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Redox Report
Communications in Free Radical Research
Volume 11, 2006 - Issue 3
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Research articles

Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species

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Pages 136-142 | Published online: 19 Jul 2013

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Bruna R. B. Gomes, Marina Firmino, Jardeson S. Jorge, Maria L. O. Ferreira, Thays M. Rodovalho, Simone N. Weis, Gloria E. P. Souza, Paulo C. Morais, Marcelo V. Sousa, Paulo E. N. Souza & Fabiane H. Veiga-Souza. (2018) Increase of reactive oxygen species in different tissues during lipopolysaccharide-induced fever and antipyresis: an electron paramagnetic resonance study. Free Radical Research 52:3, pages 351-361.
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Prakash S. Nayak, B. Narayana, B.K. Sarojini, Sana Sheik, K.S. Shashidhara & K.R. Chandrashekar. (2016) Design, synthesis, molecular docking and biological evaluation of imides, pyridazines, and imidazoles derived from itaconic anhydride for potential antioxidant and antimicrobial activities. Journal of Taibah University for Science 10:6, pages 823-838.
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Diana Couto, Daniela Ribeiro, Marisa Freitas, Ana Gomes, José L. F. C. Lima & Eduarda Fernandes. (2010) Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine. Redox Report 15:6, pages 259-267.
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David Costa, Ana Gomes, José L.F.C. Lima & Eduarda Fernandes. (2008) Singlet oxygen scavenging activity of non-steroidal anti-inflammatory drugs. Redox Report 13:4, pages 153-160.
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Articles from other publishers (25)

