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Gene Expression

Physical Mapping, Amplification, and Overexpression of the Mouse mdr Gene Family in Multidrug-Resistant Cells

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Pages 1642-1651 | Received 08 Aug 1989, Accepted 07 Dec 1989, Published online: 31 Mar 2023

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Wim van de Vrie, Richard L. Marquet, Gerrit Stoter, Ernst A. De Bruijn & Alexander M. M. Eggermont. (1998) In Vivo Model Systems in P-Glycoprotein-Mediated Multidrug Resistance. Critical Reviews in Clinical Laboratory Sciences 35:1, pages 1-57.
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M. Tien Kuo, Rohini C. Vyas, Ling-Xia Jiang & Walter N. Hittelman. (1994) Chromosome Breakage at a Major Fragile Site Associated with P-Glycoprotein Gene Amplification in Multidrug-Resistant CHO Cells. Molecular and Cellular Biology 14:8, pages 5202-5211.
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Niramol Savaraj, T. J. Lampidis, Ji-Ying Zhao, Chun Jing Wu, Larry D. Teeter & M. Tien Kuo. (1994) Two Multidrug-Resistant Friend Leukemic Cell Lines Selected with Different Drugs Exhibit Overproduction of Different P-Glycoproteins. Cancer Investigation 12:2, pages 138-144.
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Pierre Lepage, Alain Devault & Philippe Gros. (1993) Activation of the Mouse mdr3 Gene by Insertion of Retroviruses in Multidrug-Resistant P388 Tumor Cells. Molecular and Cellular Biology 13:12, pages 7380-7392.
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Fredrik Stahl, Yvonne Wettergren & Goran Levan. (1992) Amplicon Structure in Multidrug-Resistant Murine Cells: A Nonrearranged Region of Genomic DNA Corresponding to Large Circular DNA. Molecular and Cellular Biology 12:3, pages 1179-1187.
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Alan F. List & Catherine M. Spier. (1992) Multidrug Resistance in Acute Leukemia: A Conserved Physiologic Function. Leukemia & Lymphoma 8:1-2, pages 9-14.
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C.-Ting Wu, Mark Budding, Mary S. Griffin & James M. Croop. (1991) Isolation and Characterization of Drosophila Multidrug Resistance Gene Homologs. Molecular and Cellular Biology 11:8, pages 3940-3948.
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Juan C. Vera, Gonzalo R. Castillo & Ora M. Rosen. (1991) A Possible Role for a Mammalian Facilitative Hexose Transporter in the Development of Resistance to Drugs. Molecular and Cellular Biology 11:7, pages 3407-3418.
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Ellen Buschman & Philippe Gros. (1991) Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes. Molecular and Cellular Biology 11:2, pages 595-603.
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P. Borst. (1991) Genetic Mechanisms of Drug Resistance: A Review. Acta Oncologica 30:1, pages 87-105.
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Alain Devault & Philippe Gros. (1990) Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities. Molecular and Cellular Biology 10:4, pages 1652-1663.
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Satoru Kyo, Kosuke Kanno, Masahiro Takakura, Hitomi Yamashita, Masako Ishikawa, Tomoka Ishibashi, Seiya Sato & Kentaro Nakayama. (2022) Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance. Cancers 14:10, pages 2504.
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Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen, Eline van der Burg, Anders O. H. Nygren, Serge A. L. Zander, Patrick W. B. Derksen, Michiel de Bruin, John ZevenhovenAlan Lau, Robert Boulter, Aaron Cranston, Mark J. O'Connor, Niall M. B. Martin, Piet Borst & Jos Jonkers. (2008) High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proceedings of the National Academy of Sciences 105:44, pages 17079-17084.
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Sven Rottenberg, Anders O. H. Nygren, Marina Pajic, Fijs W. B. van Leeuwen, Ingrid van der Heijden, Koen van de Wetering, Xiaoling Liu, Karin E. de Visser, Kenneth G. Gilhuijs, Olaf van Tellingen, Jan P. Schouten, Jos Jonkers & Piet Borst. (2007) Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proceedings of the National Academy of Sciences 104:29, pages 12117-12122.
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Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar, Carla A. A. M. Mol, Liesbeth van Deemter, Jaap J. M. Smit, Martin A. van der Valk, Arie C. Voordouw, Hergen Spits, Olaf van Tellingen, J. Mark J. M. Zijlmans, Willem E. Fibbe & Piet Borst. (1997) Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proceedings of the National Academy of Sciences 94:8, pages 4028-4033.
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