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Redox Report
Communications in Free Radical Research
Volume 6, 2001 - Issue 3
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Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role

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Pages 143-151 | Published online: 19 Jul 2013

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Ming-Chieh Shun, Weiping Yu, Abdul Gapor, Rachel Parsons, Jeffrey Atkinson, Bob G. Sanders & Kimberly Kline. (2004) Pro-apoptotic Mechanisms of Action of a Novel Vitamin E Analog (α-TEA) and a Naturally Occurring Form of Vitamin E (δ-Tocotrienol) in MDA-MB-435 Human Breast Cancer Cells. Nutrition and Cancer 48:1, pages 95-105.
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Articles from other publishers (37)

Guangzheng Ma, Wenya Chong, Yuan Qi, Zeping Lu, Zihan Zhang, Binbin Nian & Yi Hu. (2023) Can vitamin E ester derivatives be excellent alternatives of vitamin E: state of art. Bioprocess and Biosystems Engineering 46:12, pages 1695-1709.
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Sachiho Taniguchi, Yuji Ono, Yukako Doi, Shogo Taniguchi, Yuta Matsuura, Ayuka Iwasaki, Noriaki Hirata, Ryosuke Fukuda, Keitaro Inoue, Miho Yamaguchi, Anju Tashiro, Daichi Egami, Shunsuke Aoki, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Hiroyuki Kumeta, Tomohide Saio & Tsukasa Okiyoneda. (2023) Identification of α-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis. Biochemical Pharmacology 215, pages 115730.
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Zsófia Kőhidai, Angéla Takács, Eszter Lajkó, Zoltán Géczi, Éva Pállinger, Orsolya Láng & László Kőhidai. (2022) The effects of mouthwashes in human gingiva epithelial progenitor (HGEPp) cells. Clinical Oral Investigations 26:6, pages 4559-4574.
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Seher Gok, Oleksandr Kuzmenko, Andrii Babinskyi & Feride Severcan. (2021) Vitamin E Derivative with Modified Side Chain Induced Apoptosis by Modulating the Cellular Lipids and Membrane Dynamics in MCF7 Cells. Cell Biochemistry and Biophysics 79:2, pages 271-287.
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Michał Ciebiera, Mohamed Ali, Magdalena Zgliczyńska, Maciej Skrzypczak & Ayman Al-Hendy. (2020) Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. International Journal of Molecular Sciences 21:15, pages 5528.
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Carlos Godoy-Parejo, Chunhao Deng, Yumeng Zhang, Weiwei Liu & Guokai Chen. (2019) Roles of vitamins in stem cells. Cellular and Molecular Life Sciences 77:9, pages 1771-1791.
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Elisa Dalla Pozza, Ilaria Dando, Raffaella Pacchiana, Elio Liboi, Maria Teresa Scupoli, Massimo Donadelli & Marta Palmieri. (2020) Regulation of succinate dehydrogenase and role of succinate in cancer. Seminars in Cell & Developmental Biology 98, pages 4-14.
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Paul W. Sylvester. 2019. Vitamin E in Human Health. Vitamin E in Human Health 125 140 .
Yaru Jing, Rongxiu Zhu, Chengbu Liu & Dongju Zhang. (2017) Theoretical Elucidation of the Mechanism and Kinetic Experimental Phenomena on the Esterification of α-Tocopherol with Succinic Anhydride: Catalysis of a Histidine Derivative vs an Imidazolium-Based Ionic Liquid. The Journal of Organic Chemistry 82:23, pages 12267-12275.
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M. A. Savitskaya & G. E. Onischenko. (2016) α-Tocopheryl succinate affects malignant cell viability, proliferation, and differentiation. Biochemistry (Moscow) 81:8, pages 806-818.
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Xiu-Xiu Chen, Feng-Feng Xie, Xiu-Jie Zhu, Feng Lin, Shi-Shi Pan, Li-Hua Gong, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Xiao-Long Mei, You-Qiu Xue, Wu-Ming Qin, Zhi Shi & Xiao-Jian Yan. (2015) Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer. Oncotarget 6:17, pages 14926-14939.
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Katarina Kluckova, Ayanachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong & Jiri Neuzil. (2013) Mitochondrial complex II, a novel target for anti-cancer agents. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1827:5, pages 552-564.
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Dave Lanoix, Andrée-Anne Lacasse, Russel J. Reiter & Cathy Vaillancourt. (2012) Melatonin: The smart killer. Molecular and Cellular Endocrinology 348:1, pages 1-11.
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Izabela J. Rzepczynska, Nastaran Foyouzi, Piotr C. Piotrowski, Ciler Celik-Ozenci, Amanda Cress & Antoni J. Duleba. (2011) Antioxidants Induce Apoptosis of Rat Ovarian Theca-Interstitial Cells1. Biology of Reproduction 84:1, pages 162-166.
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. 2011. A Guide to Evidence-based Integrative and Complementary Medicine. A Guide to Evidence-based Integrative and Complementary Medicine 200 247 .
Yvette Drabsch, Robert G Ramsay & Thomas J Gonda. (2010) MYBsuppresses differentiation and apoptosis of human breast cancer cells. Breast Cancer Research 12:4.
