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Cell Growth and Development

Role of SH-PTP2, a Protein-Tyrosine Phosphatase with Src Homology 2 Domains, in Insulin-Stimulated Ras Activation

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Pages 6674-6682 | Received 19 May 1994, Accepted 19 Jul 1994, Published online: 30 Mar 2023

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Ryouhei Tsutsumi, Atsushi Takahashi, Takeshi Azuma, Hideaki Higashi & Masanori Hatakeyama. (2006) Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA. Molecular and Cellular Biology 26:1, pages 261-276.
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Masahiro Nishi, Eric D. Werner, Byung-Chul Oh, J. Daniel Frantz, Sirano Dhe-Paganon, Lone Hansen, Jongsoon Lee & Steven E. Shoelson. (2005) Kinase Activation through Dimerization by Human SH2-B. Molecular and Cellular Biology 25:7, pages 2607-2621.
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Yehenew M. Agazie & Michael J. Hayman. (2003) Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling. Molecular and Cellular Biology 23:21, pages 7875-7886.
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Si Qing Zhang, William G. Tsiaras, Toshiyuki Araki, Gengyun Wen, Liliana Minichiello, Ruediger Klein & Benjamin G. Neel. (2002) Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2. Molecular and Cellular Biology 22:12, pages 4062-4072.
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Maria I. Kontaridis, Xiangdong Liu, Lei Zhang & Anton M. Bennett. (2002) Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts. Molecular and Cellular Biology 22:11, pages 3875-3891.
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Yan Liu, Brendan Jenkins, Jung Lim Shin & Larry R. Rohrschneider. (2001) Scaffolding Protein Gab2 Mediates Differentiation Signaling Downstream of Fms Receptor Tyrosine Kinase. Molecular and Cellular Biology 21:9, pages 3047-3056.
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Kaku Tsuruzoe, Renee Emkey, Kristina M. Kriauciunas, Kohjiro Ueki & C. Ronald Kahn. (2001) Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling. Molecular and Cellular Biology 21:1, pages 26-38.
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Takuya Ohtani, Katsuhiko Ishihara, Toru Atsumi, Yuichi Yoshida, Keigo Nishida, Masahiro Narimatsu, Takahiro Shirogane, Masahiko Hibi & Toshio Hirano. (2000) gp130-mediated signalling as a therapeutic target. Emerging Therapeutic Targets 4:4, pages 459-479.
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Zhong-Qing Shi, De-Hua Yu, Morag Park, Mark Marshall & Gen-Sheng Feng. (2000) Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity. Molecular and Cellular Biology 20:5, pages 1526-1536.
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Adrian V. Lee, Jennifer L. Gooch, Steffi Oesterreich, Rebecca L. Guler & Douglas Yee. (2000) Insulin-Like Growth Factor I-Induced Degradation of Insulin Receptor Substrate 1 Is Mediated by the 26S Proteasome and Blocked by Phosphatidylinositol 3′-Kinase Inhibition. Molecular and Cellular Biology 20:5, pages 1489-1496.
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Roland P. Bourette & Larry R. Rohrschneider. (2000) Early Events in M-CSF Receptor Signaling. Growth Factors 17:3, pages 155-166.
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Alana M. O'Reilly, Scott Pluskey, Steven E. Shoelson & Benjamin G. Neel. (2000) Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps. Molecular and Cellular Biology 20:1, pages 299-311.
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Yaron Hakak & G. Steven Martin. (1999) Cas Mediates Transcriptional Activation of the Serum Response Element by Src. Molecular and Cellular Biology 19:10, pages 6953-6962.
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Min You, De-Hua Yu & Gen-Sheng Feng. (1999) Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway. Molecular and Cellular Biology 19:3, pages 2416-2424.
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Toshiyuki Fukada, Yuichi Yoshida, Keigo Nishida, Takuya Ohtani, Takahiro Shirogane, Masahiko Hibi & Toshio Hirano. (1999) Signaling Through Gp130: Toward a General Scenario of Cytokine Action. Growth Factors 17:2, pages 81-91.
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Cheng-Kui Qu, Wen-Mei Yu, Biagio Azzarelli, Scott Cooper, Hal E. Broxmeyer & Gen-Sheng Feng. (1998) Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells. Molecular and Cellular Biology 18:10, pages 6075-6082.
