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Molecular and Cellular Biology Volume 26, 2006 - Issue 2
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Article

Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks

Alexandra Sobeck1 Division of Biochemistry and Molecular Biology
,
Stacie Stone1 Division of Biochemistry and Molecular Biology
,
Vincenzo Costanzo7 Genome Stability Unit, Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, HertsEN6 3LD, United Kingdom
,
Bendert de Graaf1 Division of Biochemistry and Molecular Biology
,
Tanja Reuter1 Division of Biochemistry and Molecular Biology
,
Johan de Winter5 Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BTAmsterdam, The Netherlands
,
Michael Wallisch1 Division of Biochemistry and Molecular Biology
,
Yassmine Akkari2 Department of Molecular and Medical Genetics
,
Susan Olson2 Department of Molecular and Medical Genetics
,
Weidong Wang6 National Institute on Aging, National Institutes of Health, 333 Cassell Dr., TRIAD Center Room 3000, Baltimore, Maryland21224
,
Hans Joenje5 Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BTAmsterdam, The Netherlands
,
Jan L. Christian3 Department of Cell and Developmental Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, Oregon97239
,
Patrick J. Lupardus8 Department of Molecular Pharmacology, Stanford University, Stanford, California94305
,
Karlene A. Cimprich8 Department of Molecular Pharmacology, Stanford University, Stanford, California94305
,
Jean Gautier4 Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York10032
&
Maureen E. Hoatlin1 Division of Biochemistry and Molecular BiologyCorrespondence[email protected]
 show all
Pages 425-437 | Received 16 Jun 2005, Accepted 13 Oct 2005, Published online: 27 Mar 2023

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Maya Raghunandan, Indrajit Chaudhury, Stephanie L. Kelich, Helmut Hanenberg & Alexandra Sobeck. (2015) FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. Cell Cycle 14:3, pages 342-353.
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Andreja Leskovac, Sandra Petrovic, Marija Guc-Scekic, Dragana Vujic & Gordana Joksic. (2014) Radiation-induced mitotic catastrophe in FANCD2 primary fibroblasts. International Journal of Radiation Biology 90:5, pages 373-381.
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Lily C Wang & Jean Gautier. (2010) The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Critical Reviews in Biochemistry and Molecular Biology 45:5, pages 424-439.
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Kerstin Gari & Angelos Constantinou. (2009) The role of the Fanconi anemia network in the response to DNA replication stress. Critical Reviews in Biochemistry and Molecular Biology 44:5, pages 292-325.
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Yuliang Wu, Kazuo Shin-ya & Robert M. Brosh$suffix/text()$suffix/text(). (2008) FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability. Molecular and Cellular Biology 28:12, pages 4116-4128.
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A. Sobeck, S. Stone & M. E. Hoatlin. (2007) DNA Structure-Induced Recruitment and Activation of the Fanconi Anemia Pathway Protein FANCD2. Molecular and Cellular Biology 27:12, pages 4283-4292.
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Marcello Germoglio, Anna Valenti, Ines Gallo, Chiara Forenza, Pamela Santonicola, Nicola Silva & Adele Adamo. (2020) In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans. Scientific Reports 10:1.
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Elizabeth L. Thompson, Jung E. Yeo, Eun-A Lee, Yinan Kan, Maya Raghunandan, Constanze Wiek, Helmut Hanenberg, Orlando D. Schärer, Eric A. Hendrickson & Alexandra Sobeck. (2017) FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Research 45:20, pages 11837-11857.
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Heidi S. Bretscher & Donald T. Fox. (2016) Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. Developmental Cell 37:5, pages 444-457.
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Xiaoyu Xue, Patrick Sung & Xiaolan Zhao. (2015) Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes & Development 29:17, pages 1777-1788.
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Magda Budzowska, Thomas GW Graham, Alexandra Sobeck, Shou Waga & Johannes C Walter. (2015) Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link . The EMBO Journal 34:14, pages 1971-1985.
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Meghan Larin, David Gallo, Laura Tamblyn, Jay Yang, Hudson Liao, Nestor Sabat, Grant W. Brown & J. Peter McPherson. (2014) Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Research 42:15, pages 9807-9820.
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Spencer W. Luebben, Tsuyoshi Kawabata, Charles S. Johnson, M. Gerard O'Sullivan & Naoko Shima. (2014) A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression. Nucleic Acids Research 42:9, pages 5605-5615.
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Anaid Benitez, Fenghua Yuan, Satoshi Nakajima, Leizhen Wei, Liangyue Qian, Richard Myers, Jennifer J. Hu, Li Lan & Yanbin Zhang. (2014) Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. Nucleic Acids Research 42:3, pages 1671-1683.
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Liangyue Qian, Fenghua Yuan, Paola Rodriguez-Tello, Suyog Padgaonkar & Yanbin Zhang. (2013) Human Fanconi Anemia Complementation Group A Protein Stimulates the 5’ Flap Endonuclease Activity of FEN1. PLoS ONE 8:12, pages e82666.
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Indrajit Chaudhury, Archana Sareen, Maya Raghunandan & Alexandra Sobeck. (2013) FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery. Nucleic Acids Research 41:13, pages 6444-6459.
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Changxian Shen, Duane Oswald, Doris Phelps, Hakan Cam, Christopher E. Pelloski, Qishen Pang & Peter J. Houghton. (2013) Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks. Cancer Research 73:11, pages 3393-3401.
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