Citations (59)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (28)
Pierluigi Scalia, Stephen J Williams, Yoko Fujita-Yamaguchi & Antonio Giordano. (2023) Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation. Cell Cycle 22:1, pages 1-37.
Read now
Read now
Haim Werner, Rive Sarfstein & Ilan Bruchim. (2019) Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy. Expert Opinion on Investigational Drugs 28:12, pages 1101-1112.
Read now
Read now
Ilan Bruchim & Haim Werner. (2013) Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opinion on Therapeutic Targets 17:3, pages 307-320.
Read now
Read now
Cristina E Tognon & Poul HB Sorensen. (2012) Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opinion on Therapeutic Targets 16:1, pages 33-48.
Read now
Read now
Domenico Coppola, Abderrahman Ouban & Enid Gilbert-Barness. (2009) EXPRESSION OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR 1 DURING HUMAN EMBRYOGENESIS. Fetal and Pediatric Pathology 28:2, pages 47-54.
Read now
Read now
Colin R Lindsay & TR Jeffry Evans. (2008) The insulin-like growth factor system and its receptors: A potential novel anticancer target. Biologics: Targets and Therapy 2:4, pages 855-864.
Read now
Read now
John SP Yuen & Valentine M Macaulay. (2008) Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opinion on Therapeutic Targets 12:5, pages 589-603.
Read now
Read now
Maria C Shoshan & Stig Linder. (2008) Target specificity and off-target effects as determinants of cancer drug efficacy. Expert Opinion on Drug Metabolism & Toxicology 4:3, pages 273-280.
Read now
Read now
Jeffrey Way & Michael Super. (2008) The potential for cancer combination therapy with multi-targeted, single-protein pharmaceuticals. Expert Opinion on Drug Discovery 3:2, pages 147-152.
Read now
Read now
Francesco Frasca, Giuseppe Pandini, Laura Sciacca, Vincenzo Pezzino, Sebastiano Squatrito, Antonio Belfiore & Riccardo Vigneri. (2008) The role of insulin receptors and IGF-I receptors in cancer and other diseases. Archives of Physiology and Biochemistry 114:1, pages 23-37.
Read now
Read now
Patrick A. Kiely, Denise O'Gorman, Ken Luong, Dorit Ron & Rosemary O'Connor. (2006) Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and β1 Integrin To Promote Cell Migration. Molecular and Cellular Biology 26:11, pages 4041-4051.
Read now
Read now
Matthew J. Martin, Nataliya Melnyk, Michelle Pollard, Mary Bowden, Hon Leong, Thomas J. Podor, Martin Gleave & Poul H. B. Sorensen. (2006) The Insulin-Like Growth Factor I Receptor Is Required for Akt Activation and Suppression of Anoikis in Cells Transformed by the ETV6-NTRK3 Chimeric Tyrosine Kinase. Molecular and Cellular Biology 26:5, pages 1754-1769.
Read now
Read now
Renato Baserga. (2005) The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opinion on Therapeutic Targets 9:4, pages 753-768.
Read now
Read now
Constantine S Mitsiades & Nicholas Mitsiades. (2005) Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling. Expert Review of Anticancer Therapy 5:3, pages 487-499.
Read now
Read now
Hua Zhang & Douglas Yee. (2004) The therapeutic potential of agents targeting the type I insulin-like growth factor receptor. Expert Opinion on Investigational Drugs 13:12, pages 1569-1577.
Read now
Read now
Jennifer Wessells, Shoshana Yakar & Peter F. Johnson. (2004) Critical Prosurvival Roles for C/EBPβ and Insulin-Like Growth Factor I in Macrophage Tumor Cells. Molecular and Cellular Biology 24:8, pages 3238-3250.
Read now
Read now
Deirdre A. Buckley, Alan Cheng, Patrick A. Kiely, Michel L. Tremblay & Rosemary O'Connor. (2002) Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts. Molecular and Cellular Biology 22:7, pages 1998-2010.
Read now
Read now
Kaku Tsuruzoe, Renee Emkey, Kristina M. Kriauciunas, Kohjiro Ueki & C. Ronald Kahn. (2001) Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling. Molecular and Cellular Biology 21:1, pages 26-38.
