6
Views
30
CrossRef citations to date
0
Altmetric
Signal Transduction

Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk

, , , , &
Pages 3831-3841 | Received 24 Jun 2004, Accepted 23 Dec 2004, Published online: 27 Mar 2023

REFERENCES

  • Belsches, A. P., M. D. Haskell, and S. J. Parsons. 1997. Role of c-Src tyrosine kinase in EGF-induced mitogenesis. Front. Biosci. 2:d501–d518.
  • Belsches-Jablonski, A. P., J. S. Biscardi, D. R. Peavy, D. A. Tice, D. A. Romney, and S. J. Parsons. 2001. Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene 20:1465–1475.
  • Biscardi, J. S., R. C. Ishizawar, C. M. Silva, and S. J. Parsons. 2000. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res. 2:203–210.
  • Carpino, N., D. Wisniewski, A. Strife, D. Marshak, R. Kobayashi, B. Stillman, and B. Clarkson. 1997. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 88:197–204.
  • Coll, M. L., K. Rosen, V. Ladeda, and J. Filmus. 2002. Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells. Oncogene 21:2908–2913.
  • Cong, F., B. Yuan, and S. P. Goff. 1999. Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Mol. Cell. Biol. 19:8314–8325.
  • Cooper, J. A., and T. Hunter. 1983. Identification and characterization of cellular targets for tyrosine protein kinases. J. Biol. Chem. 258:1108–1115.
  • Cooper, J. A., and C. S. King. 1986. Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60 c-src. Mol. Cell. Biol. 6:4467–4477.
  • den Hertog, J., C. E. Pals, M. P. Peppelenbosch, L. G. Tertoolen, S. W. de Laat, and W. Kruijer. 1993. Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. EMBO J. 12:3789–3798.
  • Di Cristofano, A., N. Carpino, N. Dunant, G. Friedland, R. Kobayashi, A. Strife, D. Wisniewski, B. Clarkson, P. P. Pandolfi, and M. D. Resh. 1998. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. J. Biol. Chem. 273:4827–4830.
  • Di Cristofano, A., M. Niki, M. Zhao, F. G. Karnell, B. Clarkson, W. S. Pear, L. Van Aelst, and P. P. Pandolfi. 2001. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J. Exp. Med. 194:275–284.
  • Fang, K. S., H. Sabe, H. Saito, and H. Hanafusa. 1994. Comparative study of three protein-tyrosine phosphatases. Chicken protein-tyrosine phosphatase lambda dephosphorylates c-Src tyrosine 527. J. Biol. Chem. 269:20194–20200.
  • Fiorini, M., M. Alimandi, L. Fiorentino, G. Sala, and O. Segatto. 2001. Negative regulation of receptor tyrosine kinase signals. FEBS Lett. 490:132–141.
  • Grimm, J., M. Sachs, S. Britsch, S. Di Cesare, T. Schwarz-Romond, K. Alitalo, and W. Birchmeier. 2001. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J. Cell Biol. 154:345–354.
  • Gugasyan, R., C. Quilici, T. T. I. Stacey, D. Grail, A. M. Verhagen, A. Roberts, T. Kitamura, A. R. Dunn, and P. Lock. 2002. Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. J. Cell Biol. 158:115–125.
  • Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271:695–701.
  • Hlavacek, W. S., J. R. Faeder, M. L. Blinov, A. S. Perelson, and B. Goldstein. 2003. The complexity of complexes in signal transduction. Biotechnol. Bioeng. 84:783–794.
  • James, S. R., C. P. Downes, R. Gigg, S. J. Grove, A. B. Holmes, and D. R. Alessi. 1996. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem. J. 315:709–713.
  • Jones, N., and D. J. Dumont. 1998. The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene 17:1097–1108.
  • Jones, N., and D. J. Dumont. 1999. Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of erk MAP kinase activation. Curr. Biol. 9:1057–1060.
  • Kashige, N., N. Carpino, and R. Kobayashi. 2000. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Proc. Natl. Acad. Sci. USA 97:2093–2098. (Erratum, 97:6236.)
  • Kassenbrock, C. K., S. Hunter, P. Garl, G. L. Johnson, and S. M. Anderson. 2002. Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J. Biol. Chem. 277:24967–24975.
  • Kong, M., C. Mounier, V. Dumas, and B. I. Posner. 2003. Epidermal growth factor-induced DNA synthesis. Key role for Src phosphorylation of the docking protein Gab2. J. Biol. Chem. 278:5837–5844.
  • Latour, S., G. Gish, C. D. Helgason, R. K. Humphries, T. Pawson, and A. Veillette. 2001. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat. Immunol. 2:681–690.
