Publication Cover
Redox Report
Communications in Free Radical Research
Volume 8, 2003 - Issue 2
535
Views
68
CrossRef citations to date
0
Altmetric
Review

An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse

, , , , &
Pages 69-79 | Published online: 19 Jul 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Mostafa Saif-Elnasr, Nahed Abdel-Aziz & Ahmed Ibrahim El-Batal. (2019) Ameliorative effect of selenium nanoparticles and fish oil on cisplatin and gamma irradiation-induced nephrotoxicity in male albino rats. Drug and Chemical Toxicology 42:1, pages 94-103.
Read now
P.F. Surai, I.I. Kochish & V.I. Fisinin. (2018) Glutathione peroxidases in poultry biology: Part 1. Classification and mechanisms of action. World's Poultry Science Journal 74:2, pages 185-198.
Read now
S. M. Tan, A. Sharma, N. Stefanovic & J. B. de Haan. (2015) Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy. Free Radical Research 49:3, pages 219-227.
Read now
Ezekiel U. Nwose, Herbert F. Jelinek, Ross S. Richards & Philip G. Kerr. (2006) Changes in the erythrocyte glutathione concentration in the course of diabetes mellitus. Redox Report 11:3, pages 99-104.
Read now

Articles from other publishers (63)

Wenyi Wu, Jianan Zheng, Ru Wang & Yibing Wang. (2023) Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators. Biochemical Pharmacology 218, pages 115863.
Crossref
Tabael L. Turan, Holger J. Klein, Julian Hackler, Livia Hoerner, Eddy Rijntjes, Theresia Reding Graf, Jan A. Plock & Lutz Schomburg. (2023) Serum Selenium-Binding Protein 1 (SELENBP1) in Burn Injury: A Potential Biomarker of Disease Severity and Clinical Course. Antioxidants 12:11, pages 1927.
Crossref
Domenico Lapenna. (2023) Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful Aging. Ageing Research Reviews, pages 102066.
Crossref
Yikun Wu, Hua Shi, Yuangao Xu, Rao Wen, Maodi Gong, Guangyi Hong & Shuxiong Xu. (2022) Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia–Reperfusion Injury in Rats and Ebselen Intervention Effects. Biological Trace Element Research 201:4, pages 1792-1805.
Crossref
Xi Yan, Zeping Zhao, Jeremy Weaver, Tao Sun, Jun-Won Yun, Carol A. Roneker, Fenghua Hu, Nicolai M. Doliba, Charles Chipley W. McCormick, Marko Z. Vatamaniuk & Xin Gen Lei. (2022) Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction. Redox Biology 56, pages 102457.
Crossref
Louise Woodhams, Tin Fei Sim, Leanne Chalmers, Bu Yeap, Daniel Green, Markus Schlaich, Carl Schultz & Graham Hillis. (2021) Diabetic kidney disease in type 2 diabetes: a review of pathogenic mechanisms, patient-related factors and therapeutic options. PeerJ 9, pages e11070.
Crossref
Chisato Kinoshita & Koji Aoyama. (2021) The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione. International Journal of Molecular Sciences 22:8, pages 4245.
Crossref
Elizabeth S. Greene, Nima K. Emami & Sami Dridi. (2021) Research Note: Phytobiotics modulate the expression profile of circulating inflammasome and cyto(chemo)kine in whole blood of broilers exposed to cyclic heat stress. Poultry Science 100:3, pages 100801.
Crossref
Mustafa B. Acar, Domenico Aprile, Serife Ayaz-Guner, Huseyin Guner, Coskun Tez, Giovanni Di Bernardo, Gianfranco Peluso, Servet Ozcan & Umberto Galderisi. (2021) Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis. International Journal of Molecular Sciences 22:4, pages 2064.
Crossref
Naomi Perry, Laura Martin, Frank Rosenfeldt, Ruchong Ou, Renee Rowsell & Con Stough. 2021. Nutraceuticals in Brain Health and Beyond. Nutraceuticals in Brain Health and Beyond 57 80 .
Jakob Appel Østergaard, Mark Emmanuel Cooper & Karin Agnes Maria Jandeleit-Dahm. (2020) Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease. Journal of Nephrology 33:5, pages 917-929.
Crossref
Nayoung Ahn. (2020) Effects of Combine Exercise on HSP70 and SOD1 Expression of Aorta, Skeletal Muscle and Myocardium in High Fat Diet induced Obese Aging Rats. Exercise Science 29:3, pages 248-255.
Crossref
Katharina Bell, Ines Rosignol, Elena Sierra-Filardi, Natalia Rodriguez-Muela, Carsten Schmelter, Francesco Cecconi, Franz Grus & Patricia Boya. (2020) Age related retinal Ganglion cell susceptibility in context of autophagy deficiency. Cell Death Discovery 6:1.
