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Research Article

Rapid Cytoplasmic Turnover of c-myc mRNA: Requirement of the 3′ Untranslated Sequences

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Pages 4513-4521 | Received 08 May 1987, Accepted 09 Sep 1987, Published online: 31 Mar 2023

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Amy S. Farrell, Carl Pelz, Xiaoyan Wang, Colin J. Daniel, Zhiping Wang, Yulong Su, Mahnaz Janghorban, Xiaoli Zhang, Charlie Morgan, Soren Impey & Rosalie C. Sears. (2013) Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis. Molecular and Cellular Biology 33:15, pages 2930-2949.
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Kishore B. Challagundla, Xiao-Xin Sun, Xiaoli Zhang, Tiffany DeVine, Qinghong Zhang, Rosalie C. Sears & Mu-Shui Dai. (2011) Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress. Molecular and Cellular Biology 31:19, pages 4007-4021.
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Don Benjamin & Christoph Moroni. (2007) mRNA stability and cancer: an emerging link?. Expert Opinion on Biological Therapy 7:10, pages 1515-1529.
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Hugh K. Arnold & Rosalie C. Sears. (2006) Protein Phosphatase 2A Regulatory Subunit B56α Associates with c-Myc and Negatively Regulates c-Myc Accumulation. Molecular and Cellular Biology 26:7, pages 2832-2844.
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Laurent Créancier, Pascale Mercier, Anne-Catherine Prats & Dominique Morello. (2001) c-myc Internal Ribosome Entry Site Activity Is Developmentally Controlled and Subjected to a Strong Translational Repression in Adult Transgenic Mice. Molecular and Cellular Biology 21:5, pages 1833-1840.
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Georg Stoecklin, Xiu-Fen Ming, Renate Looser & Christoph Moroni. (2000) Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway. Molecular and Cellular Biology 20:11, pages 3753-3763.
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Gia K. Voeltz & Joan A. Steitz. (1998) AUUUA Sequences Direct mRNA Deadenylation Uncoupled from Decay during Xenopus Early Development. Molecular and Cellular Biology 18:12, pages 7537-7545.
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J. Eric Russell, Julia Morales, Aleksandr V. Makeyev & Stephen A. Liebhaber. (1998) Sequence Divergence in the 3′ Untranslated Regions of Human ζ- and α-Globin mRNAs Mediates a Difference in Their Stabilities and Contributes to Efficient α-to-ζ Gene Developmental Switching. Molecular and Cellular Biology 18:4, pages 2173-2183.
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Newman M. Yeilding & William M. F. Lee. (1997) Coding Elements in Exons 2 and 3 Target c-myc mRNA Downregulation during Myogenic Differentiation. Molecular and Cellular Biology 17:5, pages 2698-2707.
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Newman M. Yeilding, Muhammad T. Rehman & William M. F. Lee. (1996) Identification of Sequences in c-myc mRNA That Regulate Its Steady-State Levels. Molecular and Cellular Biology 16:7, pages 3511-3522.
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Anna Maria Curatola, Marcela S. Nadal & Robert J. Schneider. (1995) Rapid Degradation of AU-Rich Element (ARE) mRNAs Is Activated by Ribosome Transit and Blocked by Secondary Structure at Any Position 5′ to the ARE. Molecular and Cellular Biology 15:11, pages 6331-6340.
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Agnès Lavenu, Sergio Pistoi, Sandrine Pournin, Charles Babinet & Dominique Morello. (1995) Both Coding Exons Of The c-myc Gene Contribute to Its Posttranscriptional Regulation in the Quiescent Liver and Regenerating Liver and after Protein Synthesis Inhibition. Molecular and Cellular Biology 15:8, pages 4410-4419.
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Ana M. Zubiaga, Joel G. Belasco & Michael E. Greenberg. (1995) The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation. Molecular and Cellular Biology 15:4, pages 2219-2230.
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Jane M. Moseley, Matthew T. Gillespie & Mark A. Thiede. (1995) Parathyroid Hormone-Related Protein. Critical Reviews in Clinical Laboratory Sciences 32:3, pages 299-343.
