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Cell Growth and Development

Effect of a Null Mutation of the Insulin-Like Growth Factor I Receptor Gene on Growth and Transformation of Mouse Embryo Fibroblasts

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Pages 3604-3612 | Received 29 Dec 1993, Accepted 01 Mar 1994, Published online: 30 Mar 2023

REFERENCES

  • Aaronson, S. 1991. Growth factors and cancer. Science 254: 1146–1153.
  • Ando, K., F. Ajchenbaum-Cymbalista, and J. D. Griffin. 1993. Regulation of G/l/S transition by cyclins D2 and D3 in hematopoietic cells. Proc. Natl. Acad. Sci. USA 90: 9571–9575.
  • Baker, J., J. P. Liu, E. J. Robertson, and A. Efstratiadis. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75: 73–82.
  • Baltensperger, K., L. M. Kozma, A. D. Cherniack, J. K. Klarlund, A. Chawla, U. Banerjee, and M. P. Czech. 1993. Binding of the ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science 260: 1950–1952.
  • Baserga, R. 1985. The biology of cell reproduction. Harvard University Press, Cambridge, Mass.
  • Baserga, R. 1993. The double life of the IGF-1 receptor. Receptor 2: 261–266.
  • Baserga, R., and R. Rubin. 1993. Cell cycle and growth control. Crit. Rev. Eukaryotic Gene Expression 3: 47–61.
  • Baserga, R., C. Sell, P. L. Porcu, and M. Rubini. 1994. The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell. Prolif. 27: 63–71.
  • Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat. 1993. Protein kinase zeta isoform is critical for mitogenic signal transduction. Cell 74: 555–563.
  • Brown, P. H., R. Alani, L. H. Preis, E. Szabo, and M. J. Birrer. 1993. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 8: 877–886.
  • Cai, H., P. Erhardt, J. Szeberenyi, M. T. Diaz-Meco, T. Johansen, J. Moscat, and G. M. Cooper. 1992. Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Mol. Cell. Biol. 12: 5329–5335.
  • Campisi, J., and A. B. Pardee. 1984. Posttranscriptional control of the onset of DNA synthesis by an insulin-like growth factor. Mol. Cell. Biol. 4: 1807–1814.
  • Carpenter, G. 1992. Receptor tyrosine kinase substrates: src homology domains and signal transduction. FASEB J. 6: 3283–3289.
  • Cristofalo, V. J., P. D. Phillips, T. Sorger, and G. Gerhard. 1989. Alterations in the responsiveness of senescent cells to growth factors. J. Gerontol. 44: 55–62.
  • DeChiara, T. M., A. Efstradiatis, and E. J. Robertson. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (London) 345: 78–80.
  • Divecha, N., H. Banfic, and R. F. Irvine. 1993. Inositides and the nucleus and inositides in the nucleus. Cell 74: 405–407.
  • Drummond, I. A., S. L. Madden, P. Rohwer-Nutter, G. I. Bell, V. P. Sukhatme, and F. J. RauscherIII. 1992. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science 257: 674–678.
  • Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (London) 363: 45–51.
  • Egan, S. E., and R. A. Weinberg. 1993. The pathway to signal achievement. Nature (London) 365: 781–783.
  • Falco, J. P., W. G. Taylor, P. P. DiFiore, B. E. Weissman, and S. A. Aaronson. 1988. Interaction of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes. Oncogene 2: 573–578.
  • Fantl, W. J., D. E. Johnson, and L. T. Williams. 1993. Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62: 435–481.
  • Gai, X. X., M. G. Rizzo, J. Lee, A. Ullrich, and R. Baserga. 1988. Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and IGF-1 gene. Oncogene Res. 3: 377–386.
  • Geffner, M. E., R. C. Bailey, N. Bersch, J. C. Vera, and D. W. Golde. 1993. Insulin-like growth factor I unresponsiveness in an EFE pigmy. Biochem. Biophys. Res. Commun. 193: 1216–1223.
  • Goldring, M. B., and S. R. Goldring. 1991. Cytokines and cell growth control. Eukaryotic Gene Expression 1: 301–326.
  • Gritz, L., and J. Davies. 1983. Plasmid-encoded hygromycin B resistance: the sequence of hygromycin phosphotransferase and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene 25: 179–188.
