, pages 326-342.
Crossref
Crossref
Ann-Sofie Gustafsson, Andris Abramenkovs & Bo Stenerlöw. (2014) Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 769, pages 1-10.
Crossref
Crossref
Anthony J. Davis, Linfeng Chi, Sairei So, Kyung-Jong Lee, Eiichiro Mori, Kazi Fattah, Jun Yang & David J. Chen. (2014) BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Nucleic Acids Research 42:18, pages 11487-11501.
Crossref
Crossref
Pauline Douglas, Ruiqiong Ye, Laura Trinkle-Mulcahy, Jessica A. NealVeerle De Wever, Nick A. MorriceKatheryn MeekSusan P. Lees-Miller. (2014) Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports 34:3.
Crossref
Crossref
Anthony J. Davis, Benjamin P.C. Chen & David J. Chen. (2014) DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair 17, pages 21-29.
Crossref
Crossref
Shaun Moore, Fintan K.T. Stanley & Aaron A. Goodarzi. (2014) The repair of environmentally relevant DNA double strand breaks caused by high linear energy transfer irradiation – No simple task. DNA Repair 17, pages 64-73.
Crossref
Crossref
Sarvan Kumar Radhakrishnan, Nicholas Jette & Susan P. Lees-Miller. (2014) Non-homologous end joining: Emerging themes and unanswered questions. DNA Repair 17, pages 2-8.
Crossref
Crossref
Catherine J. Pears & Nicholas D. Lakin. (2014) Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining. DNA Repair 17, pages 121-131.
Crossref
Crossref
Yu-Fen Lin, Hatsumi Nagasawa, John B. Little, Takamitsu A. Kato, Hung-Ying Shih, Xian-Jin Xie, Paul F. Wilson Jr.John R. Brogan, Akihiro Kurimasa, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2014) Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles. PLoS ONE 9:4, pages e93579.
Crossref
Crossref
Yi Zhou, Pierre Caron, Gaëlle Legube & Tanya T. Paull. (2014) Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Research 42:3, pages e19-e19.
Crossref
Crossref
Salim Abdisalaam, Anthony J. Davis, David J. Chen & George Alexandrakis. (2014) Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Research 42:1, pages e5-e5.
Crossref
Crossref
Payel Chatterjee, Dragos Plesca, Suparna Mazumder, Jean Boutros, Steven M. Yannone & Alexandru Almasan. (2013) Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment. Nucleic Acids Research 41:22, pages 10157-10169.
Crossref
Crossref
Yi Zhou & Tanya T. Paull. (2013) DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM). Journal of Biological Chemistry 288:52, pages 37112-37125.
Crossref
Crossref
Julien Vignard, Gladys Mirey & Bernard Salles. (2013) Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up. Radiotherapy and Oncology 108:3, pages 362-369.
Crossref
Crossref
Aya Kurosawa, Shinta Saito, Sairei So, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi, Haruka Watabe & Noritaka Adachi. (2013) DNA Ligase IV and Artemis Act Cooperatively to Suppress Homologous Recombination in Human Cells: Implications for DNA Double-Strand Break Repair. PLoS ONE 8:8, pages e72253.
Crossref
Crossref
Reza Taleei & Hooshang Nikjoo. (2013) Biochemical DSB-repair model for mammalian cells in G1 and early S phases of the cell cycle. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 756:1-2, pages 206-212.
Crossref
Crossref
Lisa Woodbine, Jessica A. Neal, Nanda-Kumar Sasi, Mayuko Shimada, Karen Deem, Helen Coleman, William B. Dobyns, Tomoo Ogi, Katheryn Meek, E. Graham Davies & Penny A. Jeggo. (2013) PRKDC mutations in a SCID patient with profound neurological abnormalities. Journal of Clinical Investigation 123:7, pages 2969-2980.
Crossref
Crossref
Reza Taleei & Hooshang Nikjoo. (2013) The Non-homologous End-Joining (NHEJ) Pathway for the Repair of DNA Double-Strand Breaks: I. A Mathematical Model. Radiation Research 179:5, pages 530-539.
