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Molecular and Cellular Biology Volume 14, 1994 - Issue 8
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Transcriptional Regulation

PEBP2/CBF, the Murine Homolog of the Human Myeloid AML1 and PEBP2β/CBFβ Proto-oncoproteins, Regulates the Murine Myeloperoxidase and Neutrophil Elastase Genes in Immature Myeloid Cells

Issarang Nuchprayoon1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland21287
,
Shari Meyers2 Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee38105
,
Linda M. Scott1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland21287
,
Joseph Suzow1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland21287
,
Scott Hiebert2 Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee38105
&
Alan D. Friedman1 Division of Pediatric Oncology, The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland21287
Pages 5558-5568 | Received 08 Feb 1994, Accepted 05 May 1994, Published online: 30 Mar 2023

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Miyuki Obata, Seiji Tsutsumi, Satoshi Makino, Kanako Takahashi, Norikazu Watanabe, Takayuki Yoshida, Gen Tamiya & Hirohisa Kurachi. (2015) Whole-exome sequencing confirmation of a novel heterozygous mutation in RUNX1 in a pregnant woman with platelet disorder. Platelets 26:4, pages 364-369.
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Francesca Buchi, Erico Masala, Alessia Rossi, Ana Valencia, Elena Spinelli, Alessandro Sanna, Antonella Gozzini & Valeria Santini. (2014) Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target gene IL3. Epigenetics 9:3, pages 387-395.
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Yoichi Imai, Mineo Kurokawa, Yuko Yamaguchi, Koji Izutsu, Eriko Nitta, Kinuko Mitani, Masanobu Satake, Tetsuo Noda, Yoshiaki Ito & Hisamaru Hirai. (2004) The Corepressor mSin3A Regulates Phosphorylation-Induced Activation, Intranuclear Location, and Stability of AML1. Molecular and Cellular Biology 24:3, pages 1033-1043.
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Kristie L. Durst, Bart Lutterbach, Tanawan Kummalue, Alan D. Friedman & Scott W. Hiebert. (2003) The inv(16) Fusion Protein Associates with Corepressors via a Smooth Muscle Myosin Heavy-Chain Domain. Molecular and Cellular Biology 23:2, pages 607-619.
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Joëlle Michaud, Hamish S. Scott & Robert Escher. (2003) AML1 Interconnected Pathways of Leukemogenesis. Cancer Investigation 21:1, pages 105-136.
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Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. van Wijnen, Je-Y. Choi, Jitesh Pratap & S. Kaleem Zaidi. (2003) Temporal and Spatial Parameters of Skeletal Gene Expression: Targeting RUNX Factors and their Coregulatory Proteins to Subnuclear Domains. Connective Tissue Research 44:1, pages 149-153.
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Tanawan Kummalue, Jianrong Lou & Alan D. Friedman. (2002) Multimerization via Its Myosin Domain Facilitates Nuclear Localization and Inhibition of Core Binding Factor (CBF) Activities by the CBFβ-Smooth Muscle Myosin Heavy Chain Myeloid Leukemia Oncoprotein. Molecular and Cellular Biology 22:23, pages 8278-8291.
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Katherine R. Calvo, David B. Sykes, Martina Pasillas & Mark P. Kamps. (2000) Hoxa9 Immortalizes a Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Promyelocyte Capable of Biphenotypic Differentiation to Neutrophils or Macrophages, Independent of Enforced Meis Expression. Molecular and Cellular Biology 20:9, pages 3274-3285.
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Jürgen Krauter, Gerhard Heil & Arnold Ganser. (2000) The AML1/MTG8 Fusion Transcript in t(8;21) Positive AML and its Implication for the Detection of Minimal Residual Disease. Hematology 5:5, pages 369-381.
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Shifeng Mao, Richard C. Frank, Jin Zhang, Yasushi Miyazaki & Stephen D. Nimer. (1999) Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias. Molecular and Cellular Biology 19:5, pages 3635-3644.
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Vania Gelmetti, Jinsong Zhang, Mirco Fanelli, Saverio Minucci, Pier Giuseppe Pelicci & Mitchell A. Lazar. (1998) Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO. Molecular and Cellular Biology 18:12, pages 7185-7191.
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Batu Erman, Marta Cortes, Barbara S. Nikolajczyk, Nancy A. Speck & Ranjan Sen. (1998) ETS-Core Binding Factor: a Common Composite Motif in Antigen Receptor Gene Enhancers. Molecular and Cellular Biology 18:3, pages 1322-1330.