  • Lemay, S., D. Davidson, S. Latour, and A. Veillette. 2000. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol. Cell. Biol. 20:2743–2754.
  • Lindquist, J. A., L. Simeoni, and B. Schraven. 2003. Transmembrane adapters: attractants for cytoplasmic effectors. Immunol. Rev. 191:165–182.
  • Lock, P., F. Casagranda, and A. R. Dunn. 1999. Independent SH2-binding sites mediate interaction of dok-related protein with RasGTPase-activating protein and Nck. J. Biol. Chem. 274:22775–22784.
  • Maa, M. C., T. H. Leu, D. J. McCarley, R. C. Schatzman, and S. J. Parsons. 1995. Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers. Proc. Natl. Acad. Sci. USA 92:6981–6985.
  • Master, Z., J. Tran, A. Bishnoi, S. H. Chen, J. M. Ebos, P. Van Slyke, R. S. Kerbel, and D. J. Dumont. 2003. Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization. J. Biol. Chem. 278:30170–30179.
  • Mustelin, T., and K. Tasken. 2003. Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem. J. 371:15–27.
  • Nelms, K., A. L. Snow, J. Hu-Li, and W. E. Paul. 1998. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity 9:13–24.
  • Okada, M., S. Nada, Y. Yamanashi, T. Yamamoto, and H. Nakagawa. 1991. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem. 266:24249–24252.
  • Ott, V. L., I. Tamir, M. Niki, P. P. Pandolfi, and J. C. Cambier. 2002. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. J. Immunol. 168:4430–4439.
  • Pawson, T., and J. D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278:2075–2080.
  • Peng, Z. Y., and C. A. Cartwright. 1995. Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. Oncogene 11:1955–1962.
  • Poppleton, H. M., G. J. Wiepz, P. J. Bertics, and T. B. Patel. 1999. Modulation of the protein tyrosine kinase activity and autophosphorylation of the epidermal growth factor receptor by its juxtamembrane region. Arch. Biochem. Biophys. 363:227–236.
  • Sato, K., A. Sato, M. Aoto, and Y. Fukami. 1995. c-Src phosphorylates epidermal growth factor receptor on tyrosine 845. Biochem. Biophys. Res. Commun. 215:1078–1087.
  • Shah, K., and K. M. Shokat. 2002. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem. Biol. 9:35–47.
  • Shen, Z., A. Batzer, J. A. Koehler, P. Polakis, J. Schlessinger, N. B. Lydon, and M. F. Moran. 1999. Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src. Oncogene 18:4647–4653.
  • Songyang, Z., Y. Yamanashi, D. Liu, and D. Baltimore. 2001. Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. J. Biol. Chem. 276:2459–2465.
  • Stover, D. R., M. Becker, J. Liebetanz, and N. B. Lydon. 1995. Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. J. Biol. Chem. 270:15591–15597.
  • Takeuchi, S., Y. Takayama, A. Ogawa, K. Tamura, and M. Okada. 2000. Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk. J. Biol. Chem. 275:29183–29186.
  • Thomas, S. M., and J. S. Brugge. 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13:513–609.
  • Tice, D. A., J. S. Biscardi, A. L. Nickles, and S. J. Parsons. 1999. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc. Natl. Acad. Sci. USA 96:1415–1420.
  • Wang, S. C., K. Makino, W. Xia, J. S. Kim, S. A. Im, H. Peng, S. C. Mok, S. E. Singletary, and M. C. Hung. 2001. DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway. Oncogene 20:6960–6964.
  • Windham, T. C., N. U. Parikh, D. R. Siwak, J. M. Summy, D. J. McConkey, A. J. Kraker, and G. E. Gallick. 2002. Src activation regulates anoikis in human colon tumor cell lines. Oncogene 21:7797–7807.
  • Yamanashi, Y., and D. Baltimore. 1997. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Cell 88:205–211.
  • Yamanashi, Y., T. Tamura, T. Kanamori, H. Yamane, H. Nariuchi, T. Yamamoto, and D. Baltimore. 2000. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes. Dev. 14:11–16.
  • Zhao, M., A. A. Schmitz, Y. Qin, A. Di Cristofano, P. P. Pandolfi, and L. Van Aelst. 2001. Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J. Exp. Med. 194:265–274.
  • Zheng, X. M., R. J. Resnick, and D. Shalloway. 2000. A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J. 19:964–978.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.