Crossref
Crossref
Svitlana Malyarchuk, Reneau Castore, Runhua Shi & Lynn Harrison. (2013) Artemis is required to improve the accuracy of repair of double-strand breaks with 5′-blocked termini generated from non-DSB-clustered lesions. Mutagenesis 28:3, pages 357-366.
Crossref
Crossref
Anthony J. Davis, Kyung-Jong Lee & David J. Chen. (2013) The N-terminal Region of the DNA-dependent Protein Kinase Catalytic Subunit Is Required for Its DNA Double-stranded Break-mediated Activation. Journal of Biological Chemistry 288:10, pages 7037-7046.
Crossref
Crossref
Jessica Cottarel, Philippe Frit, Oriane Bombarde, Bernard Salles, Aurélie Négrel, Stéphanie Bernard, Penny A. Jeggo, Michael R. Lieber, Mauro Modesti & Patrick Calsou. (2013) A noncatalytic function of the ligation complex during nonhomologous end joining. Journal of Cell Biology 200:2, pages 173-186.
Crossref
Crossref
Ying Tu, Chao Ji, Bo Yang, Zhi Yang, Hua Gu, Chun-Cheng Lu, Rong Wang, Zhong-Lan Su, Bin Chen, Wei-Ling Sun, Ji-Ping Xia, Zhi-Gang Bi & Li He. (2013) DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival. Molecular Cancer 12:1, pages 172.
Crossref
Crossref
Fengxiang Wei, Judy Yan, Damu Tang, Xiaozeng Lin, Lizhi He, Yanyun Xie, Lijian Tao & Shaojuan Wang. (2013) Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:1, pages 90-100.
Crossref
Crossref
Aaron A. Goodarzi & Penelope A. Jeggo. 2013.
1
45
.
Bernard Salles, Patrick Calsou & Gladys Mirey. 2013. Advances in DNA Repair in Cancer Therapy. Advances in DNA Repair in Cancer Therapy
25
44
.
E. Aaron Runkle, Hongtao Zhang, Zheng Cai, Zhiqiang Zhu, Barry L. Karger, Shiaw-Lin Wu, Donald M. O'Rourke, Zhaocai Zhou, Qiang Wang & Mark I. Greene. (2012) Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and Molecular Pathology 93:3, pages 324-333.
Crossref
Crossref
Xiaonan Sun, Chunying Yang, Hai Liu, Qi Wang, Shi-Xiu Wu, Xia Li, Tian Xie, Kathryn L. Brinkman, Bin S. Teh, E. Brian Butler, Bo Xu & Shu Zheng. (2012) Identification and Characterization of a Small Inhibitory Peptide That Can Target DNA-PKcs Autophosphorylation and Increase Tumor Radiosensitivity. International Journal of Radiation Oncology*Biology*Physics 84:5, pages 1212-1219.
Crossref
Crossref
Prashanthi Javvadi, Haruhiko Makino, Amit K. Das, Yu-Fen Lin, David J. Chen, Benjamin P. Chen & Chaitanya S. Nirodi. (2012) Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance. Molecular Cancer Research 10:10, pages 1359-1368.
Crossref
Crossref
Larry H. Thompson. (2012) Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography. Mutation Research/Reviews in Mutation Research 751:2, pages 158-246.
Crossref
Crossref
M. Martín, M. Terradas, L. Tusell & A. Genescà. (2012) ATM and DNA-PKcs make a complementary couple in DNA double strand break repair. Mutation Research/Reviews in Mutation Research 751:1, pages 29-35.
Crossref
Crossref
Hairong Xiong, Robert J. Lee, Eric B. Haura, John G. Edwards, William S. Dynan & Shuyi Li. (2012) Intranuclear Delivery of a Novel Antibody-Derived Radiosensitizer Targeting the DNA-Dependent Protein Kinase Catalytic Subunit. International Journal of Radiation Oncology*Biology*Physics 83:3, pages 1023-1030.
Crossref
Crossref
K. Meek, S. P. Lees-Miller & M. Modesti. (2011) N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research 40:7, pages 2964-2973.
