Signaling Through Gp130: Toward a General Scenario of Cytokine Action

Toshiyuki Fukada Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Yuichi Yoshida Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Keigo Nishida Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Takuya Ohtani Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Takahiro Shirogane Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Masahiko Hibi Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, Japan

Toshio Hirano Division of Molecular Oncology (C7), Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Yamada-oka Suita, Osaka, 565-0871, JapanCorrespondence[email protected]

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Abstract

Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines. We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.

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Signaling Through Gp130: Toward a General Scenario of Cytokine Action

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