Read now
Read now
Weiqun Li, Yi-Xing Jiang, Jiachang Zhang, Lilian Soon, Lawrence Flechner, Veena Kapoor, Jacalyn H. Pierce & Lu-Hai Wang. (1998) Protein Kinase C-δ Is an Important Signaling Molecule in Insulin-Like Growth Factor I Receptor-Mediated Cell Transformation. Molecular and Cellular Biology 18:10, pages 5888-5898.
Read now
Read now
Barbara Valentinis, Andrea Morrione, Stephen J. Taylor & Renato Baserga. (1997) Insulin-Like Growth Factor I Receptor Signaling in Transformation by src Oncogenes. Molecular and Cellular Biology 17:7, pages 3744-3754.
Read now
Read now
Jens C. Brüning, Jonathon Winnay, Bentley Cheatham & C. Ronald Kahn. (1997) Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells. Molecular and Cellular Biology 17:3, pages 1513-1521.
Read now
Read now
Marco Prisco, Atsushi Hongo, Maria Giulia Rizzo, Ada Sacchi & Renato Baserga. (1997) The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal. Molecular and Cellular Biology 17:3, pages 1084-1092.
Read now
Read now
Rosemary O’Connor, Andrea Kauffmann-Zeh, Yimao Liu, Sophie Lehar, Gerard I. Evan, Renato Baserga & Walter A. Blättler. (1997) Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis. Molecular and Cellular Biology 17:1, pages 427-435.
Read now
Read now
Chuanshu Huang, Wei-Ya Ma & Zigang Dong. (1996) Requirement for Phosphatidylinositol 3-Kinase in Epidermal Growth Factor-Induced AP-1 Transactivation and Transformation in JB6 P+ Cells. Molecular and Cellular Biology 16:11, pages 6427-6435.
Read now
Read now
Qinghua Xiong, Joseph L.-K. Chan, Cong S. Zong & Lu-Hai Wang. (1996) Two Chimeric Receptors of Epidermal Growth Factor Receptor and c-Ros That Differ in Their Transmembrane Domains Have Opposite Effects on Cell Growth. Molecular and Cellular Biology 16:4, pages 1509-1518.
Read now
Read now
Zhou-Li Fei, Consuelo D'Ambrosio, Shiwei Li, Ewa Surmacz & Renato Baserga. (1995) Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen. Molecular and Cellular Biology 15:8, pages 4232-4239.
Read now
Read now
Motoyoshi Sakaue, David Bowtell & Masato Kasuga. (1995) A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways. Molecular and Cellular Biology 15:1, pages 379-388.
Read now
Read now
Domenico Coppola, Andres Ferber, Masahiko Miura, Christian Sell, Consuelo D'Ambrosio, Raphael Rubin & Renato Baserga. (1994) A Functional Insulin-Like Growth Factor I Receptor Is Required for the Mitogenic and Transforming Activities of the Epidermal Growth Factor Receptor. Molecular and Cellular Biology 14:7, pages 4588-4595.
Read now
Read now
Articles from other publishers (31)
Haim Werner & Derek LeRoith. (2022) Hallmarks of cancer: The insulin-like growth factors perspective. Frontiers in Oncology 12.
Crossref
Crossref
Kaiwu zhang, Dengxiang Du & Wei Wang. (2022) Transcriptome Profiling of Different State Callus Induced from Immature Embryo in Maize. Journal of Chemistry 2022, pages 1-12.
Crossref
Crossref
Shee Chee Ong, Alessia Belgi, Allanah L. Merriman, Carlie A. Delaine, Bianca van Lierop, Sofianos Andrikopoulos, Andrea J. Robinson & Briony E. Forbes. (2022) Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond. Frontiers in Endocrinology 13.
Crossref
Crossref
Ferenc Sipos, Bettina Bohusné Barta, Ágnes Simon, Lőrinc Nagy, Titanilla Dankó, Regina Eszter Raffay, Gábor Petővári, Viktória Zsiros, Barnabás Wichmann, Anna Sebestyén & Györgyi Műzes. (2022) Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response. Pathology and Oncology Research 28.
Crossref
Crossref
Huiyuan Zheng, Hongchang Shen, Iulian Oprea, Claire Worrall, Radu Stefanescu, Ada Girnita & Leonard Girnita. (2012) β-Arrestin–biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor–targeting antibodies in Ewing’s sarcoma. Proceedings of the National Academy of Sciences 109:50, pages 20620-20625.