Crossref
Crossref
Amol S. Hosing, Nicholas C.K. Valerie, Jaroslaw Dziegielewski, David L. Brautigan & James M. Larner. (2012) PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase. Journal of Biological Chemistry 287:12, pages 9230-9239.
Crossref
Crossref
Sara N. Andres, Alexandra Vergnes, Dejan Ristic, Claire Wyman, Mauro Modesti & Murray Junop. (2012) A human XRCC4–XLF complex bridges DNA. Nucleic Acids Research 40:4, pages 1868-1878.
Crossref
Crossref
S. Roy, S. N. Andres, A. Vergnes, J. A. Neal, Y. Xu, Y. Yu, S. P. Lees-Miller, M. Junop, M. Modesti & K. Meek. (2012) XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research 40:4, pages 1684-1694.
Crossref
Crossref
Qiao Cheng, Nadia Barboule, Philippe Frit, Dennis Gomez, Oriane Bombarde, Bettina Couderc, Guo-Sheng Ren, Bernard Salles & Patrick Calsou. (2011) Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Research 39:22, pages 9605-9619.
Crossref
Crossref
Euan A. Stronach, Michelle Chen, Elaina N. Maginn, Roshan Agarwal, Gordon B. Mills, Harpreet Wasan & Hani Gabra. (2011) DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance. Neoplasia 13:11, pages 1069-IN35.
Crossref
Crossref
Penny A. Jeggo, Verena Geuting & Markus Löbrich. (2011) The role of homologous recombination in radiation-induced double-strand break repair. Radiotherapy and Oncology 101:1, pages 7-12.
Crossref
Crossref
Gina M. Kavanaugh, Trisha M. Wise-Draper, Richard J. Morreale, Monique A. Morrison, Boris Gole, Sandy Schwemberger, Elisia D. Tichy, Lu Lu, George F. Babcock, James M. Wells, Rachid Drissi, John J. Bissler, Peter J. Stambrook, Paul R. Andreassen, Lisa Wiesmüller & Susanne I. Wells. (2011) The human DEK oncogene regulates DNA damage response signaling and repair. Nucleic Acids Research 39:17, pages 7465-7476.
Crossref
Crossref
Edward A. Nam, Runxiang Zhao, Gloria G. Glick, Carol E. Bansbach, David B. Friedman & David Cortez. (2011) Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase. Journal of Biological Chemistry 286:33, pages 28707-28714.
Crossref
Crossref
Yongfeng Li & Francis A. Cucinotta. (2011) Modeling non-homologous end joining. Journal of Theoretical Biology 283:1, pages 122-135.
Crossref
Crossref
Xianming Kong, Ying Shen, Na Jiang, Xin Fei & Jun Mi. (2011) Emerging roles of DNA-PK besides DNA repair. Cellular Signalling 23:8, pages 1273-1280.
Crossref
Crossref
Edward P. Morris, Angel Rivera-Calzada, Paula C. A. da Fonseca, Oscar Llorca, Laurence H. Pearl & Laura Spagnolo. (2011) Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Research 39:13, pages 5757-5767.
Crossref
Crossref
Katherine S PawelczakSara M BennettJohn J Turchi. (2011) Coordination of DNA–PK Activation and Nuclease Processing of DNA Termini in NHEJ. Antioxidants & Redox Signaling 14:12, pages 2531-2543.
Crossref
Crossref
Jessica A. Neal & Katheryn Meek. (2011) Choosing the right path: Does DNA-PK help make the decision?. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 73-86.
Crossref
Crossref
Emil Mladenov & George Iliakis. (2011) Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 711:1-2, pages 61-72.
Crossref
Crossref
K. C. Summers, F. Shen, E. A. Sierra Potchanant, E. A. Phipps, R. J. Hickey & L. H. Malkas. (2011) Phosphorylation: The Molecular Switch of Double-Strand Break Repair. International Journal of Proteomics 2011, pages 1-8.