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Issay Kitabayashi, Kohmei Ida, Fumiko Morohoshi, Akihiko Yokoyama, Naoko Mitsuhashi, Kimiko Shimizu, Nobuo Nomura, Yasuhide Hayashi & Misao Ohki. (1998) The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1. Molecular and Cellular Biology 18:2, pages 846-858.
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Nyla A. Heerema. (1998) Cytogenetics of Leukemia. Cancer Investigation 16:2, pages 127-134.
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Jennifer J. Westendorf, Cindy M. Yamamoto, Noel Lenny, James R. Downing, Michael E. Selsted & Scott W. Hiebert. (1998) The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation. Molecular and Cellular Biology 18:1, pages 322-333.
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Martin Britos-Bray & Alan D. Friedman. (1997) Core Binding Factor Cannot Synergistically Activate the Myeloperoxidase Proximal Enhancer in Immature Myeloid Cells without c-Myb. Molecular and Cellular Biology 17:9, pages 5127-5135.
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Yu-Wen Zhang, Suk-Chul Bae, Gang Huang, Yang-Xin Fu, Jie Lu, Mee-Young Ahn, Yuka Kanno, Tomohiko Kanno & Yoshiaki Ito. (1997) A Novel Transcript Encoding an N-Terminally Truncated AML1/PEBP2αB Protein Interferes with Transactivation and Blocks Granulocytic Differentiation of 32Dcl3 Myeloid Cells. Molecular and Cellular Biology 17:7, pages 4133-4145.
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Hirofumi Kobayashi, Noriko Satake & Yasuhiko Kaneko. (1997) Detection of the Der (21)t(12;21) Chromosome Forming the TEL-AML1 Fusion Gene in Childhood Acute Lymphoblastic Leukemia. Leukemia & Lymphoma 28:1-2, pages 43-50.
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Michael Oelgeschläger, Issarang Nuchprayoon, Bernhard Lüscher & Alan D. Friedman. (1996) C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter. Molecular and Cellular Biology 16:9, pages 4717-4725.
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Tomoyuki Tanaka, Mineo Kurokawa, Kohjiro Ueki, Kozo Tanaka, Yoichi Imai, Kinuko Mitani, Kenji Okazaki, Noriyuki Sagata, Yoshio Yazaki, Yoichi Shibata, Takashi Kadowaki & Hisamaru Hirai. (1996) The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability. Molecular and Cellular Biology 16:7, pages 3967-3979.
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Dong-Er Zhang, Christopher J. Hetherington, Shari Meyers, Kristina L. Rhoades, Christopher J. Larson, Hui-Min Chen, Scott W. Hiebert & Daniel G. Tenen. (1996) CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter. Molecular and Cellular Biology 16:3, pages 1231-1240.
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Patricia Ducy, ValéRie Geoffroy & GéRard Karsenty. (1996) Study of Osteoblast-Specific Expression of One Mouse Osteocalcin Gene: Characterization of the Factor Binding to OSE2. Connective Tissue Research 35:1-4, pages 7-14.
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Michael Oelgeschläger, Joachim Krieg, Juliane M. Lüscher-Firzlaff & Bernhard Lüscher. (1995) Casein Kinase II Phosphorylation Site Mutations in c-Myb Affect DNA Binding and Transcriptional Cooperativity with NF-M. Molecular and Cellular Biology 15:11, pages 5966-5974.
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Stefan Hohaus, Martha S. Petrovick, Maria Teresa Voso, Zijie Sun, Dong-Er Zhang & Daniel G. Tenen. (1995) PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene. Molecular and Cellular Biology 15:10, pages 5830-5845.
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Amitav Hajra, P. Paul Liu, Nancy A. Speck & Francis S. Collins. (1995) Overexpression of Core-Binding Factor α (CBFα) Reverses Cellular Transformation by the CBFβ-Smooth Muscle Myosin Heavy Chain Chimeric Oncoprotein. Molecular and Cellular Biology 15:9, pages 4980-4989.
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Cristina Hernandez-Munain & Michael S. Krangel. (1995) c-Myb and Core-Binding Factor/PEBP2 Display Functional Synergy but Bind Independently to Adjacent Sites in the T-Cell Receptor δ Enhancer. Molecular and Cellular Biology 15:6, pages 3090-3099.
