Literature Cited
- Ames, G. F.-L. 1986. Bacterial periplasmic transport systems: structure, mechanism and evolution. Annu. Rev. Biochem. 55:397–425.
- Arceci, R. J., J. M. Croop, S. B. Horwitz, and D. E. Housman. 1988. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc. Natl. Acad. Sci. USA 85:4350–4354.
- Ardeshir, F., E. Guilotto, J. Zieg, O. Brison, W. S. L. Liao, and G. R. Stark. 1983. Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol. Cell. Biol. 3:2076–2088.
- Azzaria, M., E. Schurr, and P. Gros. 1989. Discrete mutations introduced in the predicted nucleotide-binding sites of the mdrl gene abolish its ability to confer multidrug resistance. Mol. Cell. Biol. 9:5289–5297.
- Cangelosi, G. A., G. Martinetti, J. A. Leigh, C. C. Lee, C. Theines, and E. W. Nester. 1989. Role of Agrobacterium tume- faciens ChvA protein in export of β-1,2-glucan J. Bacteriol. 171:1609–1615.
- Chirgwin, J. M., A. A. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5306.
- Chen, C., J. E. Chin, K. Ueda, D. P. Clark, I. Pastan, M. M. Gottesman, and I. B. Roninson. 1986. Internal duplication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381–389.
- Croop, J. M., P. Gros, and D. H. Housman. 1988. Genetics of multidrug resistance. J. Clin. Invest. 81:1303–1309.
- Croop, J. M., M. Raymond, D. Haber, A. Devault, R. J. Arceci, P. Gros, and D. E. Housman. 1989. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol. Cell. Biol. 9:1346–1350.
- De Bruijn, M. H. L., A. M. Van der Bliek, J. L. Biedler, and P. Borst. 1986. Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines. Mol. Cell. Biol. 6:4717–4722.
- Devault, A., and P. Gros. 1990. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol. Cell. Biol. 10:1652–1666.
- Endicott, J. A., P. F. Juranka, F. Sarangi, J. H. Gerlach, K. L. Deuchars, and V. Ling. 1987. Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells. Mol. Cell. Biol. 7:4075–4081.
- Endicott, J. A., and V. Ling. 1989. The biochemistry of P- glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137–171.
- Feinberg, A. P., and B. Vogelstein. 1984. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:266–267.
- Felmlee, T., S. Pellett, and R. A. Welch. 1985. Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J. Bacteriol. 163:94–105.
- Gottesman, M. M., and I. Pastan. 1988. The multidrug transporter, a double-edged sword. J. Biol. Chem. 263:12163–12166.
- Greenberger, L. M., L. Lothstein, S. S. Williams, and S. B. Horwitz. 1988. Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc. Natl. Acad. Sci. USA 85:3762–3766.
- Greenberger, L. M., S. S. Williams, and S. B. Horwitz. 1987. Biosynthesis of heterogeneous forms of multidrug resistance- associated glycoproteins. J. Biol. Chem. 262:13685–13689.
- Gros, P., Y. Ben Neriah, J. M. Croop, and D. E. Housman. 1986. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (London) 323:728–731.
- Gros, P., J. Croop, and D. E. Housman. 1986. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371–380.
- Gros, P., M. Raymond, J. Bell, and D. E. Housman. 1988. Cloning and characterization of a second member of the mouse mdr gene family. Mol. Cell. Biol. 8:2770–2778.
- Hsu, S. I. H., L. Lothstein, and S. B. Horwitz. 1989. Differential overexpression of three mdr gene family members in multidrugresistant J774-2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. J. Biol. Chem. 264:12053–12062.
- Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
- Martinsson, T., and G. Levan. 1987. Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization. Cyto- genet. Cell. Genet. 45:99–101.
- Ng, W. F., F. Sarangi, R. L. Zastawny, L. Veinot-Drebot, and V. Ling. 1989. Identification of members of the P-glycoprotein multigene family. Mol. Cell. Biol. 9:1224–1232.
- Raymond, M., and P. Gros. 1989. Mammalian multidrug resistance gene: correlation of exon organization with structural domains and duplication of ancestral gene. Proc. Natl. Acad. Sci. USA 86:6488–6492.
- Riordan, J. R., K. Deuchars, N. Kartner, N. Alon, J. Trent, and V. Ling. 1985. Amplification of P-glycoprotein genes in multidrug resistant mammalian cell lines. Nature (London) 316:817–819.
- Roninson, I. B., J. E. Chin, K. Choi, P. Gros, D. E. Housman, A. Fojo, D. W. Shen, M. M. Gottesman, and I. Pastan. 1986. Isolation of human mdr DNA sequences amplified in multidrug resistant KB carcinoma cells. Proc. Natl. Acad. Sci. USA 83:4538–4542.
- Ruiz, J. C., K. Choi, D. D. von Hoff, D. B. Roninson, and G. M. Wahl. 1989. Autonomously replicating episomes contain mdrl genes in a multidrug-resistant human cell line. Mol. Cell. Biol. 9:109–115.
- Schurr, E., M. Raymond, J. C. Bell, and P. Gros. 1989. Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdrl cDNA. Cancer Res. 49:2729–2734.
- Schwartz, D. C., and C. R. Cantor. 1984. Separation of yeast chromosome-sized DNAs by pulse field gradient gel electrophoresis. Cell 37:67–75.
- Stanfield, S. W., L. Ielpi, D. O'Brochta, D. R. Helinski, and G. S. Ditta. 1988. The ndvA gene product of Rhizobium meliloti is required for β-(1→2)-glucan production and has homology to the ATP-binding export protein HlyB. J. Bacteriol. 170:3523–3530.
- Stark, G. R. 1986. DNA amplification in drug resistant cells and in tumours. Cancer Surv. 5:1–23.
- Ueda, K., C. Cardarelli, M. M. Gottesman, and I. Pastan. 1987. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. USA 84:3004–3008.
- Van der Bliek, A. M., F. Baas, T. Ten Houte de Lange, P. M. Kooiman, T. Van der Velde-Koerts, and P. Borst. 1987. The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J. 6:3325–3331.
- Van der Bliek, A. M., F. Baas, T. Van der Velde-Koerts, J. L. Biedler, M. B. Meyers, R. F. Ozols, T. C. Hamilton, H. Joenje, and P. Borst. 1988. Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res. 48:5927–5932.
- Van der Bliek, A. M., T. Van der Velde-Koerts, V. Ling, and P. Borst. 1986. Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol. Cell. Biol. 6:1671–1678.