Crossref
Crossref
Atsushi Shibata, Sandro Conrad, Julie Birraux, Verena Geuting, Olivia Barton, Amani Ismail, Andreas Kakarougkas, Katheryn Meek, Gisela Taucher-Scholz, Markus Löbrich & Penny A Jeggo. (2011) Factors determining DNA double-strand break repair pathway choice in G2 phase. The EMBO Journal 30:6, pages 1079-1092.
Crossref
Crossref
Eric J. Gapud, Yair Dorsett, Bu Yin, Elsa CallenAndrea Bredemeyer, Grace K. Mahowald, Kazuo Q. Omi, Laura M. Walker, Jeffrey J. BednarskiPeter J. McKinnon, Craig H. Bassing, Andre NussenzweigBarry P. Sleckman. (2011) Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences 108:5, pages 2022-2027.
Crossref
Crossref
Hatsumi Nagasawa, John B. Little, Yu-Fen Lin, Sairei So, Akihiro Kurimasa, Yuanlin Peng, John R. Brogan, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2011) Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability. Radiation Research 175:1, pages 83-89.
Crossref
Crossref
Li Du, Li-Jun Zhou, Xiu-Jie Pan, Yu-Xiao Wang, Qin-Zhi Xu, Zhi-Hua Yang, Yu Wang, Xiao-Dan Liu, Mao-Xiang Zhu & Ping-Kun Zhou. (2010) Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo. Radiation Oncology 5:1.
Crossref
Crossref
Tracey A. Dobbs, John A. Tainer & Susan P. Lees-Miller. (2010) A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair 9:12, pages 1307-1314.
Crossref
Crossref
Liu Ting, Huang Jun & Chen Junjie. (2010) RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair 9:12, pages 1241-1248.
Crossref
Crossref
Marcelo de Campos-Nebel, Irene Larripa & Marcela González-Cid. (2010) Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous Recombination. PLoS ONE 5:9, pages e12541.
Crossref
Crossref
Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann & Thomas A. Winters. (2010)
Coincident
In Vitro
Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining
. Journal of Nucleic Acids 2010, pages 1-11.
Crossref
Crossref
Takashi Ochi, Bancinyane Lynn Sibanda, Qian Wu, Dimitri Y. Chirgadze, Victor M. Bolanos-Garcia & Tom L. Blundell. (2010) Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining. Journal of Nucleic Acids 2010, pages 1-19.
Crossref
Crossref
Michal Hammel, Yaping Yu, Brandi L. Mahaney, Brandon Cai, Ruiqiong Ye, Barry M. Phipps, Robert P. Rambo, Greg L. Hura, Martin Pelikan, Sairei So, Ramin M. Abolfath, David J. Chen, Susan P. Lees-Miller & John A. Tainer. (2010) Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex. Journal of Biological Chemistry 285:2, pages 1414-1423.
Crossref
Crossref
Xiaoping Cui & Michael R. Lieber. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling
2165
2170
.
Mirjam van der Burg, Jacques JM van Dongen & Dik C van Gent. (2009) DNA-PKcs deficiency in human: long predicted, finally found. Current Opinion in Allergy & Clinical Immunology 9:6, pages 503-509.
Crossref
Crossref
Penny A. Jeggo. (2009) RISKS FROM LOW DOSE/DOSE RATE RADIATION: WHAT AN UNDERSTANDING OF DNA DAMAGE RESPONSE MECHANISMS CAN TELL US. Health Physics 97:5, pages 416-425.
Crossref
Crossref
Qinhong Wang, Fengqin Gao, Ton Wang, Tammy Flagg & Xingming Deng. (2009) A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair. Neoplasia 11:10, pages 1012-IN10.
Crossref
Crossref
Dong Yu, Emiko Sekine-Suzuki, Lian Xue, Akira Fujimori, Nobuo Kubota & Ryuichi Okayasu. (2009) Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells. International Journal of Cancer 125:5, pages 1205-1211.
