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Molecular and Cellular Biology Volume 13, 1993 - Issue 8
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Gene Expression

Translation of the Yeast Transcriptional Activator GCN4 Is Stimulated by Purine Limitation: Implications for Activation of the Protein Kinase GCN2

Ronda J. RolfesSection on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland20892.
&
Alan G. HinnebuschSection on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland20892.
Pages 5099-5111 | Received 11 Mar 1993, Accepted 24 May 1993, Published online: 31 Mar 2023

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Mauricio Menacho-Márquez, Carlos J Rodríguez-Hernández, M Ángeles Villaronga, Jorge Pérez-Valle, José Gadea, Borja Belandia & José R Murguía. (2015) eIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells. Cell Cycle 14:4, pages 630-640.
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Anne-Laure Todeschini, Antonin Morillon, Mathias Springer & Pascale Lesage. (2005) Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae. Molecular and Cellular Biology 25:17, pages 7459-7472.
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Kaushik Chakravarty, Hanoch Cassuto, Lea Reshef & Richard W. Hanson. (2005) Factors That Control the Tissue-Specific Transcription of the Gene for Phosphoenolpyruvate Carboxykinase-C. Critical Reviews in Biochemistry and Molecular Biology 40:3, pages 129-154.
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L. E. A. Holmes, S. G. Campbell, S. K. De Long, A. B. Sachs & M. P. Ashe. (2004) Loss of Translational Control in Yeast Compromised for the Major mRNA Decay Pathway. Molecular and Cellular Biology 24:7, pages 2998-3010.
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Revital Shemer, Ariella Meimoun, Tsvi Holtzman & Daniel Kornitzer. (2002) Regulation of the Transcription Factor Gcn4 by Pho85 Cyclin Pcl5. Molecular and Cellular Biology 22:15, pages 5395-5404.
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Antonin Morillon, Lionel Bénard, Mathias Springer & Pascale Lesage. (2002) Differential Effects of Chromatin and Gcn4 on the 50-Fold Range of Expression among Individual Yeast Ty1 Retrotransposons. Molecular and Cellular Biology 22:7, pages 2078-2088.
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Krishnamurthy Natarajan, Michael R. Meyer, Belinda M. Jackson, David Slade, Christopher Roberts, Alan G. Hinnebusch & Matthew J. Marton. (2001) Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast. Molecular and Cellular Biology 21:13, pages 4347-4368.
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Ruojing Yang, Sheree A. Wek & Ronald C. Wek. (2000) Glucose Limitation Induces GCN4 Translation by Activation of Gcn2 Protein Kinase. Molecular and Cellular Biology 20:8, pages 2706-2717.
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Fan Zhang, Martha Kirouac, Nannan Zhu, Alan G. Hinnebusch & Ronda J. Rolfes. (1997) Evidence that Complex Formation by Bas1p and Bas2p (Pho2p) Unmasks the Activation Function of Bas1p in an Adenine-Repressible Step of ADE Gene Transcription. Molecular and Cellular Biology 17:6, pages 3272-3283.
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Thomas E. Dever, Weimin Yang, Stefan Åström, Anders S. Byström & Alan G. Hinnebusch. (1995) Modulation of tRNA(iMet), eIF-2, and eIF-2B Expression Shows that GCN4 Translation Is Inversely Coupled to the Level of eIF-2·GTP·Met-tRNA(iMet) Ternary Complexes. Molecular and Cellular Biology 15:11, pages 6351-6363.
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Carlos R. Vazquez De Aldana & Alan G. Hinnebusch. (1994) Mutations in the GCD7 Subunit of Yeast Guanine Nucleotide Exchange Factor eIF-2B Overcome the Inhibitory Effects of Phosphorylated eIF-2 on Translation Initiation. Molecular and Cellular Biology 14:5, pages 3208-3222.
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Articles from other publishers (5)

Rebecca N. Koehler, Nicole Rachfall & Ronda J. Rolfes. (2007) Activation of the ADE Genes Requires the Chromatin Remodeling Complexes SAGA and SWI/SNF . Eukaryotic Cell 6:8, pages 1474-1485.
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Chaoguang Tian, Takao Kasuga, Matthew S. Sachs & N. Louise Glass. (2007) Transcriptional Profiling of Cross Pathway Control in Neurospora crassa and Comparative Analysis of the Gcn4 and CPC1 Regulons . Eukaryotic Cell 6:6, pages 1018-1029.
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Lotte Steffensen & Per Amstrup Pedersen. (2006) Heterologous Expression of Membrane and Soluble Proteins Derepresses GCN4 mRNA Translation in the Yeast Saccharomyces cerevisiae . Eukaryotic Cell 5:2, pages 248-261.
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Indrani SomRebecca N. MitschJennifer L. UrbanowskiRonda J. Rolfes. (2005) DNA-Bound Bas1 Recruits Pho2 To Activate ADE Genes in Saccharomyces cerevisiae . Eukaryotic Cell 4:10, pages 1725-1735.
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Alan G. Hinnebusch & Krishnamurthy Natarajan. (2002) Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress. Eukaryotic Cell 1:1, pages 22-32.
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