Crossref
Crossref
Woo-Young Kim, Quanri Jin, Seung-Hyun Oh, Edward S. Kim, Youn Joo Yang, Dong Hoon Lee, Lei Feng, Carmen Behrens, Ludmila Prudkin, York E. Miller, J. Jack Lee, Scott M. Lippman, Waun Ki Hong, Ignacio I. Wistuba & Ho-Young Lee. (2009) Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development. Cancer Research 69:18, pages 7439-7448.
Crossref
Crossref
Apostolos Klinakis, Matthias Szabolcs, Guoying Chen, Shouhong Xuan, Hanina Hibshoosh & Argiris Efstratiadis. (2009) Igf1r as a therapeutic target in a mouse model of basal-like breast cancer. Proceedings of the National Academy of Sciences 106:7, pages 2359-2364.
Crossref
Crossref
Beate C. Litzenburger, Hyun-Jung Kim, Isere Kuiatse, Joan M. Carboni, Ricardo M. Attar, Marco M. Gottardis, Craig R. Fairchild & Adrian V. Lee. (2009) BMS-536924 Reverses IGF-IR-Induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells. Clinical Cancer Research 15:1, pages 226-237.
Crossref
Crossref
Pei-Hsuan Chen & Chia-Ron Yang. (2008) Decoy Receptor 3 Expression in AsPC-1 Human Pancreatic Adenocarcinoma Cells via the Phosphatidylinositol 3-Kinase-, Akt-, and NF-κB-Dependent Pathway. The Journal of Immunology 181:12, pages 8441-8449.
Crossref
Crossref
Jennifer H. Law, Golareh Habibi, Kaiji Hu, Hamid Masoudi, Michelle Y.C. Wang, Anna L. Stratford, Eugene Park, Julia M.W. Gee, Pauline Finlay, Helen E. Jones, Robert I. Nicholson, Joan Carboni, Marco Gottardis, Michael Pollak & Sandra E. Dunn. (2008) Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival. Cancer Research 68:24, pages 10238-10246.
Crossref
Crossref
Meenali M. Chitnis, John S.P. Yuen, Andrew S. Protheroe, Michael Pollak & Valentine M. Macaulay. (2008) The Type 1 Insulin-Like Growth Factor Receptor Pathway. Clinical Cancer Research 14:20, pages 6364-6370.
Crossref
Crossref
Brent W. Sutherland, Sue E. Knoblaugh, Paula J. Kaplan-Lefko, Fen Wang, Martin Holzenberger & Norman M. Greenberg. (2008) Conditional Deletion of Insulin-like Growth Factor-I Receptor in Prostate Epithelium. Cancer Research 68:9, pages 3495-3504.
Crossref
Crossref
Ashok K. Chakraborty, Ke Liang & Michael P. DiGiovanna. (2008) Co-Targeting Insulin-Like Growth Factor I Receptor and HER2: Dramatic Effects of HER2 Inhibitors on Nonoverexpressing Breast Cancer. Cancer Research 68:5, pages 1538-1545.
Crossref
Crossref
Christopher J. Barnes, Kazufumi Ohshiro, Suresh K. Rayala, Adel K. El-Naggar & Rakesh Kumar. (2007) Insulin-like Growth Factor Receptor as a Therapeutic Target in Head and Neck Cancer. Clinical Cancer Research 13:14, pages 4291-4299.
Crossref
Crossref
Ming Li, Zhiwei He, Svetlana Ermakova, Duo Zheng, Faqing Tang, Yong-Yeon Cho, Feng Zhu, Wei-Ya Ma, Yuk Sham, Evgeny A. Rogozin, Ann M. Bode, Ya Cao & Zigang Dong. (2007) Direct Inhibition of Insulin-Like Growth Factor-I Receptor Kinase Activity by (−)−Epigallocatechin-3-Gallate Regulates Cell Transformation. Cancer Epidemiology, Biomarkers & Prevention 16:3, pages 598-605.
Crossref
Crossref
Deepali Sachdev & Douglas Yee. (2007) Disrupting insulin-like growth factor signaling as a potential cancer therapy. Molecular Cancer Therapeutics 6:1, pages 1-12.
Crossref
Crossref
Giada Monami, Eva M. Gonzalez, Michelle Hellman, Leonard G. Gomella, Raffaele Baffa, Renato V. Iozzo & Andrea Morrione. (2006) Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex. Cancer Research 66:14, pages 7103-7110.
