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Molecular and Cellular Biology Volume 8, 1988 - Issue 4
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Research Article

The Carboxy Terminus of pp60c-src is a Regulatory Domain and is Involved in Complex Formation with the Middle-T Antigen of Polyomavirus

Seng H. Cheng1 Laboratory of Cellular Regulation, Integrated Genetics Inc., 31 New York Avenue, Framingham, Massachusetts01701
,
Helen Piwnica-Worms2 Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts02115
,
Robert W. Harvey1 Laboratory of Cellular Regulation, Integrated Genetics Inc., 31 New York Avenue, Framingham, Massachusetts01701
,
Thomas M. Roberts2 Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts02115
&
Alan E. Smith1 Laboratory of Cellular Regulation, Integrated Genetics Inc., 31 New York Avenue, Framingham, Massachusetts01701
Pages 1736-1747 | Received 03 Nov 1987, Accepted 19 Jan 1988, Published online: 31 Mar 2023

Citations (11)

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Read on this site (8)

Qun-Xing Zhang & Graham S. Baldwin. (1994) Platelet-Derived Growth Factor Induces Phosphatidylinositol 3-Kinase Release from the Middle T-pp60c-src Complex and Association with the Platelet-Derived Growth Factor Receptor. Growth Factors 10:1, pages 41-51.
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Kirsten B. Bibbins, Helene Boeuf & Harold E. Varmus. (1993) Binding of the Src SH2 Domain to Phosphopeptides is Determined by Residues in both the SH2 Domain and the Phosphopeptides. Molecular and Cellular Biology 13:12, pages 7278-7287.
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Reed E. Drews, Victor T.-W. Chan & Lowell E. Schnipper. (1992) Oncogenes Result in Genomic Alterations That Activate a Transcriptionally Silent, Dominantly Selectable Reporter Gene (neo). Molecular and Cellular Biology 12:1, pages 198-206.
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Bradley S. Cobb, D. Michael Payne, Albert B. Reynolds & J. Thomas Parsons. (1991) Regulation of the Oncogenic Activity of the Cellular src Protein Requires the Correct Spacing between the Kinase Domain and the C-Terminal Phosphorylated Tyrosine (Tyr-527). Molecular and Cellular Biology 11:12, pages 5832-5838.
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Seng H. Cheng, Pearl C. Espino, John Marshall, Robert Harvey & Alan E. Smith. (1990) Stoichiometry of Cellular and Viral Components in the Polyomavirus Middle-T Antigen-Tyrosine Kinase Complex. Molecular and Cellular Biology 10:10, pages 5569-5574.
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Robert Harvey, Kathleen M. Hehir, Alan E. Smith & Seng H. Cheng. (1989) pp60c- Variants Containing Lesions That Affect Phosphorylation at Tyrosines 416 and 527. Molecular and Cellular Biology 9:9, pages 3647-3656.
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Alasdair Macauley & Jonathan A. Cooper. (1989) Structural Differences between Repressed and Derepressed Forms of p60c-. Molecular and Cellular Biology 9:6, pages 2648-2656.
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Alasdair MacAuley & Jonathan A. Cooper. (1988) The Carboxy-Terminal Sequence of p56 Can Regulate p60c-. Molecular and Cellular Biology 8:8, pages 3560-3564.
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Articles from other publishers (3)

Michele M. Fluck & Brian S. Schaffhausen. (2009) Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen. Microbiology and Molecular Biology Reviews 73:3, pages 542-563.
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Natalia Ichaso & Stephen M Dilworth. (2001) Cell transformation by the middle T-antigen of polyoma virus. Oncogene 20:54, pages 7908-7916.
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Keith A. Gottlieb & Luis P. Villarreal. (2001) Natural Biology of Polyomavirus Middle T Antigen. Microbiology and Molecular Biology Reviews 65:2, pages 288-318.
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