  • Kaleko, M., W. G. Rutter, and A. D. Miller. 1990. Overexpression of the human insulin-like growth factor 1 receptor promotes ligand-dependent neoplastic transformation. Mol. Cell. Biol. 10: 464–473.
  • Kato, H., T. N. Faria, B. Stannard, C. T. RobertsJr., and D. LeRoith. 1993. Role of the tyrosine kinase domain in signal transduction by the insulin-like growth factor 1 IGF-1 receptor. J. Biol. Chem. 268: 2655–2661.
  • Lammers, R., E. Van Obberghen, R. Balloti, J. Schlessinger, and A. Ullrich. 1990. Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation. J. Biol. Chem. 265: 16886–16890.
  • Leof, E. B., R. M. Lyons, M. R. Cunningham, and D. O'suIlivan. 1989. Mid-G/1 arrest and epidermal growth factor independence of ras-transfected mouse cells. Cancer Res. 49: 2356–2361.
  • Leof, E. B., W. Wharton, J. J. Van Wyk, and W. J. Pledger. 1982. Epidermal growth factor EGF and somatomedin C regulated G, progression in competent BALB/c3T3 cells. Exp. Cell Res. 141: 107–115.
  • Li, N., A. Batzer, R. Daly, V. Yajnik, E. Skolnik, P. Chardin, D. Bar-Sagi, B. Margolis, and J. Schlessinger. 1993. Guanine-nucle-otide-releasing factor hSosl binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (London) 363: 85–88.
  • Liu, J. P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igflr). Cell 75: 59–72.
  • Lowe, W. L.Jr.. 1991. Biological actions of the insulin-like growth factors, p. 49–85. In D. LeRoith (ed.), Insulin-like growth factors: molecular and cellular aspects. CRC Press, Boca Raton, Fla.
  • Lu, K., R. A. Levine, and J. Campisi. 1989. c-ras-Ha gene expression is regulated by insulin or insulin-like growth factor and by epidermal growth factor in murine fibroblasts. Mol. Cell. Biol. 9: 3411–3417.
  • Macaulay, V. M. 1992. Insulin-like growth factors and cancer. Br. J. Cancer 65: 311–320.
  • Matuoka, K., F. Shibasaki, M. Shibata, and T. Takenawa. 1993. Ash/Grb2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J. 12: 3467–3473.
  • McCormick, F. 1993. How receptors turn Ras on. Nature (London) 363: 15–16.
  • Medema, R. H., and J. L. Bos. 1993. The role of p21 ras in receptor tyrosine kinase signaling. Crit. Rev. Oncogenes 4: 615–661.
  • Medema, R. H., R. Wubbolts, and J. L. Bos. 1991. Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression. Mol. Cell. Biol. 11: 5963–5967.
  • Nigg, E. A. 1993. Cellular substrates of the p34/cdc2 and its companion cyclin-dependent kinases. Trends Cell Biol. 3: 296–301.
  • Ohtsubo, M., and J. M. Roberts. 1993. Cyclin-dependent regulation of G/l in mammalian fibroblasts. Science 259: 1908–1912.
  • Panayotou, G., and M. D. Waterfield. 1993. The assembly of signalling complexes by receptor tyrosine kinases. Bioessays 15: 171–177.
  • Pietrzkowski, Z., R. Lammers, G. Carpenter, A. M. Soderquist, M. Limardo, P. D. Phillips, A. Ullrich, and R. Baserga. 1992. Constitutive expression of IGF-1 and IGF-1 receptor abrogates all requirements for exogenous growth factors. Cell Growth Differ. 3: 199–205.
  • Pietrzkowski, Z., G. Mulholland, L. Gomella, B. A. Jameson, D. Wernicke, and R. Baserga. 1993. Inhibition of growth of prostatic cancer cell lines by peptide analogs of IGF-1. Cancer Res. 53: 1102–1106.
  • Pietrzkowski, Z., D. Wernicke, P. Porcu, B. A. Jameson, and R. Baserga. 1992. Inhibition of cell proliferation by peptide analogs of IGF-1. Cancer Res. 52: 6447–6451.
  • Ponten, J. 1971. Spontaneous and virus induced transformation in cell culture. Springer-Verlag, New York.
  • Porcu, P., A. Ferber, Z. Pietrzkowski, C. T. Roberts, M. Adamo, D. LeRoith, and R. Baserga. 1992. The growth stimulatory effect of simian virus 40 T antigen requires the interaction of insulin-like growth factor I with its receptor. Mol. Cell. Biol. 12: 3883–3889.
  • Quelle, D. E., R. A. Ashmun, S. A. Shurtleff, J. Kato, D. Bar-Sagi, M. F. Roussel, and C. J. Sherr. 1993. Overexpression of mouse D-type cyclins accelerates G/l phase in rodent fibroblasts. Genes Dev. 7: 1559–1571.
