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Molecular and Cellular Biology Volume 25, 2005 - Issue 9
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Signal Transduction

Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk

Paul Van Slyke1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, CanadaM4N 3M5;2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
,
Mariano Loza Coll1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, CanadaM4N 3M5;2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
,
Zubin Master1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, CanadaM4N 3M5;2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
,
Harold Kim2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
,
Jorge Filmus1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, CanadaM4N 3M5;2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;3 Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
&
Daniel J. Dumont1 Division of Molecular and Cellular Biology Research, Sunnybrook and Women's Research Institute, Toronto, Ontario, CanadaM4N 3M5;2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;3 Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada;4 Heart & Stroke/Richard Lewar Centre of Excellence, Faculty of Medicine, University of Toronto, Ontario, CanadaCorrespondence[email protected]
Pages 3831-3841 | Received 24 Jun 2004, Accepted 23 Dec 2004, Published online: 27 Mar 2023

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Justyna A. Janas & Linda Van Aelst. (2011) Oncogenic Tyrosine Kinases Target Dok-1 for Ubiquitin-Mediated Proteasomal Degradation To Promote Cell Transformation. Molecular and Cellular Biology 31:13, pages 2552-2565.
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Mingming Zhao, Justyna A. Janas, Masaru Niki, Pier Paolo Pandolfi & Linda Van Aelst. (2006) Dok-1 Independently Attenuates Ras/Mitogen-Activated Protein Kinase and Src/c-Myc Pathways To Inhibit Platelet-Derived Growth Factor-Induced Mitogenesis. Molecular and Cellular Biology 26:7, pages 2479-2489.
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Articles from other publishers (28)