Crossref
Gaurav Singhal, Julie Morgan, Magdalene C. Jawahar, Frances Corrigan, Emily J. Jaehne, Catherine Toben, James Breen, Stephen M. Pederson, Jim Manavis, Anthony J. Hannan & Bernhard T. Baune. (2020) Effects of aging on the motor, cognitive and affective behaviors, neuroimmune responses and hippocampal gene expression. Behavioural Brain Research 383, pages 112501.
Crossref
Vidisha Tomer, Ashwani Kumar, Kritika Gupta, Swati Shukla & Shafiya Rafiq. 2020. Antioxidants in Vegetables and Nuts - Properties and Health Benefits. Antioxidants in Vegetables and Nuts - Properties and Health Benefits 385 422 .
Martha A. Sánchez-Rodríguez, Mariano Zacarías-Flores, Alicia Arronte-Rosales & Víctor Manuel Mendoza-Núñez. (2019) Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study. PLOS ONE 14:9, pages e0214264.
Crossref
Shanshan Lin, Aiguo Ren, Linlin Wang, Yun Huang, Yuanyuan Wang, Caiyun Wang & Nicholas D. Greene. (2018) Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects. Free Radical Biology and Medicine 116, pages 149-158.
Crossref
Yang Jiao, Yirong Wang, Shanchun Guo & Guangdi Wang. (2017) Glutathione peroxidases as oncotargets. Oncotarget 8:45, pages 80093-80102.
Crossref
Susanne Kluge, Sander Bekeschus, Claudia Bender, Hicham Benkhai, Axel Sckell, Harald Below, Matthias B. Stope & Axel Kramer. (2016) Investigating the Mutagenicity of a Cold Argon-Plasma Jet in an HET-MN Model. PLOS ONE 11:9, pages e0160667.
Crossref
Srdjan Ljubisavljevic, Tatjana Cvetkovic, Lilika Zvezdanovic, Svetlana Stojanovic, Ivana Stojanovic, Gordana Kocic, Miroslava Zivkovic, Lidija Paunovic, Ljiljana Milenkovic, Dragisa Lukic, Jelena Stamenovic & Dusica Pavlovic. (2015) The Differences in the Cellular and Plasma Antioxidative Capacity Between Transient and Defined Focal Brain Ischemia: Does it Suggest Supporting Time-Dependent Neuroprotection Therapy?. Cellular and Molecular Neurobiology 36:5, pages 789-800.
Crossref
Arpeeta Sharma, Derek Yuen, Olivier Huet, Raelene Pickering, Nada Stefanovic, Pascal Bernatchez & Judy B. de Haan. (2016) Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium. Vascular Pharmacology 79, pages 32-42.
Crossref
Anke Schmidt, Thomas von Woedtke & Sander Bekeschus. (2016) Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin . Oxidative Medicine and Cellular Longevity 2016, pages 1-17.
Crossref
Junling Guo, Xiaowei Wang, Darren C. Henstridge, Joseph J. Richardson, Jiwei Cui, Arpeeta Sharma, Mark A. Febbraio, Karlheinz Peter, Judy B. de Haan, Christoph E. Hagemeyer & Frank Caruso. (2015) Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide. Advanced Healthcare Materials 4:14, pages 2170-2175.
Crossref
Giacinta Guarini, Alda Huqi, Doralisa Morrone, Paola Capozza, Giancarlo Todiere & Mario Marzilli. (2014) Pharmacological approaches to coronary microvascular dysfunction. Pharmacology & Therapeutics 144:3, pages 283-302.
Crossref
Arpeeta Sharma & Judy B. de Haan. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 3467 3491 .
Ding Yuan, Hongwu Wang, Haibo He, Liangliang Jia, Yumin He, Ting Wang, Xiao Zeng, Yuzhou Li, Shouchao Li & Changcheng Zhang. (2014) Protective Effects of Total Flavonoids from Epimedium on the Male Mouse Reproductive System Against Cyclophosphamide-Induced Oxidative Injury by Up-Regulating the Expressions of SOD3 and GPX1 . Phytotherapy Research 28:1, pages 88-97.
Crossref
Jade de Oliveira, Eduardo Luiz Gasnhar Moreira, Gianni Mancini, Mariana Appel Hort, Alexandra Latini, Rosa Maria Ribeiro-do-Valle, Marcelo Farina, João Batista Teixeira da Rocha & Andreza Fabro de Bem. (2013) Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice. Neurochemical Research 38:10, pages 2028-2036.
Crossref
Fei Cheng, Michael Torzewski, Adriana Degreif, Heidi Rossmann, Antje Canisius & Karl J. Lackner. (2013) Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis. PLoS ONE 8:8, pages e72063.