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Shari Meyers, Noel Lenny & Scott W. Hiebert. (1995) The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation. Molecular and Cellular Biology 15:4, pages 1974-1982.
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Dong-Er Zhang, Ken-Ichiro Fujioka, Christopher J. Hetherington, Linda H. Shapiro, Hui-Min Chen, A. Thomas Look & Daniel G. Tenen. (1994) Identification of a Region Which Directs the Monocytic Activity of the Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating Factor) Receptor Promoter and Binds PEBP2/CBF (AML1). Molecular and Cellular Biology 14:12, pages 8085-8095.
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J Lausen, S Liu, M Fliegauf, M Lübbert & M H Werner. (2005) ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene 25:9, pages 1349-1357.
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Joseph R. Biggs, Youhong Zhang, Luke F. Peterson, Marileila Garcia, Dong-Er Zhang & Andrew S. Kraft. (2005) Phosphorylation of AML1/RUNX1 Regulates Its Degradation and Nuclear Matrix Association. Molecular Cancer Research 3:7, pages 391-401.
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Manfred Fliegauf, Michael Stock, Tobias Berg & Michael Lübbert. (2004) Williams–Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO. Oncogene 23:56, pages 9070-9081.
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Gary S Stein, Jane B Lian, Andre J van Wijnen, Janet L Stein, Martin Montecino, Amjad Javed, Sayyed K Zaidi, Daniel W Young, Je-Yong Choi & Shirwin M Pockwinse. (2004) Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23:24, pages 4315-4329.
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Rebecca Cleaves, Qian-fei Wang & Alan D Friedman. (2004) C/EBPαp30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site-selective inhibition of C/EBP DNA binding. Oncogene 23:3, pages 716-725.
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Alan D Friedman. (2002) Transcriptional regulation of granulocyte and monocyte development. Oncogene 21:21, pages 3377-3390.
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Joseph M Scandura, Piernicola Boccuni, Jorg Cammenga & Stephen D Nimer. (2002) Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21:21, pages 3422-3444.
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Florence Bernardin & Alan D Friedman. (2002) AML1 stimulates G1 to S progression via its transactivation domain. Oncogene 21:20, pages 3247-3252.
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Jonathan D Licht. (2001) AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:40, pages 5660-5679.
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Victor I Sementchenko & Dennis K Watson. (2001) Ets target genes: past, present and future. Oncogene 19:55, pages 6533-6548.
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Jianrong Lou, Wangsen Cao, Florence Bernardin, Kasirajan Ayyanathan, Frank J Rauscher & Alan D Friedman. (2000) Exogenous cdk4 overcomes reducedcdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF – a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 19:22, pages 2695-2703.
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Amy F. Lewis, Terryl Stacy, William R. Green, Lekidelu Taddesse-Heath, Janet W. Hartley & Nancy A. Speck. (1999) Core-Binding Factor Influences the Disease Specificity of Moloney Murine Leukemia Virus. Journal of Virology 73:7, pages 5535-5547.
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Scott C. KoganEric LagasseSusan AtwaterSuk-chul BaeIrving WeissmanYoshiaki ItoJ. Michael Bishop. (1998) The PEBP2 β MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia . Proceedings of the National Academy of Sciences 95:20, pages 11863-11868.
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Corinne Barat & Eric Rassart. (1998) Members of the GATA Family of Transcription Factors Bind to the U3 Region of Cas-Br-E and Graffi Retroviruses and Transactivate Their Expression. Journal of Virology 72:7, pages 5579-5588.
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Ari L. Zaiman, Angel Nieves & Jack Lenz. (1998) CBF, Myb, and Ets Binding Sites Are Important for Activity of the Core I Element of the Murine Retrovirus SL3-3 in T Lymphocytes. Journal of Virology 72:4, pages 3129-3137.
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Congmei Zeng, André J. van Wijnen, Janet L. Stein, Shari Meyers, Wuhua Sun, Lindsay Shopland, Jeanne B. Lawrence, Sheldon Penman, Jane B. Lian, Gary S. Stein & Scott W. Hiebert. (1997) Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-α transcription factors. Proceedings of the National Academy of Sciences 94:13, pages 6746-6751.
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S. Fears, M. Gavin, D.-E. Zhang, C. Hetherington, Y. Ben-David, J. D. Rowley & G. Nucifora. (1997) Functional characterization of ETV6 and ETV6/CBFA 2 in the regulation of the MCSFR proximal promoter . Proceedings of the National Academy of Sciences 94:5, pages 1949-1954.
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