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Molecular and Cellular Biology Volume 10, 1990 - Issue 10
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Cell Growth and Development

Activation of p56lck through Mutation of a Regulatory CarboxyTerminal Tyrosine Residue Requires Intact Sites of Autophosphorylation and Myristylation

Ninan Abraham1 McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, Quebec, CanadaH3G 1Y6
&
André Veillette1 McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, Quebec, CanadaH3G 1Y6;2 Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, CanadaH3G 1Y6
Pages 5197-5206 | Received 15 May 1990, Accepted 18 Jul 1990, Published online: 31 Mar 2023

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Mei-Lian Cai, Meng-Yan Wang, Cong-Hui Zhang, Jun-Xia Wang, Hong Liu, Hong-Wei He, Wu-Li Zhao, Gui-Ming Xia & Rong-Guang Shao. (2020) Role of co- and post-translational modifications of SFKs in their kinase activation. Journal of Drug Targeting 28:1, pages 23-32.
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Parag Patwardhan & Marilyn D. Resh. (2010) Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity. Molecular and Cellular Biology 30:17, pages 4094-4107.
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Marie-José Bijlmakers. (2009) Protein acylation and localization in T cell signaling (Review). Molecular Membrane Biology 26:1-2, pages 93-103.
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John R. Seavitt, Lynn S. White, Kenneth M. Murphy, Dennis Y. Loh, Roger M. Perlmutter & Matthew L. Thomas. (1999) Expression of the p56 Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development. Molecular and Cellular Biology 19:6, pages 4200-4208.
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Sho Yamasaki, Masako Takamatsu & Makio Iwashima. (1996) The Kinase, SH3, and SH2 Domains of Lck Play Critical Roles in T-Cell Activation after ZAP-70 Membrane Localization. Molecular and Cellular Biology 16:12, pages 7151-7160.
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Lara K. Yurchak & Bartholomew M. Sefton. (1995) Palmitoylation of Either Cys-3 or Cys-5 Is Required for the Biological Activity of the Lck Tyrosine Protein Kinase. Molecular and Cellular Biology 15:12, pages 6914-6922.
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François G. Gervais & André Veillette. (1995) The Unique Amino-Terminal Domain of p56 Regulates Interactions with Tyrosine Protein Phosphatases in T Lymphocytes. Molecular and Cellular Biology 15:5, pages 2393-2401.
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Hiroshi Shibuya, Kazuyoshi Kohu, Kyoko Yamada, Edward L. Barsoumian, Roger M. Perlmutter & Tadatsugu Taniguchi. (1994) Functional Dissection of p56, a Protein Tyrosine Kinase Which Mediates Interleukin-2-Induced Activation of the c-fos Gene. Molecular and Cellular Biology 14:9, pages 5812-5819.
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Dominique Davidson, Jean Viallet & André Veillette. (1994) Unique Catalytic Properties Dictate the Enhanced Function of p59, the Hemopoietic Cell-Specific Isoform of the Fyn Tyrosine Protein Kinase, in T cells. Molecular and Cellular Biology 14:7, pages 4554-4564.
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François G. Gervais, Lionel M. L. Chow, Joseph M. Lee, Philip E. Branton & André Veillette. (1993) The SH2 Domain is Required for Stable Phosphorylation of p56 at Tyrosine 505, the Negative Regulatory Site. Molecular and Cellular Biology 13:11, pages 7112-7121.
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Kunxin Luo & Bartholomew M. Sefton. (1992) Activated lek Tyrosine Protein Kinase Stimulates AntigenIndependent Interleukin-2 Production in T Cells. Molecular and Cellular Biology 12:10, pages 4724-4732.
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Lorraine Caron, Ninan Abraham, Tony Pawson & André Veillette. (1992) Structural Requirements for Enhancement of T-Cell Responsiveness by the Lymphocyte-Specific Tyrosine Protein Kinase p56. Molecular and Cellular Biology 12:6, pages 2720-2729.
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Lionel M. L. Chow, Michael J. H. Ratcliffe & Andre Veillette. (1992) tkl Is the Avian Homolog of the Mammalian Ick Tyrosine Protein Kinase Gene. Molecular and Cellular Biology 12:3, pages 1226-1233.
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Peter Lock, Stephen Ralph, Edouard Stanley, Isabelle Boulet, Robert Ramsay & Ashley R. Dunn. (1991) Two Isoforms of Murine hck, Generated by Utilization of Alternative Translational Initiation Codons, Exhibit Different Patterns of Subcellular Localization. Molecular and Cellular Biology 11:9, pages 4363-4370.
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Articles from other publishers (10)

Shan FengXi ChengLin ZhangXuemin LuSeema ChaudharyRuifang TengChristian FredericksonMatthew M. ChampionRen ZhaoLiang ChengYiyi GongHaiteng DengXin Lu. (2018) Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers. Proceedings of the National Academy of Sciences 115:40, pages 10094-10099.
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Askar M. Akimzhanov & Darren Boehning. (2015) Rapid and transient palmitoylation of the tyrosine kinase Lck mediates Fas signaling. Proceedings of the National Academy of Sciences 112:38, pages 11876-11880.
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Melany J. Wagner & James R. Smiley. (2009) Herpes Simplex Virus Requires VP11/12 To Induce Phosphorylation of the Activation Loop Tyrosine (Y394) of the Src Family Kinase Lck in T Lymphocytes. Journal of Virology 83:23, pages 12452-12461.
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Andrew Filby, Benedict Seddon, Joanna Kleczkowska, Robert Salmond, Peter Tomlinson, Michal Smida, Jonathan A. Lindquist, Burkhart Schraven & Rose Zamoyska. (2007) Fyn Regulates the Duration of TCR Engagement Needed for Commitment to Effector Function. The Journal of Immunology 179:7, pages 4635-4644.
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Maureen A. McGargill, Leslie L. Sharp, Jack D. Bui, Stephen M. Hedrick & Sébastien Calbo. (2005) Active Ca2+/Calmodulin-Dependent Protein Kinase IIγB Impairs Positive Selection of T Cells by Modulating TCR Signaling. The Journal of Immunology 175:2, pages 656-664.
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Shin-Young Na, Amiya Patra, Yvonne Scheuring, Alexander Marx, Mauro Tolaini, Dimitris Kioussis, Brian Hemmings, Thomas Hünig & Ursula Bommhardt. (2003) Constitutively Active Protein Kinase B Enhances Lck and Erk Activities and Influences Thymocyte Selection and Activation. The Journal of Immunology 171:3, pages 1285-1296.
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Margaret M. Morgan, Christine M. Labno, Gijs A. Van Seventer, Michael F. Denny, David B. Straus & Janis K. Burkhardt. (2001) Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70. The Journal of Immunology 167:10, pages 5708-5718.
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Vibeke Sundvold, Knut Martin Torgersen, Nicholas H. Post, Francesc Marti, Philip D. King, John Arne Røttingen, Anne Spurkland & Tor Lea. (2000) Cutting Edge: T Cell-Specific Adapter Protein Inhibits T Cell Activation by Modulating Lck Activity. The Journal of Immunology 165:6, pages 2927-2931.
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Lorraine E Laham, Nishit Mukhopadhyay & Thomas M Roberts. (2000) The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene 19:35, pages 3961-3970.
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Troy C. Lund, Paul C. Prator, Maria M. Medveczky & Peter G. Medveczky. (1999) The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells. Journal of Virology 73:2, pages 1689-1694.
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