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Gene Expression

Complex Formation by Positive and Negative Translational Regulators of GCN4

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Pages 3217-3228 | Received 18 Jan 1991, Accepted 27 Mar 1991, Published online: 01 Apr 2023

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Kamal Dev, Hongfang Qiu, Jinsheng Dong, Fan Zhang, Dominik Barthlme & Alan G. Hinnebusch. (2010) The β/Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo. Molecular and Cellular Biology 30:21, pages 5218-5233.
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Daniel S. Ginsburg, Chhabi K. Govind & Alan G. Hinnebusch. (2009) NuA4 Lysine Acetyltransferase Esa1 Is Targeted to Coding Regions and Stimulates Transcription Elongation with Gcn5. Molecular and Cellular Biology 29:24, pages 6473-6487.
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Fan Zhang, Naseem A. Gaur, Jiri Hasek, Soon-ja Kim, Hongfang Qiu, Mark J. Swanson & Alan G. Hinnebusch. (2008) Disrupting Vesicular Trafficking at the Endosome Attenuates Transcriptional Activation by Gcn4. Molecular and Cellular Biology 28:22, pages 6796-6818.
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Chi-Ming Wong, Hongfang Qiu, Cuihua Hu, Jinsheng Dong & Alan G. Hinnebusch. (2007) Yeast Cap Binding Complex Impedes Recruitment of Cleavage Factor IA to Weak Termination Sites. Molecular and Cellular Biology 27:18, pages 6520-6531.
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Sarah S. Mohammad-Qureshi, Raphaël Haddad, Elizabeth J. Hemingway, Jonathan P. Richardson & Graham D. Pavitt. (2007) Critical Contacts between the Eukaryotic Initiation Factor 2B (eIF2B) Catalytic Domain and both eIF2β and -2γ Mediate Guanine Nucleotide Exchange. Molecular and Cellular Biology 27:14, pages 5225-5234.
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Hongfang Qiu, Cuihua Hu, Chi-Ming Wong & Alan G. Hinnebusch. (2006) The Spt4p Subunit of Yeast DSIF Stimulates Association of the Paf1 Complex with Elongating RNA Polymerase II. Molecular and Cellular Biology 26:8, pages 3135-3148.
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Klaus H. Nielsen, Leos Valášek, Caroah Sykes, Antonina Jivotovskaya & Alan G. Hinnebusch. (2006) Interaction of the RNP1 Motif in PRT1 with HCR1 Promotes 40S Binding of Eukaryotic Initiation Factor 3 in Yeast. Molecular and Cellular Biology 26:8, pages 2984-2998.
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Soon-ja Kim, Mark J. Swanson, Hongfang Qiu, Chhabi K. Govind & Alan G. Hinnebusch. (2005) Activator Gcn4p and Cyc8p/Tup1p Are Interdependent for Promoter Occupancy at ARG1 In Vivo. Molecular and Cellular Biology 25:24, pages 11171-11183.
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Hongfang Qiu, Cuihua Hu, Fan Zhang, Gwo Jiunn Hwang, Mark J. Swanson, Cheunchit Boonchird & Alan G. Hinnebusch. (2005) Interdependent Recruitment of SAGA and Srb Mediator by Transcriptional Activator Gcn4p. Molecular and Cellular Biology 25:9, pages 3461-3474.
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Hongfang Qiu, Cuihua Hu, Sungpil Yoon, Krishnamurthy Natarajan, Mark J. Swanson & Alan G. Hinnebusch. (2004) An Array of Coactivators Is Required for Optimal Recruitment of TATA Binding Protein and RNA Polymerase II by Promoter-Bound Gcn4p. Molecular and Cellular Biology 24:10, pages 4104-4117.
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Jonathan P. Richardson, Sarah S. Mohammad & Graham D. Pavitt. (2004) Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity. Molecular and Cellular Biology 24:6, pages 2352-2363.
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Sungpil Yoon, Hongfang Qiu, Mark J. Swanson & Alan G. Hinnebusch. (2003) Recruitment of SWI/SNF by Gcn4p Does Not Require Snf2p or Gcn5p but Depends Strongly on SWI/SNF Integrity, SRB Mediator, and SAGA. Molecular and Cellular Biology 23:23, pages 8829-8845.
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Thanuja Krishnamoorthy, Graham D. Pavitt, Fan Zhang, Thomas E. Dever & Alan G. Hinnebusch. (2001) Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation. Molecular and Cellular Biology 21:15, pages 5018-5030.
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Sang Ki Choi, DeAnne S. Olsen, Antonina Roll-Mecak, Agnes Martung, Keith L. Remo, Stephen K. Burley, Alan G. Hinnebusch & Thomas E. Dever. (2000) Physical and Functional Interaction between the Eukaryotic Orthologs of Prokaryotic Translation Initiation Factors IF1 and IF2. Molecular and Cellular Biology 20:19, pages 7183-7191.
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Olga Calvo, Rafael Cuesta, James Anderson, Noelia Gutiérrez, Minerva Teresa García-Barrio, Alan G. Hinnebusch & Mercedes Tamame. (1999) GCD14p, a Repressor of GCN4 Translation, Cooperates with Gcd10p and Lhp1p in the Maturation of Initiator Methionyl-tRNA in Saccharomyces cerevisiae. Molecular and Cellular Biology 19:6, pages 4167-4181.