Crossref
Crossref
Susan L. Spence, Arthur L. Shaffer, Louis M. Staudt, Sewit Amde, Sutana Manney, Cheryl Terry, Keith Weisz & Peter Nissley. (2006) Transformation of Late Passage Insulin-Like Growth Factor-I Receptor Null Mouse Embryo Fibroblasts by SV40 T Antigen. Cancer Research 66:8, pages 4233-4239.
Crossref
Crossref
T DeAngelis, J Chen, A Wu, M Prisco & R Baserga. (2005) Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling. Oncogene 25:1, pages 32-42.
Crossref
Crossref
Gary Loughran, Merei Huigsloot, Patrick A Kiely, Loraine M Smith, Suzanne Floyd, Veronica Ayllon & Rosemary O'Connor. (2005) Gene expression profiles in cells transformed by overexpression of the IGF-I receptor. Oncogene 24:40, pages 6185-6193.
Crossref
Crossref
Yan Wang, Judith Hailey, Denise Williams, Yaolin Wang, Philip Lipari, Michael Malkowski, Xiaoying Wang, Lei Xie, Guanghua Li, Deba Saha, Wai Lam W. Ling, Susan Cannon-Carlson, Robert Greenberg, Robert A. Ramos, Robert Shields, Leonard Presta, Peter Brams, W. Robert Bishop & Jonathan A. Pachter. (2005) Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti–IGF-IR antibody. Molecular Cancer Therapeutics 4:8, pages 1214-1221.
Crossref
Crossref
Hira Lal Goel, Michael Breen, Jianzhong Zhang, Ishita Das, Sadie Aznavoorian-Cheshire, Norman M. Greenberg, Ada Elgavish & Lucia R. Languino. (2005) β1A Integrin Expression Is Required for Type 1 Insulin-Like Growth Factor Receptor Mitogenic and Transforming Activities and Localization to Focal Contacts. Cancer Research 65:15, pages 6692-6700.
Crossref
Crossref
Ricardo López de Cicco, Daniel E. Bassi, Stanley Zucker, Nabil G. Seidah & Andrés J.P. Klein-Szanto. (2005) Human Carcinoma Cell Growth and Invasiveness Is Impaired by the Propeptide of the Ubiquitous Proprotein Convertase Furin. Cancer Research 65:10, pages 4162-4171.
Crossref
Crossref
Yasir H. Ibrahim & Douglas Yee. (2005) Insulin-Like Growth Factor-I and Breast Cancer Therapy. Clinical Cancer Research 11:2, pages 944s-950s.
Crossref
Crossref
Arianna Maiorana, Xiao Tu, Guanjun Cheng & Renato Baserga. (2004) Role of pescadillo in the transformation and immortalization of mammalian cells. Oncogene 23:42, pages 7116-7124.
Crossref
Crossref
Renato Baserga. (2000) The contradictions of the insulin-like growth factor 1 receptor. Oncogene 19:49, pages 5574-5581.
Crossref
Crossref
Martin P. Playford, David Bicknell, Walter F. Bodmer & Valentine M. Macaulay. (2000) Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin. Proceedings of the National Academy of Sciences 97:22, pages 12103-12108.
Crossref
Crossref
Maria Eugenia Balañá, Ruth Lupu, Leticia Labriola, Eduardo H Charreau & Patricia V Elizalde. (1999) Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas. Oncogene 18:46, pages 6370-6379.
Crossref
Crossref
O. O. Adesanya, J. Zhou, C. Samathanam, L. Powell-Braxton & C. A. Bondy. (1999)
Insulin-like growth factor 1 is required for G
2
progression in the estradiol-induced mitotic cycle
. Proceedings of the National Academy of Sciences 96:6, pages 3287-3291.
Crossref
Crossref
Andrea Morrione, Barbara Valentinis, Shi-qiong Xu, Gladys Yumet, Angeliki Louvi, Argiris Efstratiadis & Renato Baserga. (1997) Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proceedings of the National Academy of Sciences 94:8, pages 3777-3782.
Crossref
Crossref
Daniela Drummond-Barbosa & Daniel DiMaio. (1997) Virocrine transformation. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1332:1, pages M1-M17.
Crossref
Crossref