Advanced search
Publication Cover
Molecular and Cellular Biology Volume 26, 2006 - Issue 2
Submit an article Journal homepage
58
Views
60
CrossRef citations to date
0
Altmetric
Article

The Transcriptional Histone Acetyltransferase Cofactor TRRAP Associates with the MRN Repair Complex and Plays a Role in DNA Double-Strand Break Repair

Flavie Robert1 Department of Transcription, Institut de Génétique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS, F-67404 Illkirch Cedex, CU de Strasbourg, France
,
Sara Hardy1 Department of Transcription, Institut de Génétique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS, F-67404 Illkirch Cedex, CU de Strasbourg, France
,
Zita Nagy1 Department of Transcription, Institut de Génétique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS, F-67404 Illkirch Cedex, CU de Strasbourg, France
,
Céline Baldeyron2 UMR 218 of CNRS, Institut Curie, F-75248 Paris Cedex 05, France
,
Rabih Murr3 International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, F-69372Lyon, France
,
Ugo Déry4 Centre de Recherche, L'Hôtel-Dieu-de-Québec, Université Laval, Quebec, Canada
,
Jean-Yves Masson4 Centre de Recherche, L'Hôtel-Dieu-de-Québec, Université Laval, Quebec, Canada
,
Dora Papadopoulo2 UMR 218 of CNRS, Institut Curie, F-75248 Paris Cedex 05, France
,
Zdenko Herceg3 International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, F-69372Lyon, France
&
Làszlò Tora1 Department of Transcription, Institut de Génétique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS, F-67404 Illkirch Cedex, CU de Strasbourg, FranceCorrespondence[email protected]
 show all
Pages 402-412 | Received 06 Apr 2005, Accepted 21 Oct 2005, Published online: 27 Mar 2023

Citations (60)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Alan C. M. Cheung & Luis Miguel Díaz-Santín. (2019) Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes. Transcription 10:1, pages 37-43.
Read now
Romain Drissi, Anaïs Chauvin, Alyson McKenna, Dominique Lévesque, Simon Blais-Brochu, Dominique Jean & François-Michel Boisvert. (2018) Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks. Cell Cycle 17:23, pages 2593-2609.
Read now
Masae Ikura, Kanji Furuya, Shun Matsuda, Ryo Matsuda, Hiroki Shima, Jun Adachi, Tomonari Matsuda, Takuma Shiraki & Tsuyoshi Ikura. (2015) Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin. Molecular and Cellular Biology 35:24, pages 4147-4157.
Read now
Dominique Helmlinger. (2012) New insights into the SAGA complex from studies of the Tra1 subunit in budding and fission yeast. Transcription 3:1, pages 13-18.
Read now
Natsuko Izumi, Akio Yamashita & Shigeo Ohno. (2012) Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2. Nucleus 3:1, pages 29-43.
Read now
Adrien Eberlin, Cédric Grauffel, Mustapha Oulad-Abdelghani, Flavie Robert, Maria-Elena Torres-Padilla, Romain Lambrot, Danièle Spehner, Lourdes Ponce-Perez, Jean-Marie Würtz, Roland H. Stote, Sarah Kimmins, Patrick Schultz, Annick Dejaegere & Laszlo Tora. (2008) Histone H3 Tails Containing Dimethylated Lysine and Adjacent Phosphorylated Serine Modifications Adopt a Specific Conformation during Mitosis and Meiosis. Molecular and Cellular Biology 28:5, pages 1739-1754.
Read now
Michael DeRan, Mary Pulvino, Eriko Greene, Chuan Su & Jiyong Zhao. (2008) Transcriptional Activation of Histone Genes Requires NPAT-Dependent Recruitment of TRRAP-Tip60 Complex to Histone Promoters during the G1/S Phase Transition. Molecular and Cellular Biology 28:1, pages 435-447.