Venkatasamy Meenatchi, Ankur Sood, Rakesh Bhaskar & Sung Soo Han. (2024) Electrospun hydroxypropyl-β-cyclodextrin nanofibers loaded with anti-inflammatory drugs for potential therapeutic wound dressings. Journal of Molecular Liquids 393, pages 123558.
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Naresh Damuka, Nagaraju Bashetti, Akiva Mintz, Avinash H. Bansode, Mack Miller, Ivan Krizan, Cristina Furdui, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, JV Shanmukha Kumar, Gagan Deep, Greg Dugan, Mark Cline & Kiran Kumar Solingapuram Sai. (2022) [18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates. Biomedicine & Pharmacotherapy 156, pages 113937.
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Lorena M. Gomes, Daniele A. Moysés, Henrique F. S. Nascimento, Tatiane C. Mota, Lais T. Bonfim, Plínio C. S. Cardoso, Rommel M. R. Burbano & Marcelo O. Bahia. (2021) Genotoxic and cytotoxic effects of the drug dipyrone sodium in African green monkey kidney (Vero) cell line exposed in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology 394:7, pages 1529-1535.
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Minaxi Saini, Dinesh Kumar Mehta & Rina Das. (2020) Biological Evaluation and Molecular Docking Studies of Synthesized 5-Substituted-2-chlorophenyl-4-chloro Derivatives Bearing Pyridazinone Moiety. Letters in Organic Chemistry 17:3, pages 170-183.
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Wafaa S. Hamama, Moustafa A. Gouda, Hadwah A. Kamal El‐din & Hanafi H. Zoorob. (2019) Highlights on the synthesis of novel phenothiazine‐based azines scaffold as antioxidant agents. Journal of Heterocyclic Chemistry 57:1, pages 257-267.
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Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui & Akiva Mintz. (2019) Initial biological evaluations of 18F-KS1, a novel ascorbate derivative to image oxidative stress in cancer. EJNMMI Research 9:1.
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Mathias Lutz. (2019) Metamizole (Dipyrone) and the Liver: A Review of the Literature. The Journal of Clinical Pharmacology 59:11, pages 1433-1442.
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Ziqi Tao, Sobhi M. Gomha, Mohamed G. Badrey, Tamer T. El-Idreesy & Taha M. A. Eldebss. (2018) Novel 4-Heteroaryl-antipyrines: Synthesis, Molecular Docking, and Evaluation as Potential Anti-breast Cancer Agents. Journal of Heterocyclic Chemistry 55:10, pages 2408-2416.
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Galal H. Elgemeie, Mamdouh A. Abu-Zaied & Samah A. Loutfy. (2017) 4-Aminoantipyrine in carbohydrate research: Design, synthesis and anticancer activity of thioglycosides of a novel class of 4-aminoantipyrines and their corresponding pyrazolopyrimidine and pyrazolopyridine thioglycosides. Tetrahedron 73:40, pages 5853-5861.
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Wafaa S. Hamama, Moustafa A. Gouda, Hadwah A. Kamal El-din & Hanafi H. Zoorob. (2017) Synthesis and Antioxidant Activity of Some New Binary Pyrazoles Containing Core Phenothiazine Moiety. Journal of Heterocyclic Chemistry 54:2, pages 1369-1377.
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Moustafa A. Gouda, Moged A. Berghot, Ghada E. Abd El-Ghani & Abd El-Galil M. Khalil. (2016) Synthesis and Antioxidant Evaluation of Some Nicotinonitriles. Journal of Heterocyclic Chemistry 53:4, pages 1241-1250.
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Chai-Siah Lee, Muoi Tang, Sheau-Ling Ho & Yan-Ping Chen. (2015) Recrystallization and Micronization of 4-Dimethylaminoantipyrine Using the Rapid Expansion of Supercritical Solution (RESS) Process. International Journal of Chemical Engineering and Applications 6:6, pages 427-431.
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Moustafa A. Gouda. (2015) Synthesis and Antioxidant Evaluation of Some New Pyridopyrazolotriazine Derivatives. Journal of Heterocyclic Chemistry 52:4, pages 990-998.
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Moustafa Ahmed Gouda & Mohamed Hamdy Helal. (2015) Synthesis and antioxidant evaluation of some new pyridines. European Journal of Chemistry 6:1, pages 84-87.
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Galal H. Elgemeie, Mamdouh Abouzeid & Peter G. Jones. (2015) Crystal structure of 4-{[(cyanoimino)(methylsulfanyl)methyl]amino}-1,5-dimethyl-2-phenyl-2,3-dihydro-1 H -pyrazol-3-one . Acta Crystallographica Section E Crystallographic Communications 71:1, pages 104-106.
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M.A. Metwally, M.A. Gouda, Ammar N. Harmal & A.M. Khalil. (2012) Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety. European Journal of Medicinal Chemistry 56, pages 254-262.
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Ana Gomes, Diana Couto, Andreia Alves, Irene Dias, Marisa Freitas, Graça Porto, José Alberto Duarte & Eduarda Fernandes. (2012) Trihydroxyflavones with antioxidant and anti-inflammatory efficacy. BioFactors 38:5, pages 378-386.
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Mohammad Sayed Alam, Jung-Hyun Choi & Dong-Ung Lee. (2012) Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity. Bioorganic & Medicinal Chemistry 20:13, pages 4103-4108.
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C. Remes, A. Paun, I. Zarafu, M. Tudose, M.T. Caproiu, G. Ionita, C. Bleotu, L. Matei & P. Ionita. (2012) Chemical and biological evaluation of some new antipyrine derivatives with particular properties. Bioorganic Chemistry 41-42, pages 6-12.
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Joana P. N. Ribeiro, Luís M. Magalhães, Marcela A. Segundo, Salette Reis & José L. F. C. Lima. (2010) Fully automatic flow method for the determination of scavenging capacity against nitric oxide radicals. Analytical and Bioanalytical Chemistry 397:7, pages 3005-3014.
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Pedro M.P. Santos, Alexandra M.M. Antunes, João Noronha, Eduarda Fernandes & Abel J.S.C. Vieira. (2010) Scavenging activity of aminoantipyrines against hydroxyl radical. European Journal of Medicinal Chemistry 45:6, pages 2258-2264.
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Ana Gomes, Eduarda Fernandes, Artur M.S. Silva, Diana C.G.A. Pinto, Clementina M.M. Santos, José A.S. Cavaleiro & José L.F.C. Lima. (2009) Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways. Biochemical Pharmacology 78:2, pages 171-177.
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Luís M. Magalhães, Marcela A. Segundo, Salette Reis & José L.F.C. Lima. (2008) Methodological aspects about in vitro evaluation of antioxidant properties. Analytica Chimica Acta 613:1, pages 1-19.
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T Saussele, O Burk, J K Blievernicht, K Klein, A Nussler, N Nussler, J G Hengstler, M Eichelbaum, M Schwab & U M Zanger. (2007) Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole. Clinical Pharmacology & Therapeutics 82:3, pages 265-274.
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S C Pierre, R Schmidt, C Brenneis, M Michaelis, G Geisslinger & K Scholich. (2007) Inhibition of Cyclooxygenases by Dipyrone. British Journal of Pharmacology 151:4, pages 494-503.
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