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Chyi-Ying A. Chen & Ann-Bin Shyu. (1994) Selective Degradation of Early-Response-Gene mRNAs: Functional Analyses of Sequence Features of the AU-Rich Elements. Molecular and Cellular Biology 14:12, pages 8471-8482.
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Cathy A. Lagnado, Cheryl Y. Brown & Gregory J. Goodall. (1994) AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A). Molecular and Cellular Biology 14:12, pages 7984-7995.
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Rika Nanbu, Pierre-Alain Menoud & Yoshikuni Nagamine. (1994) Multiple Instability-Regulating Sites in the 3′ Untranslated Region of the Urokinase-Type Plasminogen Activator mRNA. Molecular and Cellular Biology 14:7, pages 4920-4928.
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Robin E. Dodson & David J. Shapiro. (1994) An Estrogen-Inducible Protein Binds Specifically to a Sequence in the 3′ Untranslated Region of Estrogen-Stabilized Vitellogenin mRNA. Molecular and Cellular Biology 14:5, pages 3130-3138.
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Chyi-Ying Chen, Tsuey-Ming Chen & Ann-Bin Shyu. (1994) Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Molecular and Cellular Biology 14:1, pages 416-426.
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Wei Zhang, Belinda J. Wagner, Karen Ehrenman, Andrew W. Schaefer, Christine T. DeMaria, Dinene Crater, Kristin DeHaven, Laura Long & Gary Brewer. (1993) Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1. Molecular and Cellular Biology 13:12, pages 7652-7665.
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Todd D. Levine, Fenbiao Gao, Peter H. King, Lucy G. Andrews & Jack D. Keene. (1993) Hel-N1: an Autoimmune RNA-Binding Protein with Specificity for 3' Uridylate-Rich Untranslated Regions of Growth Factor mRNAs. Molecular and Cellular Biology 13:6, pages 3494-3504.
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Vincent C. Bond & Barbara Wold. (1993) Nucleolar Localization of myc Transcripts. Molecular and Cellular Biology 13:6, pages 3221-3230.
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Nicole Schreiber-Agus, Jim Horner, Richard Torres, Fung-Chow Chiu & Ronald A. DePinho. (1993) Zebra Fish myc Family and max Genes: Differential Expression and Oncogenic Activity throughout Vertebrate Evolution. Molecular and Cellular Biology 13:5, pages 2765-2775.
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Jean Vacher, Sally A. Camper, Robb Krumlauf, Reid S. Compton & Shirley M. Tilghman. (1992) raf Regulates the Postnatal Repression of the Mouse α-Fetoprotein Gene at the Posttranscriptional Level. Molecular and Cellular Biology 12:2, pages 856-864.
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Louis J. Rezanka, Jennifer L. Rojko & James C. Neil. (1992) Feline Leukemia Virus: Pathogenesis of Neoplastic Disease. Cancer Investigation 10:5, pages 371-389.
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Nadya L. Lumelsky & Bernard G. Forget. (1991) Negative Regulation of Globin Gene Expression during Megakaryocytic Differentiation of a Human Erythroleukemic Cell Line. Molecular and Cellular Biology 11:7, pages 3528-3536.
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Evangelia Vakalopoulou, Jerome Schaack & Thomas Shenk. (1991) A 32-Kilodalton Protein Binds to AU-Rich Domains in the 3′ Untranslated Regions of Rapidly Degraded mRNAs. Molecular and Cellular Biology 11:6, pages 3355-3364.
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Paul R. Bohjanen, Bronislawa Petryniak, Carl H. June, Craig B. Thompson & Tullia Lindsten. (1991) An Inducible Cytoplasmic Factor (AU-B) Binds Selectively to AUUUA Multimers in the 3′ Untranslated Region of Lymphokine mRNA. Molecular and Cellular Biology 11:6, pages 3288-3295.
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Gary Brewer. (1991) An A+U-Rich Element RNA-Binding Factor Regulates c-myc mRNA Stability In Vitro. Molecular and Cellular Biology 11:5, pages 2460-2466.