P SUN, R LI, Y MENG, S XI, Q WANG, X YANG, X PENG & J CAI. (2021) Introduction to DOK2 and its Potential Role in Cancer. Physiological Research, pages 671-685.
Crossref
Gaëtan Blaize, Hélène Daniels-Treffandier, Meryem Aloulou, Nelly Rouquié, Cui YangMarlène MarcellinMylène GadorMehdi BenamarMariette Ducatez, Ki-duk Song, Odile Burlet-SchiltzAbdelhadi Saoudi, Paul E. Love, Nicolas Fazilleau, Anne Gonzalez de Peredo & Renaud Lesourne. (2020) CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens. Proceedings of the National Academy of Sciences 117:23, pages 12969-12979.
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Soumia Lahmidi, Ulrike Strunk, James R. Smiley, Angela Pearson & Pascale Duplay. (2017) Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2. Virology 511, pages 66-73.
Crossref
Lusik Cherkezyan, Di Zhang, Hariharan Subramanian, Allen Taflove & Vadim Backman. (2016) Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy. Journal of Biomedical Optics 21:2, pages 025007.
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Malgorzata Kluba, Yves Engelborghs, Johan Hofkens & Hideaki Mizuno. (2015) Inhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR Signaling. PLOS ONE 10:10, pages e0139971.
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J. J. Bromfield, J. E. P Santos, J. Block, R. S. Williams & I. M. Sheldon. (2015) PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow1,2. Journal of Animal Science 93:5, pages 2021-2033.
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Tamara Ghanem. (2014) mRNA expression of DOK1-6 in human breast cancer. World Journal of Clinical Oncology 5:2, pages 156.
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Alice H. Berger, Ming Chen, Alessandro Morotti, Justyna A. Janas, Masaru Niki, Roderick T. Bronson, Barry S. Taylor, Marc Ladanyi, Linda Van Aelst, Katerina Politi, Harold E. Varmus & Pier Paolo Pandolfi. (2013) DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma. PLoS ONE 8:11, pages e79526.
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Eric J. Downer, Daniel G.W. Johnston & Marina A. Lynch. (2013) Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia. Molecular and Cellular Neuroscience 56, pages 148-158.
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Hiromichi Miyagaki, Makoto Yamasaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Hiroshi Miyata, Kiyokazu Nakajima, Shuji Takiguchi, Yoshiyuki Fujiwara, Masaki Mori & Yuichiro Doki. (2011) DOK2 as a Marker of Poor Prognosis of Patients with Gastric Adenocarcinoma After Curative Resection. Annals of Surgical Oncology 19:5, pages 1560-1567.
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Liudmilla RubbiBjörn TitzLauren BrownErica GalvanEvangelia KomisopoulouSharon S. ChenTracey LowMartik TahmasianBrian SkaggsMarkus MüschenMatteo PellegriniThomas G. Graeber. (2011) Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling. Science Signaling 4:166.
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Jianping Zhao, Yongjun Zhang, Sujay Subbayya Ithychanda, Yizeng Tu, Ka Chen, Jun Qin & Chuanyue Wu. (2009) Migfilin Interacts with Src and Contributes to Cell-Matrix Adhesion-mediated Survival Signaling. Journal of Biological Chemistry 284:49, pages 34308-34320.
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Alexander Annenkov. (2009) The Insulin-Like Growth Factor (IGF) Receptor Type 1 (IGF1R) as an Essential Component of the Signalling Network Regulating Neurogenesis. Molecular Neurobiology 40:3, pages 195-215.
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Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka & Yuji Yamanashi. (2009) The roles of Dok family adapters in immunoreceptor signaling. Immunological Reviews 232:1, pages 273-285.
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Guang Yang, Qingrun Li, Siyuan Ren, Xuefeng Lu, Longhou Fang, Wenchao Zhou, Fan Zhang, Feilai Xu, Zhe Zhang, Rong Zeng, Friedrich Lottspeich & Zhengjun Chen. (2009) Proteomic, functional and motif-based analysis of C-terminal Src kinase-interacting proteins. PROTEOMICS 9:21, pages 4944-4961.
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Hariharan Subramanian, Prabhakar Pradhan, Yang Liu, Ilker R. Capoglu, Xu Li, Jeremy D. Rogers, Alexander Heifetz, Dhananjay Kunte, Hemant K. Roy, Allen Taflove & Vadim Backman. (2008) Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells. Proceedings of the National Academy of Sciences 105:51, pages 20118-20123.
Crossref
Paul Van Slyke & Dan Dumont. (2008) Dok2. AfCS-Nature Molecule Pages.
Crossref
Oreste Acuto, Vincenzo Di Bartolo & Frédérique Michel. (2008) Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nature Reviews Immunology 8:9, pages 699-712.
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Keum-Jin Yang, Sanghee Shin, Longzhen Piao, Eulsoon Shin, Yuwen Li, Kyeong Ah Park, Hee Sun Byun, Minho Won, Janghee Hong, Gi Ryang Kweon, Gang Min Hur, Jeong Ho Seok, Taehoon Chun, Derek P. Brazil, Brian A. Hemmings & Jongsun Park. (2008) Regulation of 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) by Src Involves Tyrosine Phosphorylation of PDK1 and Src Homology 2 Domain Binding. Journal of Biological Chemistry 283:3, pages 1480-1491.
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Natasha R. Locke, Natasha K. Crellin & Megan K. Levings. 2008. Regulatory T Cells and Clinical Application. Regulatory T Cells and Clinical Application 135 152 .
Emanuela Matteucci, Elisa Ridolfi, Paola Maroni, Paola Bendinelli & Maria Alfonsina Desiderio. (2007) c-Src/Histone Deacetylase 3 Interaction Is Crucial for Hepatocyte Growth Factor–Dependent Decrease of CXCR4 Expression in Highly Invasive Breast Tumor Cells. Molecular Cancer Research 5:8, pages 833-845.
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Azadeh Jila, Harold Kim, Vicky P.K.H Nguyen, Daniel J. Dumont, John Semple, Dianna Armstrong, Eva Seto & Miles Johnston. (2007) Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep. Microvascular Research 73:3, pages 214-223.
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Lei Shi, Jiping Yue, Yuangang You, Bin Yin, Yanhua Gong, Caimin Xu, Boqin Qiang, Jiangang Yuan, Yongjian Liu & Xiaozhong Peng. (2006) Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Cellular Signalling 18:11, pages 1995-2003.
Crossref
Shen Dong, Béatrice Corre, Eliane Foulon, Evelyne Dufour, André Veillette, Oreste Acuto & Frédérique Michel. (2006) T cell receptor for antigen induces linker for activation of T cell–dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. Journal of Experimental Medicine 203:11, pages 2509-2518.
Crossref
L Q Jiang, X Feng, W Zhou, P G Knyazev, A Ullrich & Z Chen. (2006) Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation. Oncogene 25:40, pages 5495-5506.
Crossref
Ágnes Csiszár. (2006) Structural and functional diversity of adaptor proteins involved in tyrosine kinase signalling. BioEssays 28:5, pages 465-479.
Crossref
Miyuki Honma, Osamu Higuchi, Masaki Shirakata, Tomoharu Yasuda, Hiroshi Shibuya, Shun-ichiro Iemura, Tohru Natsume & Yuji Yamanashi. (2006) Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes to Cells 11:2, pages 143-151.
Crossref
Atsuko Kasai, Takaki Shima & Masato Okada. (2005) Role of Src family tyrosine kinases in the down-regulation of epidermal growth factor signaling in PC12 cells. Genes to Cells 10:12, pages 1175-1187.
Crossref

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