  • Reiss, K., P. Porcu, C. Sell, Z. Pietrzkowski, and R. Baserga. 1992. The insulin-like growth factor 1 receptor is required for the proliferation of hemopoietic cells. Oncogene 7: 2243–2248.
  • Resnicoff, M. et al. Submitted for publication.
  • Rozakis-Adcock, M., R. Fernley, J. Wade, T. Pawson, and D. Bowtell. 1993. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSosl. Nature (London) 363: 83–85.
  • Russell, W. E., J. J. Van Wyk, and W. J. Pledger. 1984. Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin-C. Proc. Natl. Acad. Sci. USA 81: 2389–2392.
  • Sara, V. R., and K. Hall. 1990. Insulin-like growth factors and their binding proteins. Physiol. Rev. 70: 591–614.
  • Scher, C. D., R. C. Shephard, H. N. Antoniades, and C. D. Stiles. 1979. Platelet derived growth factor and the regulation of the mammalian fibroblasts cell cycles. Biochim. Biophys. Acta 560: 217–241.
  • Sell, C., M. Rubini, R. Rubin, J. P. Liu, A. Efstratiadis, and R. Baserga. 1993. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type-1 IGF receptor. Proc. Natl. Acad. Sci. USA 90: 11217–11221.
  • Skolnik, E. Y., A. Batzer, N. Li, C. H. Lee, E. Lowenstein, M. Mohammadi, B. Margolis, and J. Schlessinger. 1993. The function of Grb2 in linking the insulin receptor to ras signaling pathways. Science 260: 1953–1955.
  • Smith, M. R., S. J. DeGudicibus, and D. W. Stacey. 1986. Requirement for c-ras proteins during viral oncogene transformation. Nature (London) 320: 540–543.
  • Stiles, C. D., G. T. Capone, C. D. Scher, N. H. Antoniades, J. J. Van Wyk, and W. J. Pledger. 1979. Dual control of cell growth by somatomedins and platelet derived growth factor. Proc. Natl. Acad. Sci. USA 76: 1279–1283.
  • Surmacz, E., P. Nugent, Z. Pietrzkowski, and R. Baserga. 1992. The role of the IGF-I receptor in the regulation of cdc2 mRNA levels in fibroblasts. Exp. Cell Res. 199: 275–278.
  • Surmacz, E., K. Reiss, C. Sell, and R. Baserga. 1992. Cyclin Dl messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts. Cancer Res. 52: 4522–4525.
  • Tobe, K., K. Matuoka, H. Tamemoto, K. Ueki, Y. Kaburagi, S. Asai, T. Noguchi, M. Matsuda, S. Tanaka, S. Hattori, Y. Fukui, Y. Akanuma, Y. Yazaki, T. Takenawa, and T. Kadowaki. 1993. Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. J. Biol. Chem. 268: 11167–11171.
  • Ullrich, A., A. W. Gray, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. LeBon, S. Katchuria, E. Chen, S. Jacobs, D. Francke, J. Ramachandran, and Y. Fujita-Yamaguchi. 1986. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5: 2503–2512.
  • Valentinis, B., P. L. Porcu, K. Quinn, and R. Baserga. The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. Oncogene 9: 825–831.
  • Vara, J. A., A. Portela, and A. Jimenez. 1986. Expression in mammalian cells of a gene from Streptomyces alboniger conferring puromycin resistance. Nucleic Acids Res. 14: 4617–4624.
  • Waters, S. B., K. Yamauchi, and J. E. Pessin. 1993. Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. J. Biol. Chem. 268: 22231–22234.
  • Werner, H., M. Woloschak, B. Stannard, Z. Shen-Orr, C. T. RobertsJr., and D. LeRoith. 1991. The insulin-like growth factor 1 receptor: molecular biology, heterogeneity, and regulation, p. 17–47. In D. LeRoith (ed.), Insulin-like growth factors: molecular and cellular aspects. CRC Press, Boca Raton, Fla.
  • Wharton, W., and M. Smyth. 1989. Growth and maintenance of Balb/c 3T3 cells, p. 139–153. In R. Baserga (ed.), Cell growth and division: a practical approach. IRL Press, Oxford.
  • Yamada, H., T. Omata-Yamada, N. Wakabayashi-Ito, S. G. Carter, and P. Lengyel. 1990. Isolation of recessive (mediator-) revertants from NIH 3T3 cells transformed with a c-Ha-ras oncogene. Mol. Cell. Biol. 10: 1822–1827.
  • Yoshinouchi, M., and R. Baserga. 1993. The role of the IGF-I receptor in the stimulation of cells by short pulses of growth factors. Cell. Prolif. 26: 139–146.

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