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Molecular and Cellular Biology Volume 6, 1986 - Issue 7
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Research Article

PEP4 Gene of Saccharomyces cerevisiae Encodes Proteinase A, a Vacuolar Enzyme Required for Processing of Vacuolar Precursors

Gustav Ammerer1 Zymogenetics, Inc., Seattle, Washington98103
,
Craig P. Hunter2 Institute of Molecular Biology, University of Oregon, Eugene, Oregon97403
,
Joel H. Rothman2 Institute of Molecular Biology, University of Oregon, Eugene, Oregon97403
,
Gene C. Saari1 Zymogenetics, Inc., Seattle, Washington98103
,
Luis A. Valls2 Institute of Molecular Biology, University of Oregon, Eugene, Oregon97403
&
Tom H. Stevens2 Institute of Molecular Biology, University of Oregon, Eugene, Oregon97403
Pages 2490-2499 | Received 26 Dec 1985, Accepted 07 Mar 1986, Published online: 31 Mar 2023

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Austin Folger, Chuan Chen, Marie-Helene Kabbaj, Karina Frey & Yanchang Wang. (2023) Neurodegenerative disease-associated inclusion bodies are cleared by selective autophagy in budding yeast. Autophagy Reports 2:1.
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Xin Wen, Damián Gatica, Zhangyuan Yin, Zehan Hu, Jörn Dengjel & Daniel J. Klionsky. (2020) The transcription factor Spt4-Spt5 complex regulates the expression of ATG8 and ATG41. Autophagy 16:7, pages 1172-1185.
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Katherine R. Parzych & Daniel J. Klionsky. (2019) Vacuolar hydrolysis and efflux: current knowledge and unanswered questions. Autophagy 15:2, pages 212-227.
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Karen A Hecht, Allyson F O’Donnell & Jeffrey L Brodsky. (2014) The proteolytic landscape of the yeast vacuole. Cellular Logistics 4:1.
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Surya P. Manandhar, Florante Ricarte, Stephanie M. Cocca & Editte Gharakhanian. (2013) Env7 Is a Novel Serine/Threonine Kinase 16-Related Protein Kinase and Negatively Regulates Organelle Fusion at the Lysosomal Vacuole. Molecular and Cellular Biology 33:3, pages 526-542.
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Usha Nair, Wei-Lien Yen, Muriel Mari, Yang Cao, Zhiping Xie, Misuzu Baba, Fulvio Reggiori & Daniel J Klionsky. (2012) A role for Atg8–PE deconjugation in autophagosome biogenesis. Autophagy 8:5, pages 780-793.
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Bruno Aluisio Coutinho de Assis Tacco, Juliana Alves Parente, Mônica Santiago Barbosa, Sônia Nairs Báo, Tércio de Souza Gsóes, Maristela Pereira & Célia Maria de Almeida Soares. (2009) Characterization of a secreted aspartyl protease of the fungal pathogen Paracoccidioides brasiliensis. Medical Mycology 47:8, pages 845-854.
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David J. Katzmann, Eric A. Epping & W. Scott Moye-Rowley. (1999) Mutational Disruption of Plasma Membrane Trafficking of Saccharomyces cerevisiae Yor1p, a Homologue of Mammalian Multidrug Resistance Protein. Molecular and Cellular Biology 19:4, pages 2998-3009.
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Steven F. Nothwehr, Nia J. Bryant & Tom H. Stevens. (1996) The Newly Identified Yeast GRD Genes Are Required for Retention of Late-Golgi Membrane Proteins. Molecular and Cellular Biology 16:6, pages 2700-2707.
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Kirk Ekena & Tom H. Stevens. (1995) The Saccharomyces cerevisiae MVP1 Gene Interacts with VPS1 and Is Required for Vacuolar Protein Sorting. Molecular and Cellular Biology 15:3, pages 1671-1678.
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Claus Bornæs, Mette W. Ignjatovic, Peter Schjerling, Morten C. Kielland-Brandt & Steen Holmberg. (1993) A Regulatory Element in the CHA1 Promoter Which Confers Inducibility by Serine and Threonine on Saccharomyces cerevisiae Genes. Molecular and Cellular Biology 13:12, pages 7604-7611.
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Pan Zheng, David S. Fay, Janet Burton, Hong Xiao, Jennifer L. Pinkham & David F. Stern. (1993) SPK1 Is an Essential S-Phase-Specific Gene of Saccharomyces cerevisiae That Encodes a Nuclear Serine/Threonine/Tyrosine Kinase. Molecular and Cellular Biology 13:9, pages 5829-5842.
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Claudio Brigati, Stephen Kurtz, Dina Balderes, Giorgio Vidali & David Shore. (1993) An Essential Yeast Gene Encoding a TTAGGG Repeat-Binding Protein. Molecular and Cellular Biology 13:2, pages 1306-1314.
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Yoshiyuki Imai & Masayuki Yamamoto. (1992) Schizosaccharomyces pombe sxal and sxa2 Encode Putative Proteases Involved in the Mating Response. Molecular and Cellular Biology 12:4, pages 1827-1834.
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Karen Blöchlinger & Heidi Diggelmann. (1992) Expression of the Mouse Mammary Tumor Virus ORF Gene in Cultured Cells. International Reviews of Immunology 8:4, pages 337-355.
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K. Takahashi. (1992) Gene structures of pepsinogens A and C. Scandinavian Journal of Clinical and Laboratory Investigation 52:sup210, pages 97-110.
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Jane S. Robinson, Todd R. Graham & Scott D. Emr. (1991) A Putative Zinc Finger Protein, Saccharomyces cerevisiae Vpsl8p, Affects Late Golgi Functions Required for Vacuolar Protein Sorting and Efficient α-Factor Prohormone Maturation. Molecular and Cellular Biology 11:12, pages 5813-5824.
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Robert A. Preston, Morris F. Manolson, Kathleen Becherer, Elaine Weidenhammer, David Kirkpatrick, Robin Wright & Elizabeth W. Jones. (1991) Isolation and Characterization of PEP3, a Gene Required for Vacuolar Biogenesis in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:12, pages 5801-5812.
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Charles M. Moehle & Alan G. Hinnebusch. (1991) Association of RAP1 Binding Sites with Stringent Control of Ribosomal Protein Gene Transcription in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:5, pages 2723-2735.
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Naoyuki Hayashi & Yasuji Oshima. (1991) Specific cis-Acting Sequence for PH08 Expression Interacts with PH04 Protein, a Positive Regulatory Factor, in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:2, pages 785-794.
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David Dailey, Gary L. Schieven, Moon Young Lim, Hans Marquardt, Thomas Gilmore, Jeremy Thorner & G. Steven Martin. (1990) Novel Yeast Protein Kinase (YPK1 Gene Product) Is a 40-Kilodalton Phosphotyrosyl Protein Associated with Protein-Tyrosine Kinase Activity. Molecular and Cellular Biology 10:12, pages 6244-6256.
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Carl T. Yamashiro, Patricia M. Kane, David F. Wolczyk, Robert A. Preston & Tom H. Stevens. (1990) Role of Vacuolar Acidification in Protein Sorting and Zymogen Activation: a Genetic Analysis of the Yeast Vacuolar Proton-Translocating ATPase. Molecular and Cellular Biology 10:7, pages 3737-3749.
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Yoh Wada, Katsuhiko Kitamoto, Toshio Kanbe, Kenji Tanaka & Yasuhiro Anraku. (1990) The SLP1 Gene of Saccharomyces cerevisiae Is Essential for Vacuolar Morphogenesis and Function. Molecular and Cellular Biology 10:5, pages 2214-2223.
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Jane S. Robinson, Daniel J. Klionsky, Lois M. Banta & Scott D. Emr. (1988) Protein Sorting in Saccharomyces cerevisiae: Isolation of Mutants Defective in the Delivery and Processing of Multiple Vacuolar Hydrolases. Molecular and Cellular Biology 8:11, pages 4936-4948.
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Sam Matoba, June Fukayama, Rod A. Wing & David M. Ogrydziak. (1988) Intracellular Precursors and Secretion of Alkaline Extracellular Protease of Yarrowia lipolytica. Molecular and Cellular Biology 8:11, pages 4904-4916.
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Daniel J. Klionsky, Lois M. Banta & Scott D. Emr. (1988) Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information. Molecular and Cellular Biology 8:5, pages 2105-2116.
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Charles M. Moehle, Richard Tizard, Sandra K. Lemmon, John Smart & Elizabeth W. Jones. (1987) Protease B of the Lysosomelike Vacuole of the Yeast Saccharomyces Cerevisiae Is Homologous to the Subtilisin Family of Serine Proteases. Molecular and Cellular Biology 7:12, pages 4390-4399.
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Articles from other publishers (7)