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Toshiyuki Otsuka, Satoshi Hagiwara, Hiroki Tojima, Hiroaki Yoshida, Tetsushi Takahashi, Kazumi Nagasaka, Shinichi Tomioka, Tetsu Ando, Kunio Takeuchi, Takayuki Kori, Yoshihiro Ohno, Satoru Kakizaki, Hitoshi Takagi & Masatomo Mori. (2007) Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration. Internal Medicine 46:11, pages 711-716.
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Marco Tomasetti & Jiri Neuzil. 2007. Vitamin E. Vitamin E 463 491 .
Kimberly Kline, Karla A. Lawson, Weiping Yu & Bob G. Sanders. 2007. Vitamin E. Vitamin E 435 461 .
Paul W. Sylvester. 2007. Vitamin E. Vitamin E 329 356 .
Angelo Azzi & Jean-Marc Zingg. 2006. Phytochemicals. Phytochemicals 175 206 .
Lalitha V. Ramanathapuram, Tobias Hahn, Michael W. Graner, Emmanuel Katsanis & Emmanuel T. Akporiaye. (2005) Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines. Cancer Immunology, Immunotherapy 55:2, pages 166-177.
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Yoshihisa Yano, Haruna Satoh, Keiko Fukumoto, Itsumaro Kumadaki, Tomio Ichikawa, Kazuhiko Yamada, Kiyokazu Hagiwara & Tomohiro Yano. (2005) Induction of cytotoxicity in human lung adenocarcinoma cells by 6‐ O ‐carboxypropyl‐α‐tocotrienol, a redox‐silent derivative of α‐tocotrienol . International Journal of Cancer 115:5, pages 839-846.
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Kimberly Kline, Weiping Yu & Bob G. Sanders. (2004) Vitamin E and Breast Cancer. The Journal of Nutrition 134:12, pages 3458S-3462S.
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Kristen Anderson, Marla Simmons-Menchaca, Karla A. Lawson, Jeffrey Atkinson, Bob G. Sanders & Kimberly Kline. (2004) Differential Response of Human Ovarian Cancer Cells to Induction of Apoptosis by Vitamin E Succinate and Vitamin E Analogue, α-TEA. Cancer Research 64:12, pages 4263-4269.
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Adelina Munteanu, Jean-Marc Zingg, Esra Ogru, Roksan Libinaki, Robert Gianello, Simon West, Yesim Negis & Angelo Azzi. (2004) Modulation of cell proliferation and gene expression by α-tocopheryl phosphates: relevance to atherosclerosis and inflammation. Biochemical and Biophysical Research Communications 318:1, pages 311-316.
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Kentaro Kogure, Susumu Hama, Mayumi Kisaki, Hideaki Takemasa, Akira Tokumura, Ichiro Suzuki & Kenji Fukuzawa. (2004) Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of α-tocopheryl esters. Biochimica et Biophysica Acta (BBA) - General Subjects 1672:2, pages 93-99.
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Peter Jacobs & Lucille Wood. (2004) Macronutrients. Disease-a-Month 50:2, pages 69-75.
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Kentaro Kogure & Kenji Fukuzawa. (2004) Tocopheryl Succinate—Versatile Functions due to Its Unique Physicochemical Properties. Journal of Clinical Biochemistry and Nutrition 35:1, pages 29-34.
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G. Riccioni, N. D'Orazio, V. Menna & A. De Lorenzo. (2016) Fat Soluble Vitamins and Immune System: An Overview. European Journal of Inflammation 1:2, pages 59-64.
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Kentaro Kogure, Sachie Manabe, Susumu Hama, Akira Tokumura & Kenji Fukuzawa. (2003) Potentiation of anti-cancer effect by intravenous administration of vesiculated α-tocopheryl hemisuccinate on mouse melanoma in vivo. Cancer Letters 192:1, pages 19-24.
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Kentaro Kogure, Susumu Hama, Sachie Manabe, Akira Tokumura & Kenji Fukuzawa. (2002) High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems. Cancer Letters 186:2, pages 151-156.
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Yen-Chou Chen, Shing-Chuan Shen, Woan-Ruoh Lee, Foun-Lin Hsu, Hui-Yi Lin, Ching-Huai Ko & Shi-Wen Tseng. (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochemical Pharmacology 64:12, pages 1713-1724.
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Kevin T. Barnett, Frida D. Fokum & Mokenge P. Malafa. (2002) Vitamin E Succinate Inhibits Colon Cancer Liver Metastases. Journal of Surgical Research 106:2, pages 292-298.
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Yu Zhang, Jing Ni, Edward M. Messing, Eugene Chang, Chin-Rang Yang & Shuyuan Yeh. (2002) Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proceedings of the National Academy of Sciences 99:11, pages 7408-7413.
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Kentaro Kogure, Motoki Morita, Susumu Hama, Sawa Nakashima, Akira Tokumura & Kenji Fukuzawa. (2002) Enhancement by α‐tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon‐γ through the upregulation of protein kinase C in rat vascular smooth muscle cells. European Journal of Biochemistry 269:9, pages 2367-2372.
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Jiri Neuzil. (2002) α-Tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion. Biochemical and Biophysical Research Communications 293:5, pages 1309-1313.
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