Read now
Tsuyoshi Ikura, Satoshi Tashiro, Akemi Kakino, Hiroki Shima, Naduparambil Jacob, Ravindra Amunugama, Kristine Yoder, Shunsuke Izumi, Isao Kuraoka, Kiyoji Tanaka, Hiroshi Kimura, Masae Ikura, Shuichi Nishikubo, Takashi Ito, Akihiko Muto, Kiyoshi Miyagawa, Shunichi Takeda, Richard Fishel, Kazuhiko Igarashi & Kenji Kamiya. (2007) DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics. Molecular and Cellular Biology 27:20, pages 7028-7040.
Read now

Articles from other publishers (52)

Andreas Herchenröther, Tim M. Wunderlich, Jie Lan & Sandra B. Hake. (2023) Spotlight on histone H2A variants: From B to X to Z. Seminars in Cell & Developmental Biology 135, pages 3-12.
Crossref
Carlotta Kreienbaum, Lena W. Paasche & Sandra B. Hake. (2022) H2A.Z's ‘social’ network: functional partners of an enigmatic histone variant. Trends in Biochemical Sciences 47:11, pages 909-920.
Crossref
Anahita Lashgari, Pata-Eting Kougnassoukou Tchara, Jean-Philippe Lambert & Jacques Côté. (2022) New insights into the DNA repair pathway choice with NuA4/TIP60. DNA Repair 113, pages 103315.
Crossref
Tanner M. Tessier, Mackenzie J. Dodge, Katelyn M. MacNeil, Andris M. Evans, Martin A. Prusinkiewicz & Joe S. Mymryk. (2021) Almost famous: Human adenoviruses (and what they have taught us about cancer). Tumour Virus Research 12, pages 200225.
Crossref
Michelle L. Swift, Kate Beishline & Jane Azizkhan-Clifford. (2021) Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70. DNA Repair 105, pages 103171.
Crossref
S. Nishad, Pankaj Kumar Chauhan, R. Sowdhamini & Anu Ghosh. (2021) Chronic exposure of humans to high level natural background radiation leads to robust expression of protective stress response proteins. Scientific Reports 11:1.
Crossref
Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake & Tilman Borggrefe. (2019) The histone variant H2A.Z in gene regulation. Epigenetics & Chromatin 12:1.
Crossref
Anahita Lashgari, Myriam Fauteux, Alexandre Maréchal & Luc Gaudreau. (2018) Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells. Scientific Reports 8:1.
Crossref
Benedetto Daniele Giaimo, Francesca Ferrante, Diana M Vallejo, Kerstin Hein, Irene Gutierrez-Perez, Andrea Nist, Thorsten Stiewe, Gerhard Mittler, Susanne Herold, Tobias Zimmermann, Marek Bartkuhn, Peggy Schwarz, Franz Oswald, Maria Dominguez & Tilman Borggrefe. (2018) Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Research 46:16, pages 8197-8215.
Crossref
Jeffrey Lynham & Walid A. Houry. 2018. Prefoldins: the new chaperones. Prefoldins: the new chaperones 37 72 .
Yi-Li Feng, Ji-Feng Xiang, Si-Cheng Liu, Tao Guo, Guo-Fang Yan, Ye Feng, Na Kong, Hao- Dan Li, Yang Huang, Hui Lin, Xiu-Jun Cai & An-Yong Xie. (2017) H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Research 45:18, pages 10614-10633.
Crossref
Ignacio Torrecilla, Judith Oehler & Kristijan Ramadan. (2017) The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks. Philosophical Transactions of the Royal Society B: Biological Sciences 372:1731, pages 20160282.
Crossref
Nikolaos Vosnakis, Marc Koch, Elisabeth Scheer, Pascal Kessler, Yves Mély, Pascal Didier & László Tora. (2017) Coactivators and general transcription factors have two distinct dynamic populations dependent on transcription. The EMBO Journal 36:18, pages 2710-2725.
Crossref
Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan & Alan CM Cheung. (2017) Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution. eLife 6.
Crossref
Rebecca J. Smith, Matthew S. Savoian, Lauren E. Weber & Jeong Hyeon Park. (2016) Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response. BMC Molecular Biology 17:1.