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Lee E. Babiss & Jeffrey M. Friedman. (1990) Regulation of N-myc Gene Expression: Use of an Adenovirus Vector To Demonstrate Posttranscriptional Control. Molecular and Cellular Biology 10:12, pages 6700-6708.
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Ite A. Laird-Offringa, Carla L. De Wit, Peter Elfferich & Alex J. Van Der Eb. (1990) Poly(A) Tail Shortening Is the Translation-Dependent Step in c-myc mRNA Degradation. Molecular and Cellular Biology 10:12, pages 6132-6140.
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Ruth E. Wager & Richard K. Assoian. (1990) A Phorbol Ester-Regulated Ribonuclease System Controlling Transforming Growth Factor β1 Gene Expression in Hematopoietic Cells. Molecular and Cellular Biology 10:11, pages 5983-5990.
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Mark A. Labow, Steven B. Baim, Thomas Shenk & Arnold J. Levine. (1990) Conversion of the lac Repressor into an Allosterically Regulated Transcriptional Activator for Mammalian Cells. Molecular and Cellular Biology 10:7, pages 3343-3356.
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David Herrick, Roy Parker & Allan Jacobson. (1990) Identification and Comparison of Stable and Unstable mRNAs in Saccharomyces cerevisiae. Molecular and Cellular Biology 10:5, pages 2269-2284.
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Lisa-Anne Whittemore & Tom Maniatis. (1990) Postinduction Turnoff of Beta-Interferon Gene Expression. Molecular and Cellular Biology 10:4, pages 1329-1337.
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Susan E. Mango, Gregory D. Schuler, Mary Ellen R. Steele & Michael D. Cole. (1989) Germ Line c-myc Is Not Down-Regulated by Loss or Exclusion of Activating Factors in myc-Induced Macrophage Tumors. Molecular and Cellular Biology 9:8, pages 3482-3490.
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Gary Brewer & Jeffrey Ross. (1989) Regulation of c-myc mRNA Stability In Vitro by a Labile Destabilizer with an Essential Nucleic Acid Component. Molecular and Cellular Biology 9:5, pages 1996-2006.
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Jacek Kowalski & David T. Denhardt. (1989) Regulation of the mRNA for Monocyte-Derived NeutrophilActivating Peptide in Differentiating HL60 Promyelocytes. Molecular and Cellular Biology 9:5, pages 1946-1957.
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Karen S. Kabnick & David E. Housman. (1988) Determinants that Contribute to Cytoplasmic Stability of Human c-fos and β-Globin mRNAs are Located at Several Sites in Each mRNA. Molecular and Cellular Biology 8:8, pages 3244-3250.
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Neil Parkin, André Darveau, Robert Nicholson & Nahum Sonenberg. (1988) cis-Acting Translational Effects of the 5′ Noncoding Region of c-myc mRNA. Molecular and Cellular Biology 8:7, pages 2875-2883.
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Rui Pei & Kathryn Calame. (1988) Differential Stability of c-myc mRNAS in a Cell-Free System. Molecular and Cellular Biology 8:7, pages 2860-2868.
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Mohit Sachdeva, Shoumin Zhu, Fangting Wu, Hailong Wu, Vijay Walia, Sumit Kumar, Randolph Elble, Kounosuke Watabe & Yin-Yuan Mo. (2009) p53 represses c-Myc through induction of the tumor suppressor miR-145 . Proceedings of the National Academy of Sciences 106:9, pages 3207-3212.
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Shanhai Xie, Hui Lin, Tong Sun & Ralph B Arlinghaus. (2002) Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene 21:47, pages 7137-7146.
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Darja Kanduc. (2002) Translational Regulation of Human Papillomavirus Type 16 E7 mRNA by the Peptide SEQIKA, Shared by Rabbit α 1 -Globin and Human Cytokeratin 7 . Journal of Virology 76:14, pages 7040-7048.
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Francina Langa, Isabelle Lafon, Sandrine Vandormael-Pournin, Michel Vidaud, Charles Babinet & Dominique Morello. (2001) Healthy mice with an altered c-myc gene: role of the 3′ untranslated region revisited. Oncogene 20:32, pages 4344-4353.
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