PEBP2/CBF, the Murine Homolog of the Human Myeloid AML1 and PEBP2β/CBFβ Proto-oncoproteins, Regulates the Murine Myeloperoxidase and Neutrophil Elastase Genes in Immature Myeloid Cells

References

• Akira, S., H. Isshiki, T. Suguita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897–1906.
   PubMed Web of Science ®Google Scholar
• Almeida, R. P., M. Melchior, D. Campanelli, C. Nathan, and J. E. Gabay. 1991. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. Biochem. Biophys. Res. Commun. 177:688–695.
   PubMedGoogle Scholar
• Bae, S.-C., E. Ogawa, M. Maruyama, H. Oka, M. Satake, K. Shigesada, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and Y. Ito. 1994. PEBP2αB/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol. Cell. Biol. 14:3242–3252.
   PubMed Web of Science ®Google Scholar
• Bae, S.-C., Y. Yamaguchi-Iwai, E. Ogawa, M. Maruyama, M. Inuzuka, H. Kagoshima, K. Shigesada, M. Satake, and Y. Ito. 1993. Isolation of PEBP2aB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene 8:809–814.
   PubMed Web of Science ®Google Scholar
• Biedenkapp, H., U. Borgmeyer, A. E. Sippel, and K.-H. Klempnauer. 1988. Viral myb oncogene encodes a sequence-specific DNA binding activity. Nature (London) 335:835–837.
   PubMed Web of Science ®Google Scholar
• Böttinger, E. P., C. S. Shelley, O. C. Farokhzad, and M. A. Arnaout. 1994. The human β2 integrin CD018 promoter consists of two inverted Ets cis elements. Mol. Cell. Biol. 14:2604–2615.
   PubMedGoogle Scholar
• Chodosh, L. A., A. S. Baldwin, R. W. Carthew, and P. A. Sharp. 1988. Human CCAAT-binding proteins have heterologous sub-units. Cell 53:11–24.
   PubMed Web of Science ®Google Scholar
• Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform ex- traction. Anal. Biochem. 162:152–159.
   Google Scholar
• Davidson, I., J. H. Xiao, R. Rosales, A. Staub, and P. Chambon. 1988. The Hela cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence. Cell 54:931–942.
   PubMedGoogle Scholar
• Descombes, P., M. Chojkier, S. Lichsteiner, E. Falvey, and U. Schibler. 1990. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4:1541–1551.
   PubMedGoogle Scholar
• Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Erickson, P., J. Gao, K.-S. Chang, T. Look, E. Whisenant, S. Raimondi, R. Lasher, J. Trujillo, J. H. Rowley, and H. Drabkin. 1992. Identification of breakpoints in t(8;21) acute myeloid leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825–1831.
   PubMed Web of Science ®Google Scholar
• Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiola-beling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6–13.
   PubMed Web of Science ®Google Scholar
• Fouret, P., R. M. duBois, J.-F. Bernaudin, H. Takahashi, V. J. Ferrans, and R. G. Crystal. 1989. Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J. Exp. Med. 169:833–845.
   PubMed Web of Science ®Google Scholar
• Friedman, A. D., B. L. Krieder, D. Venturelli, and G. Rovera. 1991. Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13. Blood 78:2426–2432.
   PubMed Web of Science ®Google Scholar
• Hernandez-Munain, C., and M. S. Krangel. 1994. Regulation of the T-cell receptor δ enhancer by functional cooperation between c-Myb and core-binding factors. Mol. Cell. Biol. 14:473–483.
   PubMed Web of Science ®Google Scholar
• Johnson, K. R., I. Gemperlein, S. Hudson, S. Shane, and G. Rovera. 1989. Complete nucleotide sequence of the human myeloperoxidase gene. Nucleic Acids. Res. 17:7985–7986.
   PubMed Web of Science ®Google Scholar
• Johnson, P. F., W. H. Landschulz, Β. J. Graves, and S. L. McKnight. 1987. Identification of a rat liver nuclear protein that binds the enhancer core element of three animal viruses. Genes Dev. 1:133–146.
   PubMed Web of Science ®Google Scholar
• Jorgenson, K. F., G. R. Antoun, and I. F. Zipf. 1991. Chromatin structural analysis of the 5′ end and contiguous flanking region of the myeloperoxidase gene. Blood 77:159–164.
   PubMed Web of Science ®Google Scholar
• Kamachi, Y., E. Ogawa, M. Asano, S. Ishida, Y. Murakami, M. Satake, Y. Ito, and K. Shigesada. 1990. Purification of a mouse nuclear factor that binds to both the A and Β cores of the Polyomavirus enhancer. J. Virol. 64:4808–4819.
   PubMed Web of Science ®Google Scholar
• Kania, M. A., A. S. Bonner, J. B. Duffy, and J. P. Gergen. 1990. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 4:1701–1703.