Crossref
Ozge Gursoy-Yuzugullu, Nealia House & Brendan D. Price. (2016) Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks. Journal of Molecular Biology 428:9, pages 1846-1860.
Crossref
Mary Ann Stevenson & Stuart K. Calderwood. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 41 50.e2 .
Sarina Ravens, Changwei Yu, Tao Ye, Matthieu Stierle & Laszlo Tora. (2015) Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells. Epigenetics & Chromatin 8:1.
Crossref
Maristella De Cicco, Munirah Rahim & Sonja Dames. (2015) Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting. Membranes 5:4, pages 553-575.
Crossref
Derek J. Richard, Emma Bolderson, Anne-Marie Baird & Kenneth J. O’Byrne. 2015. Epigenetic Cancer Therapy. Epigenetic Cancer Therapy 595 612 .
Heather M. O'Hagan. (2014) Chromatin modifications during repair of environmental exposure-induced DNA damage: A potential mechanism for stable epigenetic alterations. Environmental and Molecular Mutagenesis 55:3, pages 278-291.
Crossref
G Ichim, M Mola, M G Finkbeiner, M-P Cros, Z Herceg & H Hernandez-Vargas. (2013) The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle. Oncogene 33:2, pages 181-192.
Crossref
Fintan K.T. Stanley, Shaun Moore & Aaron A. Goodarzi. (2013) CHD chromatin remodelling enzymes and the DNA damage response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 750:1-2, pages 31-44.
Crossref
Lisa A.M. Sommer, Martin Schaad & Sonja A. Dames. (2013) NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK). Journal of Biological Chemistry 288:27, pages 20046-20063.
Crossref
Simona Pavan, Martina Olivero, Davide Corà & Maria Flavia Di Renzo. (2013) IRF-1 expression is induced by cisplatin in ovarian cancer cells and limits drug effectiveness. European Journal of Cancer 49:4, pages 964-973.
Crossref
Larry H. Thompson. (2012) Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography. Mutation Research/Reviews in Mutation Research 751:2, pages 158-246.
Crossref
Hua Zhang, Andrew Photiou, Arnhild Grothey, Justin Stebbing & Georgios Giamas. (2012) The role of pseudokinases in cancer. Cellular Signalling 24:6, pages 1173-1184.
Crossref
Natsuko Izumi, Akio Yamashita, Hisashi Hirano & Shigeo Ohno. (2012) Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex. Cancer Science 103:1, pages 50-57.
Crossref
Mary Ann Stevenson & Stuart K. Calderwood. 2012. Clinical Radiation Oncology. Clinical Radiation Oncology 43 52 .
Ye Xu, Chang Xu & Brendan D. Price. 2012. Mechanisms of DNA Repair. Mechanisms of DNA Repair 263 288 .
Shahzad Bhatti, Sergei Kozlov, Ammad Ahmad Farooqi, Ali Naqi, Martin Lavin & Kum Kum Khanna. (2011) ATM protein kinase: the linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences 68:18, pages 2977-3006.
Crossref
H Ogiwara, A Ui, A Otsuka, H Satoh, I Yokomi, S Nakajima, A Yasui, J Yokota & T Kohno. (2011) Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 30:18, pages 2135-2146.
Crossref
Kendra L. CannGraham Dellaire. (2011) Heterochromatin and the DNA damage response: the need to relaxThis paper is one of a selection of papers in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.. Biochemistry and Cell Biology 89:1, pages 45-60.
Crossref
Anastas Gospodinov & Zdenko Herceg. 2011. Post-Translational Modifications in Health and Disease. Post-Translational Modifications in Health and Disease 387 409 .
Ye Xu, Yingli Sun, Xiaofeng Jiang, Marina K. Ayrapetov, Patryk Moskwa, Shenghong Yang, David M. Weinstock & Brendan D. Price. (2010) The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. Journal of Cell Biology 191:1, pages 31-43.