Crossref
E.T. Mohammed & G.M. Safwat. (2013) Assessment of the ameliorative role of selenium nanoparticles on the oxidative stress of acetaminophen in some tissues of male albino rats. Beni-Suef University Journal of Basic and Applied Sciences 2:2, pages 80-85.
Crossref
Frank Wagener, Carine Carels & Ditte Lundvig. (2013) Targeting the Redox Balance in Inflammatory Skin Conditions. International Journal of Molecular Sciences 14:5, pages 9126-9167.
Crossref
Sarah McCann & Carli Roulston. (2013) NADPH Oxidase as a Therapeutic Target for Neuroprotection against Ischaemic Stroke: Future Perspectives. Brain Sciences 3:4, pages 561-598.
Crossref
Franklin Rosenfeldt, Mark Wilson, Geraldine Lee, Christina Kure, Ruchong Ou, Lesley Braun & Judy de Haan. (2013) Oxidative stress in surgery in an ageing population: Pathophysiology and therapy. Experimental Gerontology 48:1, pages 45-54.
Crossref
Sirous Sadeghian, Gholam Ali Kojouri & Abdonnaser Mohebbi. (2011) Nanoparticles of Selenium as Species with Stronger Physiological Effects in Sheep in Comparison with Sodium Selenite. Biological Trace Element Research 146:3, pages 302-308.
Crossref
Arpeeta Sharma, Pascal N. Bernatchez & Judy B. de Haan. (2012) Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes. International Journal of Vascular Medicine 2012, pages 1-12.
Crossref
Bhagyalakshmi Neelwarne & Jyothi Maria Veigas. 2012. Emerging Trends in Dietary Components for Preventing and Combating Disease. Emerging Trends in Dietary Components for Preventing and Combating Disease 487 519 .
CONNIE H.Y. WONG, LATASHA D. ABEYNAIKE, PETER J. CRACK & MICHAEL J. HICKEY. (2011) Divergent Roles of Glutathione Peroxidase-1 (Gpx1) in Regulation of Leukocyte-Endothelial Cell Interactions in the Inflamed Cerebral Microvasculature. Microcirculation 18:1, pages 12-23.
Crossref
Judy B. de Haan, Karin A. Jandeleit-Dahm & Terri J. Allen. 2011. Studies on Experimental Models. Studies on Experimental Models 3 38 .
Esther Shohami & Ron Kohen. 2011. Oxidative Stress and Free Radical Damage in Neurology. Oxidative Stress and Free Radical Damage in Neurology 99 118 .
Phyllis ChewDerek Y.C. YuenNada StefanovicJosefa PeteMelinda T. CoughlanKarin A. Jandeleit-DahmMerlin C. ThomasFranklin RosenfeldtMark E. CooperJudy B. de Haan. (2010) Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse. Diabetes 59:12, pages 3198-3207.
Crossref
Yan Xu, Chika Saegusa, Angelica Schehr, Shawn Grant, Jeffrey A. Whitsett & Machiko Ikegami. (2009) C/EBPα is required for pulmonary cytoprotection during hyperoxia. American Journal of Physiology-Lung Cellular and Molecular Physiology 297:2, pages L286-L298.
Crossref
Phyllis ChewDerek Y.C. YuenPhilip KohNada StefanovicMark A. FebbraioIsmail KolaMark E. CooperJudy B. de Haan. (2009) Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse. Arteriosclerosis, Thrombosis, and Vascular Biology 29:6, pages 823-830.
Crossref
Diane E. Handy, Edith Lubos, Yi Yang, John D. Galbraith, Neil Kelly, Ying-Yi Zhang, Jane A. Leopold & Joseph Loscalzo. (2009) Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses. Journal of Biological Chemistry 284:18, pages 11913-11921.
Crossref
Atsuko Kamijo-Ikemori, Takeshi Sugaya, Ayako Sekizuka, Kazuaki Hirata & Kenjiro Kimura. (2009) Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice. Nephrology Dialysis Transplantation 24:3, pages 788-800.
Crossref
JW Holder. (2008) Analysis of chloroethane toxicity and carcinogenicity including a comparison with bromoethane. Toxicology and Industrial Health 24:10, pages 655-675.
Crossref
Dean P. Jones. (2008) Radical-free biology of oxidative stress. American Journal of Physiology-Cell Physiology 295:4, pages C849-C868.
Crossref
Sophocles ChrissobolisSean P. DidionDale A. KinzenbawLaura I. SchraderSanjana DayalSteven R. LentzFrank M. Faraci. (2008) Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II–Induced Vascular Dysfunction. Hypertension 51:4, pages 872-877.
Crossref
A. B. Salmon, A. A. S. Akha, R. Buffenstein & R. A. Miller. (2008) Fibroblasts From Naked Mole-Rats Are Resistant to Multiple Forms of Cell Injury, But Sensitive to Peroxide, Ultraviolet Light, and Endoplasmic Reticulum Stress. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63:3, pages 232-241.