Pei-Heng Jiang, Chen-Yan Hou & Shu-Chun Teng. (2021) An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase. BMC Biology 19:1.
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Midori Umekawa. (2018) [Review] Metabolism of Mannoside Glycan and Nutrition Response in Yeast【ミニレビュー：―第6回応用糖質フレッシュシンポジウム―】　酵母におけるマンノシド糖鎖の細胞内代謝と栄養応答. Bulletin of Applied Glycoscience 8:3, pages 217-223.
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Hema Adhikari, Lauren M. Caccamise, Tanaya Pande & Paul J. Cullen. (2015) Comparative Analysis of Transmembrane Regulators of the Filamentous Growth Mitogen-Activated Protein Kinase Pathway Uncovers Functional and Regulatory Differences. Eukaryotic Cell 14:9, pages 868-883.
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Neha Sarode, Bethany Miracle, Xin Peng, Owen Ryan & Todd B. Reynolds. (2011) Vacuolar Protein Sorting Genes Regulate Mat Formation in Saccharomyces cerevisiae by Flo11p-Dependent and -Independent Mechanisms. Eukaryotic Cell 10:11, pages 1516-1526.
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Elżbieta Skrzypek, Tanya Myers-Morales, Sidney W. Whiteheart & Susan C. Straley. (2003) Application of a Saccharomyces cerevisiae Model To Study Requirements for Trafficking of Yersinia pestis YopM in Eucaryotic Cells . Infection and Immunity 71:2, pages 937-947.
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Mala B. Rao, Aparna M. Tanksale, Mohini S. Ghatge & Vasanti V. Deshpande. (1998) Molecular and Biotechnological Aspects of Microbial Proteases. Microbiology and Molecular Biology Reviews 62:3, pages 597-635.
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Nia J. Bryant & Tom H. Stevens. (1998) Vacuole Biogenesis in Saccharomyces cerevisiae : Protein Transport Pathways to the Yeast Vacuole . Microbiology and Molecular Biology Reviews 62:1, pages 230-247.
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