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Jomar P. Laurino, Glória M. Thompson, Eliza Pacheco & Beatriz A. Castilho. (1999) The β Subunit of Eukaryotic Translation Initiation Factor 2 Binds mRNA through the Lysine Repeats and a Region Comprising the C2-C2 Motif. Molecular and Cellular Biology 19:1, pages 173-181.
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Lon Phan, Xiaolong Zhang, Katsura Asano, James Anderson, Hans-Peter Vornlocher, Jay R. Greenberg, Jun Qin & Alan G. Hinnebusch. (1998) Identification of a Translation Initiation Factor 3 (eIF3) Core Complex, Conserved in Yeast and Mammals, That Interacts with eIF5. Molecular and Cellular Biology 18:8, pages 4935-4946.
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Dominic P. Eisinger, Frederick A. Dick, Elke Denke & Bernard L. Trumpower. (1997) SQT1, Which Encodes an Essential WD Domain Protein of Saccharomyces cerevisiae, Suppresses Dominant-Negative Mutations of the Ribosomal Protein Gene QSR1. Molecular and Cellular Biology 17:9, pages 5146-5155.
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Graham D. Pavitt, Weimin Yang & Alan G. Hinnebusch. (1997) Homologous Segments in Three Subunits of the Guanine Nucleotide Exchange Factor eIF2B Mediate Translational Regulation by Phosphorylation of eIF2. Molecular and Cellular Biology 17:3, pages 1298-1313.
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Tatjana Naranda, Susan E. Macmillan, Thomas F. Donahue & John W. B. Hershey. (1996) SUI1/p16 Is Required for the Activity of Eukaryotic Translation Initiation Factor 3 in Saccharomyces cerevisiae. Molecular and Cellular Biology 16:5, pages 2307-2313.
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Thomas E. Dever, Weimin Yang, Stefan Åström, Anders S. Byström & Alan G. Hinnebusch. (1995) Modulation of tRNA(iMet), eIF-2, and eIF-2B Expression Shows that GCN4 Translation Is Inversely Coupled to the Level of eIF-2·GTP·Met-tRNA(iMet) Ternary Complexes. Molecular and Cellular Biology 15:11, pages 6351-6363.
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Zongli Luo, Michael Freitag & Matthew S. Sachs. (1995) Translational Regulation in Response to Changes in Amino Acid Availability in Neurospora crassa. Molecular and Cellular Biology 15:10, pages 5235-5245.
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David R. H. Evans, Charlotte Rasmussen, Pamela J. Hanic-Joyce, Gerald C. Johnston, Richard A. Singer & Christine A. Barnes. (1995) Mutational Analysis of the Prt1 Protein Subunit of Yeast Translation Initiation Factor 3. Molecular and Cellular Biology 15:8, pages 4525-4535.
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Marco Foiani, Giordano Liberi, Giovanna Lucchini & Paolo Plevani. (1995) Cell Cycle-Dependent Phosphorylation and Dephosphorylation of the Yeast DNA Polymerase α-Primase B Subunit. Molecular and Cellular Biology 15:2, pages 883-891.
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Janet L. Bushman, Marco Foiani, A. Mark Cigan, Christopher J. Paddon & Alan G. Hinnebusch. (1993) Guanine Nucleotide Exchange Factor for Eukaryotic Translation Initiation Factor 2 in Saccharomyces cerevisiae: Interactions between the Essential Subunits GCD2, GCD6, and GCD7 and the Regulatory Subunit GCN3. Molecular and Cellular Biology 13:8, pages 4618-4631.
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Janet L. Bushman, Agatha I. Asuru, Robert L. Matts & Alan G. Hinnebusch. (1993) Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 13:3, pages 1920-1932.
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Ernest M. Hannig, A. Mark Cigan, Barbara A. Freeman & Terri Goss Kinzy. (1993) GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 13:1, pages 506-520.
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Manuel Ramirez, Ronald C. Wek, Carlos R. Vazquez De Aldana, Belinda M. Jackson, Barbara Freeman & Alan G. Hinnebusch. (1992) Mutations Activating the Yeast eIF-2a Kinase GCN2: Isolation of Alleles Altering the Domain Related to Histidyl-tRNA Synthetases. Molecular and Cellular Biology 12:12, pages 5801-5815.
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Ronald C. Wek, John F. Cannon, Thomas E. Dever & Alan G. Hinnebusch. (1992) Truncated Protein Phosphatase GLC7 Restores Translational Activation of GCN4 Expression in Yeast Mutants Defective for the eIF-2α Kinase GCN2. Molecular and Cellular Biology 12:12, pages 5700-5710.
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Marco Foiani, A. Mark Cigan, Christopher J. Paddon, Satoshi Harashima & Alan G. Hinnebusch. (1991) GCD2, a Translational Repressor of the GCN4 Gene, Has a General Function in the Initiation of Protein Synthesis in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:6, pages 3203-3216.
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Manuel Ramirez, Ronald C. Wek & Alan G. Hinnebusch. (1991) Ribosome Association of GCN2 Protein Kinase, a Translational Activator of the GCN4 Gene of Saccharomyces cerevisiae. Molecular and Cellular Biology 11:6, pages 3027-3036.
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