Crossref
Helen E. Gruber, Jean-Luc Mougeot, Gretchen Hoelscher, Jane A. Ingram & Edward N. HanleyJrJr. (2007) Microarray Analysis of Laser Capture Microdissected-Anulus Cells From the Human Intervertebral Disc. Spine 32:11, pages 1181-1187.
Crossref
Paul LewisNada StefanovicJosefa PeteAnna C. CalkinSara GiuntiVicki Thallas-BonkeKarin A. Jandeleit-DahmTerri J. AllenIsmail KolaMark E. CooperJudy B. de Haan. (2007) Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice. Circulation 115:16, pages 2178-2187.
Crossref
Viera Danielisová, Miroslav Gottlieb, Miroslava Némethová & Jozef Burda. (2007) Activities of endogenous antioxidant enzymes in the cerebrospinal fluid and the hippocampus after transient forebrain ischemia in rat. Journal of the Neurological Sciences 253:1-2, pages 61-65.
Crossref
Margarita L. Alexandrova & Petyo G. Bochev. 2007. Oxidative Stress and Neurodegenerative Disorders. Oxidative Stress and Neurodegenerative Disorders 313 368 .
Atsuko Kamijo-Ikemori, Takeshi Sugaya, Ayako Obama, Junya Hiroi, Hiroshi Miura, Minoru Watanabe, Toshio Kumai, Ritsuko Ohtani-Kaneko, Kazuaki Hirata & Kenjiro Kimura. (2006) Liver-Type Fatty Acid-Binding Protein Attenuates Renal Injury Induced by Unilateral Ureteral Obstruction. The American Journal of Pathology 169:4, pages 1107-1117.
Crossref
Sukkyoo Lee, H. Stella Shin, Paula K. Shireman, Aphrodite Vasilaki, Holly Van Remmen & Marie E. Csete. (2006) Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radical Biology and Medicine 41:7, pages 1174-1184.
Crossref
Judy B. de Haan, Paul K. Witting, Nada Stefanovic, Josefa Pete, Michael Daskalakis, Ismail Kola, Roland Stocker & Joseph J. Smolich. (2006) Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. Journal of Lipid Research 47:6, pages 1157-1167.
Crossref
Alexandra Stolzing & Andrew Scutt. (2006) Age-related impairment of mesenchymal progenitor cell function. Aging Cell 5:3, pages 213-224.
Crossref
Ahmad A. Elesber, Piero O. Bonetti & Amir Lerman. (2006) Endothelial function and cerebrovascular disease: Implications for diagnosis and treatment. Current Treatment Options in Cardiovascular Medicine 8:3, pages 213-219.
Crossref
Sara M Beni, Jeanna Tsenter, Alexander G Alexandrovich, Nili Galron-Krool, Ari Barzilai, Ron Kohen, Nikolas Grigoriadis, Constantina Simeonidou & Esther Shohami. (2005) CuZn-SOD Deficiency, Rather than Overexpression, is Associated with Enhanced Recovery and Attenuated Activation of NF- κ B After Brain Trauma in Mice . Journal of Cerebral Blood Flow & Metabolism 26:4, pages 478-490.
Crossref
Cindy D. Davis & John A. Milner. 2006. Selenium. Selenium 367 378 .
Judy B. de Haan, Nada Stefanovic, David Nikolic-Paterson, Lyndee L. Scurr, Kevin D. Croft, Trevor A. Mori, Paul Hertzog, Ismail Kola, Robert C. Atkins & Gregory H. Tesch. (2005) Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. American Journal of Physiology-Renal Physiology 289:3, pages F544-F551.
Crossref
Margarita L. Alexandrova & Petyo G. Bochev. (2005) Oxidative stress during the chronic phase after stroke. Free Radical Biology and Medicine 39:3, pages 297-316.
Crossref
Gabriele Saretzki, Lyle Armstrong, Alan Leake, Majlinda Lako & Thomas von Zglinicki. (2008) Stress Defense in Murine Embryonic Stem Cells Is Superior to That of Various Differentiated Murine Cells. STEM CELLS 22:6, pages 962-971.
Crossref
Jürgen Zitzler, Dieter Link, Rolf Schäfer, Wolfgang Liebetrau, Michael Kazinski, Angelika Bonin-Debs, Christian Behl, Peter Buckel & Ulrich Brinkmann. (2004) High-throughput Functional Genomics Identifies Genes That Ameliorate Toxicity Due to Oxidative Stress in Neuronal HT-22 Cells. Molecular & Cellular Proteomics 3:8, pages 834-840.
Crossref
Jinsong Zhang, Huali Wang, Yongping Bao & Lide Zhang. (2004) Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sciences 75:2, pages 237-244.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.