Crossref
Crossref
Katheryn Meek, Ari Jutkowitz, Lisa Allen, Jillian Glover, Erin Convery, Alisha Massa, Tom Mullaney, Bryden Stanley, Diana Rosenstein, Susan M. Bailey, Cheri Johnson & George Georges. (2009) SCID Dogs: Similar Transplant Potential but Distinct Intra-Uterine Growth Defects and Premature Replicative Senescence Compared with SCID Mice. The Journal of Immunology 183:4, pages 2529-2536.
Crossref
Crossref
Angela Y.J. Li, Lee Ming Boo, Shih-Ya Wang, H. Helen Lin, Clay C.C. Wang, Yun Yen, Benjamin P.C. Chen, David J. Chen & David K. Ann. (2009) Suppression of Nonhomologous End Joining Repair by Overexpression of HMGA2. Cancer Research 69:14, pages 5699-5706.
Crossref
Crossref
Kerry A. George, Megumi Hada, Lori J. Jackson, Todd Elliott, Tetsuya Kawata, Janice M. Pluth & Francis A. Cucinotta. (2009) Dose Response of γ Rays and Iron Nuclei for Induction of Chromosomal Aberrations in Normal and Repair-Deficient Cell Lines. Radiation Research 171:6, pages 752-763.
Crossref
Crossref
Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tanja Hardt, Evelin Schrock, Susan P. Lees-Miller, Katheryn Meek, Robert L. Ullrich & Susan M. Bailey. (2009) Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence. Cancer Research 69:5, pages 2100-2107.
Crossref
Crossref
Jun Mi, Jaroslaw Dziegielewski, Elzbieta Bolesta, David L. Brautigan & James M. Larner. (2009) Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6. PLoS ONE 4:2, pages e4395.
Crossref
Crossref
Brandi L. Mahaney, Katheryn MeekSusan P. Lees-Miller. (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochemical Journal 417:3, pages 639-650.
Crossref
Crossref
N. A. Koltovaya. (2009) Activation of repair and checkpoints by double-strand DNA breaks: Activational cascade of protein phosphorylation. Russian Journal of Genetics 45:1, pages 1-15.
Crossref
Crossref
Mirjam van der Burg, Hanna IJspeert, Nicole S. Verkaik, Tuba Turul, Wouter W. Wiegant, Keiko Morotomi-Yano, Pierre-Olivier Mari, Ilhan Tezcan, David J. Chen, Malgorzata Z. Zdzienicka, Jacques J.M. van Dongen & Dik C. van Gent. (2008) A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining. Journal of Clinical Investigation.
Crossref
Crossref
Sarah S. Durkin, Xin Guo, Kimberly A. Fryrear, Valia T. Mihaylova, Saurabh K. Gupta, S. Mehdi Belgnaoui, Abdelali Haoudi, Gary M. Kupfer & O. John Semmes. (2008) HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase. Journal of Biological Chemistry 283:52, pages 36311-36320.
Crossref
Crossref
E. N. Andreyeva, T. D. Kolesnikova, E. S. Belyaeva, R. L. Glaser & I. F. Zhimulev. (2008) Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes. Chromosome Research 16:6, pages 851-862.
Crossref
Crossref
W. Y. Mansour, S. Schumacher, R. Rosskopf, T. Rhein, F. Schmidt-Petersen, F. Gatzemeier, F. Haag, K. Borgmann, H. Willers & J. Dahm-Daphi. (2008) Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks. Nucleic Acids Research 36:12, pages 4088-4098.
Crossref
Crossref
Dong Yu, Emiko Sekine, Akira Fujimori, Takahiro Ochiya & Ryuichi Okayasu. (2008) Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo. Cancer Science 99:4, pages 810-815.
Crossref
Crossref
Dewight R. Williams, Kyung-Jong Lee, Jian Shi, David J. Chen & Phoebe L. Stewart. (2008) Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding. Structure 16:3, pages 468-477.
Crossref
Crossref
Francis A. Cucinotta, Janice M. Pluth, Jennifer A. Anderson, Jane V. Harper & Peter O'Neill. (2008) Biochemical Kinetics Model of DSB Repair and Induction of γ-H2AX Foci by Non-homologous End Joining. Radiation Research 169:2, pages 214-222.
