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Molecular and Cellular Biology Volume 9, 1989 - Issue 12
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Gene Expression

Discrete Mutations Introduced in the Predicted Nucleotide-Binding Sites of the mdr1 Gene Abolish Its Ability To Confer Multidrug Resistance

Marie AzzariaDepartment of Biochemistry, McGill University, Montreal, Quebec, CanadaH3G IY6
,
Erwin SchurrDepartment of Biochemistry, McGill University, Montreal, Quebec, CanadaH3G IY6
&
Philippe GrosDepartment of Biochemistry, McGill University, Montreal, Quebec, CanadaH3G IY6
Pages 5289-5297 | Received 13 Jun 1989, Accepted 16 Aug 1989, Published online: 31 Mar 2023

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Tomris Özben & Ilhan Akan. (2004) Rapid Production of Chicken Egg Yolk Antibodies Against Multidrug Resistance-Associated Protein 1 (MRP-1). Critical Reviews in Analytical Chemistry 34:3-4, pages 195-199.
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Patrick Chène. (2003) The ATPases: a new family for a family-based drug design approach. Expert Opinion on Therapeutic Targets 7:3, pages 453-461.
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Christina M. Trambas, H. Konrad Muller & Gregory M. Woods. (1997) P-glycoprotein mediated multidrug resistance and its implications for pathology. Pathology 29:2, pages 122-130.
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James R. Woodhouse & David R. Ferry. (1995) The Genetic Basis of Resistance to Cancer Chemotherapy. Annals of Medicine 27:2, pages 157-167.
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Libin Ma, Antonia Westbroek, Aart G. Jochemsen, Geert Weeda, Anne Bosch, Dirk Bootsma, Jan H. J. Hoeijmakers & Alex J. Van Der Eb. (1994) Mutational Analysis of ERCC3, Which Is Involved in DNA Repair and Transcription Initiation: Identification of Domains Essential for the DNA Repair Function. Molecular and Cellular Biology 14:6, pages 4126-4134.
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Ahmad R. Safa. (1993) Photoaffinity Labeling of P-Glycoprotein in Multidrug-Resistant Cells. Cancer Investigation 11:1, pages 46-56.
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Ahmad R. Safa. (1992) Photoaffinity Labeling of P-Glycoprotein in Multidrug-Resistant Cells. Cancer Investigation 10:4, pages 295-305.
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Richard J. Gregory, Devra P. Rich, Seng H. Cheng, David W. Souza, Sucharita Paul, Parthasarathy Manavalan, Matthew P. Anderson, Michael J. Welsh & Alan E. Smith. (1991) Maturation and Function of Cystic Fibrosis Transmembrane Conductance Regulator Variants Bearing Mutations in Putative Nucleotide-Binding Domains 1 and 2. Molecular and Cellular Biology 11:8, pages 3886-3893.
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Juan C. Vera, Gonzalo R. Castillo & Ora M. Rosen. (1991) A Possible Role for a Mammalian Facilitative Hexose Transporter in the Development of Resistance to Drugs. Molecular and Cellular Biology 11:7, pages 3407-3418.
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Ellen Buschman & Philippe Gros. (1991) Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes. Molecular and Cellular Biology 11:2, pages 595-603.
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Jane A. Endicott, Farida Sarangi & Victor Ling. (1991) Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family. DNA Sequence 2:2, pages 89-101.
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Maarit I. Tiirikainen & Tom Krusius. (1991) Multidrug Resistance. Annals of Medicine 23:5, pages 509-520.
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Philippe Gros & Chaim Shustik. (1991) Multidrug Resistance: A Novel Class of Membrane-Associated Transport Proteins is Identified. Cancer Investigation 9:5, pages 563-569.
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P. Borst. (1991) Genetic Mechanisms of Drug Resistance: A Review. Acta Oncologica 30:1, pages 87-105.
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Martine Raymond, Elise Rose, David E. Housman & Philippe Gros. (1990) Physical Mapping, Amplification, and Overexpression of the Mouse mdr Gene Family in Multidrug-Resistant Cells. Molecular and Cellular Biology 10:4, pages 1642-1651.
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Articles from other publishers (8)

Erin E. Fetsch & Amy L. Davidson. (2002) Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter. Proceedings of the National Academy of Sciences 99:15, pages 9685-9690.
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Tip W. Loo & David M. Clarke. (2002) Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site. Proceedings of the National Academy of Sciences 99:6, pages 3511-3516.
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Amy L. Davidson. (2002) Mechanism of Coupling of Transport to Hydrolysis in Bacterial ATP-Binding Cassette Transporters. Journal of Bacteriology 184:5, pages 1225-1233.
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Frank ReimannFrances M. AshcroftFiona M. Gribble. (2001) Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action. Diabetes 50:10, pages 2253-2259.
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Jaana T. Karttunen, Paul J. Lehner, Soma Sen Gupta, Eric W. Hewitt & Peter Cresswell. (2001) Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP). Proceedings of the National Academy of Sciences 98:13, pages 7431-7436.
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Susan Sharma & Amy L. Davidson. (2000) Vanadate-Induced Trapping of Nucleotides by Purified Maltose Transport Complex Requires ATP Hydrolysis. Journal of Bacteriology 182:23, pages 6570-6576.
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Roberto T. F. Celis, Peter F. Leadlay, Ipsita Roy & Anne Hansen. (1998) Phosphorylation of the Periplasmic Binding Protein in Two Transport Systems for Arginine Incorporation in Escherichia coli K-12 Is Unrelated to the Function of the Transport System . Journal of Bacteriology 180:18, pages 4828-4833.
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Saibal Dey, Muralidhara Ramachandra, Ira Pastan, Michael M. Gottesman & Suresh V. Ambudkar. (1997) Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proceedings of the National Academy of Sciences 94:20, pages 10594-10599.
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