1
Views
17
CrossRef citations to date
0
Altmetric
Gene Expression

Position Independence and Proper Developmental Control of γ-Globin Gene Expression Require both a 5′ Locus Control Region and a Downstream Sequence Element

&
Pages 6087-6096 | Received 11 Apr 1994, Accepted 23 Jun 1994, Published online: 30 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Man Yu, Hemei Han, Ping Xiang, Qiliang Li & George Stamatoyannopoulos. (2006) Autonomous Silencing as Well as Competition Controls γ-Globin Gene Expression during Development. Molecular and Cellular Biology 26:13, pages 4775-4781.
Read now
Susanna Harju, Patrick A. Navas, George Stamatoyannopoulos & Kenneth R. Peterson. (2005) Genome Architecture of the Human β-Globin Locus Affects Developmental Regulation of Gene Expression. Molecular and Cellular Biology 25:20, pages 8765-8778.
Read now
Jane M. Mcinerney, Michael J. Nemeth & Christopher H. Lowrey. (1999) Slow and Steady Wins The Race? Progress in the Development of Vectors for Gene Therapy of β-Thalassemia and Sickle Cell Disease. Hematology 4:5, pages 437-455.
Read now
Patrick A. Navas, Kenneth R. Peterson, Qiliang Li, Eva Skarpidi, Alex Rohde, Sara E. Shaw, Christopher H. Clegg, Haruhiko Asano & George Stamatoyannopoulos. (1998) Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion. Molecular and Cellular Biology 18:7, pages 4188-4196.
Read now
Murat O. Arcasoy, Marc Romana, Mary E. Fabry, Eva Skarpidi, Ronald L. Nagel & Bernard G. Forget. (1997) High Levels of Human γ-Globin Gene Expression in Adult Mice Carrying a Transgene of Deletion-Type Hereditary Persistence of Fetal Hemoglobin. Molecular and Cellular Biology 17:4, pages 2076-2089.
Read now
M. H. Steinberg. (1996) Modulation of the Phenotypic Diversity of Sickle Cell Anemia. Hemoglobin 20:1, pages 1-19.
Read now

Articles from other publishers (10)

Fabrizio Martelli, Paola Verachi, Maria Zingariello, Maria Mazzarini, Alessandro M. Vannucchi, Annalisa Lonetti, Barbara Bacci, Giuseppe Sarli & Anna Rita Migliaccio. (2021) hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1low Mutation in Mice. Frontiers in Genetics 12.
Crossref
Hua Cao, Manfred Jung & George Stamatoyannopoulos. (2005) Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce γ gene expression in vivo. Experimental Hematology 33:12, pages 1443-1449.
Crossref
Qiliang Li, Xiangdong Fang, Hemei Han & George Stamatoyannopoulos. (2004) The minimal promoter plays a major role in silencing of the galago γ-globin gene in adult erythropoiesis. Proceedings of the National Academy of Sciences 101:21, pages 8096-8101.
Crossref
Karin M. L. Gaensler, Zemin Zhang, Chin Lin, Suya Yang, Karin Hardt & Linda Flebbe-Rehwaldt. (2003) Sequences in the A γ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus . Proceedings of the National Academy of Sciences 100:6, pages 3374-3379.
Crossref
Evangelia Skarpidi, Hua Cao, Birgit Heltweg, Brian F White, Ronald L Marhenke, Manfred Jung & George Stamatoyannopoulos. (2003) Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression. Experimental Hematology 31:3, pages 197-203.
Crossref
Zhi-Jun Duan, Xiangdong Fang, Alex Rohde, Hemei Han, George Stamatoyannopoulos & Qiliang Li. (2002) Developmental specificity of recruitment of TBP to the TATA box of the human γ-globin gene. Proceedings of the National Academy of Sciences 99:8, pages 5509-5514.
Crossref
Dmitry M. Shayakhmetov, Cheryl A. Carlson, Hartmut Stecher, Qiliang Li, George Stamatoyannopoulos & André Lieber. (2002) A High-Capacity, Capsid-Modified Hybrid Adenovirus/Adeno-Associated Virus Vector for Stable Transduction of Human Hematopoietic Cells. Journal of Virology 76:3, pages 1135-1143.
Crossref
Yoshiaki Onishi, Yuko Wada-Kiyama & Ryoiti Kiyama. (1998) Expression-dependent perturbation of nucleosomal phases at HS2 of the human β-LCR: possible correlation with periodic bent DNA. Journal of Molecular Biology 284:4, pages 989-1004.
Crossref
Qinghui Liu, Keiji Tanimoto, Jörg Bungert & James Douglas Engel. (1998) The Aγ-globin 3′ element provides no unique function(s) for human β-globin locus gene regulation. Proceedings of the National Academy of Sciences 95:17, pages 9944-9949.
Crossref
Qiliang Li, Christopher Clegg, Kenneth Peterson, Sara Shaw, Natacha Raich & George Stamatoyannopoulos. (1997) Binary transgenic mouse model for studying the trans control of globin gene switching: Evidence that GATA-1 is an in vivo repressor of human ɛ gene expression . Proceedings of the National Academy of Sciences 94:6, pages 2444-2448.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.