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Cell Growth and Development

Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor

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Pages 5192-5201 | Received 01 Feb 1994, Accepted 05 May 1994, Published online: 30 Mar 2023

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Seandean Lykke Harwood, Ana Alvarez-Cienfuegos, Natalia Nuñez-Prado, Marta Compte, Sara Hernández-Pérez, Nekane Merino, Jaume Bonet, Rocio Navarro, Paul M. P. Van Bergen en Henegouwen, Simon Lykkemark, Kasper Mikkelsen, Kasper Mølgaard, Frederic Jabs, Laura Sanz, Francisco J. Blanco, Pedro Roda-Navarro & Luis Alvarez-Vallina. (2018) ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy. OncoImmunology 7:1.
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Kei-ichiro Arimoto, Christoph Burkart, Ming Yan, Dan Ran, Stephanie Weng & Dong-Er Zhang. (2014) Plakophilin-2 Promotes Tumor Development by Enhancing Ligand-Dependent and -Independent Epidermal Growth Factor Receptor Dimerization and Activation. Molecular and Cellular Biology 34:20, pages 3843-3854.
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John G Shelton, Linda S Steelman, Steve L Abrams, Fred E Bertrand, Richard A Franklin, Martin McMahon & James A McCubrey. (2005) The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what’s genetics got to do with it?. Expert Opinion on Therapeutic Targets 9:5, pages 1009-1030.
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Heather M. Bill, Beatrice Knudsen, Sheri L. Moores, Senthil K. Muthuswamy, Vikram R. Rao, Joan S. Brugge & Cindy K. Miranti. (2004) Epidermal Growth Factor Receptor-Dependent Regulation of Integrin-Mediated Signaling and Cell Cycle Entry in Epithelial Cells. Molecular and Cellular Biology 24:19, pages 8586-8599.
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Betty Lamothe, Masashi Yamada, Ute Schaeper, Walter Birchmeier, Irit Lax & Joseph Schlessinger. (2004) The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway. Molecular and Cellular Biology 24:13, pages 5657-5666.
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Mihail S. Iordanov, Remy J. Choi, Olga P. Ryabinina, Thanh-Hoai Dinh, Robert K. Bright & Bruce E. Magun. (2002) The UV (Ribotoxic) Stress Response of Human Keratinocytes Involves the Unexpected Uncoupling of the Ras-Extracellular Signal-Regulated Kinase Signaling Cascade from the Activated Epidermal Growth Factor Receptor. Molecular and Cellular Biology 22:15, pages 5380-5394.
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Matthew Wheeler & Jan Domin. (2001) Recruitment of the Class II Phosphoinositide 3-Kinase C2β to the Epidermal Growth Factor Receptor: Role of Grb2. Molecular and Cellular Biology 21:19, pages 6660-6667.
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Gerard A. Rodrigues, Marco Falasca, Zhongtao Zhang, Siew Hwa Ong & Joseph Schlessinger. (2000) A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling. Molecular and Cellular Biology 20:4, pages 1448-1459.
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J. Andreev, J.-P. Simon, D. D. Sabatini, J. Kam, G. Plowman, P. A. Randazzo & J. Schlessinger. (1999) Identification of a New Pyk2 Target Protein with Arf-GAP Activity. Molecular and Cellular Biology 19:3, pages 2338-2350.
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Y. R. Hadari, H. Kouhara, I. Lax & J. Schlessinger. (1998) Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation. Molecular and Cellular Biology 18:7, pages 3966-3973.
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Tony Tiganis, Anton M. Bennett, Kodimangalam S. Ravichandran & Nicholas K. Tonks. (1998) Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase. Molecular and Cellular Biology 18:3, pages 1622-1634.
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Xiaolan Qian, William C. Vass, Alex G. Papageorge, Pieter H. Anborgh & Douglas R. Lowy. (1998) N Terminus of Sos1 Ras Exchange Factor: Critical Roles for the Dbl and Pleckstrin Homology Domains. Molecular and Cellular Biology 18:2, pages 771-778.
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David L. Dankort, Zhixiang Wang, Valerie Blackmore, Michael F. Moran & William J. Muller. (1997) Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation. Molecular and Cellular Biology 17:9, pages 5410-5425.
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Peter van der Geer, Mark Henkemeyer, Yler Jacks & Tony Pawson. (1997) Aberrant Ras Regulation and Reduced p190 Tyrosine Phosphorylation in Cells Lacking p120-Gap. Molecular and Cellular Biology 17:4, pages 1840-1847.
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Jean-Paul Borg, James Ooi, Efrat Levy & Ben Margolis. (1996) The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein. Molecular and Cellular Biology 16:11, pages 6229-6241.
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M. Mohammadi, I. Dikic, A. Sorokin, W. H. Burgess, M. Jaye & J. Schlessinger. (1996) Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction. Molecular and Cellular Biology 16:3, pages 977-989.
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Vered Ribon, Susan Hubbell, Roman Herrera & Alan R. Saltiel. (1996) The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner. Molecular and Cellular Biology 16:1, pages 45-52.
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Douglas W. Leaman, Sobha Pisharody, Thomas W. Flickinger, Mairead A. Commane, Joseph Schlessinger, Ian M. Kerr, David E. Levy & George R. Stark. (1996) Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor. Molecular and Cellular Biology 16:1, pages 369-375.
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Ka-Man Venus Lai, Jean Paul Olivier, Gerald D. Gish, Mark Henkemeyer, Jane Mcglade & Tony Pawson. (1995) A Drosophila shc Gene Product Is Implicated in Signaling by the DER Receptor Tyrosine Kinase. Molecular and Cellular Biology 15:9, pages 4810-4818.
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A. G. Batzer, P. Blaikie, K. Nelson, J. Schlessinger & B. Margolis. (1995) The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor. Molecular and Cellular Biology 15:8, pages 4403-4409.
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Herman Meisner, Bruce R. Conway, David Hartley & Michael P. Czech. (1995) Interactions of Cbl with Grb2 and Phosphatidylinositol 3′-Kinase in Activated Jurkat Cells. Molecular and Cellular Biology 15:7, pages 3571-3578.
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Michael D. Schaller & J. Thomas Parsons. (1995) pp125FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk. Molecular and Cellular Biology 15:5, pages 2635-2645.
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Thomas A. Gustafson, Weimin He, Ann Craparo, Charles D. Schaub & Thomas J. O'Neill. (1995) Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain. Molecular and Cellular Biology 15:5, pages 2500-2508.
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Diana Graus-Porta, Roger R. Beerli & Nancy E. Hynes. (1995) Single-Chain Antibody-Mediated Intracellular Retention of ErbB-2 Impairs Neu Differentiation Factor and Epidermal Growth Factor Signaling. Molecular and Cellular Biology 15:3, pages 1182-1191.
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