Crossref
Teresa M Calonge, Majid Eshaghi, Jianhua Liu, Ze'ev Ronai & Matthew J O'Connell. (2010) Transformation/Transcription Domain-Associated Protein (TRRAP)-Mediated Regulation of Wee1. Genetics 185:1, pages 81-93.
Crossref
Catherine Chailleux, Sandrine Tyteca, Christophe Papin, François Boudsocq, Nadine Puget, Céline Courilleau, Mikhaïl Grigoriev, Yvan Canitrot & Didier Trouche. (2010) Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. Biochemical Journal 426:3, pages 365-371.
Crossref
Thomas Vaissière & Zdenko Herceg. (2010) Histone code in the cross-talk during DNA damage signaling. Cell Research 20:2, pages 113-115.
Crossref
Heiko Wurdak, Shoutian Zhu, Angelica Romero, Mihaela Lorger, James Watson, Chih-yuan Chiang, Jay Zhang, Vanita S. Natu, Luke L. Lairson, John R. Walker, Christopher M. Trussell, Griffith R. Harsh, Hannes Vogel, Brunhilde Felding-Habermann, Anthony P. Orth, Loren J. Miraglia, Daniel R. Rines, Stephen L. Skirboll & Peter G. Schultz. (2010) An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation. Cell Stem Cell 6:1, pages 37-47.
Crossref
H Christian Reinhardt & Michael B Yaffe. (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Current Opinion in Cell Biology 21:2, pages 245-255.
Crossref
Kenta Iijima, Chizuko Muranaka, Junya Kobayashi, Shuichi Sakamoto, Kenshi Komatsu, Shinya Matsuura, Nobuo Kubota & Hiroshi Tauchi. (2008) NBS1 regulates a novel apoptotic pathway through Bax activation. DNA Repair 7:10, pages 1705-1716.
Crossref
Carla Sawan, Thomas Vaissière, Rabih Murr & Zdenko Herceg. (2008) Epigenetic drivers and genetic passengers on the road to cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 642:1-2, pages 1-13.
Crossref
Eliana B Gómez, Rebecca L Nugent, Sebastián Laria & Susan L Forsburg. (2008) Schizosaccharomyces pombe Histone Acetyltransferase Mst1 (KAT5) Is an Essential Protein Required for Damage Response and Chromosome Segregation . Genetics 179:2, pages 757-771.
Crossref
Krista D Meyer, Aaron J Donner, Matthew T Knuesel, Autumn G York, Joaquín M Espinosa & and Dylan J Taatjes. (2008) Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. The EMBO Journal.
Crossref
Kenta IIJIMA, Maki OHARA, Ryota SEKI & Hiroshi TAUCHI. (2008) Dancing on Damaged Chromatin: Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular Responses to DNA Damage. Journal of Radiation Research 49:5, pages 451-464.
Crossref
R Murr, T Vaissière, C Sawan, V Shukla & Z Herceg. (2007) Orchestration of chromatin-based processes: mind the TRRAP. Oncogene 26:37, pages 5358-5372.
Crossref
Kazuto Kugou, Hiroyuki Sasanuma, Kouji Matsumoto, Katsuhiko Shirahige & Kunihiro Ohta. (2007) Mre11 mediates gene regulation in yeast spore development. Genes & Genetic Systems 82:1, pages 21-33.
Crossref
Roni H. G. WrightEdward S. DornanMary M. DonaldsonIain M. Morgan. (2006) TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochemical Journal 400:3, pages 573-582.
Crossref
Yi Tang, Jianyuan Luo, Wenzhu Zhang & Wei Gu. (2006) Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis. Molecular Cell 24:6, pages 827-839.
Crossref
Massimo Squatrito, Chiara Gorrini & Bruno Amati. (2006) Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends in Cell Biology 16:9, pages 433-442.
Crossref
Yun-Gui Yang, Pierre-Olivier Frappart, Lucien Frappart, Zhao-Qi Wang & Wei-Min Tong. (2006) A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. DNA Repair 5:8, pages 885-893.
Crossref
Johanna A. Smith & René Daniel. (2006) Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses. ACS Chemical Biology 1:4, pages 217-226.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.