   PubMed Web of Science ®Google Scholar
• Kit, S., D. R. Dubbs, L. J. Piekarski, and T. C. Hsu. 1963. Deletion of thymidine kinase activity from L cells resistant to bromode-oxyuridine. Exp. Cell Res. 31:297–312.
   PubMed Web of Science ®Google Scholar
• Lee, Κ. A., A. Bindereif, and M. R. Green. 1988. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Tech. 5:22–31.
   PubMedGoogle Scholar
• Liu, P., S. A. Tarle, A. Hajre, D. F. Claxton, P. Marlton, M. Freedman, M. J. Siciliano, and F. S. Collins. 1993. Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia. Science 261:1041–1044.
   PubMed Web of Science ®Google Scholar
• Lubbert, M., C. W. Miller, and H. P. Koeffler. 1991. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation. Blood 78:345–356.
   PubMed Web of Science ®Google Scholar
• Meyers, S., J. R. Downing, and S. W. Hiebert. 1993. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13:6336–6345.
   PubMed Web of Science ®Google Scholar
• Meyers, S., and S. Hiebert. Unpublished data.
   Google Scholar
• Mitani, K., S. Ogawa, H. Miyoshi, H. Mano, Υ. Yazaki, M. Ohki, and H. Hirai. 1994. Generation of the AML1/Evi-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis of chronic myelocytic leukemia. EMBO J. 13:504–510.
   PubMed Web of Science ®Google Scholar
• Miyoshi, Η., Τ. Kozu, Κ. Shimizu, Κ. Enomoto, Ν. Maseki, Y. Kaneko, Ν. Kamada, and M. Ohki. 1993. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 12:2715–2721.
   PubMed Web of Science ®Google Scholar
• Miyoshi, H., K. Shimizu, T. Kozu, N. Maseki, Y. Kaneko, and M. Ohki. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc. Natl. Acad. Sci. USA 88:10431–10434.
   PubMed Web of Science ®Google Scholar
• Murcurio, F., and M. Karin. 1989. Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner. EMBO J. 8:1455–1460.
   PubMedGoogle Scholar
• Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto. 1992. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79:460–466.
   PubMed Web of Science ®Google Scholar
• Nauseef, W. M., J. A. Metcalf, and R. K. Root. 1983. Role of myeloperoxidase in the respiratory burst of human neutrophils. Blood 79:460–466.
   Google Scholar
• Ness, S. A., E. Kowenz-Leutz, Τ. Casini, Τ. Graf, and A. Leutz. 1993. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7:749–459.
   PubMedGoogle Scholar
• Nucifora, G., C. R. Begy, P. Erickson, H. A. Drabkin, and J. D. Rowley. 1993. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER1. Proc. Natl. Acad. Sci. USA 90:7784–7788.
   PubMed Web of Science ®Google Scholar
• Ogawa, E., M. Inuzuka, M. Maruyamna, M. Satake, M. Naito-Fujimoto, Y. Ito, and K. Shigesada. 1993. Molecular cloning and characterization of PEBP2ß, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194:314–331.
   PubMed Web of Science ®Google Scholar
• Ogawa, E., M. Maruyama, H. Kagoshima, M. Inuzuka, J. Lu, M. Satake, K. Shigesada, and Y. Ito. 1993. PEBP2/PEA2 represents a family of transcription factors homolgous to the products of the Drosphila runt gene and the human AML1 gene. Proc. Natl. Acad. Sci. USA 90:6859–6863.
   PubMed Web of Science ®Google Scholar
• Pahi, H. L., R. J. Scheibe, H.-M. Chen, D.-E. Zhang, D. L. Galson, R. A. Maki, and D. G. Tenen. 1993. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J. Biol. Chem. 61:1053–1095.
   Google Scholar
• Pryzwansky, K. B., L. E. Martin, and J. K. Spitznagel. 1978. Immunocytochemical localization of myeloperoxidase, lactoferrin, lysozyme, and neutral proteases in human monocytes and neutrophilic granulocytes. J. Reticuloendothel. Soc. 24:295–310.
   PubMedGoogle Scholar
• Sagoh, T., and M. Yamada. 1988. Transcriptional regulation of myeloperoxidase gene expression in myeloid leukemia HL-60 cells during differentiation into granulocytes and macrophages. Arch. Biochem. Biophys. 262:599–604.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Sanger, F., and A. R. Coulson. 1975. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Mol. Biol. 94:441–448.
   PubMed Web of Science ®Google Scholar
• Satake, M., M. Inuzuka, K. Shigesada, T. Oikawa, and Y. Ito. 1992. Differential expression of subspecies of Polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells. Jpn. J. Cancer Res. 83:714–722.
   PubMedGoogle Scholar
• Scott, L. M., C. I. Civin, P. Rorth, and A. D. Friedman. 1992. A novel expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725–1735.