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Mariko Takahashi-Tezuka, Yuichi Yoshida, Toshiyuki Fukada, Takuya Ohtani, Yojiro Yamanaka, Keigo Nishida, Koichi Nakajima, Masahiko Hibi & Toshio Hirano. (1998) Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase. Molecular and Cellular Biology 18:7, pages 4109-4117.
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Masahiko Hibi & Toshio Hirano. (1998) Signal TransductionThrough Cytokine Receptors. International Reviews of Immunology 17:1-4, pages 75-102.
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Alana M. O’Reilly & Benjamin G. Neel. (1998) Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction. Molecular and Cellular Biology 18:1, pages 161-177.
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Zhong-Yin Zhang. (1998) Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis. Critical Reviews in Biochemistry and Molecular Biology 33:1, pages 1-52.
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Cheng-Kui Qu, Zhong-Qing Shi, Randy Shen, Fong-Ying Tsai, Stuart H. Orkin & Gen-Sheng Feng. (1997) A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development. Molecular and Cellular Biology 17:9, pages 5499-5507.
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Sophie Giorgetti-Peraldi, Elizabeth Ottinger, Gert Wolf, Bin Ye, Terrence R. Burke$suffix/text()$suffix/text() & Steven E. Shoelson. (1997) Cellular Effects of Phosphotyrosine-Binding Domain Inhibitors on Insulin Receptor Signaling and Trafficking. Molecular and Cellular Biology 17:3, pages 1180-1188.
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Yohsuke Fujioka, Takashi Matozaki, Tetsuya Noguchi, Akihiro Iwamatsu, Takuji Yamao, Nobuaki Takahashi, Masahiro Tsuda, Toshiyuki Takada & Masato Kasuga. (1996) A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion. Molecular and Cellular Biology 16:12, pages 6887-6899.
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Stefan Krautwald, Dirk Büscher, Veronika Kummer, Sylke Buder & Manuela Baccarini. (1996) Involvement of the Protein Tyrosine Phosphatase SHP-1 in Ras-Mediated Activation of the Mitogen-Activated Protein Kinase Pathway. Molecular and Cellular Biology 16:11, pages 5955-5963.
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Raul Mendez, Martin G. Myers$suffix/text()$suffix/text(), Morris F. White & Robert E. Rhoads. (1996) Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase. Molecular and Cellular Biology 16:6, pages 2857-2864.
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Marianne Gamper, Peter K. Howard, Tony Hunter & Richard A. Firtel. (1996) Multiple Roles of the Novel Protein Tyrosine Phosphatase PTP3 during Dictyostelium Growth and Development. Molecular and Cellular Biology 16:5, pages 2431-2444.
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Anton M. Bennett, Sharon F. Hausdorff, Alana M. O’Reilly, Robert M. Freeman$suffix/text()$suffix/text() & Benjamin G. Neel. (1996) Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression. Molecular and Cellular Biology 16:3, pages 1189-1202.
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Michael David, Haiyan E. Chen, Susan Goelz, Andrew C. Larner & Benjamin G. Neel. (1995) Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1. Molecular and Cellular Biology 15:12, pages 7050-7058.
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Motoyoshi Sakaue, David Bowtell & Masato Kasuga. (1995) A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways. Molecular and Cellular Biology 15:1, pages 379-388.
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Articles from other publishers (2)

Sara Bobone, Luca Pannone, Barbara Biondi, Maja Solman, Elisabetta Flex, Viviana Claudia Canale, Paolo Calligari, Chiara De Faveri, Tommaso Gandini, Andrea Quercioli, Giuseppe Torini, Martina Venditti, Antonella Lauri, Giulia Fasano, Jelmer Hoeksma, Valerio Santucci, Giada Cattani, Alessio Bocedi, Giovanna Carpentieri, Valentina Tirelli, Massimo Sanchez, Cristina Peggion, Fernando Formaggio, Jeroen den Hertog, Simone Martinelli, Gianfranco Bocchinfuso, Marco Tartaglia & Lorenzo Stella. (2021) Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein–Protein Interactions. Journal of Medicinal Chemistry 64:21, pages 15973-15990.
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Cristina M. Rondinone, Ling-Mei Wang, Peter Lonnroth, Christian Wesslau, Jacalyn H. Pierce & Ulf Smith. (1997) Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences 94:8, pages 4171-4175.
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