Crossref
Crossref
Alexander E. Ochem, Hocine Rechreche, Doris Skopac & Arturo Falaschi. (2008) Stimulation of the DNA unwinding activity of human DNA helicase II/Ku by phosphorylation. Archives of Biochemistry and Biophysics 470:1, pages 1-7.
Crossref
Crossref
Susan M. Bailey. (2008) Telomeres and Double-Strand Breaks – All's Well that “Ends” Well. …. Radiation Research 169:1, pages 1-7.
Crossref
Crossref
Eric Weterings & David J Chen. (2008) The endless tale of non-homologous end-joining. Cell Research 18:1, pages 114-124.
Crossref
Crossref
Meena Shrivastav, Leyma P De Haro & Jac A Nickoloff. (2007) Regulation of DNA double-strand break repair pathway choice. Cell Research 18:1, pages 134-147.
Crossref
Crossref
Katheryn Meek, Van Dang & Susan P. Lees-Miller. 2008.
33
58
.
D C van Gent & M van der Burg. (2007) Non-homologous end-joining, a sticky affair. Oncogene 26:56, pages 7731-7740.
Crossref
Crossref
Xiaoping Cui & Katheryn Meek. (2007) Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proceedings of the National Academy of Sciences 104:43, pages 17046-17051.
Crossref
Crossref
Eric Weterings & David J. Chen. (2007) DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?. Journal of Cell Biology 179:2, pages 183-186.
Crossref
Crossref
Lawrence F. Povirk, Rui-Zhe Zhou, Dale A. Ramsden, Susan P. Lees-Miller & Kristoffer Valerie. (2007) Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research 35:12, pages 3869-3878.
Crossref
Crossref
Silvia Costantini, Lisa Woodbine, Lucia Andreoli, Penny A. Jeggo & Alessandro Vindigni. (2007) Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair 6:6, pages 712-722.
Crossref
Crossref
Ugo Déry & Jean-Yves Masson. (2007) Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications. DNA Repair 6:5, pages 561-577.
Crossref
Crossref
Naoya Uematsu, Eric Weterings, Ken-ichi Yano, Keiko Morotomi-Yano, Burkhard Jakob, Gisela Taucher-Scholz, Pierre-Olivier Mari, Dik C. van Gent, Benjamin P.C. Chen & David J. Chen. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. The Journal of Cell Biology 177:2, pages 219-229.
Crossref
Crossref
Doris Niewolik, Ulrich Pannicke, Haihui Lu, Yunmei Ma, Ling-Chi Vicky Wang, Peter Kulesza, Ebrahim Zandi, Michael R. Lieber & Klaus Schwarz. (2006) DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5′ or 3′ Overhangs. Journal of Biological Chemistry 281:45, pages 33900-33909.
Crossref
Crossref
Jérôme Drouet, Philippe Frit, Christine Delteil, Jean-Pierre de Villartay, Bernard Salles & Patrick Calsou. (2006) Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA Ends. Journal of Biological Chemistry 281:38, pages 27784-27793.
Crossref
Crossref
Penny A. Jeggo & Markus Löbrich. (2006) Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair 5:9-10, pages 1192-1198.
Crossref
Crossref
Aaron A Goodarzi, Yaping Yu, Enriqueta Riballo, Pauline Douglas, Sarah A Walker, Ruiqiong Ye, Christine Härer, Caterina Marchetti, Nick Morrice, Penny A Jeggo & Susan P Lees-Miller. (2006) DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The EMBO Journal 25:16, pages 3880-3889.
Crossref
Crossref
Maria Pia Longhese, Davide Mantiero & Michela Clerici. (2006) The cellular response to chromosome breakage. Molecular Microbiology 60:5, pages 1099-1108.
Crossref
Crossref
Christopher J. Buehl, Noah J. Goff, Steven W. Hardwick, Martin Gellert, Tom L. Blundell, Wei Yang, Amanda K. Chaplin & Katheryn Meek. (2022) Evidence for Separate Functions for Two Distinct Non-Homologous End Joining Long-Range Synaptic Complexes. SSRN Electronic Journal.
Crossref
Crossref