   PubMed Web of Science ®Google Scholar
• Shelley, C. S., O. C. Farokhzad, and M. A. Arnaout. 1993. Identification of cell specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CDlla gene. Proc. Natl. Acad. Sci. USA 90:5364–5368.
   PubMedGoogle Scholar
• Smith, M. 1985. In vitro mutagenesis. Annu. Rev. Genet. 19:423–463.
   PubMed Web of Science ®Google Scholar
• Stroble, H., M. Takimoto, O. Majdic, G. Fritsch, C. Scheinecker, P. Hocker, and W. Knapp. 1993. Myeloperoxidase expression in CD34+ normal human hematopoietic cells. Blood 82:2069–2078.
   PubMedGoogle Scholar
• Suzow, J., and A. D. Friedman. 1993. The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Mol. Cell. Biol. 13:2141–2151.
   PubMed Web of Science ®Google Scholar
• Takahashi, H., T. Nukiwa, P. Basset, and R. G. Crystal. 1988. Myelomonocytic cell lineage expression of the neutrophil elastase gene. J. Biol. Chem. 263:2543–2547.
   PubMed Web of Science ®Google Scholar
• Takahashi, H., T. Nukiwa, K. Yoshimura, C. D. Quick, D. J. States, M. D. Holmes, J. Whang-Peng, T. Knutsen, and R. G. Crystal. 1988. Structure of the human neutrophil elastase gene. J. Biol. Chem. 263:14739–14747.
   PubMed Web of Science ®Google Scholar
• Thornell, A., Β. Hallberg, and Τ. Grundstrom. 1988. Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3. Mol. Cell. Biol. 8:1625–1637.
   PubMedGoogle Scholar
• Tobler, A., C. W. Miller, K. R. Johnson, M. E. Selsted, G. Rovera, and P. Koeffler. 1988. Regulation of gene expression of myeloperoxidase during myeloid differentiation. J Cell. Physiol. 136:215–225.
   PubMed Web of Science ®Google Scholar
• Tsai, S., S. Bartelmez, R. Heyman, K. Damm, R. Evans, and S. J. Collins. 1992. A mutated retinoic acid receptor-α exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. Genes Dev. 6:2258–2269.
   PubMed Web of Science ®Google Scholar
• Valtieri, M., D. J. Tweardy, D. Caracciolo, Κ. Johnson, F. Mavilio, S. Altman, D. Snatoli, and G. Rovera. 1987. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 138:3829–3835.
   PubMed Web of Science ®Google Scholar
• van Zonneveld, A.-J., S. A. Curriden, and D. J. Loskutoff. 1988. Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc. Natl. Acad. Sci. USA 85:5525–5529.
   PubMedGoogle Scholar
• Venturelli, D., S. Bittenbender, and G. Rovera. 1989. Sequence of the murine myeloperoxidase (MPO) gene. Nucleic Acids Res. 17:7987–7988.
   PubMed Web of Science ®Google Scholar
• Wang, S., and N. A. Speck. 1992. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol. Cell. Biol. 12:89–102.
   PubMedGoogle Scholar
• Wang, S., Q. Wang, B. E. Crate, I. N. Melnikova, S. R. Keller, and N. A. Speck. 1993. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol. Cell. Biol. 13:3324–3339.
   PubMed Web of Science ®Google Scholar
• Warner, N. L., M. A. S. Moore, and D. Metcalf. 1969. A transplantable myelomonocytic leukemia in Balb/c mice: cytology, karyotype, and murimidase content. J. Natl. Cancer Inst. 43:963–982.
   PubMed Web of Science ®Google Scholar
• Weiher, Η., M. Konig, and P. Grass. 1983. Multiple point mutation affecting the simian virus 40 enhancer. Science 219:626–631.
   PubMed Web of Science ®Google Scholar
• Wilde, C. G., J. L. Snable, J. E. Griffith, and R. W. Scott. 1990. Characterization of two azurophil granule proteases with active-site homology to neutrophil elastase. J. Biol. Chem. 265:2038–2041.
   PubMed Web of Science ®Google Scholar
• Wotton, D., J. Ghysdael, S. Wang, N. A. Speck, and M. J. Owen. 1994. Cooperative binding of Ets-1 and core binding factor to DNA. Mol. Cell. Biol. 14:840–850.
   PubMed Web of Science ®Google Scholar
• Yoshimura, K., and R. G. Crystal. 1992. Transcriptional and posttranscriptional modulation of human neutrophil elastase gene expression. Blood 79:2733–2740.
   PubMedGoogle Scholar
• Zhang, D.-E., C. J. Hetherington, H.-M. Chen, and D. G. Tenen. 1994. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol. Cell. Biol. 14:373–381.
   PubMedGoogle Scholar